MCL_genes.md
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@@ -9,95 +9,95 @@ link-citations: true
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![](MCL_sankey-1.svg)
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-## Tier 1 MCL genes
12
+## Tier 1, high-confidence MCL genes
13 13
14 14
### *23 total*
15 15
16
-|Gene|Tier| First MCL evidence | Other entities |
17
-|:-:|:-:|:--|:-|
18
-|[ATM](ATM)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]|[@braggioGenomicAnalysisMarginal2012; @reddyGeneticFunctionalDrivers2017]|
19
-|[BIRC3](BIRC3)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]|[@dunsCharacterizationDLBCLPMBL2021b; @rossiAlterationBIRC3Multiple2011a; @arthurGenomewideDiscoverySomatic2018]|
20
-|[CARD11](CARD11)|1|[Wu et al](papers/wuGeneticHeterogeneityPrimary2016)[@wuGeneticHeterogeneityPrimary2016]|[@yanBCRTLRSignaling2012a; @lenzOncogenicCARD11Mutations2008; @morinFrequentMutationHistonemodifying2011]|
21
-|[CCND1](CCND1)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
22
-|[DAZAP1](DAZAP1)|1|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]||
23
-|[EWSR1](EWSR1)|1|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]||
24
-|[HNRNPH1](HNRNPH1)|1|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]||
25
-|[KMT2D](KMT2D)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]|[@grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c; @deschGenotypingCirculatingTumor2020; @morinFrequentMutationHistonemodifying2011]|
26
-|[MEF2B](MEF2B)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]|[@morinFrequentMutationHistonemodifying2011]|
27
-|[NFKBIE](NFKBIE)|1|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]|[@mansouriFrequentNFKBIEDeletions2016; @morinGeneticLandscapesRelapsed2016]|
28
-|[NOTCH1](NOTCH1)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]|[@loveGeneticLandscapeMutations2012; @pasqualucciAnalysisCodingGenome2011; @rossiCodingGenomeSplenic2012c]|
29
-|[NOTCH2](NOTCH2)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]|[@zhangGeneticHeterogeneityDiffuse2013; @rossiCodingGenomeSplenic2012c]|
30
-|[NSD2](NSD2)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]|[@zhangGeneticHeterogeneityDiffuse2013]|
31
-|[POT1](POT1)|1|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
32
-|[RB1](RB1)|1|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]|[@morinMutationalStructuralAnalysis2013]|
33
-|[S1PR1](S1PR1)|1|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]|[@lohrDiscoveryPrioritizationSomatic2012a]|
34
-|[SMARCA4](SMARCA4)|1|[Nadeu et al](papers/nadeuGenomicEpigenomicInsights2020b)[@nadeuGenomicEpigenomicInsights2020b]|[@richterRecurrentMutationID32012a; @lohrDiscoveryPrioritizationSomatic2012a; @krysiakRecurrentSomaticMutations2017b]|
35
-|[SP140](SP140)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
36
-|[SYNE1](SYNE1)|1|[Nadeu et al](papers/nadeuGenomicEpigenomicInsights2020b)[@nadeuGenomicEpigenomicInsights2020b]||
37
-|[TERT](TERT)|1|[Nadeu et al](papers/nadeuGenomicEpigenomicInsights2020b)[@nadeuGenomicEpigenomicInsights2020b]||
38
-|[TLR2](TLR2)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]|[@chapuyMolecularSubtypesDiffuse2018b]|
39
-|[TP53](TP53)|1|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]|[@tiacciPervasiveMutationsJAKSTAT2018b; @morinFrequentMutationHistonemodifying2011; @wildaInactivationARFMDM2p53Pathway2004; @rossiCodingGenomeSplenic2012c; @lohrDiscoveryPrioritizationSomatic2012a]|
40
-|[UBR5](UBR5)|1|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]|[@zhangGeneticHeterogeneityDiffuse2013]|
16
+|Gene|Summary| First MCL study | Other entities | QC result |
17
+|:-:|:--:|:-:|:-|:-|
18
+|[ATM](ATM)|Tier 1 GE[@beaLandscapeSomaticMutations2013], FE[@camachoATMGeneInactivation2002]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|[@braggioGenomicAnalysisMarginal2012; @reddyGeneticFunctionalDrivers2017]||
19
+|[BIRC3](BIRC3)|Tier 1 GE[@beaLandscapeSomaticMutations2013], aSHM|[Bea et al](papers/beaLandscapeSomaticMutations2013)|[@arthurGenomewideDiscoverySomatic2018; @dunsCharacterizationDLBCLPMBL2021; @rossiAlterationBIRC3Multiple2011]||
20
+|[CARD11](CARD11)|Tier 1 GE[@wuGeneticHeterogeneityPrimary2016], FE[@lenzOncogenicCARD11Mutations2008]|[Wu et al](papers/wuGeneticHeterogeneityPrimary2016)|[@lenzOncogenicCARD11Mutations2008; @morinFrequentMutationHistonemodifying2011; @yanBCRTLRSignaling2012]||
21
+|[CCND1](CCND1)|Tier 1 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
22
+|[DAZAP1](DAZAP1)|Tier 1 GE[@pararajalingamCodingNoncodingDrivers2020]|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)|||
23
+|[EWSR1](EWSR1)|Tier 1 GE[@pararajalingamCodingNoncodingDrivers2020]|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)|||
24
+|[HNRNPH1](HNRNPH1)|Tier 1 GE[@pararajalingamCodingNoncodingDrivers2020]|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)|||
25
+|[KMT2D](KMT2D)|Tier 1 GE[@beaLandscapeSomaticMutations2013], FE[@zhangDisruptionKMT2DPerturbs2015]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|[@deschGenotypingCirculatingTumor2020; @grandeGenomewideDiscoverySomatic2019; @morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012]||
26
+|[MEF2B](MEF2B)|Tier 1 GE[@beaLandscapeSomaticMutations2013], FE[@ponMEF2BMutationsNonHodgkin2015], aSHM|[Bea et al](papers/beaLandscapeSomaticMutations2013)|[@morinFrequentMutationHistonemodifying2011]||
27
+|[NFKBIE](NFKBIE)|Tier 1 GE[@pararajalingamCodingNoncodingDrivers2020], FE[@mansouriFunctionalLossIkBe2015]|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)|[@mansouriFrequentNFKBIEDeletions2016; @morinGeneticLandscapesRelapsed2016]||
28
+|[NOTCH1](NOTCH1)|Tier 1 GE[@beaLandscapeSomaticMutations2013], FE[@ryanCellRegulomeLinks2017]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|[@loveGeneticLandscapeMutations2012; @pasqualucciAnalysisCodingGenome2011; @rossiCodingGenomeSplenic2012]||
29
+|[NOTCH2](NOTCH2)|Tier 1 GE[@beaLandscapeSomaticMutations2013], FE[@leeGainoffunctionMutationsCopy2009]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|[@rossiCodingGenomeSplenic2012; @zhangGeneticHeterogeneityDiffuse2013]||
30
+|[NSD2](NSD2)|Tier 1 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|[@zhangGeneticHeterogeneityDiffuse2013]||
31
+|[POT1](POT1)|Tier 1 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
32
+|[RB1](RB1)|Tier 1 GE[@zhangGenomicLandscapeMantle2014], FE[@pinyolInactivationRB1Mantlecell2007]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|[@morinMutationalStructuralAnalysis2013]||
33
+|[S1PR1](S1PR1)|Tier 1 GE[@pararajalingamCodingNoncodingDrivers2020]|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)|[@lohrDiscoveryPrioritizationSomatic2012]||
34
+|[SMARCA4](SMARCA4)|Tier 1 GE[@nadeuGenomicEpigenomicInsights2020b], FE[@fernandoFunctionalCharacterizationSMARCA42020]|[Nadeu et al](papers/nadeuGenomicEpigenomicInsights2020b)|[@krysiakRecurrentSomaticMutations2017; @reddyGeneticFunctionalDrivers2017; @richterRecurrentMutationID32012]||
35
+|[SP140](SP140)|Tier 1 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
36
+|[SYNE1](SYNE1)|Tier 1 GE[@nadeuGenomicEpigenomicInsights2020b]|[Nadeu et al](papers/nadeuGenomicEpigenomicInsights2020b)|||
37
+|[TERT](TERT)|Tier 1 GE[@nadeuGenomicEpigenomicInsights2020b]|[Nadeu et al](papers/nadeuGenomicEpigenomicInsights2020b)|||
38
+|[TLR2](TLR2)|Tier 1 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|[@chapuyMolecularSubtypesDiffuse2018]||
39
+|[TP53](TP53)|Tier 1 GE[@beaLandscapeSomaticMutations2013], FE[@katoUnderstandingFunctionstructureFunctionmutation2003]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|[@morinFrequentMutationHistonemodifying2011; @rossiCodingGenomeSplenic2012; @tiacciPervasiveMutationsJAKSTAT2018; @wildaInactivationARFMDM2p53Pathway2004]||
40
+|[UBR5](UBR5)|Tier 1 GE[@pararajalingamCodingNoncodingDrivers2020]|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)|[@albuquerqueEnhancingKnowledgeDiscovery2017]||
41 41
42
-## Tier 2 MCL genes
42
+## Tier 2, low-confidence MCL genes
43 43
44 44
### *46 total*
45 45
46
-|Gene|Tier| First MCL evidence | Other entities |
47
-|:-:|:-:|:--|:-|
48
-|[ABCA3](ABCA3)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]|[@zhangGeneticHeterogeneityDiffuse2013]|
49
-|[ABCC9](ABCC9)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
50
-|[ANK2](ANK2)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]|[@zhangGeneticHeterogeneityDiffuse2013]|
51
-|[ARID1B](ARID1B)|2||[@reddyGeneticFunctionalDrivers2017]|
52
-|[ATP11C](ATP11C)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
53
-|[B2M](B2M)|2|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]|[@morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015a]|
54
-|[BCOR](BCOR)|2|[Nadeu et al](papers/nadeuGenomicEpigenomicInsights2020b)[@nadeuGenomicEpigenomicInsights2020b]|[@jalladesExomeSequencingIdentifies2017]|
55
-|[CDH8](CDH8)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]|[@reddyGeneticFunctionalDrivers2017]|
56
-|[CHMP4C](CHMP4C)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
57
-|[COL11A1](COL11A1)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
58
-|[COL16A1](COL16A1)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
59
-|[CRYBG3](CRYBG3)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
60
-|[CTNNA2](CTNNA2)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
61
-|[DCP1B](DCP1B)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
62
-|[DHDH](DHDH)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
63
-|[DLC1](DLC1)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
64
-|[DLGAP2](DLGAP2)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
65
-|[DNAJC6](DNAJC6)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
66
-|[EIF2AK4](EIF2AK4)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
67
-|[ESX1](ESX1)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
68
-|[FAT4](FAT4)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]|[@morinMutationalStructuralAnalysis2013; @parryWholeExomeSequencing2013]|
69
-|[GRIN2A](GRIN2A)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
70
-|[HEPH](HEPH)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
71
-|[KCNC2](KCNC2)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
72
-|[KIAA1671](KIAA1671)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
73
-|[KMT2C](KMT2C)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]|[@sarkozyMutationalLandscapeGray2021a; @zhangGeneticHeterogeneityDiffuse2013; @zhouSporadicEndemicBurkitt2019]|
74
-|[LUZP4](LUZP4)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
75
-|[MRGPRF](MRGPRF)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
76
-|[NIN](NIN)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
77
-|[OGDHL](OGDHL)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
78
-|[PCDHB2](PCDHB2)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
79
-|[PCSK2](PCSK2)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
80
-|[PDLIM3](PDLIM3)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
81
-|[PLXNB3](PLXNB3)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]|[@spinaGeneticsNodalMarginal2016b]|
82
-|[RGS4](RGS4)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
83
-|[ROBO2](ROBO2)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
84
-|[SALL3](SALL3)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]|[@loveGeneticLandscapeMutations2012]|
85
-|[SI](SI)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
86
-|[SLC17A6](SLC17A6)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
87
-|[SMARCB1](SMARCB1)|2|[Nadeu et al](papers/nadeuGenomicEpigenomicInsights2020b)[@nadeuGenomicEpigenomicInsights2020b]||
88
-|[SMC1A](SMC1A)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
89
-|[TBC1D26](TBC1D26)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
90
-|[TNRC6B](TNRC6B)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
91
-|[TRPM6](TRPM6)|2|[Bea et al](papers/beaLandscapeSomaticMutations2013)[@beaLandscapeSomaticMutations2013]||
92
-|[ZNF117](ZNF117)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
93
-|[ZNF296](ZNF296)|2|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)[@zhangGenomicLandscapeMantle2014]||
46
+|Gene|Summary| First MCL study | Other entities | QC result |
47
+|:-:|:--:|:-:|:-|:-|
48
+|[ABCA3](ABCA3)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|[@zhangGeneticHeterogeneityDiffuse2013]||
49
+|[ABCC9](ABCC9)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
50
+|[ANK2](ANK2)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|[@zhangGeneticHeterogeneityDiffuse2013]||
51
+|[ARID1B](ARID1B)|Tier 2 GE[@]||[@reddyGeneticFunctionalDrivers2017]||
52
+|[ATP11C](ATP11C)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
53
+|[B2M](B2M)|Tier 2 GE[@pararajalingamCodingNoncodingDrivers2020], FE[@challa-malladiCombinedGeneticInactivation2011]|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)|[@morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015]||
54
+|[BCOR](BCOR)|Tier 2 GE[@nadeuGenomicEpigenomicInsights2020b]|[Nadeu et al](papers/nadeuGenomicEpigenomicInsights2020b)|[@jalladesExomeSequencingIdentifies2017]||
55
+|[CDH8](CDH8)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|[@reddyGeneticFunctionalDrivers2017]||
56
+|[CHMP4C](CHMP4C)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
57
+|[COL11A1](COL11A1)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
58
+|[COL16A1](COL16A1)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
59
+|[CRYBG3](CRYBG3)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
60
+|[CTNNA2](CTNNA2)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
61
+|[DCP1B](DCP1B)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
62
+|[DHDH](DHDH)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
63
+|[DLC1](DLC1)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
64
+|[DLGAP2](DLGAP2)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
65
+|[DNAJC6](DNAJC6)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
66
+|[EIF2AK4](EIF2AK4)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
67
+|[ESX1](ESX1)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
68
+|[FAT4](FAT4)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|[@morinMutationalStructuralAnalysis2013; @parryWholeExomeSequencing2013]||
69
+|[GRIN2A](GRIN2A)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
70
+|[HEPH](HEPH)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
71
+|[KCNC2](KCNC2)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
72
+|[KIAA1671](KIAA1671)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
73
+|[KMT2C](KMT2C)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|[@sarkozyMutationalLandscapeGray2021; @zhangGeneticHeterogeneityDiffuse2013; @zhouSporadicEndemicBurkitt2019]||
74
+|[LUZP4](LUZP4)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
75
+|[MRGPRF](MRGPRF)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
76
+|[NIN](NIN)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
77
+|[OGDHL](OGDHL)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
78
+|[PCDHB2](PCDHB2)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
79
+|[PCSK2](PCSK2)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
80
+|[PDLIM3](PDLIM3)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
81
+|[PLXNB3](PLXNB3)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|[@spinaGeneticsNodalMarginal2016]||
82
+|[RGS4](RGS4)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
83
+|[ROBO2](ROBO2)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
84
+|[SALL3](SALL3)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|[@loveGeneticLandscapeMutations2012]||
85
+|[SI](SI)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
86
+|[SLC17A6](SLC17A6)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
87
+|[SMARCB1](SMARCB1)|Tier 2 GE[@nadeuGenomicEpigenomicInsights2020b]|[Nadeu et al](papers/nadeuGenomicEpigenomicInsights2020b)|||
88
+|[SMC1A](SMC1A)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
89
+|[TBC1D26](TBC1D26)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
90
+|[TNRC6B](TNRC6B)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
91
+|[TRPM6](TRPM6)|Tier 2 GE[@beaLandscapeSomaticMutations2013]|[Bea et al](papers/beaLandscapeSomaticMutations2013)|||
92
+|[ZNF117](ZNF117)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
93
+|[ZNF296](ZNF296)|Tier 2 GE[@zhangGenomicLandscapeMantle2014]|[Zhang et al](papers/zhangGenomicLandscapeMantle2014)|||
94 94
95
-## Tier 3 MCL genes
95
+## Tier 3, retired MCL genes
96 96
97 97
### *0 total*
98 98
99
-|Gene|Tier| First MCL evidence | Other entities |
100
-|:-:|:-:|:--|:-|
99
+|Gene|Summary| First MCL study | Other entities | QC result |
100
+|:-:|:--:|:-:|:-|:-|
101 101
102 102
103 103
# References