DLBCL_genes.md
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@@ -82,7 +82,7 @@ link-citations: true
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|[KLHL14](KLHL14)|Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013], FE[@choiRegulationCellReceptordependent2020], CE[@hodkinsonBiomarkersResponseIbrutinib2021]|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)|||
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|[KLHL6](KLHL6)|Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@merirantaDisruptionKLHL6Fuels2024]|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)|[@ganapathiGeneticLandscapeDural2016]||
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|[KMT2C](KMT2C)|Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013]|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)|[@sarkozyMutationalLandscapeGray2021a; @zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019]||
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-|[KMT2D](KMT2D)|Tier 1 GE[@morinFrequentMutationHistonemodifying2011]|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)|[@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]||
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+|[KMT2D](KMT2D)|Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@liLossCREBBPKMT2D2024], CE[@rushtonGeneticEvolutionaryPatterns2020]|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)|[@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]||
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|[KRAS](KRAS)|Tier 1 GE[@lohrDiscoveryPrioritizationSomatic2012a]|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)|||
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|[LCOR](LCOR)|Tier 1 GE[@arthurGenomewideDiscoverySomatic2018]|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)|||
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|[LRRN3](LRRN3)|Tier 1 GE[@zhangGeneticHeterogeneityDiffuse2013]|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)|[@sarkozyMutationalLandscapeGray2021a]||
morinlab.bib
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@@ -1,3 +1,23 @@
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+@article{liLossCREBBPKMT2D2024,
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+ title = {Loss of {{CREBBP}} and {{KMT2D}} Cooperate to Accelerate Lymphomagenesis and Shape the Lymphoma Immune Microenvironment},
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+ author = {Li, Jie and Chin, Christopher R. and Ying, Hsia-Yuan and Meydan, Cem and Teater, Matthew R. and Xia, Min and Farinha, Pedro and Takata, Katsuyoshi and Chu, Chi-Shuen and Jiang, Yiyue and Eagles, Jenna and Passerini, Verena and Tang, Zhanyun and Rivas, Martin A. and Weigert, Oliver and Pugh, Trevor J. and Chadburn, Amy and Steidl, Christian and Scott, David W. and Roeder, Robert G. and Mason, Christopher E. and Zappasodi, Roberta and Béguelin, Wendy and Melnick, Ari M.},
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+ date = {2024-04-03},
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+ journaltitle = {Nature Communications},
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+ shortjournal = {Nat Commun},
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+ volume = {15},
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+ number = {1},
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+ eprint = {38570506},
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+ eprinttype = {pmid},
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+ pages = {2879},
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+ issn = {2041-1723},
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+ doi = {10.1038/s41467-024-47012-1},
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+ abstract = {Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploinsufficiency of Crebbp and Kmt2d induces a more severe mouse lymphoma phenotype (vs either allele alone) and unexpectedly confers an immune evasive microenvironment manifesting as CD8+ T-cell exhaustion and reduced infiltration. This is linked to profound repression of immune synapse genes that mediate crosstalk with T-cells, resulting in aberrant GC B cell fate decisions. From the epigenetic perspective, we observe interaction and mutually dependent binding and function of CREBBP and KMT2D on chromatin. Their combined deficiency preferentially impairs activation of immune synapse-responsive super-enhancers, pointing to a particular dependency for both co-activators at these specialized regulatory elements. Together, our data provide an example where chromatin modifier mutations cooperatively shape and induce an immune-evasive microenvironment to facilitate lymphomagenesis.},
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+ langid = {english},
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+ pmcid = {PMC10991284},
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+ keywords = {Animals,B-Lymphocytes,Chromatin,Germinal Center,Lymphoma Large B-Cell Diffuse,Mice,Mutation,Tumor Microenvironment},
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+ file = {/Users/rmorin/Zotero/storage/PMMR6G3L/Li et al. - 2024 - Loss of CREBBP and KMT2D cooperate to accelerate l.pdf}
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+}
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+
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@article{merirantaDisruptionKLHL6Fuels2024,
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title = {Disruption of {{KLHL6 Fuels Oncogenic Antigen Receptor Signaling}} in {{B-cell Lymphoma}}},
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author = {Meriranta, Leo and Sorri, Selma and Huse, Kanutte and Liu, Xiaonan and Spasevska, Ivana and Zafar, Sadia and Chowdhury, Iftekhar and Dufva, Olli and Sahlberg, Eerika and Tandaric, Luka and Karjalainen-Lindsberg, Marja-Liisa and Hyytiainen, Marko and Varjosalo, Markku and Myklebust, June H. and Leppa, Sirpa},