CD70.md
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# CD70
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## Overview
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-CD70 is a costimulatory molecule expressed on some activated lymphocytes and has a role in T-cell-mediated immune responses.<sup>1</sup> CD70 aberrations are relatively common in DLBCL and appear more frequent in certain DLBCL patient populations. For instance, in a Chinese DLBCL cohort, 24% of cases exhibited CD70 genetic changes, compared to 10.8% in a Swedish cohort.<sup>1</sup> CD70 mutations are associated with the BN2 genetic subtype of DLBCL.<sup>2</sup> The mutation pattern in CD70 is consistent with the preferential accumulation of *inactivating mutations*. Loss of CD70 protein expression has been described.<sup>1</sup> Genetic perturbation limits the development of an effective CD8+ T-cell immune response in Bcl6-driven DLBCL. In mouse models, CD70 loss promoted lymphomagenesis, indicating that CD70/CD27 co-stimulation is crucial for anti-tumor immunity
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+CD70 is a costimulatory molecule expressed on some activated lymphocytes and has a role in T-cell-mediated immune responses.<sup>1</sup> CD70 aberrations are relatively common in DLBCL and appear more frequent in certain DLBCL patient populations. For instance, in a Chinese DLBCL cohort, 24% of cases exhibited CD70 genetic changes, compared to 10.8% in a Swedish cohort.<sup>1</sup> CD70 mutations are associated with the BN2 genetic subtype of DLBCL.<sup>2</sup> The mutation pattern in CD70 is consistent with the preferential accumulation of *inactivating mutations*. Loss of CD70 protein expression has been described.<sup>1</sup> Genetic perturbation limits the development of an effective CD8+ T-cell immune response in Bcl6-driven DLBCL. In mouse models, CD70 loss promoted lymphomagenesis, consistent with its role as a tumor suppressor gene in B-cell lymphomas.<sup>1,3</sup>
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## Relevance tier by entity
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