PIM1.md
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene[@dunsCharacterizationDLBCLPMBL2021]|
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-|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@burkhardtClinicalRelevanceMolecular2022]|
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-|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene [@pasqualucciHypermutationMultipleProtooncogenes2001]|
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-|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
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+|![BL](images/icons/BL_tier2.png) |2 | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@burkhardtClinicalRelevanceMolecular2022]|
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+|![DLBCL](images/icons/DLBCL_tier1.png) |1 | aSHM target and high-confidence DLBCL gene [@pasqualucciHypermutationMultipleProtooncogenes2001]|
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+|![FL](images/icons/FL_tier1.png) |1 | aSHM target and high-confidence FL gene |
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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-|Entity|source |frequency (%)|
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-|:------:|:---------------------:|:-------------:|
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-|BL |GAMBL genomes+capture| 2.31 |
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-|BL |Thomas cohort | NA |
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-|BL |Panea cohort | NA |
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-|DLBCL |GAMBL genomes |20.27 |
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-|DLBCL |Schmitz cohort |27.66 |
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-|DLBCL |Reddy cohort |19.12 |
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-|DLBCL |Chapuy cohort |23.93 |
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-|FL |GAMBL genomes | 9.24 |
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+[[include:DLBCL_PIM1.md]]
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+[[include:FL_PIM1.md]]
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+[[include:BL_PIM1.md]]
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## Mutation pattern and selective pressure estimates
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