BCOR.md
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# BCOR
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+BCOR acts as a co-repressor of BCL6, and mutations in BCOR could impair its binding affinity to BCL6 and other partners. Overall, protein-altering mutations in BCOR seem to be rare in DLBCL and MCL.<sup>1,2</sup> One study reported a much higher prevalence of a hot spot mutation in BCOR but this result has not been reproduced.<sup>1</sup>
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## Relevance tier by entity
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|Entity|Tier|Description |
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> [!NOTE]
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-> First described in MCL in 2020 by [Nadeu F](https://pubmed.ncbi.nlm.nih.gov/32584970)
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+> BCOR mutations were first described in MCL in 2020 by Nadeu et al.<sup>2</sup> and in 2021 by Kang et al, although the hot spot mutation reported in that study has not been reproduced.<sup>1</sup>
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## BCOR Hotspots
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View all variants in GenomePaint [hg19](https://www.bcgsc.ca/downloads/morinlab/GAMBL/test/genes/BCOR.html) or [hg38](https://www.bcgsc.ca/downloads/morinlab/GAMBL/test/genes/BCOR_hg38.html)
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![image](images/proteinpaint/BCOR.svg)
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+## References
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+1. *Kang JH, Lee SH, Lee J, Choi M, Cho J, Kim SJ, Kim WS, Ko YH, Yoo HY. The mutation of BCOR is highly recurrent and oncogenic in mature T-cell lymphoma. BMC Cancer. 2021 Jan 19;21(1):82. doi: 10.1186/s12885-021-07806-8. PMID: 33468080; PMCID: PMC7816311.*
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+2. *Nadeu F, Martin-Garcia D, Clot G, Díaz-Navarro A, Duran-Ferrer M, Navarro A, Vilarrasa-Blasi R, Kulis M, Royo R, Gutiérrez-Abril J, Valdés-Mas R, López C, Chapaprieta V, Puiggros M, Castellano G, Costa D, Aymerich M, Jares P, Espinet B, Muntañola A, Ribera-Cortada I, Siebert R, Colomer D, Torrents D, Gine E, López-Guillermo A, Küppers R, Martin-Subero JI, Puente XS, Beà S, Campo E. Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes. Blood. 2020 Sep 17;136(12):1419-1432. doi: 10.1182/blood.2020005289. PMID: 32584970; PMCID: PMC7498364.*