89a479ea3272124d6eb765748de202e36672d2ca
TET2.md
| ... | ... | @@ -6,23 +6,18 @@ |
| 6 | 6 | timeline |
| 7 | 7 | title Publication timing |
| 8 | 8 | 2017-05-01 : Albuquerque : DLBCL |
| 9 | - 2019-09-26 : Panea : BL |
|
| 10 | 9 | ``` |
| 11 | 10 | |
| 12 | 11 | ## Relevance tier by entity |
| 13 | 12 | |
| 14 | 13 | |Entity|Tier|Description | |
| 15 | 14 | |:------:|:----:|--------------------------------------| |
| 16 | -| |2 |relevance in BL not firmly established| |
|
| 17 | 15 | | |1 |high-confidence DLBCL gene | |
| 18 | 16 | |
| 19 | 17 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 20 | 18 | |
| 21 | 19 | |Entity|source |frequency (%)| |
| 22 | 20 | |:------:|:---------------------:|:-------------:| |
| 23 | -|BL |GAMBL genomes+capture| 5.31 | |
|
| 24 | -|BL |Thomas cohort | 5.10 | |
|
| 25 | -|BL |Panea cohort |10.90 | |
|
| 26 | 21 | |DLBCL |GAMBL genomes | 5.54 | |
| 27 | 22 | |DLBCL |Schmitz cohort |11.70 | |
| 28 | 23 | |DLBCL |Reddy cohort | 7.41 | |
| ... | ... | @@ -50,9 +45,7 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/T |
| 50 | 45 | ## TET2 Expression |
| 51 | 46 |  |
| 52 | 47 | <!-- ORIGIN: 28327945 --> |
| 53 | -<!-- BL: paneaWholeGenomeLandscape2019 --> |
|
| 54 | 48 | <!-- DLBCL: albuquerqueEnhancingKnowledgeDiscovery2017a --> |
| 55 | 49 | |
| 56 | 50 | ## References |
| 57 | 51 | 1. Albuquerque MA, Grande BM, Ritch EJ, Pararajalingam P, Jessa S, Krzywinski M, Grewal JK, Shah SP, Boutros PC, Morin RD. Enhancing knowledge discovery from cancer genomics data with Galaxy. Gigascience. 2017 May 1;6(5):1–13. PMCID: PMC5437943 |
| 58 | -2. Panea R, Love C, Shingleton JR, Reddy A, Bailey J, Moormann A, Otieno J, Ong’echa J, Oduor C, Schroêder K, Masalu N, Chao N, Agajanian M, Major M, Fedoriw Y, Richards K, Rymkiewicz G, Miles R, Alobeid B, Bhagat G, Flowers C, Ondrejka S, Hsi E, Choi W, Au-Yeung R, Hartmann W, Lenz G, Meyerson H, Lin YY, Zhuang Y, Luftig M, Waldrop A, Dave T, Thakkar D, Sahay H, Li G, Palus B, Seshadri V, Kim S, Gascoyne R, Levy S, Mukhopadhyay M, Dunson D, Dave S. The whole genome landscape of Burkitt lymphoma subtypes. Blood. 2019; |
papers/paneaWholeGenomeLandscape2019.md
| ... | ... | @@ -76,11 +76,9 @@ All other BL studies, BL Tier 2, 111 |
| 76 | 76 | |[PXDNL](../PXDNL)|2 |★ ☆ ☆ ☆ ☆| |
| 77 | 77 | |[RNF144B](../RNF144B)|2 |★ ★ ★ ☆ ☆| |
| 78 | 78 | |[SNTB2](../SNTB2)|2 |★ ★ ☆ ☆ ☆| |
| 79 | -|[SYNCRIP](../SYNCRIP)|2 |☆ ☆ ☆ ☆ ☆| |
|
| 80 | -|[TET2](../TET2)|2 |☆ ☆ ☆ ☆ ☆| |
|
| 81 | -|[WDR7](../WDR7)|2 |☆ ☆ ☆ ☆ ☆| |
|
| 82 | -|[WNK2](../WNK2)|2 |☆ ☆ ☆ ☆ ☆| |
|
| 83 | -|[ZFP36L1](../ZFP36L1)|2 |☆ ☆ ☆ ☆ ☆| |
|
| 79 | +|[WDR7](../WDR7)|2 |★ ★ ☆ ☆ ☆| |
|
| 80 | +|[WNK2](../WNK2)|2 |★ ★ ★ ★ ☆| |
|
| 81 | +|[ZFP36L1](../ZFP36L1)|2 |★ ★ ★ ★ ☆| |
|
| 84 | 82 | |
| 85 | 83 | |
| 86 | 84 | # Details |
papers/paneaWholeGenomeLandscape2019.pdf
papers/paneaWholeGenomeLandscape2019_tmp.html
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| 368 | +<h1 id="paneawholegenomelandscape2019">@paneaWholeGenomeLandscape2019</h1> |
|
| 369 | +<h2 id="summary-of-novel-genes">Summary of novel genes</h2> |
|
| 370 | +<table> |
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| 371 | +<thead> |
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| 372 | +<tr> |
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| 373 | +<th style="text-align:center">Entity</th> |
|
| 374 | +<th style="text-align:center">Tier 1 genes</th> |
|
| 375 | +<th style="text-align:center">Tier 2 genes</th> |
|
| 376 | +</tr> |
|
| 377 | +</thead> |
|
| 378 | +<tbody> |
|
| 379 | +<tr> |
|
| 380 | +<td style="text-align:center">BL</td> |
|
| 381 | +<td style="text-align:center">4</td> |
|
| 382 | +<td style="text-align:center">39</td> |
|
| 383 | +</tr> |
|
| 384 | +</tbody> |
|
| 385 | +</table> |
|
| 386 | +<pre><code class="language-mermaid"><div class="mermaid">--- |
|
| 387 | +config: |
|
| 388 | + sankey: |
|
| 389 | + showValues: true |
|
| 390 | + linkColor: target |
|
| 391 | + width: 600 |
|
| 392 | + height: 300 |
|
| 393 | + nodeAlignment: right |
|
| 394 | + prefix: '(' |
|
| 395 | + suffix: ' genes)' |
|
| 396 | +--- |
|
| 397 | +sankey-beta |
|
| 398 | +This study, New Tier 1, 4 |
|
| 399 | +New Tier 1, BL Tier 1, 4 |
|
| 400 | +This study, New Tier 2, 39 |
|
| 401 | +New Tier 2, BL Tier 2, 39 |
|
| 402 | +All other BL studies, BL Tier 1, 25 |
|
| 403 | +All other BL studies, BL Tier 2, 111 |
|
| 404 | +</div></code></pre> |
|
| 405 | +<h2 id="novel-genes-reported-in-this-study">Novel genes reported in this study</h2> |
|
| 406 | +<h3 id="tier-1">Tier 1</h3> |
|
| 407 | +<table> |
|
| 408 | +<thead> |
|
| 409 | +<tr> |
|
| 410 | +<th style="text-align:left">New gene</th> |
|
| 411 | +<th style="text-align:center">BL tier</th> |
|
| 412 | +</tr> |
|
| 413 | +</thead> |
|
| 414 | +<tbody> |
|
| 415 | +<tr> |
|
| 416 | +<td style="text-align:left"><a href="../BMP7">BMP7</a></td> |
|
| 417 | +<td style="text-align:center">1</td> |
|
| 418 | +</tr> |
|
| 419 | +<tr> |
|
| 420 | +<td style="text-align:left"><a href="../EIF4A1">EIF4A1</a></td> |
|
| 421 | +<td style="text-align:center">1</td> |
|
| 422 | +</tr> |
|
| 423 | +<tr> |
|
| 424 | +<td style="text-align:left"><a href="../EPPK1">EPPK1</a></td> |
|
| 425 | +<td style="text-align:center">1</td> |
|
| 426 | +</tr> |
|
| 427 | +<tr> |
|
| 428 | +<td style="text-align:left"><a href="../HNRNPU">HNRNPU</a></td> |
|
| 429 | +<td style="text-align:center">1</td> |
|
| 430 | +</tr> |
|
| 431 | +</tbody> |
|
| 432 | +</table> |
|
| 433 | +<h3 id="tier-2">Tier 2</h3> |
|
| 434 | +<table> |
|
| 435 | +<thead> |
|
| 436 | +<tr> |
|
| 437 | +<th style="text-align:left">New gene</th> |
|
| 438 | +<th style="text-align:center">BL tier</th> |
|
| 439 | +<th style="text-align:center">Rating of reviewed variants</th> |
|
| 440 | +</tr> |
|
| 441 | +</thead> |
|
| 442 | +<tbody> |
|
| 443 | +<tr> |
|
| 444 | +<td style="text-align:left"><a href="../ALPK2">ALPK2</a></td> |
|
| 445 | +<td style="text-align:center">2</td> |
|
| 446 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 447 | +</tr> |
|
| 448 | +<tr> |
|
| 449 | +<td style="text-align:left"><a href="../CD79B">CD79B</a></td> |
|
| 450 | +<td style="text-align:center">2</td> |
|
| 451 | +<td style="text-align:center">★ ★ ☆ ☆ ☆</td> |
|
| 452 | +</tr> |
|
| 453 | +<tr> |
|
| 454 | +<td style="text-align:left"><a href="../CD83">CD83</a></td> |
|
| 455 | +<td style="text-align:center">2</td> |
|
| 456 | +<td style="text-align:center">★ ★ ★ ☆ ☆</td> |
|
| 457 | +</tr> |
|
| 458 | +<tr> |
|
| 459 | +<td style="text-align:left"><a href="../CTCF">CTCF</a></td> |
|
| 460 | +<td style="text-align:center">2</td> |
|
| 461 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 462 | +</tr> |
|
| 463 | +<tr> |
|
| 464 | +<td style="text-align:left"><a href="../CXCR4">CXCR4</a></td> |
|
| 465 | +<td style="text-align:center">2</td> |
|
| 466 | +<td style="text-align:center">★ ★ ★ ★ ☆</td> |
|
| 467 | +</tr> |
|
| 468 | +<tr> |
|
| 469 | +<td style="text-align:left"><a href="../DNMT1">DNMT1</a></td> |
|
| 470 | +<td style="text-align:center">2</td> |
|
| 471 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 472 | +</tr> |
|
| 473 | +<tr> |
|
| 474 | +<td style="text-align:left"><a href="../DTX1">DTX1</a></td> |
|
| 475 | +<td style="text-align:center">2</td> |
|
| 476 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 477 | +</tr> |
|
| 478 | +<tr> |
|
| 479 | +<td style="text-align:left"><a href="../ETS1">ETS1</a></td> |
|
| 480 | +<td style="text-align:center">2</td> |
|
| 481 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 482 | +</tr> |
|
| 483 | +<tr> |
|
| 484 | +<td style="text-align:left"><a href="../FZD3">FZD3</a></td> |
|
| 485 | +<td style="text-align:center">2</td> |
|
| 486 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 487 | +</tr> |
|
| 488 | +<tr> |
|
| 489 | +<td style="text-align:left"><a href="../HIST1H1C">HIST1H1C</a></td> |
|
| 490 | +<td style="text-align:center">2</td> |
|
| 491 | +<td style="text-align:center">★ ★ ☆ ☆ ☆</td> |
|
| 492 | +</tr> |
|
| 493 | +<tr> |
|
| 494 | +<td style="text-align:left"><a href="../HIST1H2AG">HIST1H2AG</a></td> |
|
| 495 | +<td style="text-align:center">2</td> |
|
| 496 | +<td style="text-align:center">★ ★ ☆ ☆ ☆</td> |
|
| 497 | +</tr> |
|
| 498 | +<tr> |
|
| 499 | +<td style="text-align:left"><a href="../HIST1H2AM">HIST1H2AM</a></td> |
|
| 500 | +<td style="text-align:center">2</td> |
|
| 501 | +<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td> |
|
| 502 | +</tr> |
|
| 503 | +<tr> |
|
| 504 | +<td style="text-align:left"><a href="../HIST1H2BK">HIST1H2BK</a></td> |
|
| 505 | +<td style="text-align:center">2</td> |
|
| 506 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 507 | +</tr> |
|
| 508 | +<tr> |
|
| 509 | +<td style="text-align:left"><a href="../HIST1H3D">HIST1H3D</a></td> |
|
| 510 | +<td style="text-align:center">2</td> |
|
| 511 | +<td style="text-align:center">★ ★ ★ ☆ ☆</td> |
|
| 512 | +</tr> |
|
| 513 | +<tr> |
|
| 514 | +<td style="text-align:left"><a href="../HIST1H3H">HIST1H3H</a></td> |
|
| 515 | +<td style="text-align:center">2</td> |
|
| 516 | +<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td> |
|
| 517 | +</tr> |
|
| 518 | +<tr> |
|
| 519 | +<td style="text-align:left"><a href="../HIST1H3I">HIST1H3I</a></td> |
|
| 520 | +<td style="text-align:center">2</td> |
|
| 521 | +<td style="text-align:center">★ ★ ★ ★ ☆</td> |
|
| 522 | +</tr> |
|
| 523 | +<tr> |
|
| 524 | +<td style="text-align:left"><a href="../HIST1H3J">HIST1H3J</a></td> |
|
| 525 | +<td style="text-align:center">2</td> |
|
| 526 | +<td style="text-align:center">☆ ☆ ☆ ☆ ☆</td> |
|
| 527 | +</tr> |
|
| 528 | +<tr> |
|
| 529 | +<td style="text-align:left"><a href="../HIST1H4J">HIST1H4J</a></td> |
|
| 530 | +<td style="text-align:center">2</td> |
|
| 531 | +<td style="text-align:center">★ ★ ☆ ☆ ☆</td> |
|
| 532 | +</tr> |
|
| 533 | +<tr> |
|
| 534 | +<td style="text-align:left"><a href="../IGLL5">IGLL5</a></td> |
|
| 535 | +<td style="text-align:center">2</td> |
|
| 536 | +<td style="text-align:center">★ ★ ★ ★ ☆</td> |
|
| 537 | +</tr> |
|
| 538 | +<tr> |
|
| 539 | +<td style="text-align:left"><a href="../IKZF3">IKZF3</a></td> |
|
| 540 | +<td style="text-align:center">2</td> |
|
| 541 | +<td style="text-align:center">★ ★ ★ ☆ ☆</td> |
|
| 542 | +</tr> |
|
| 543 | +<tr> |
|
| 544 | +<td style="text-align:left"><a href="../IRF8">IRF8</a></td> |
|
| 545 | +<td style="text-align:center">2</td> |
|
| 546 | +<td style="text-align:center">★ ★ ★ ★ ☆</td> |
|
| 547 | +</tr> |
|
| 548 | +<tr> |
|
| 549 | +<td style="text-align:left"><a href="../KCNK10">KCNK10</a></td> |
|
| 550 | +<td style="text-align:center">2</td> |
|
| 551 | +<td style="text-align:center">★ ★ ☆ ☆ ☆</td> |
|
| 552 | +</tr> |
|
| 553 | +<tr> |
|
| 554 | +<td style="text-align:left"><a href="../MCL1">MCL1</a></td> |
|
| 555 | +<td style="text-align:center">2</td> |
|
| 556 | +<td style="text-align:center">★ ★ ★ ★ ☆</td> |
|
| 557 | +</tr> |
|
| 558 | +<tr> |
|
| 559 | +<td style="text-align:left"><a href="../MME">MME</a></td> |
|
| 560 | +<td style="text-align:center">2</td> |
|
| 561 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 562 | +</tr> |
|
| 563 | +<tr> |
|
| 564 | +<td style="text-align:left"><a href="../MTOR">MTOR</a></td> |
|
| 565 | +<td style="text-align:center">2</td> |
|
| 566 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 567 | +</tr> |
|
| 568 | +<tr> |
|
| 569 | +<td style="text-align:left"><a href="../PABPC4L">PABPC4L</a></td> |
|
| 570 | +<td style="text-align:center">2</td> |
|
| 571 | +<td style="text-align:center">★ ★ ☆ ☆ ☆</td> |
|
| 572 | +</tr> |
|
| 573 | +<tr> |
|
| 574 | +<td style="text-align:left"><a href="../PCDHA11">PCDHA11</a></td> |
|
| 575 | +<td style="text-align:center">2</td> |
|
| 576 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 577 | +</tr> |
|
| 578 | +<tr> |
|
| 579 | +<td style="text-align:left"><a href="../PDZRN3">PDZRN3</a></td> |
|
| 580 | +<td style="text-align:center">2</td> |
|
| 581 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 582 | +</tr> |
|
| 583 | +<tr> |
|
| 584 | +<td style="text-align:left"><a href="../PIK3R1">PIK3R1</a></td> |
|
| 585 | +<td style="text-align:center">2</td> |
|
| 586 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 587 | +</tr> |
|
| 588 | +<tr> |
|
| 589 | +<td style="text-align:left"><a href="../PLCG2">PLCG2</a></td> |
|
| 590 | +<td style="text-align:center">2</td> |
|
| 591 | +<td style="text-align:center">★ ★ ★ ☆ ☆</td> |
|
| 592 | +</tr> |
|
| 593 | +<tr> |
|
| 594 | +<td style="text-align:left"><a href="../PXDNL">PXDNL</a></td> |
|
| 595 | +<td style="text-align:center">2</td> |
|
| 596 | +<td style="text-align:center">★ ☆ ☆ ☆ ☆</td> |
|
| 597 | +</tr> |
|
| 598 | +<tr> |
|
| 599 | +<td style="text-align:left"><a href="../RNF144B">RNF144B</a></td> |
|
| 600 | +<td style="text-align:center">2</td> |
|
| 601 | +<td style="text-align:center">★ ★ ★ ☆ ☆</td> |
|
| 602 | +</tr> |
|
| 603 | +<tr> |
|
| 604 | +<td style="text-align:left"><a href="../SNTB2">SNTB2</a></td> |
|
| 605 | +<td style="text-align:center">2</td> |
|
| 606 | +<td style="text-align:center">★ ★ ☆ ☆ ☆</td> |
|
| 607 | +</tr> |
|
| 608 | +<tr> |
|
| 609 | +<td style="text-align:left"><a href="../WDR7">WDR7</a></td> |
|
| 610 | +<td style="text-align:center">2</td> |
|
| 611 | +<td style="text-align:center">★ ★ ☆ ☆ ☆</td> |
|
| 612 | +</tr> |
|
| 613 | +<tr> |
|
| 614 | +<td style="text-align:left"><a href="../WNK2">WNK2</a></td> |
|
| 615 | +<td style="text-align:center">2</td> |
|
| 616 | +<td style="text-align:center">★ ★ ★ ★ ☆</td> |
|
| 617 | +</tr> |
|
| 618 | +<tr> |
|
| 619 | +<td style="text-align:left"><a href="../ZFP36L1">ZFP36L1</a></td> |
|
| 620 | +<td style="text-align:center">2</td> |
|
| 621 | +<td style="text-align:center">★ ★ ★ ★ ☆</td> |
|
| 622 | +</tr> |
|
| 623 | +</tbody> |
|
| 624 | +</table> |
|
| 625 | +<h1 id="details">Details</h1> |
|
| 626 | +
|
|
| 627 | +</body>
|
|
| 628 | +</html>
|
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