fix format

# DLC1

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2014-05-08 : Zhang : MCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |1.697 |0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DLC1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DLC1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DLC1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DLC1_hg38.html)

## DLC1 Expression

<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->

<!-- MCL: zhangGenomicLandscapeMantle2014 -->

## References

1. Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.

# DLGAP1

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2012-12-01 : Love : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.682 |0 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DLGAP1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DLGAP1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DLGAP1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DLGAP1_hg38.html)

## DLGAP1 Expression

<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->

<!-- BL: loveGeneticLandscapeMutations2012 -->

## References

1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

# DNAH5

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

2013-08-15 : Morin : DLBCL

2017-07-27 : Jallades : MZL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |1.327 |0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DNAH5_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DNAH5_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DNAH5.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DNAH5_hg38.html)

## DNAH5 Expression

<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->

<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->

<!-- MZL: jalladesExomeSequencingIdentifies2017 -->

## References

1. Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992

2. Jallades L, Baseggio L, Sujobert P, Huet S, Chabane K, Callet-Bauchu E, Verney A, Hayette S, Desvignes JP, Salgado D, Levy N, Béroud C, Felman P, Berger F, Magaud JP, Genestier L, Salles G, Traverse-Glehen A. Exome sequencing identifies recurrent BCOR alterations and the absence of KLF2, TNFAIP3 and MYD88 mutations in splenic diffuse red pulp small B-cell lymphoma. Haematologica. 2017 Oct;102(10):1758–1766. PMCID: PMC5622860

# DNM2

## History

Mutations in this gene were first described in DLBCL and FL in 2021 by Hübschmann et al.¹

title Publication timing

2021-05-05 : H : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DNM2_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DNM2_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DNM2.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DNM2_hg38.html)

## DNM2 Expression

## References

1. Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S, Hansmann ML, Hoell JI, Hovestadt V, Huang B, Hummel M, Jäger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Martín-Subero JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Möller P, Loeffler M, Eils R, Klapper W, Hoffmann S, Trümper L, ICGC MMML-Seq consortium, ICGC DE-Mining consortium, BLUEPRINT consortium, Küppers R, Schlesner M, Siebert R. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021 Jul;35(7):2002–2016. PMCID: PMC8257491

# DNMT1

## History

```mermaid

title Publication timing

2019-09-26 : Panea : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |2.053 |0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DNMT1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DNMT1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DNMT1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DNMT1_hg38.html)

## DNMT1 Expression

<!-- ORIGIN: paneaWholeGenomeLandscape2019 -->

<!-- BL: paneaWholeGenomeLandscape2019 -->

## References

1. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;

# DNMT3A

## History

```mermaid

title Publication timing

2017-10-10 : Reddy : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0 |0 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DNMT3A_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DNMT3A_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DNMT3A.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DNMT3A_hg38.html)

## DNMT3A Expression

<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->

<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

## References

1. Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481-494.e15.

# DOCK1

## History

```mermaid

title Publication timing

2018-05-01 : Chapuy : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |1.838 |0 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DOCK1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DOCK1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DOCK1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DOCK1_hg38.html)

## DOCK1 Expression

<!-- ORIGIN: chapuyMolecularSubtypesDiffuse2018b -->

<!-- DLBCL: chapuyMolecularSubtypesDiffuse2018b -->

## References

1. Chapuy B, Stewart C, Dunford AJ, Kim J, Kamburov A, Redd RA, Lawrence MS, Roemer MGM, Li AJ, Ziepert M, Staiger AM, Wala JA, Ducar MD, Leshchiner I, Rheinbay E, Taylor-Weiner A, Coughlin CA, Hess JM, Pedamallu CS, Livitz D, Rosebrock D, Rosenberg M, Tracy AA, Horn H, van Hummelen P, Feldman AL, Link BK, Novak AJ, Cerhan JR, Habermann TM, Siebert R, Rosenwald A, Thorner AR, Meyerson ML, Golub TR, Beroukhim R, Wulf GG, Ott G, Rodig SJ, Monti S, Neuberg DS, Loeffler M, Pfreundschuh M, Trümper L, Getz G, Shipp MA. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018 May;24(5):679–690. PMCID: PMC6613387

# DSG4

## History

```mermaid

title Publication timing

2013-08-15 : Morin : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |1.374 |0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DSG4_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DSG4_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DSG4.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DSG4_hg38.html)

## DSG4 Expression

<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->

<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->

## References

1. Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992

# DTX1

## Overview

Mutations in the DTX1 gene, which encodes the E3 ubiquitin ligase Deltex 1, have been identified in various B-cell lymphomas, including diffuse large B-cell lymphoma (DLBCL). DTX1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. These mutations are associated with the BN2 genetic subgroup of DLBCL.¹ There are numerous mutation hotspots in this gene with some leading to a truncated protein. DTX1 functions as a negative regulator of the Notch signaling pathway. Some DTX1 mutations impair its function, thereby dysregulating Notch signaling, which is crucial for normal B-cell development and function. ²

## History

2019-09-26 : Panea : BL

2023-11-15 : Gomez : PMBL

```

## Relevance tier by entity

|Entity|Tier|Description |

|:--------:|:----------:|:---------:|:--------------------------------------------------------------------------------------------:|:------------------:|

|chr12 |113492311 |113497546|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr12%3A113492311%2D113497546)|NA |

## DTX1 Hotspots

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DTX1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DTX1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DTX1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DTX1_hg38.html)

## DTX1 Expression

## References

1. *Wright GW, Huang DW, Phelan JD, Coulibaly ZA, Roulland S, Young RM, Wang JQ, Schmitz R, Morin RD, Tang J, Jiang A, Bagaev A, Plotnikova O, Kotlov N, Johnson CA, Wilson WH, Scott DW, Staudt LM. A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications. Cancer Cell. 2020 Apr 13;37(4):551-568.e14. doi: 10.1016/j.ccell.2020.03.015. PMID: 32289277; PMCID: PMC8459709.*

# DUSP2

## Overview

DUSP2 functions as a negative regulator of MAPK signaling, particularly affecting the ERK1/2 pathway. DUSP2 mutations have been reported in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL),<sup>1</sup> T-cell/histiocyte-rich large B-cell lymphoma (T/HRLBCL)<sup>2</sup> and they are relatively frequent in DLBCL. DUSP2 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. These mutations are associated with the ST2 genetic subgroup of DLBCL. This gene has some recurrent sites of mutations (hot spots). The mutation pattern in DLBCL implies the preferential accumulation of *inactivating mutations*.

2013-08-15 : Morin : DLBCL

2021-07-15 : Duns : PMBL

```

## Relevance tier by entity

|Entity|Tier|Description |

|:--------:|:----------:|:--------:|:----------------------------------------------------------------------------------------------:|:------------------:|

|chr2 |96808901 |96811913|[intron-1](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr2%3A96808901%2D96811913)|enhancer |

## DUSP2 Hotspots

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DUSP2_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DUSP2_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/DUSP2.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/DUSP2_hg38.html)

## References

1. *Hartmann, S., Schuhmacher, B., Rausch, T., Fuller, L., Döring, C., Weniger, M., Lollies, A., Weiser, C., Thurner, L., Rengstl, B., Brunnberg, U., Vornanen, M., Pfreundschuh, M., Beneš, V., Küppers, R., Newrzela, S., & Hansmann, M. (2016). Highly recurrent mutations of SGK1, DUSP2 and JUNB in nodular lymphocyte predominant Hodgkin lymphoma. Leukemia, 30, 844-853. https://doi.org/10.1038/leu.2015.328.*

2. *Schuhmacher, B., Bein, J., Rausch, T., Beneš, V., Tousseyn, T., Vornanen, M., Ponzoni, M., Thurner, L., Gascoyne, R., Steidl, C., Küppers, R., Hansmann, M., & Hartmann, S. (2018). JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma. Haematologica, 104, 330 - 337. https://doi.org/10.3324/haematol.2018.203224.*

3. *Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM. Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma. N Engl J Med. 2018 Apr 12;378(15):1396-1407. doi: 10.1056/NEJMoa1801445. PMID: 29641966; PMCID: PMC6010183.*

## DUSP2 Expression

<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->

<!-- PMBL: dunsCharacterizationDLBCLPMBL2021b -->

<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->

# E2F2

## History

```mermaid

title Publication timing

2022-07-06 : Burkhardt : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.000 | 0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E2F2_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/E2F2_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/E2F2.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/E2F2_hg38.html)

## E2F2 Expression

<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->

<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->

## References

1. Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584

# EBF1

## Overview

EBF1 is a critical transcription factor in early B-cell development, regulating the expression of key genes involved in B-cell differentiation, survival, and function. EBF1 is essential for proper B-cell receptor (BCR) signaling.¹ Mutations in EBF1 can impair BCR signaling pathways, affecting B-cell survival and proliferation.¹ EBF1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. This gene has some recurrent sites of mutations (hot spots) but the mutation pattern in DLBCL and FL implies the preferential accumulation of *inactivating mutations*.

2012-10-01 : Bohle : DLBCL

2015-02-12 : Reichel : PMBL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EBF1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EBF1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EBF1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EBF1_hg38.html)

## References

1. *Györy I, Boller S, Nechanitzky R, Mandel E, Pott S, Liu E, Grosschedl R. Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev. 2012 Apr 1;26(7):668-82. doi: 10.1101/gad.187328.112. Epub 2012 Mar 19. PMID: 22431510; PMCID: PMC3323878.*

## EBF1 Expression

<!-- ORIGIN: 23174882 -->

<!-- BL: 2 -->

<!-- PMBL: reichelFlowSortingExome2015a -->

# EDNRB

## History

```mermaid

title Publication timing

2022-07-06 : Burkhardt : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |2.521 |28.057 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EDNRB_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EDNRB_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EDNRB.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EDNRB_hg38.html)

## EDNRB Expression

<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->

<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->

## References

1. Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584

# EEF1A1

## Overview

Mutations in the EEF1A1 gene, which encodes the eukaryotic translation elongation factor 1A1, have been reported in DLBCL and FL.¹ This gene has some recurrent sites of mutations (hot spots). The mutation pattern in DLBCL and FL implies the preferential accumulation of *inactivating mutations*. Paradoxically, one study showed that EEF1A1 knock down reduced proliferation in vitro and in xenograft experiments.²

2015-02-12 : Reichel : PMBL

2021-05-05 : H : FL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EEF1A1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EEF1A1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EEF1A1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EEF1A1_hg38.html)

## References

1. *Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S, Hansmann ML, Hoell JI, Hovestadt V, Huang B, Hummel M, Jäger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Martín-Subero JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Möller P, Loeffler M, Eils R, Klapper W, Hoffmann S, Trümper L; ICGC MMML-Seq consortium; ICGC DE-Mining consortium; BLUEPRINT consortium; Küppers R, Schlesner M, Siebert R. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021 Jul;35(7):2002-2016. doi: 10.1038/s41375-021-01251-z. Epub 2021 May 5. PMID: 33953289; PMCID: PMC8257491.*

2. *Gong T, Shuang Y. Expression and Clinical Value of Eukaryotic Translation Elongation Factor 1A1 (EEF1A1) in Diffuse Large B Cell Lymphoma. Int J Gen Med. 2021 Oct 27;14:7247-7258. doi: 10.2147/IJGM.S324645. PMID: 34737619; PMCID: PMC8559353.*

## EEF1A1 Expression

<!-- ORIGIN: reichelFlowSortingExome2015a -->

<!-- DLBCL: hubschmannMutationalMechanismsShaping2021b -->

<!-- FL: hubschmannMutationalMechanismsShaping2021b -->

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EHD1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EHD1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EHD1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EHD1_hg38.html)

## EHD1 Expression

<!-- ORIGIN: Unknown -->

<!-- BL: 2 -->

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EIF2AK3_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EIF2AK3_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EIF2AK3.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EIF2AK3_hg38.html)

## EIF2AK3 Expression

<!-- ORIGIN: Unknown -->

# EIF2AK4

## History

```mermaid

title Publication timing

2014-05-08 : Zhang : MCL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EIF2AK4_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EIF2AK4_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EIF2AK4.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EIF2AK4_hg38.html)

## EIF2AK4 Expression

<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->

<!-- MCL: zhangGenomicLandscapeMantle2014 -->

## References

1. Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.

# EIF2C4

## History

```mermaid

title Publication timing

2012-12-01 : Love : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EIF2C4_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EIF2C4_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EIF2C4.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EIF2C4_hg38.html)

## EIF2C4 Expression

<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->

<!-- BL: loveGeneticLandscapeMutations2012 -->

## References

1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

# EIF4A1

## History

```mermaid

title Publication timing

2019-09-26 : Panea : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EIF4A1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EIF4A1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EIF4A1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EIF4A1_hg38.html)

## EIF4A1 Expression

<!-- ORIGIN: paneaWholeGenomeLandscape2019 -->

<!-- BL: paneaWholeGenomeLandscape2019 -->

## References

1. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;

# EML2

## History

```mermaid

title Publication timing

2012-12-01 : Love : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |3.717 |0 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EML2_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EML2_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EML2.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EML2_hg38.html)

## EML2 Expression

<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->

<!-- BL: loveGeneticLandscapeMutations2012 -->

## References

1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

# ENTPD3

## History

```mermaid

title Publication timing

2012-12-01 : Love : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.000 | 0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ENTPD3_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ENTPD3_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ENTPD3.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ENTPD3_hg38.html)

## ENTPD3 Expression

<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->

<!-- BL: loveGeneticLandscapeMutations2012 -->

## References

1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

# EP300

## Overview

Mutations in EP300 are significant contributors to the pathogenesis and progression of B-cell lymphomas such as DLBCL and FL. These mutations impair histone acetylation, disrupt epigenetic gene regulation. This gene has some recurrent sites of mutations (hot spots), which typically impact its HAT domain, a region crucial for acetylating histones and non-histone proteins.^1,2 Studies using genome-wide CRISPR-Cas9 screens have identified synthetic lethal interactions between CREBBP and EP300, suggesting that targeting one may affect the viability of cells with mutations in the other.³

2011-03-10 : Pasqualucci : FL

2012-08-27 : Rossi : MZL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EP300_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EP300_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EP300.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EP300_hg38.html)

## EP300 Expression

## References

1. *Pasqualucci, L., Dominguez-Sola, D., Chiarenza, A., Fabbri, G., Grunn, A., Trifonov, V., Kasper, L., Lerach, S., Tang, H., Ma, J., Rossi, D., Chadburn, A., Murty, V., Mullighan, C., Gaidano, G., Rabadán, R., Brindle, P., & Dalla-Favera, R. (2010). Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature, 471, 189 - 195. https://doi.org/10.1038/nature09730.*

# EPHB2

## History

title Publication timing

2012-12-01 : Love : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.000 |0 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EPHB2_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EPHB2_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EPHB2.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EPHB2_hg38.html)

## EPHB2 Expression

<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->

<!-- BL: loveGeneticLandscapeMutations2012 -->

## References

1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

# EPPK1

## History

```mermaid

title Publication timing

2019-09-26 : Panea : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EPPK1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EPPK1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EPPK1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EPPK1_hg38.html)

## EPPK1 Expression

<!-- ORIGIN: paneaWholeGenomeLandscape2019 -->

<!-- BL: paneaWholeGenomeLandscape2019 -->

## References

1. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;

# ERAP1

## History

```mermaid

title Publication timing

2022-07-06 : Burkhardt : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.000 |0 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ERAP1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ERAP1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ERAP1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ERAP1_hg38.html)

## ERAP1 Expression

<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->

<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->

## References

1. Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584

# ESX1

## History

```mermaid

title Publication timing

2014-05-08 : Zhang : MCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.000 |0 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ESX1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ESX1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ESX1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ESX1_hg38.html)

## ESX1 Expression

<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->

<!-- MCL: zhangGenomicLandscapeMantle2014 -->

## References

1. Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.

# ETS1

## Overview

ETS1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. This gene has some recurrent sites of mutations (hot spots). The mutation pattern in DLBCL implies the preferential accumulation of *inactivating mutations*.

## History

2011-07-27 : Morin : DLBCL

2019-09-26 : Panea : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ETS1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ETS1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ETS1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ETS1_hg38.html)

## ETS1 Expression

## References

1. *Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298-303. doi: 10.1038/nature10351. PMID: 21796119; PMCID: PMC3210554.*

# ETV6

## Overview

ETV6 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. The prevalence of mutations in DLBCL has varied across different studies and may occur in as many as 10% of patients. This gene has some recurrent sites of mutations (hot spots) including multiple mutations predicted to affect splicing of ETV6 pre-mRNA. The mutation pattern in DLBCL mplies the preferential accumulation of *inactivating mutations*. Coding and non-coding mutations in this gene are associated with the MCD genetic subgroup of DLBCL.

## History

title Publication timing

2018-10-01 : Arthur : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ETV6_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ETV6_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ETV6.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ETV6_hg38.html)

## ETV6 Expression

<!-- ORIGIN: arthurGenomewideDiscoverySomatic2018 -->

<!-- DLBCL: arthurGenomewideDiscoverySomatic2018 -->

## References

1. Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma. Nat Commun. 2018 Oct 1;9(1):4001. PMCID: PMC6167379

title Publication timing

2020-07-30 : Pararajalingam : MCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |3.052 |0.00 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EWSR1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EWSR1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EWSR1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EWSR1_hg38.html)

## EWSR1 Expression

<!-- ORIGIN: pararajalingamCodingNoncodingDrivers2020 -->

<!-- MCL: pararajalingamCodingNoncodingDrivers2020 -->

## References

1. Pararajalingam P, Coyle KM, Arthur SE, Thomas N, Alcaide M, Meissner B, Boyle M, Qureshi Q, Grande BM, Rushton C, Slack GW, Mungall AJ, Tam CS, Agarwal R, Dawson SJ, Lenz G, Balasubramanian S, Gascoyne RD, Steidl C, Connors J, Villa D, Audas TE, Marra MA, Johnson NA, Scott DW, Morin RD. Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing. Blood. 2020 Jul 30;136(5):572–584. PMCID: PMC7440974

# EXOSC6

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2012-10-04 : Schmitz : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0 |0 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EXOSC6_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EXOSC6_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EXOSC6.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EXOSC6_hg38.html)

## EXOSC6 Expression

<!-- ORIGIN: schmitzBurkittLymphomaPathogenesis2012 -->

<!-- BL: schmitzBurkittLymphomaPathogenesis2012 -->

## References

1. Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012 Oct 4;490(7418):116–120. PMCID: PMC3609867

# EZH2

## Overview

# EZR

## History

```mermaid

title Publication timing

2019-08-20 : Desch : PMBL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EZR_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EZR_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/EZR.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/EZR_hg38.html)

## EZR Expression

<!-- ORIGIN: deschGenotypingCirculatingTumor2020 -->

<!-- PMBL: deschGenotypingCirculatingTumor2020 -->

## References

1. Desch AK, Hartung K, Botzen A, Brobeil A, Rummel M, Kurch L, Georgi T, Jox T, Bielack S, Burdach S, Classen CF, Claviez A, Debatin KM, Ebinger M, Eggert A, Faber J, Flotho C, Frühwald M, Graf N, Jorch N, Kontny U, Kramm C, Kulozik A, Kühr J, Sykora KW, Metzler M, Müller HL, Nathrath M, Nüßlein T, Paulussen M, Pekrun A, Reinhardt D, Reinhard H, Rössig C, Sauerbrey A, Schlegel PG, Schneider DT, Scheurlen W, Schweigerer L, Simon T, Suttorp M, Vorwerk P, Schmitz R, Kluge R, Mauz-Körholz C, Körholz D, Gattenlöhner S, Bräuninger A. Genotyping circulating tumor DNA of pediatric Hodgkin lymphoma. Leukemia. 2020 Jan;34(1):151–166. PMID: 31431735

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FAM102A_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FAM102A_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FAM102A.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FAM102A_hg38.html)

## FAM102A Expression

<!-- ORIGIN: Unknown -->

# FAM129B

## History

```mermaid

title Publication timing

2012-12-01 : Love : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |2.483 | 0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FAM129B_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FAM129B_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FAM129B.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FAM129B_hg38.html)

## FAM129B Expression

<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->

<!-- BL: loveGeneticLandscapeMutations2012 -->

## References

1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

# FAM38B

## History

```mermaid

title Publication timing

2013-08-15 : Morin : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|

## FAM38B Expression

<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->

<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->

## References

1. Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FANK1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FANK1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FANK1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FANK1_hg38.html)

## FANK1 Expression

<!-- ORIGIN: Unknown -->

# FAS

## Overview

FAS encodes a cell surface receptor involved in the induction of apoptosis. FAS mutations are common in DLBCL and may be more frequent in primary gastric DLBCL.^1,2 Mutations also occur in FL at a lower rate.³ Although reported in one BL study,⁴ overall the evidence for FAS mutations in BL remains sparse. Mutations in FAS often lead to a loss of function, making lymphoma cells resistant to Fas ligand-induced apoptosis, thereby allowing malignant cells to evade immune surveillance.⁵ In mouse models, Fas mutations led to a significantly shorter lymphoma-specific survival and reduced sensitivity to chemotherapy.⁵

## History

2007-05-01 : Scholl : DLBCL

2016-09-08 : Spina : MZL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FAS_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FAS_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FAS.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FAS_hg38.html)

## References

4. *Panea RI, Love CL, Shingleton JR, Reddy A, Bailey JA, Moormann AM, Otieno JA, Ong'echa JM, Oduor CI, Schroeder KMS, Masalu N, Chao NJ, Agajanian M, Major MB, Fedoriw Y, Richards KL, Rymkiewicz G, Miles RR, Alobeid B, Bhagat G, Flowers CR, Ondrejka SL, Hsi ED, Choi WWL, Au-Yeung RKH, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig MA, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus BC, Seshadri V, Kim SY, Gascoyne RD, Levy S, Mukhopadyay M, Dunson DB, Dave SS. The whole-genome landscape of Burkitt lymphoma subtypes. Blood. 2019 Nov 7;134(19):1598-1607. doi: 10.1182/blood.2019001880. Erratum in: Blood. 2022 Feb 24;139(8):1256. Erratum in: Blood. 2023 Sep 7;142(10):940. PMID: 31558468; PMCID: PMC6871305.*

5. *Rys, R., Venkataraman, M., Zeng, J., Mann, K., & Johnson, N. (2019). Fas Mutations in Non-Hodgkin's Lymphoma (NHL): Implications for Disease Progression and Therapeutic Resistance. Blood. https://doi.org/10.1182/blood-2019-130602.*

## FAS Expression

<!-- ORIGIN: schollMutationsRegionFAS2007 -->

<!-- DLBCL: schollMutationsRegionFAS2007 -->

<!-- MZL: spinaGeneticsNodalMarginal2016b -->

# FAT4

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

2013-12-13 : Parry : MZL

2014-05-08 : Zhang : MCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.000 |0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FAT4_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FAT4_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FAT4.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FAT4_hg38.html)

## FAT4 Expression

<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->

<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->

<!-- MCL: zhangGenomicLandscapeMantle2014 -->

<!-- MZL: parryWholeExomeSequencing2013 -->

## References

1. Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992

2. Parry M, Rose-Zerilli MJJ, Gibson J, Ennis S, Walewska R, Forster J, Parker H, Davis Z, Gardiner A, Collins A, Oscier DG, Strefford JC. Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma. PLoS One. 2013;8(12):e83244. PMCID: PMC3862727

# FBXO11

## Overview

Somatic mutations in FBXO11 are common in BL^1,2 and appear in a small number of DLBCLs.³ This gene has some recurrent sites of mutations (hot spots). Mutations lead to stabilization of BCL6, an important transcriptional repressor involved in lymphomagenesis.⁴ These mutations present a potential novel target for therapeutic intervention, particularly through strategies aimed at degrading BCL6 or inhibiting its function.⁴

2013-12-13 : Parry : MZL

2021-05-05 : H : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No | 8.837 | 0.000 |

## FBXO11 hot spots

|Chromosome|Coordinate|Mutation|HGVSp|

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FBXO11_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FBXO11_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FBXO11.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FBXO11_hg38.html)

## References

1. *Pighi, C., Compagno, M., Wang, Q., Cheong, T., Poggio, T., Langellotto, F., Celle, P., Zamó, A., & Chiarle, R. (2015). FBXO11, a Regulator of BCL6 Stability, Is Recurrently Mutated in Burkitt Lymphoma. Blood, 126, 3673-3673. https://doi.org/10.1182/BLOOD.V126.23.3673.3673.*

4. *Pighi, C., Cheong, T., Compagno, M., Patrucco, E., Arigoni, M., Olivero, M., Wang, Q., López, C., Bernhart, S., Grande, B., Poggio, T., Langellotto, F., Bonello, L., Dall’Olio, R., Martínez-Martín, S., Molinaro, L., Celle, P., Whitfield, J., Soucek, L., Voena, C., Calogero, R., Morin, R., Staudt, L., Siebert, R., Zamó, A., & Chiarle, R. (2021). Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma.. Blood advances. https://doi.org/10.1182/bloodadvances.2021005682.*

5. *Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S, Hansmann ML, Hoell JI, Hovestadt V, Huang B, Hummel M, Jäger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Martín-Subero JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Möller P, Loeffler M, Eils R, Klapper W, Hoffmann S, Trümper L; ICGC MMML-Seq consortium; ICGC DE-Mining consortium; BLUEPRINT consortium; Küppers R, Schlesner M, Siebert R. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021 Jul;35(7):2002-2016. doi: 10.1038/s41375-021-01251-z. Epub 2021 May 5. PMID: 33953289; PMCID: PMC8257491.*

## FBXO11 Expression

<!-- ORIGIN: parryWholeExomeSequencing2013 -->

<!-- BL: richterRecurrentMutationID32012a -->

<!-- MZL: parryWholeExomeSequencing2013 -->

# FBXW7

## Overview

FBXW7 mutations are found in a range of lymphoid malignancies, including B-cell lymphomas. These mutations often include missense mutations, deletions, frameshift mutations and splice-site mutations. Overall, these mutations are relatively rare in DLBCL and occur more frequently in other solid tumors as well as T-cell acute lymphocytic leukemia.<sup>1</sup> The most commonly observed mutations in those cancers are the hot spots R465 and R479.<sup>1</sup> In leukemias, FBXW7 mutations enhance the activity of leukemia-initiating cells by stabilizing oncogenic MYC.<sup>2</sup> Whether they have this role in DLBCL remains to be determined.

## History

title Publication timing

2013-01-01 : Zhang : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FBXW7_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FBXW7_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FBXW7.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FBXW7_hg38.html)

## References

1. *Akhoondi, S., Sun, D., Lehr, N., Apostolidou, S., Klotz, K., Maljukova, A., Cepeda, D., Fiegl, H., Dafou, D., Marth, C., Mueller-Holzner, E., Corcoran, M., Dagnell, M., Nejad, S., Nayer, B., Zali, M., Hansson, J., Egyhazi, S., Petersson, F., Sangfelt, P., Nordgren, H., Grandér, D., Reed, S., Widschwendter, M., Sangfelt, O., & Spruck, C. (2007). FBXW7/hCDC4 is a general tumor suppressor in human cancer.. Cancer research, 67 19, 9006-12 . https://doi.org/10.1158/0008-5472.CAN-07-1320.*

2. *King, B., Trimarchi, T., Reavie, L., Xu, L., Mullenders, J., Ntziachristos, P., Aranda-Orgilles, B., Pérez-García, A., Shi, J., Vakoc, C., Sandy, P., Shen, S., Ferrando, A., & Aifantis, I. (2013). The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability. Cell, 153, 1552-1566. https://doi.org/10.1016/j.cell.2013.05.041.*

## FBXW7 Expression

<!-- ORIGIN: zhangGeneticHeterogeneityDiffuse2013 -->

<!-- DLBCL: zhangGeneticHeterogeneityDiffuse2013 -->

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FCRL3_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FCRL3_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FCRL3.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FCRL3_hg38.html)

## FCRL3 Expression

<!-- ORIGIN: Unknown -->

# FGFR3

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2012-12-01 : Love : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.000 |0 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FGFR3_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FGFR3_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FGFR3.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FGFR3_hg38.html)

## FGFR3 Expression

<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->

<!-- BL: loveGeneticLandscapeMutations2012 -->

## References

1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

# FLYWCH1

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2012-10-04 : Schmitz : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0 | 0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FLYWCH1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FLYWCH1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FLYWCH1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FLYWCH1_hg38.html)

## FLYWCH1 Expression

<!-- ORIGIN: schmitzBurkittLymphomaPathogenesis2012 -->

<!-- BL: schmitzBurkittLymphomaPathogenesis2012 -->

## References

1. Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012 Oct 4;490(7418):116–120. PMCID: PMC3609867

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FNBP1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FNBP1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FNBP1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FNBP1_hg38.html)

## FNBP1 Expression

<!-- ORIGIN: Unknown -->

# FNDC1

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2013-08-15 : Morin : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.000 |0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FNDC1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FNDC1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FNDC1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FNDC1_hg38.html)

## FNDC1 Expression

<!-- ORIGIN: morinMutationalStructuralAnalysis2013 -->

<!-- DLBCL: morinMutationalStructuralAnalysis2013 -->

## References

1. Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug 15;122(7):1256–1265. PMCID: PMC3744992