morinlab.bib
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+@article{skalniakRegulatoryFeedbackLoop2009a,
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+ title = {Regulatory Feedback Loop between {{NF-kappaB}} and {{MCP-1-induced}} Protein 1 {{RNase}}},
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+ author = {Skalniak, Lukasz and Mizgalska, Danuta and Zarebski, Adrian and Wyrzykowska, Paulina and Koj, Aleksander and Jura, Jolanta},
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+ date = {2009-10},
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+ journaltitle = {The FEBS journal},
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+ shortjournal = {FEBS J},
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+ volume = {276},
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+ number = {20},
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+ eprint = {19747262},
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+ eprinttype = {pmid},
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+ pages = {5892--5905},
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+ issn = {1742-4658},
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+ doi = {10.1111/j.1742-4658.2009.07273.x},
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+ abstract = {A novel gene ZC3H12A, encoding MCP-1-induced protein 1 (MCPIP), was recently identified in human peripheral blood monocytes treated with monocyte chemotactic protein 1 (MCP-1) and in human monocyte-derived macrophages stimulated with interleukin (IL)-1beta. These experiments revealed that the gene undergoes rapid and potent transcription induction upon stimulation with proinflammatory molecules, such as MCP-1, IL-1beta, tumour necrosis factor alpha and lipopolysaccharide. Here we show that the induction of ZC3H12A by IL-1beta is predominantly NF-kappaB-dependent because inhibition of this signalling pathway results in the impairment of ZC3H12A transcription activation. Our results indicate the presence of an IL-1beta-responding region within the second intron of the ZC3H12A gene, which contains four functional NF-kappaB-binding sites. Therefore, we propose that this transcription enhancer transduces a ZC3H12A transcription-inducing signal after IL-1beta stimulation. Recent reports suggest that MCPIP acts as a negative regulator of inflammatory processes because it is engaged in the degradation of transcripts coding for certain proinflammatory cytokines. Our observations provide evidence for a novel negative feedback loop in the activation of NF-kappaB and point to potential significance of MCPIP in the treatment of various pathological states, such as diabetes or cancer that involve disturbances in the functioning of the NF-kappaB system.},
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+ langid = {english},
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+ keywords = {Base Sequence,Binding Sites,Blotting Western,Cell Line Tumor,Chromatin Immunoprecipitation,Electrophoretic Mobility Shift Assay,Humans,I-kappa B Proteins,Interleukin-1beta,Molecular Sequence Data,Mutagenesis Site-Directed,NF-kappa B,Polymerase Chain Reaction,Ribonucleases,Signal Transduction,Transcription Factors,Transcription Genetic,Transcription Initiation Site}
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+}
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+
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@article{wangFasFADDDeathDomain2010,
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title = {The {{Fas-FADD}} Death Domain Complex Structure Reveals the Basis of {{DISC}} Assembly and Disease Mutations},
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author = {Wang, Liwei and Yang, Jin Kuk and Kabaleeswaran, Venkataraman and Rice, Amanda J. and Cruz, Anthony C. and Park, Ah Young and Yin, Qian and Damko, Ermelinda and Jang, Se Bok and Raunser, Stefan and Robinson, Carol V. and Siegel, Richard M. and Walz, Thomas and Wu, Hao},