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IL16.md
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| 1 | 1 | # IL16 |
| 2 | 2 | ## Overview |
| 3 | -The IL16 gene, which encodes a pro-inflammatory cytokine, plays a role in immune responses. IL-16 is highly expressed in the activated B-cell-like (ABC) subtype of DLBCL compared to the germinal center B-cell-like (GCB) subtype. The role of mutations in lymphomagenesis is not understood. *Without further support, this gene may be migrated to Tier 2.* |
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| 3 | +The IL16 gene, which encodes a pro-inflammatory cytokine, plays a role in immune responses. IL-16 is highly expressed in the activated B-cell-like (ABC) subtype of DLBCL compared to the germinal center B-cell-like (GCB) subtype. The role of mutations in lymphomagenesis is not understood. Overall, the mutation rate of IL16 is relatively low in DLBCL. *Without further support, this gene may be migrated to Tier 2.* |
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| 4 | 4 | |
| 5 | 5 | ## Relevance tier by entity |
| 6 | 6 |