HIST1H1D.md
... ...
@@ -6,7 +6,8 @@ link-citations: true
6 6
# HIST1H1D
7 7
8 8
## Overview
9
-This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.<sup>1,2</sup> Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins.
9
+This is one of several genes that encode linker histone proteins that are recurrently mutated in DLBCL and FL.[@morinMutationalStructuralAnalysis2013; @krysiakRecurrentSomaticMutations2017b]
10
+Mutations are often found in the globular domain of the protein, which is critical for its interaction with DNA and other histone proteins.
10 11
11 12
## History
12 13
```mermaid
... ...
@@ -16,6 +17,7 @@ timeline
16 17
2013-08-15 : Morin : DLBCL
17 18
2017-01-26 : Krysiak : FL
18 19
2017-07-27 : Jallades : MZL
20
+2018-05-01 : Chapuy : DLBCL
19 21
```
20 22
21 23
## Relevance tier by entity
... ...
@@ -24,7 +26,7 @@ timeline
24 26
|:------:|:----:|--------------------------------------|
25 27
|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
26 28
|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017]|
27
-|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene [@morinMutationalStructuralAnalysis2013]|
29
+|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene [@morinMutationalStructuralAnalysis2013; @chapuyMolecularSubtypesDiffuse2018b]|
28 30
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene [@krysiakRecurrentSomaticMutations2017b]|
29 31
30 32
## Mutation incidence in large patient cohorts (GAMBL reanalysis)