EZH2.md
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> First described in BL in 2012 by [Love C](https://pubmed.ncbi.nlm.nih.gov/23143597). First described in DLBCL in 2010 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/20081860). First described in FL in 2010 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/20081860)
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+ ## EZH2 Hotspots
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+| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |
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+ | :---:| :---: | :--: | :---: |
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+| chr7 | 148508745 | T>C | N640S |
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+| chr7 | 148508728 | A>T | Y646N |
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+| chr7 | 148508728 | A>G | Y646H |
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+| chr7 | 148508727 | T>G | Y646S |
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+| chr7 | 148508727 | T>C | Y646C |
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+| chr7 | 148508727 | T>A | Y646F |
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+
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View coding variants in ProteinPaint [hg19](https://www.bcgsc.ca/downloads/morinlab/GAMBL/test/genes/EZH2_protein.html) or [hg38](https://www.bcgsc.ca/downloads/morinlab/GAMBL/test/genes/EZH2_protein_hg38.html)
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![image](images/proteinpaint/EZH2_NM_001203247.svg)