fix format

title Publication timing

2021-05-05 : H : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.000 |0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ADAMTS1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ADAMTS1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ADAMTS1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ADAMTS1_hg38.html)

## ADAMTS1 Expression

## References

1. Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam N, Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H, Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez A, Doose G, Haake A, Karsch D, Haas S, Hansmann ML, Hoell JI, Hovestadt V, Huang B, Hummel M, Jäger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E, Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M, Stilgenbauer S, Stadler PF, Martín-Subero JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Möller P, Loeffler M, Eils R, Klapper W, Hoffmann S, Trümper L, ICGC MMML-Seq consortium, ICGC DE-Mining consortium, BLUEPRINT consortium, Küppers R, Schlesner M, Siebert R. Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas. Leukemia. 2021 Jul;35(7):2002–2016. PMCID: PMC8257491

# ADAMTS5

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2022-07-06 : Burkhardt : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ADAMTS5_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ADAMTS5_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ADAMTS5.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ADAMTS5_hg38.html)

## ADAMTS5 Expression

<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->

<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->

## References

1. Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584

# ADNP

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2022-07-06 : Burkhardt : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |2.254 | 0.000 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ADNP_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ADNP_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ADNP.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ADNP_hg38.html)

## ADNP Expression

<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->

<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->

## References

1. Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584

# AGO4

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2022-07-06 : Burkhardt : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/AGO4_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/AGO4_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/AGO4.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/AGO4_hg38.html)

## AGO4 Expression

<!-- ORIGIN: burkhardtClinicalRelevanceMolecular2022b -->

<!-- BL: burkhardtClinicalRelevanceMolecular2022b -->

## References

1. Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584

# AICDA

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2018-10-01 : Arthur : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|:--------:|:----------:|:--------:|:----------------------------------------------------------------------------------------:|:------------------:|

|chr12 |8762328 |8765099 |[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr12%3A8762328%2D8765099)|NA |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/AICDA_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/AICDA_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/AICDA.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/AICDA_hg38.html)

## AICDA Expression

<!-- ORIGIN: arthurGenomewideDiscoverySomatic2018 -->

<!-- DLBCL: arthurGenomewideDiscoverySomatic2018 -->

## References

1. Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma. Nat Commun. 2018 Oct 1;9(1):4001. PMCID: PMC6167379

# ALPK2

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2019-09-26 : Panea : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ALPK2_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ALPK2_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ALPK2.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ALPK2_hg38.html)

## ALPK2 Expression

<!-- ORIGIN: paneaWholeGenomeLandscape2019 -->

<!-- BL: paneaWholeGenomeLandscape2019 -->

## References

1. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019;

# ANK2

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2014-05-08 : Zhang : MCL

```

## Relevance tier by entity

|Entity|Tier|Description |

|FL |No |No |0.340 |0.0 |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ANK2_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ANK2_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ANK2.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ANK2_hg38.html)

## ANK2 Expression

<!-- ORIGIN: zhangGenomicLandscapeMantle2014 -->

<!-- MCL: zhangGenomicLandscapeMantle2014 -->

## References

1. Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.

title Publication timing

2021-05-05 : H : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ANKRD12_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ANKRD12_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ANKRD12.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ANKRD12_hg38.html)

## ANKRD12 Expression

<!-- ORIGIN: hubschmannMutationalMechanismsShaping2021b -->

## References

# ANKRD17

## History

Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.<sup>1</sup> Subsequent exome and genome-wide studies of DLBCL did not reproduce this observation.

title Publication timing

2017-10-10 : Reddy : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ANKRD17_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ANKRD17_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ANKRD17.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ANKRD17_hg38.html)

## ANKRD17 Expression

## References

1. *Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481-494.e15.*

# ARHGEF1

## History

```mermaid

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

title Publication timing

2014-12-11 : Muppidi : BL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ARHGEF1_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ARHGEF1_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ARHGEF1.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ARHGEF1_hg38.html)

## ARHGEF1 Expression

<!-- ORIGIN: muppidiLossSignalingGa132014b -->

<!-- BL: muppidiLossSignalingGa132014b -->

## References

1. Muppidi J, Schmitz R, Green JA, Green JA, Xiao W, Larsen AB, Braun S, An J, Xu Y, Rosenwald A, Ott G, Gascoyne R, Rimsza L, Campo E, Jaffe E, Delabie J, Smeland E, Braziel R, Tubbs R, Cook J, Weisenburger D, Chan W, Vaidehi N, Staudt L, Cyster J. Loss of signaling via Gα13 in germinal center B cell-derived lymphoma. Nature. 2014;516:254–258.

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ARID1A_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ARID1A_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ARID1A.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ARID1A_hg38.html)

## ARID1A Expression

<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->

<!-- MZL: rossiCodingGenomeSplenic2012c -->

<!-- DLBCL: zhangGeneticHeterogeneityDiffuse2013 -->

<!-- BL: loveGeneticLandscapeMutations2012 -->

<!-- FL: krysiakRecurrentSomaticMutations2017b -->

<!-- BL: loveGeneticLandscapeMutations2012 -->

## References

1. Rossi D, Trifonov V, Fangazio M, Bruscaggin A, Rasi S, Spina V, Monti S, Vaisitti T, Arruga F, Famà R, Ciardullo C, Greco M, Cresta S, Piranda D, Holmes A, Fabbri G, Messina M, Rinaldi A, Wang J, Agostinelli C, Piccaluga PP, Lucioni M, Tabbò F, Serra R, Franceschetti S, Deambrogi C, Daniele G, Gattei V, Marasca R, Facchetti F, Arcaini L, Inghirami G, Bertoni F, Pileri SA, Deaglio S, Foà R, Dalla-Favera R, Pasqualucci L, Rabadan R, Gaidano G. The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med. 2012 Aug 27;209(9):1537–1551. PMCID: PMC3428941

2. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561

# ARID1B

## History

Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.¹

title Publication timing

2017-10-10 : Reddy : DLBCL

```

## Relevance tier by entity

|Entity|Tier|Description |

View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ARID1B_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ARID1B_protein_hg38.html)

View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/ARID1B.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/ARID1B_hg38.html)

## ARID1B Expression

1. *Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481-494.e15.*

<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->

<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->

## References

1. Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481-494.e15.