ABCA13.md
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bibliography: 'morinlab.bib'
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csl: 'NLM.csl'
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link-citations: true
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+nocite: |
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+ @spinaGeneticsNodalMarginal2016, @sarkozyMutationalLandscapeGray2021
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---
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[[_TOC_]]
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-
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## Relevance tier by entity
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-|Entity|Tier|Description|
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-|:------:|:----:|--------------------------------------|
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-|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@spinaGeneticsNodalMarginal2016]|
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-|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@sarkozyMutationalLandscapeGray2021]|
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-
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+[[include:table1_ABCA13.md]]
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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ABCA3.md
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bibliography: 'morinlab.bib'
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csl: 'NLM.csl'
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link-citations: true
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+nocite: |
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+ @beaLandscapeSomaticMutations2013, @zhangGeneticHeterogeneityDiffuse2013
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---
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[[_TOC_]]
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-
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-
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-
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## Relevance tier by entity
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-|Entity|Tier|Description|
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-|:------:|:----:|--------------------------------------|
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-|![MCL](images/icons/MCL_tier2.png)|2|relevance in MCL not firmly established[@beaLandscapeSomaticMutations2013]|
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-
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+[[include:table1_ABCA3.md]]
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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-|Entity|source |frequency (%)|
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-|:------:|:----:|:----:|
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-|BL|GAMBL Exome |7.471 |
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-|BL|GAMBL Genome |2.703 |
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-|DLBCL|GAMBL Exome |2.911 |
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-|DLBCL|GAMBL Genome |0.94 |
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-|FL|GAMBL Exome |0.287 |
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-|MCL|GAMBL Genome |0.585 |
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-
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+[[include:DLBCL_ABCA3.md]]
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[[include:mermaid_ABCA3.md]]
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ABCB1.md
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bibliography: 'morinlab.bib'
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csl: 'NLM.csl'
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link-citations: true
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+ @fanComprehensiveCharacterizationDriver2020
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---
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[[_TOC_]]
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-
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## Relevance tier by entity
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-|Entity|Tier|Description|
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-|:------:|:----:|--------------------------------------|
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-|![DLBCL](images/icons/DLBCL_tier3.png)|3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]|
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[[include:mermaid_ABCB1.md]]
BCL2.md
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bibliography: 'morinlab.bib'
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csl: 'NLM.csl'
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link-citations: true
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+ @balSuperenhancerHypermutationAlters2022, @tanakaFrequentIncidenceSomatic1992, @sarkozyMutationalLandscapeGray2021, @burkhardtClinicalRelevanceMolecular2022
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---
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[[_TOC_]]
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## Relevance tier by entity
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-|Entity|Tier|Description |
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-|:------:|:----:|--------------------------------------|
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-|![DLBCL](images/icons/DLBCL_tier1.png) |1[@balSuperenhancerHypermutationAlters2022] |high-confidence DLBCL gene [@tanakaFrequentIncidenceSomatic1992]|
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-|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene|
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-|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established[@sarkozyMutationalLandscapeGray2021]|
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-|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established[@burkhardtClinicalRelevanceMolecular2022]|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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[[include:FL_BCL2.md]]
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[[include:BL_BCL2.md]]
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## Mutation pattern and selective pressure estimates
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[[include:dnds_BCL2.md]]
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|chr18 |60982728 |60988342|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr18%3A60982728%2D60988342) |active_promoter |
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-
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## BCL2 Hotspots
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| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |