Audit-of-B\342\200\220cell-Cancer-Genes.md
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This is a community-driven resource and knowledge base initiated by members of the Lymphoma/Leukemia Molecular Profiling Project and fuelled by results from the genomic analysis of mature B-cell lymphomas (GAMBL) project. ## ATR Expression
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![image](images/gene_expression/ATR_by_pathology.svg)
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+<!-- ORIGIN: reddyGeneticFunctionalDrivers2017 -->
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+<!-- DLBCL: reddyGeneticFunctionalDrivers2017 -->
CD79A.md
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+---
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+bibliography: 'morinlab.bib'
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+csl: 'NLM.csl'
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+link-citations: true
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+---
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# CD79A
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## History
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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-|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|
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-|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
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+|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established[@rossiCodingGenomeSplenic2012c]|
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+|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established[@burkhardtClinicalRelevanceMolecular2022b]|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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DLGAP1.md
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# DLGAP1
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+## Overview
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+
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+Due to [minimal support](DLGAP1#representative-mutation) in the original primary data, [low expression in BL](DLGAP1#dlgap1-expression) and very few mutations reported in subsequent studies, this gene is very unlikely to be relevant in BL.
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+
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## History
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+
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```mermaid
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%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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timeline
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<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->
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<!-- BL: loveGeneticLandscapeMutations2012 -->
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+## Representative Mutation
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+
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+![](primary/Love_DLGAP_chr18_3869854.png)
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+
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## References
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1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561
MYCBP2.md
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+---
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+bibliography: 'morinlab.bib'
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+csl: 'NLM.csl'
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+link-citations: true
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+---
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# MYCBP2
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## History
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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-|![FL](images/icons/FL_tier2.png) |2 |relevance in FL not firmly established|
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+|![FL](images/icons/FL_tier2.png) |2 |relevance in FL not firmly established[@hubschmannMutationalMechanismsShaping2021b]|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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