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Updated KMT2D (markdown)

rdmorin committed 2024-05-22 14:24:59 -0700 commit 909070bbe9fad8fdc4556260317f92e70e385458

				KMT2D.md
			
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           # KMT2D

          +## Overview

          +KMT2D (also known as MLL2) encodes a histone H3K4 methyltransferase, playing a crucial role in germinal center B cell development and function. Mutations in KMT2D are among the most common mutations in FL and are also common in DLBCL.<sup>1</sup> KMT2D mutations are recurrent but less common in BL and MCL and many other B-cell neoplasms. Mutations typically cause loss of KMT2D function, leading to diminished H3K4 methylation, impacting gene expression that favours lymphomagenesis. 

           ## Relevance tier by entity

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1	1	# KMT2D
	2	+## Overview
	3	+KMT2D (also known as MLL2) encodes a histone H3K4 methyltransferase, playing a crucial role in germinal center B cell development and function. Mutations in KMT2D are among the most common mutations in FL and are also common in DLBCL.<sup>1</sup> KMT2D mutations are recurrent but less common in BL and MCL and many other B-cell neoplasms. Mutations typically cause loss of KMT2D function, leading to diminished H3K4 methylation, impacting gene expression that favours lymphomagenesis.
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3	5	## Relevance tier by entity
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