DICER1.md
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[[_TOC_]]
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-<<Warn("The variants reported in this gene in DLBCL failed QC")>>
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-Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)
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## Relevance tier by entity
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|:------:|:----:|-----------------------------------------|
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|![DLBCL](images/icons/DLBCL_tier2.png) |3 |Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]|
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+<<Warn("The variants reported in this gene in DLBCL failed QC")>>
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+Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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|Entity|source |frequency (%)|
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|DLBCL |Reddy cohort |1.10 |
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|DLBCL |Chapuy cohort |2.56 |
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## Mutation pattern and selective pressure estimates
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[[include:dnds_DICER1.md]]
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[[include:browser_DICER1.md]]
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## Expression
SETD5.md
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[[_TOC_]]
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-<<Warn("Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)")>>
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## Relevance tier by entity
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|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@tiacciPervasiveMutationsJAKSTAT2018]|
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|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established[@reddyGeneticFunctionalDrivers2017]|
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+<<Warn("The variants reported in this gene in DLBCL failed QC")>>
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+Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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|Entity|source |frequency (%)|
YY1.md
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[[_TOC_]]
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-<<Warn("Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)")>>
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## Relevance tier by entity
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|:------:|:----:|-----------------------------------------|
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|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established[@reddyGeneticFunctionalDrivers2017; @chapuyMolecularSubtypesDiffuse2018]|
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+<<Warn("The variants reported in this gene in DLBCL failed QC")>>
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+Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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|Entity|source |frequency (%)|
ZFX.md
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|:------:|:----:|-----------------------------------------|
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|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established[@reddyGeneticFunctionalDrivers2017]|
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+<<Warn("The variants reported in this gene in DLBCL failed QC")>>
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+Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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|Entity|source |frequency (%)|
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|DLBCL |Reddy cohort |1.40 |
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|DLBCL |Chapuy cohort |0.43 |
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-<<Warn("Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)")>>
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## Mutation pattern and selective pressure estimates