BIRC6.md
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# BIRC6
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+## Overview
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+BIRC6, as a negative regulator of non-canonical NF-κB signaling, is implicated in lymphomagenesis. Mutations in the BIRC6 were identified in grey zone lymphoma (GZL), contributing to its distinct mutational profile compared to other related lymphomas.<sup>1</sup> These mutations are recurrent, albeit much less common, in DLBCL and FL.
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## Relevance tier by entity
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|Entity|Tier|Description |
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View all variants in GenomePaint [hg19](https://www.bcgsc.ca/downloads/morinlab/GAMBL/test/genes/BIRC6.html) or [hg38](https://www.bcgsc.ca/downloads/morinlab/GAMBL/test/genes/BIRC6_hg38.html)
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![image](images/proteinpaint/BIRC6.svg)
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+## References
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+1. *Sarkozy C, Hung SS, Chavez EA, Duns G, Takata K, Chong LC, Aoki T, Jiang A, Miyata-Takata T, Telenius A, Slack GW, Molina TJ, Ben-Neriah S, Farinha P, Dartigues P, Damotte D, Mottok A, Salles GA, Casasnovas RO, Savage KJ, Laurent C, Scott DW, Traverse-Glehen A, Steidl C. Mutational landscape of gray zone lymphoma. Blood. 2021 Apr 1;137(13):1765-1776. doi: 10.1182/blood.2020007507. PMID: 32961552.*