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updates

Ryan Morin committed 2024-06-10 16:06:46 -0700 commit 82aef3c94a1b0a105f7f42dc2a2cb875d3ec53fa

				MCL1.md
			
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           ## Overview

           MCL1 (Myeloid Cell Leukemia 1) is a member of the BCL2 family of proteins that play a critical role in inhibiting apoptosis. It is frequently overexpressed and sometimes mutated in DLBCL.<sup>1,2</sup> Recurrent chromosomal gains and amplifications of the MCL1 locus occur are frequent in ABC-DLBCLs.<sup>1</sup>  MCL1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.

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           ## History

           ```mermaid

           %%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%

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2	2
3	3	## Overview
4	4	MCL1 (Myeloid Cell Leukemia 1) is a member of the BCL2 family of proteins that play a critical role in inhibiting apoptosis. It is frequently overexpressed and sometimes mutated in DLBCL.<sup>1,2</sup> Recurrent chromosomal gains and amplifications of the MCL1 locus occur are frequent in ABC-DLBCLs.<sup>1</sup> MCL1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
	5	+
5	6	## History
6	7	```mermaid
7	8	%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%