CD83.md
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CD83 mutations in B-cell lymphomas have not been as extensively studied as mutations in some other genes. CD83 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
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No notable hot spots have been described in this gene in the context of the cancers listed below.
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-Mutations in this gene were first described in DLBCL in 2013 by Morin et al<sup>2</sup>, in BL in 2019 by Panea et al<sup>3</sup> and in FL in 2023 by Russler-Germain et al.<sup>4</sup>
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+Mutations in this gene were first described in DLBCL in 2013 by Morin et al<sup>[@morinMutationalStructuralAnalysis2013]</sup>, in BL in 2019 by Panea et al<sup>[@paneaWholeGenomeLandscape2019]</sup> and in FL in 2023 by Russler-Germain et al.<sup>[@russler-germainMutationsAssociatedProgression2023]</sup>
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@dunsCharacterizationDLBCLPMBL2021]|
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-|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene [@morinMutationalStructuralAnalysis2013; @schmitzGeneticsPathogenesisDiffuse2018; @reddyGeneticFunctionalDrivers2017]|
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-|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene [@russler-germainMutationsAssociatedProgression2023]|
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-|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@paneaWholeGenomeLandscape2019]|
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+|![DLBCL](images/icons/DLBCL_tier1.png) |1 | aSHM target and high-confidence DLBCL gene [@morinMutationalStructuralAnalysis2013; @schmitzGeneticsPathogenesisDiffuse2018; @reddyGeneticFunctionalDrivers2017]|
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+|![FL](images/icons/FL_tier1.png) |1 | aSHM target and high-confidence FL gene [@russler-germainMutationsAssociatedProgression2023]|
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+|![BL](images/icons/BL_tier2.png) |2 | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@paneaWholeGenomeLandscape2019]|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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