add incidence

-

-```mermaid

-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

-timeline

- title Publication timing

- 1992-01-01 : Tanaka : DLBCL

- 2011-07-27 : Morin : FL

- 2021-04-01 : Sarkozy : PMBL

- 2022-07-06 : Burkhardt : BL

-```

-## Overview

-

-BCL2 mutations are frequently found in DLBCL, particularly in the germinal center B-cell (GCB) subtype, and are often located in the flexible loop domain and outside the BCL2-homology domains.

-These mutations are caused by the somatic hypermutation process. The presence of these mutations are strongly correlated with the presence of a translocation between BCL2 and one of the immunoglobulin loci.

-Although missense mutations may not be under positive selective pressure in the context of lymphomagenesis, some of these mutations may interfere with the function of BCL2 antagonists.

-

-## Relevance tier by entity

-

-|Entity|Tier|Description |

-|:------:|:----:|--------------------------------------|

-| |1[@balSuperenhancerHypermutationAlters2022] |high-confidence DLBCL gene [@tanakaFrequentIncidenceSomatic1992]|

-| |1 |high-confidence FL gene|

-||2|relevance in PMBL/cHL/GZL not firmly established[@sarkozyMutationalLandscapeGray2021]|

-| |2 |relevance in BL not firmly established[@burkhardtClinicalRelevanceMolecular2022]|

- |