add header

+|Gene|Tier| First DLBCL evidence | Other entities |

+|:-:|:-:|:-|:-|

+|[ACTB](ACTB)|1, aSHM|[@lohrDiscoveryPrioritizationSomatic2012a]|[@wienandGenomicAnalysesFlowsorted2019b]|

+|[ACTG1](ACTG1)|1, aSHM|[@hubschmannMutationalMechanismsShaping2021b]|[@deschGenotypingCirculatingTumor2020; @spinaGeneticsNodalMarginal2016b]|

+|[ARID1A](ARID1A)|1|[@zhangGeneticHeterogeneityDiffuse2013]|[@wienandGenomicAnalysesFlowsorted2019b; @rossiCodingGenomeSplenic2012c; @loveGeneticLandscapeMutations2012; @krysiakRecurrentSomaticMutations2017b]|

+|[ATM](ATM)|1|[@reddyGeneticFunctionalDrivers2017]|[@braggioGenomicAnalysisMarginal2012; @beaLandscapeSomaticMutations2013]|

+|[B2M](B2M)|1|[@morinFrequentMutationHistonemodifying2011]|[@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]|

+|[BCL10](BCL10)|1|[@morinFrequentMutationHistonemodifying2011]|[@spinaGeneticsNodalMarginal2016b; @russler-germainMutationsAssociatedProgression2023b]|

+|[BCL2](BCL2)|1, aSHM|[@tanakaFrequentIncidenceSomatic1992]|[@sarkozyMutationalLandscapeGray2021a; @burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011]|

+|[BCL6](BCL6)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|

+|[BCL7A](BCL7A)|1, aSHM|[@arthurGenomewideDiscoverySomatic2018]|[@krysiakRecurrentSomaticMutations2017b; @grandeGenomewideDiscoverySomatic2019; @reichelFlowSortingExome2015a]|

+|[BIRC6](BIRC6)|1|[@reddyGeneticFunctionalDrivers2017]|[@sarkozyMutationalLandscapeGray2021a]|

+|[BRAF](BRAF)|1|[@tiacciBRAFMutationsHairycell2011a]|[@loveGeneticLandscapeMutations2012]|

+|[BTG1](BTG1)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@sarkozyMutationalLandscapeGray2021a; @burkhardtClinicalRelevanceMolecular2022b]|

+|[BTG2](BTG2)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|

+|[BTK](BTK)|1|[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@krysiakRecurrentSomaticMutations2017b]|

+|[CARD11](CARD11)|1|[@lenzOncogenicCARD11Mutations2008]|[@yanBCRTLRSignaling2012a; @wuGeneticHeterogeneityPrimary2016; @morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]|

+|[CCND3](CCND3)|1|[@morinFrequentMutationHistonemodifying2011]|[@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a]|

+|[CD58](CD58)|1|[@morinFrequentMutationHistonemodifying2011]|[@schneiderAlterationsCD58Gene2015a]|

+|[CD70](CD70)|1|[@morinFrequentMutationHistonemodifying2011]|[@russler-germainMutationsAssociatedProgression2023b]|

+|[CD79B](CD79B)|1|[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|

+|[CD83](CD83)|1, aSHM|[@morinMutationalStructuralAnalysis2013]|[@russler-germainMutationsAssociatedProgression2023b; @paneaWholeGenomeLandscape2019; @dunsCharacterizationDLBCLPMBL2021b]|

+|[CDKN2A](CDKN2A)|1|[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019; @spinaGeneticsNodalMarginal2016b]|

+|[CIITA](CIITA)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@mottokGenomicAlterationsCIITA2015b]|

+|[CREBBP](CREBBP)|1|[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013; @dunsCharacterizationDLBCLPMBL2021b]|

+|[CXCR4](CXCR4)|1, aSHM|[@khodabakhshiRecurrentTargetsAberrant2012]|[@paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b]|

+|[CXCR5](CXCR5)|1|[@schmitzGeneticsPathogenesisDiffuse2018a]|[@mottokIntegrativeGenomicAnalysis2019b]|

+|[DDX3X](DDX3X)|1|[@schmitzGeneticsPathogenesisDiffuse2018a]|[@mottokIntegrativeGenomicAnalysis2019b; @schmitzBurkittLymphomaPathogenesis2012]|

+|[DTX1](DTX1)|1, aSHM|[@schmitzGeneticsPathogenesisDiffuse2018a]|[@paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c; @gomezUltraDeepSequencingReveals2023]|

+|[DUSP2](DUSP2)|1, aSHM|[@morinMutationalStructuralAnalysis2013]|[@dunsCharacterizationDLBCLPMBL2021b]|

+|[EBF1](EBF1)|1, aSHM|[@bohleRoleEarlyBcell2013]|[@thomasGeneticSubgroupsInform2023; @reichelFlowSortingExome2015a]|

+|[EEF1A1](EEF1A1)|1|[@hubschmannMutationalMechanismsShaping2021b]|[@reichelFlowSortingExome2015a]|

+|[EP300](EP300)|1|[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]|

+|[ETS1](ETS1)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|

+|[ETV6](ETV6)|1, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[EZH2](EZH2)|1|[@morinSomaticMutationsAltering2010a]|[@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019b]|

+|[FAS](FAS)|1|[@schollMutationsRegionFAS2007]|[@spinaGeneticsNodalMarginal2016b]|

+|[FBXO11](FBXO11)|1|[@hubschmannMutationalMechanismsShaping2021b]|[@richterRecurrentMutationID32012a; @parryWholeExomeSequencing2013]|

+|[FBXW7](FBXW7)|1|[@zhangGeneticHeterogeneityDiffuse2013]||

+|[FOXO1](FOXO1)|1|[@morinFrequentMutationHistonemodifying2011]|[@schmitzBurkittLymphomaPathogenesis2012; @dunsCharacterizationDLBCLPMBL2021b]|

+|[GNA13](GNA13)|1|[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @loveGeneticLandscapeMutations2012]|

+|[GNAI2](GNAI2)|1|[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019]|

+|[GRB2](GRB2)|1|[@pasqualucciAnalysisCodingGenome2011]|[@paneaWholeGenomeLandscape2019]|

+|[GRHPR](GRHPR)|1, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[HIST1H1B](HIST1H1B)|1, aSHM|[@chapuyMolecularSubtypesDiffuse2018b]|[@sarkozyMutationalLandscapeGray2021a; @krysiakRecurrentSomaticMutations2017b]|

+|[HIST1H1C](HIST1H1C)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|

+|[HIST1H1D](HIST1H1D)|1, aSHM|[@morinMutationalStructuralAnalysis2013]|[@jalladesExomeSequencingIdentifies2017; @krysiakRecurrentSomaticMutations2017b]|

+|[HIST1H1E](HIST1H1E)|1, aSHM|[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a]|

+|[HIST1H2AC](HIST1H2AC)|1, aSHM|[@morinMutationalStructuralAnalysis2013]|[@krysiakRecurrentSomaticMutations2017b]|

+|[HIST1H2AM](HIST1H2AM)|1, aSHM||[@paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b]|

+|[HIST1H2BC](HIST1H2BC)|1, aSHM|[@reddyGeneticFunctionalDrivers2017]|[@krysiakRecurrentSomaticMutations2017b; @mottokIntegrativeGenomicAnalysis2019b]|

+|[HIST1H2BK](HIST1H2BK)|1, aSHM||[@paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c]|

+|[HIST1H3B](HIST1H3B)|1, aSHM|[@zhangGeneticHeterogeneityDiffuse2013]|[@reichelFlowSortingExome2015a]|

+|[HIST2H2BE](HIST2H2BE)|1, aSHM|[@schmitzGeneticsPathogenesisDiffuse2018a]||

+|[HLA-A](HLA-A)|1||[@deschGenotypingCirculatingTumor2020]|

+|[HLA-B](HLA-B)|1||[@wienandGenomicAnalysesFlowsorted2019b]|

+|[HLA-C](HLA-C)|1||[@gomezUltraDeepSequencingReveals2023]|

+|[HLA-DMB](HLA-DMB)|1|||

+|[HNRNPU](HNRNPU)|1, aSHM|[@reddyGeneticFunctionalDrivers2017]|[@paneaWholeGenomeLandscape2019]|

+|[HVCN1](HVCN1)|1||[@krysiakRecurrentSomaticMutations2017b]|

+|[IKZF3](IKZF3)|1|[@morinMutationalStructuralAnalysis2013]|[@paneaWholeGenomeLandscape2019]|

+|[IL4R](IL4R)|1, aSHM|[@dunsCharacterizationDLBCLPMBL2021b]|[@viganoSomaticIL4RMutations2018b]|

+|[IRF4](IRF4)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@mottokIntegrativeGenomicAnalysis2019b]|

+|[IRF8](IRF8)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019; @mottokIntegrativeGenomicAnalysis2019b]|

+|[ITPKB](ITPKB)|1, aSHM|[@schmitzGeneticsPathogenesisDiffuse2018a]|[@reichelFlowSortingExome2015a]|

+|[KLF2](KLF2)|1, aSHM|[@pasqualucciAnalysisCodingGenome2011]|[@jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020]|

+|[KLHL14](KLHL14)|1|[@zhangGeneticHeterogeneityDiffuse2013]||

+|[KLHL6](KLHL6)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@ganapathiGeneticLandscapeDural2016; @paneaWholeGenomeLandscape2019]|

+|[KMT2C](KMT2C)|1|[@zhangGeneticHeterogeneityDiffuse2013]|[@sarkozyMutationalLandscapeGray2021a; @zhouSporadicEndemicBurkitt2019; @zhangGenomicLandscapeMantle2014]|

+|[KMT2D](KMT2D)|1|[@morinFrequentMutationHistonemodifying2011]|[@grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020]|

+|[KRAS](KRAS)|1|[@lohrDiscoveryPrioritizationSomatic2012a]||

+|[LCOR](LCOR)|1|[@arthurGenomewideDiscoverySomatic2018]||

+|[LTB](LTB)|1, aSHM|[@chapuyMolecularSubtypesDiffuse2018b]|[@paneaWholeGenomeLandscape2019; @deschGenotypingCirculatingTumor2020]|

+|[MEF2B](MEF2B)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@beaLandscapeSomaticMutations2013]|

+|[MEF2C](MEF2C)|1, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[MGA](MGA)|1|[@zhangGeneticHeterogeneityDiffuse2013]|[@jalladesExomeSequencingIdentifies2017]|

+|[MPEG1](MPEG1)|1|[@morinMutationalStructuralAnalysis2013]||

+|[MS4A1](MS4A1)|1, aSHM|[@rushtonGeneticEvolutionaryPatterns2020]|[@mottokIntegrativeGenomicAnalysis2019b]|

+|[MTOR](MTOR)|1|[@zhangGeneticHeterogeneityDiffuse2013]|[@paneaWholeGenomeLandscape2019]|

+|[MYC](MYC)|1, aSHM|[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992; @dunsCharacterizationDLBCLPMBL2021b]|

+|[MYD88](MYD88)|1|[@ngoOncogenicallyActiveMYD882011a]|[@yanBCRTLRSignaling2012a]|

+|[NFKBIA](NFKBIA)|1|[@lakeMutationsNFKBIAEncoding2009]|[@russler-germainMutationsAssociatedProgression2023b; @wienandGenomicAnalysesFlowsorted2019b]|

+|[NFKBIE](NFKBIE)|1|[@morinGeneticLandscapesRelapsed2016]|[@pararajalingamCodingNoncodingDrivers2020; @mansouriFrequentNFKBIEDeletions2016]|

+|[NFKBIZ](NFKBIZ)|1, noncoding|[@morinGeneticLandscapesRelapsed2016]||

+|[NOL9](NOL9)|1, aSHM|[@schmitzGeneticsPathogenesisDiffuse2018a]|[@spinaGeneticsNodalMarginal2016b]|

+|[NOTCH1](NOTCH1)|1|[@pasqualucciAnalysisCodingGenome2011]|[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013]|

+|[NOTCH2](NOTCH2)|1|[@troenNOTCH2MutationsMarginal2008]|[@rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013; @paneaWholeGenomeLandscape2019]|

+|[OSBPL10](OSBPL10)|1, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[P2RY8](P2RY8)|1|[@lohrDiscoveryPrioritizationSomatic2012a]|[@muppidiLossSignalingGa132014b]|

+|[PIM1](PIM1)|1, aSHM|[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@burkhardtClinicalRelevanceMolecular2022b; @dunsCharacterizationDLBCLPMBL2021b]|

+|[PIM2](PIM2)|1, aSHM|[@arthurGenomewideDiscoverySomatic2018]|[@reichelFlowSortingExome2015a]|

+|[POU2AF1](POU2AF1)|1, aSHM||[@krysiakRecurrentSomaticMutations2017b]|

+|[POU2F2](POU2F2)|1|[@zhangGeneticHeterogeneityDiffuse2013]|[@krysiakRecurrentSomaticMutations2017b]|

+|[PRDM1](PRDM1)|1|[@pasqualucciInactivationPRDM1BLIMP12006a]||

+|[PTEN](PTEN)|1||[@loveGeneticLandscapeMutations2012]|

+|[PTPRD](PTPRD)|1||[@spinaGeneticsNodalMarginal2016b]|

+|[RB1](RB1)|1|[@morinMutationalStructuralAnalysis2013]|[@zhangGenomicLandscapeMantle2014]|

+|[RFX7](RFX7)|1||[@grandeGenomewideDiscoverySomatic2019]|

+|[RHOA](RHOA)|1||[@richterRecurrentMutationID32012a]|

+|[RRAGC](RRAGC)|1|[@okosunRecurrentMTORC1activatingRRAGC2016a]||

+|[S1PR2](S1PR2)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@muppidiLossSignalingGa132014b]|

+|[SETD1B](SETD1B)|1|[@reddyGeneticFunctionalDrivers2017]||

+|[SF3B1](SF3B1)|1||[@loveGeneticLandscapeMutations2012]|

+|[SGK1](SGK1)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@dunsCharacterizationDLBCLPMBL2021b]|

+|[SIN3A](SIN3A)|1||[@grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]|

+|[SMARCA4](SMARCA4)|1|[@zhangGeneticHeterogeneityDiffuse2013]|[@nadeuGenomicEpigenomicInsights2020b; @krysiakRecurrentSomaticMutations2017b; @richterRecurrentMutationID32012a]|

+|[SOCS1](SOCS1)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@wenigerMutationsTumorSuppressor2006a]|

+|[SPEN](SPEN)|1|[@rossiCodingGenomeSplenic2012c]|[@sarkozyMutationalLandscapeGray2021a]|

+|[STAT3](STAT3)|1|[@ohgamiSTAT3MutationsAre2014]||

+|[STAT6](STAT6)|1|[@yildizActivatingSTAT6Mutations2015c]|[@ritzRecurrentMutationsSTAT62009a]|

+|[TAF1](TAF1)|1|[@morinMutationalStructuralAnalysis2013]|[@spinaGeneticsNodalMarginal2016b]|

+|[TBL1XR1](TBL1XR1)|1|[@mareschalWholeExomeSequencing2016]|[@rossiCodingGenomeSplenic2012c]|

+|[TET2](TET2)|1|[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@paneaWholeGenomeLandscape2019]|

+|[TMEM30A](TMEM30A)|1|[@morinFrequentMutationHistonemodifying2011]||

+|[TMSB4X](TMSB4X)|1, aSHM|[@albuquerqueEnhancingKnowledgeDiscovery2017a]||

+|[TNFAIP3](TNFAIP3)|1|[@compagnoMutationsMultipleGenes2009a]|[@schmitzTNFAIP3A20Tumor2009a; @rossiAlterationBIRC3Multiple2011a]|

+|[TNFRSF14](TNFRSF14)|1|[@cheungAcquiredTNFRSF14Mutations2010a]|[@spinaGeneticsNodalMarginal2016b]|

+|[TOX](TOX)|1|[@reddyGeneticFunctionalDrivers2017]||

+|[TP53](TP53)|1||[@morinFrequentMutationHistonemodifying2011; @tiacciPervasiveMutationsJAKSTAT2018b; @rossiCodingGenomeSplenic2012c; @wildaInactivationARFMDM2p53Pathway2004; @beaLandscapeSomaticMutations2013]|

+|[TRRAP](TRRAP)|1|[@parryWholeExomeSequencing2013]|[@rossiCodingGenomeSplenic2012c]|

+|[UBE2A](UBE2A)|1|[@reddyGeneticFunctionalDrivers2017]|[@reichelFlowSortingExome2015a]|

+|[UNC5C](UNC5C)|1|||

+|[USP7](USP7)|1||[@grandeGenomewideDiscoverySomatic2019]|

+|[VPS13B](VPS13B)|1|||

+|[WEE1](WEE1)|1|[@schmitzGeneticsPathogenesisDiffuse2018a]|[@reichelFlowSortingExome2015a]|

+|[XPO1](XPO1)|1|[@mareschalWholeExomeSequencing2016]|[@jardinRecurrentMutationsExportin2016a]|

+|[ZC3H12A](ZC3H12A)|1|[@arthurGenomewideDiscoverySomatic2018]||

+|[ZFP36L1](ZFP36L1)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @paneaWholeGenomeLandscape2019]|

+|[ZNF292](ZNF292)|1|[@zhangGeneticHeterogeneityDiffuse2013]||

+|[ZNF608](ZNF608)|1, aSHM|[@zhangGeneticHeterogeneityDiffuse2013]|[@krysiakRecurrentSomaticMutations2017b]|

+|Gene|Tier| First DLBCL evidence | Other entities |

+|:-:|:-:|:-|:-|

+|[ABI3BP](ABI3BP)|2|[@morinMutationalStructuralAnalysis2013]||

+|[ADAMTS1](ADAMTS1)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[AICDA](AICDA)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[ANKRD12](ANKRD12)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[ANKRD17](ANKRD17)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[ARID1B](ARID1B)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[ARID5B](ARID5B)|2|[@reddyGeneticFunctionalDrivers2017]|[@gomezUltraDeepSequencingReveals2023]|

+|[ATR](ATR)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[BCL11A](BCL11A)|2, aSHM|||

+|[BCOR](BCOR)|2||[@nadeuGenomicEpigenomicInsights2020b; @jalladesExomeSequencingIdentifies2017]|

+|[BCR](BCR)|2, aSHM|||

+|[BIRC3](BIRC3)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]|[@beaLandscapeSomaticMutations2013; @rossiAlterationBIRC3Multiple2011a; @dunsCharacterizationDLBCLPMBL2021b]|

+|[BLK](BLK)|2, aSHM|||

+|[BRINP3](BRINP3)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[BTBD3](BTBD3)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[CADPS2](CADPS2)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[CASP8](CASP8)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[CBLB](CBLB)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[CCL4](CCL4)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[CD22](CD22)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[CD274](CD274)|2|[@morinFrequentMutationHistonemodifying2011]||

+|[CD36](CD36)|2|[@pasqualucciAnalysisCodingGenome2011]||

+|[CD44](CD44)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[CD74](CD74)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[CDC73](CDC73)|2|[@reddyGeneticFunctionalDrivers2017]|[@loveGeneticLandscapeMutations2012]|

+|[CDH9](CDH9)|2|[@morinMutationalStructuralAnalysis2013]||

+|[CHD1](CHD1)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[CHD8](CHD8)|2|[@reddyGeneticFunctionalDrivers2017]|[@grandeGenomewideDiscoverySomatic2019]|

+|[CHST2](CHST2)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[CNOT2](CNOT2)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[CNTNAP5](CNTNAP5)|2|[@morinMutationalStructuralAnalysis2013]||

+|[COQ7](COQ7)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[CRIP1](CRIP1)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[DAZAP1](DAZAP1)|2|[@pararajalingamCodingNoncodingDrivers2020]||

+|[DCAF6](DCAF6)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[DDX10](DDX10)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[DHX16](DHX16)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[DICER1](DICER1)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[DNAH5](DNAH5)|2|[@morinMutationalStructuralAnalysis2013]|[@jalladesExomeSequencingIdentifies2017]|

+|[DNM2](DNM2)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[DNMT3A](DNMT3A)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[DOCK1](DOCK1)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[DSG4](DSG4)|2|[@morinMutationalStructuralAnalysis2013]||

+|[EIF2AK3](EIF2AK3)|2, aSHM|||

+|[EZR](EZR)|2, aSHM||[@deschGenotypingCirculatingTumor2020]|

+|[FAM102A](FAM102A)|2, aSHM|||

+|[FAM38B](FAM38B)|2|[@morinMutationalStructuralAnalysis2013]||

+|[FANK1](FANK1)|2, aSHM|||

+|[FAT4](FAT4)|2|[@morinMutationalStructuralAnalysis2013]|[@parryWholeExomeSequencing2013; @zhangGenomicLandscapeMantle2014]|

+|[FCRL3](FCRL3)|2, aSHM|||

+|[FNBP1](FNBP1)|2, aSHM|||

+|[FNDC1](FNDC1)|2|[@morinMutationalStructuralAnalysis2013]||

+|[FOXC1](FOXC1)|2|[@schmitzGeneticsPathogenesisDiffuse2018a]||

+|[FOXP1](FOXP1)|2, aSHM|[@reddyGeneticFunctionalDrivers2017]||

+|[FUBP1](FUBP1)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[FUT5](FUT5)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[GABRA2](GABRA2)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[GAK](GAK)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[GNAS](GNAS)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[GOLGA5](GOLGA5)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[GPC5](GPC5)|2|[@schmitzGeneticsPathogenesisDiffuse2018a]||

+|[GSG2](GSG2)|2|[@schmitzGeneticsPathogenesisDiffuse2018a]||

+|[HDAC7](HDAC7)|2|[@morinMutationalStructuralAnalysis2013]||

+|[HIST1H2AG](HIST1H2AG)|2, aSHM|[@morinMutationalStructuralAnalysis2013]|[@rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b]|

+|[HLA-DMA](HLA-DMA)|2|||

+|[HLA-DQA1](HLA-DQA1)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[HNF1B](HNF1B)|2|[@pasqualucciAnalysisCodingGenome2011]||

+|[HNRNPD](HNRNPD)|2|||

+|[HNRNPH1](HNRNPH1)|2, noncoding|[@pararajalingamCodingNoncodingDrivers2020]||

+|[HRAS](HRAS)|2|[@reddyGeneticFunctionalDrivers2017]|[@jalladesExomeSequencingIdentifies2017]|

+|[ID3](ID3)|2|[@schmitzBurkittLymphomaPathogenesis2012]|[@spinaGeneticsNodalMarginal2016b; @richterRecurrentMutationID32012a]|

+|[IER2](IER2)|2|[@morinMutationalStructuralAnalysis2013]||

+|[IFNGR1](IFNGR1)|2|[@morinMutationalStructuralAnalysis2013]||

+|[IGLL5](IGLL5)|2, aSHM||[@russler-germainMutationsAssociatedProgression2023b; @deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]|

+|[IKBKB](IKBKB)|2|[@reddyGeneticFunctionalDrivers2017]|[@rossiAlterationBIRC3Multiple2011a; @wienandGenomicAnalysesFlowsorted2019b]|

+|[IKBKE](IKBKE)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[IL16](IL16)|2|||

+|[IL6](IL6)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[INO80](INO80)|2|[@zhangGeneticHeterogeneityDiffuse2013]||

+|[IRAG2](IRAG2)|2, aSHM|||

+|[IRF1](IRF1)|2, aSHM|[@hubschmannMutationalMechanismsShaping2021b]||

+|[JAK1](JAK1)|2|[@zhangGeneticHeterogeneityDiffuse2013]|[@mottokIntegrativeGenomicAnalysis2019b]|

+|[JAK3](JAK3)|2|[@zhangGeneticHeterogeneityDiffuse2013]||

+|[JUNB](JUNB)|2|[@reddyGeneticFunctionalDrivers2017]|[@mottokIntegrativeGenomicAnalysis2019b]|

+|[KCMF1](KCMF1)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[KLHL21](KLHL21)|2|[@schmitzGeneticsPathogenesisDiffuse2018a]||

+|[LAMA5](LAMA5)|2|[@schmitzGeneticsPathogenesisDiffuse2018a]||

+|[LAPTM5](LAPTM5)|2, aSHM||[@hubschmannMutationalMechanismsShaping2021b]|

+|[LIN54](LIN54)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[LPP](LPP)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[LRP12](LRP12)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[LRRN3](LRRN3)|2|[@morinMutationalStructuralAnalysis2013]|[@sarkozyMutationalLandscapeGray2021a]|

+|[LYN](LYN)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[MAGT1](MAGT1)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[MALAT1](MALAT1)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[MAP2K1](MAP2K1)|2|[@shinBRAFV600EMAP2K12015]|[@louissaintPediatrictypeNodalFollicular2016a]|

+|[MAP4K4](MAP4K4)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[MARK1](MARK1)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[MCL1](MCL1)|2|[@reddyGeneticFunctionalDrivers2017]|[@paneaWholeGenomeLandscape2019; @dunsCharacterizationDLBCLPMBL2021b]|

+|[MECOM](MECOM)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[MET](MET)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[MIR142](MIR142)|2, aSHM|[@kwanhianMicroRNA142Mutated202012b]|[@grandeGenomewideDiscoverySomatic2019]|

+|[MIR155HG](MIR155HG)|2, aSHM|||

+|[MPDZ](MPDZ)|2|[@morinMutationalStructuralAnalysis2013]|[@reichelFlowSortingExome2015a]|

+|[MSH2](MSH2)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[MSH6](MSH6)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[MYB](MYB)|2|[@reddyGeneticFunctionalDrivers2017]|[@deschGenotypingCirculatingTumor2020]|

+|[MYBPC2](MYBPC2)|2|[@schmitzGeneticsPathogenesisDiffuse2018a]||

+|[MYO1E](MYO1E)|2, aSHM|||

+|[MYOM2](MYOM2)|2|[@pasqualucciAnalysisCodingGenome2011]||

+|[N2RF2](N2RF2)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[NANOG](NANOG)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[NAV1](NAV1)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[NCOA3](NCOA3)|2, aSHM|||

+|[NCOR1](NCOR1)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[NCOR2](NCOR2)|2||[@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016b; @sarkozyMutationalLandscapeGray2021a]|

+|[NEAT1](NEAT1)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[NF1](NF1)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[NFKB1](NFKB1)|2|||

+|[NFKB2](NFKB2)|2|[@reddyGeneticFunctionalDrivers2017]|[@mottokIntegrativeGenomicAnalysis2019b]|

+|[NLRC5](NLRC5)|2|||

+|[NLRP5](NLRP5)|2|[@morinMutationalStructuralAnalysis2013]||

+|[NLRP8](NLRP8)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[ODZ3](ODZ3)|2|[@morinMutationalStructuralAnalysis2013]||

+|[P2RX5](P2RX5)|2, aSHM|[@morinMutationalStructuralAnalysis2013]||

+|[PAPOLG](PAPOLG)|2|[@schmitzGeneticsPathogenesisDiffuse2018a]||

+|[PASK](PASK)|2|[@morinMutationalStructuralAnalysis2013]||

+|[PAX5](PAX5)|2, aSHM|[@pasqualucciHypermutationMultipleProtooncogenes2001a]||

+|[PCBP1](PCBP1)|2||[@schmitzBurkittLymphomaPathogenesis2012]|

+|[PCDHB11](PCDHB11)|2|[@morinMutationalStructuralAnalysis2013]||

+|[PCLO](PCLO)|2|[@lohrDiscoveryPrioritizationSomatic2012a]||

+|[PDE4DIP](PDE4DIP)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[PDS5B](PDS5B)|2|[@morinMutationalStructuralAnalysis2013]|[@hubschmannMutationalMechanismsShaping2021b]|

+|[PHF6](PHF6)|2|[@reddyGeneticFunctionalDrivers2017]|[@thomasGeneticSubgroupsInform2023]|

+|[PIK3CD](PIK3CD)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[PIK3R1](PIK3R1)|2|[@zhangGeneticHeterogeneityDiffuse2013]|[@paneaWholeGenomeLandscape2019]|

+|[PKD1](PKD1)|2|[@morinMutationalStructuralAnalysis2013]||

+|[PNPO](PNPO)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[POGZ](POGZ)|2|[@morinMutationalStructuralAnalysis2013]||

+|[PPP1R9B](PPP1R9B)|2|||

+|[PRKCB](PRKCB)|2|[@morinMutationalStructuralAnalysis2013]||

+|[PRKDC](PRKDC)|2|[@schmitzGeneticsPathogenesisDiffuse2018a]|[@hubschmannMutationalMechanismsShaping2021b]|

+|[PRPS1](PRPS1)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[PTMA](PTMA)|2, aSHM|||

+|[PTPN1](PTPN1)|2, aSHM||[@gunawardanaRecurrentSomaticMutations2014c]|

+|[PTPN23](PTPN23)|2|[@morinMutationalStructuralAnalysis2013]||

+|[PTPN6](PTPN6)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[PTPRK](PTPRK)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[RAC2](RAC2)|2|[@hubschmannMutationalMechanismsShaping2021b]|[@paneaWholeGenomeLandscape2019]|

+|[RAD9A](RAD9A)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[RARA](RARA)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[RCC](RCC)|2, aSHM|||

+|[RFTN1](RFTN1)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]|[@dunsCharacterizationDLBCLPMBL2021b]|

+|[RFXAP](RFXAP)|2|||

+|[RHEX](RHEX)|2, aSHM|||

+|[RHOH](RHOH)|2, aSHM|[@pasqualucciHypermutationMultipleProtooncogenes2001a]||

+|[RUBCNL](RUBCNL)|2, aSHM|||

+|[RUNX1](RUNX1)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[SAMD9L](SAMD9L)|2|[@morinMutationalStructuralAnalysis2013]||

+|[SARM1](SARM1)|2|[@morinMutationalStructuralAnalysis2013]||

+|[SEL1L3](SEL1L3)|2, aSHM|||

+|[SEPTIN9](SEPTIN9)|2, aSHM|||

+|[SERPINA9](SERPINA9)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[SETD2](SETD2)|2|[@zhangGeneticHeterogeneityDiffuse2013]||

+|[SETD5](SETD5)|2|[@reddyGeneticFunctionalDrivers2017]|[@tiacciPervasiveMutationsJAKSTAT2018b]|

+|[SIAH2](SIAH2)|2|[@hubschmannMutationalMechanismsShaping2021b]|[@reichelFlowSortingExome2015a]|

+|[SLC34A2](SLC34A2)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[SMEK1](SMEK1)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|[SRRM2](SRRM2)|2|[@morinMutationalStructuralAnalysis2013]|[@russler-germainMutationsAssociatedProgression2023b]|

+|[ST6GAL1](ST6GAL1)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[STAT5B](STAT5B)|2|[@zhangGeneticHeterogeneityDiffuse2013]|[@tiacciPervasiveMutationsJAKSTAT2018b]|

+|[SYK](SYK)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[SYPL1](SYPL1)|2|[@morinMutationalStructuralAnalysis2013]||

+|[TAP1](TAP1)|2|[@schmitzGeneticsPathogenesisDiffuse2018a]||

+|[TBC1D4](TBC1D4)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[TCL1A](TCL1A)|2, aSHM||[@grandeGenomewideDiscoverySomatic2019]|

+|[TGFBR2](TGFBR2)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[TIPARP](TIPARP)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[TLR2](TLR2)|2|[@chapuyMolecularSubtypesDiffuse2018b]|[@beaLandscapeSomaticMutations2013]|

+|[TRAF3](TRAF3)|2|[@pasqualucciAnalysisCodingGenome2011]|[@rossiAlterationBIRC3Multiple2011a; @ottoGeneticLesionsTRAF32012a]|

+|[TRAF6](TRAF6)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[TRIP12](TRIP12)|2|||

+|[UBE2J1](UBE2J1)|2, aSHM|||

+|[UBR5](UBR5)|2|[@zhangGeneticHeterogeneityDiffuse2013]|[@pararajalingamCodingNoncodingDrivers2020]|

+|[UNC5B](UNC5B)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[UNC5D](UNC5D)|2|||

+|[WAC](WAC)|2|[@reddyGeneticFunctionalDrivers2017]|[@rossiCodingGenomeSplenic2012c]|

+|[WDFY3](WDFY3)|2|[@morinMutationalStructuralAnalysis2013]||

+|[WNK1](WNK1)|2|[@hubschmannMutationalMechanismsShaping2021b]|[@thomasGeneticSubgroupsInform2023; @jalladesExomeSequencingIdentifies2017]|

+|[XBP1](XBP1)|2, aSHM|||

+|[YY1](YY1)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[ZBTB7A](ZBTB7A)|2|[@reddyGeneticFunctionalDrivers2017]|[@burkhardtClinicalRelevanceMolecular2022b]|

+|[ZCCHC7](ZCCHC7)|2, aSHM|[@arthurGenomewideDiscoverySomatic2018]||

+|[ZEB2](ZEB2)|2|[@zhangGeneticHeterogeneityDiffuse2013]||

+|[ZFAT](ZFAT)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[ZFX](ZFX)|2|[@reddyGeneticFunctionalDrivers2017]||

+|[ZNF217](ZNF217)|2|[@hubschmannMutationalMechanismsShaping2021b]|[@reichelFlowSortingExome2015a]|

+|[ZNF423](ZNF423)|2|[@chapuyMolecularSubtypesDiffuse2018b]||

+|Gene|Tier| First FL evidence | Other entities |

+|:-:|:-:|:-|:-|

+|[ACTB](ACTB)|1, aSHM||[@lohrDiscoveryPrioritizationSomatic2012a; @wienandGenomicAnalysesFlowsorted2019b]|

+|[ARID1A](ARID1A)|1|[@krysiakRecurrentSomaticMutations2017b]|[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @zhangGeneticHeterogeneityDiffuse2013; @wienandGenomicAnalysesFlowsorted2019b]|

+|[ATP6AP1](ATP6AP1)|1|[@okosunRecurrentMTORC1activatingRRAGC2016a]||

+|[ATP6V1B2](ATP6V1B2)|1|[@okosunRecurrentMTORC1activatingRRAGC2016a]||

+|[B2M](B2M)|1|[@morinFrequentMutationHistonemodifying2011]|[@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]|

+|[BCL2](BCL2)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a; @tanakaFrequentIncidenceSomatic1992]|

+|[BCL6](BCL6)|1, aSHM||[@morinFrequentMutationHistonemodifying2011; @loveGeneticLandscapeMutations2012]|

+|[BCL7A](BCL7A)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]|[@arthurGenomewideDiscoverySomatic2018; @reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019]|

+|[BIRC6](BIRC6)|1||[@reddyGeneticFunctionalDrivers2017; @sarkozyMutationalLandscapeGray2021a]|

+|[BTG1](BTG1)|1, aSHM||[@morinFrequentMutationHistonemodifying2011; @burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a]|

+|[BTG2](BTG2)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|

+|[BTK](BTK)|1|[@krysiakRecurrentSomaticMutations2017b]|[@albuquerqueEnhancingKnowledgeDiscovery2017a]|

+|[CARD11](CARD11)|1|[@morinFrequentMutationHistonemodifying2011]|[@lenzOncogenicCARD11Mutations2008; @wuGeneticHeterogeneityPrimary2016; @paneaWholeGenomeLandscape2019; @yanBCRTLRSignaling2012a]|

+|[CCND3](CCND3)|1|[@morinFrequentMutationHistonemodifying2011]|[@richterRecurrentMutationID32012a; @jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020]|

+|[CD83](CD83)|1, aSHM|[@russler-germainMutationsAssociatedProgression2023b]|[@paneaWholeGenomeLandscape2019; @dunsCharacterizationDLBCLPMBL2021b; @morinMutationalStructuralAnalysis2013]|

+|[CREBBP](CREBBP)|1|[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@parryWholeExomeSequencing2013; @dunsCharacterizationDLBCLPMBL2021b; @loveGeneticLandscapeMutations2012]|

+|[CTSS](CTSS)|1|[@barariaCathepsinAlterationsInduce2020c]||

+|[DTX1](DTX1)|1, aSHM||[@schmitzGeneticsPathogenesisDiffuse2018a; @rossiCodingGenomeSplenic2012c; @gomezUltraDeepSequencingReveals2023; @paneaWholeGenomeLandscape2019]|

+|[EBF1](EBF1)|1, aSHM||[@thomasGeneticSubgroupsInform2023; @reichelFlowSortingExome2015a; @bohleRoleEarlyBcell2013]|

+|[EEF1A1](EEF1A1)|1|[@hubschmannMutationalMechanismsShaping2021b]|[@reichelFlowSortingExome2015a]|

+|[EP300](EP300)|1|[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]|

+|[EZH2](EZH2)|1|[@morinSomaticMutationsAltering2010a]|[@mottokIntegrativeGenomicAnalysis2019b; @loveGeneticLandscapeMutations2012]|

+|[FAS](FAS)|1||[@spinaGeneticsNodalMarginal2016b; @schollMutationsRegionFAS2007]|

+|[FOXO1](FOXO1)|1|[@morinFrequentMutationHistonemodifying2011]|[@schmitzBurkittLymphomaPathogenesis2012; @dunsCharacterizationDLBCLPMBL2021b]|

+|[GNA13](GNA13)|1|[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @loveGeneticLandscapeMutations2012]|

+|[GNAI2](GNAI2)|1||[@grandeGenomewideDiscoverySomatic2019; @morinMutationalStructuralAnalysis2013]|

+|[HIST1H1B](HIST1H1B)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]|[@chapuyMolecularSubtypesDiffuse2018b; @sarkozyMutationalLandscapeGray2021a]|

+|[HIST1H1C](HIST1H1C)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|

+|[HIST1H1D](HIST1H1D)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]|[@morinMutationalStructuralAnalysis2013; @jalladesExomeSequencingIdentifies2017]|

+|[HIST1H1E](HIST1H1E)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]|[@morinMutationalStructuralAnalysis2013; @reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019]|

+|[HIST1H2AC](HIST1H2AC)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]|[@morinMutationalStructuralAnalysis2013]|

+|[HIST1H2AG](HIST1H2AG)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]|[@morinMutationalStructuralAnalysis2013; @rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]|

+|[HIST1H2AM](HIST1H2AM)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]|[@paneaWholeGenomeLandscape2019]|

+|[HIST1H2BC](HIST1H2BC)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]|[@mottokIntegrativeGenomicAnalysis2019b; @reddyGeneticFunctionalDrivers2017]|

+|[HIST1H2BD](HIST1H2BD)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]||

+|[HIST1H2BG](HIST1H2BG)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]||

+|[HIST1H3B](HIST1H3B)|1, aSHM||[@zhangGeneticHeterogeneityDiffuse2013; @reichelFlowSortingExome2015a]|

+|[HIST1H3G](HIST1H3G)|1, aSHM|[@krysiakRecurrentSomaticMutations2017b]||

+|[HVCN1](HVCN1)|1|[@krysiakRecurrentSomaticMutations2017b]||

+|[IRF4](IRF4)|1, aSHM||[@mottokIntegrativeGenomicAnalysis2019b; @morinFrequentMutationHistonemodifying2011]|

+|[IRF8](IRF8)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@mottokIntegrativeGenomicAnalysis2019b; @paneaWholeGenomeLandscape2019]|

+|[ITPKB](ITPKB)|1, aSHM||[@reichelFlowSortingExome2015a; @schmitzGeneticsPathogenesisDiffuse2018a]|

+|[KLF2](KLF2)|1, aSHM||[@jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020; @pasqualucciAnalysisCodingGenome2011]|

+|[KLHL6](KLHL6)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019; @ganapathiGeneticLandscapeDural2016]|

+|[KMT2D](KMT2D)|1|[@morinFrequentMutationHistonemodifying2011]|[@grandeGenomewideDiscoverySomatic2019; @beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @rossiCodingGenomeSplenic2012c]|

+|[LTB](LTB)|1, aSHM||[@chapuyMolecularSubtypesDiffuse2018b; @deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]|

+|[MAP2K1](MAP2K1)|1|[@louissaintPediatrictypeNodalFollicular2016a]|[@shinBRAFV600EMAP2K12015]|

+|[MEF2B](MEF2B)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@beaLandscapeSomaticMutations2013]|

+|[MEF2C](MEF2C)|1, aSHM||[@arthurGenomewideDiscoverySomatic2018]|

+|[PCLO](PCLO)|1||[@lohrDiscoveryPrioritizationSomatic2012a]|

+|[PIM1](PIM1)|1, aSHM||[@dunsCharacterizationDLBCLPMBL2021b; @burkhardtClinicalRelevanceMolecular2022b; @pasqualucciHypermutationMultipleProtooncogenes2001a]|

+|[POU2AF1](POU2AF1)|1|[@krysiakRecurrentSomaticMutations2017b]||

+|[POU2F2](POU2F2)|1|[@krysiakRecurrentSomaticMutations2017b]|[@zhangGeneticHeterogeneityDiffuse2013]|

+|[PTPRD](PTPRD)|1||[@spinaGeneticsNodalMarginal2016b]|

+|[RRAGC](RRAGC)|1||[@okosunRecurrentMTORC1activatingRRAGC2016a]|

+|[S1PR2](S1PR2)|1, aSHM||[@morinFrequentMutationHistonemodifying2011; @muppidiLossSignalingGa132014b]|

+|[SGK1](SGK1)|1, aSHM|[@morinFrequentMutationHistonemodifying2011]|[@dunsCharacterizationDLBCLPMBL2021b]|

+|[SMARCA4](SMARCA4)|1|[@krysiakRecurrentSomaticMutations2017b]|[@richterRecurrentMutationID32012a; @zhangGeneticHeterogeneityDiffuse2013; @nadeuGenomicEpigenomicInsights2020b]|

+|[SOCS1](SOCS1)|1, aSHM||[@wenigerMutationsTumorSuppressor2006a; @morinFrequentMutationHistonemodifying2011]|

+|[STAT6](STAT6)|1|[@yildizActivatingSTAT6Mutations2015c]|[@ritzRecurrentMutationsSTAT62009a]|

+|[TBL1XR1](TBL1XR1)|1||[@rossiCodingGenomeSplenic2012c; @mareschalWholeExomeSequencing2016]|

+|[TMSB4X](TMSB4X)|1, aSHM||[@albuquerqueEnhancingKnowledgeDiscovery2017a]|

+|[TNFAIP3](TNFAIP3)|1||[@rossiAlterationBIRC3Multiple2011a; @compagnoMutationsMultipleGenes2009a; @schmitzTNFAIP3A20Tumor2009a]|

+|[TNFRSF14](TNFRSF14)|1|[@cheungAcquiredTNFRSF14Mutations2010a]|[@spinaGeneticsNodalMarginal2016b]|

+|[TP53](TP53)|1|[@morinFrequentMutationHistonemodifying2011]|[@wildaInactivationARFMDM2p53Pathway2004; @rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013; @tiacciPervasiveMutationsJAKSTAT2018b]|

+|[VMA21](VMA21)|1|[@hubschmannMutationalMechanismsShaping2021b]||

+|Gene|Tier| First FL evidence | Other entities |

+|:-:|:-:|:-|:-|

+|[ABL2](ABL2)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[ACTG1](ACTG1)|2, aSHM|[@hubschmannMutationalMechanismsShaping2021b]|[@spinaGeneticsNodalMarginal2016b; @deschGenotypingCirculatingTumor2020]|

+|[ATP6V1A](ATP6V1A)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[BCL10](BCL10)|2|[@russler-germainMutationsAssociatedProgression2023b]|[@morinFrequentMutationHistonemodifying2011; @spinaGeneticsNodalMarginal2016b]|

+|[CCDC42BPB](CCDC42BPB)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[CD70](CD70)|2|[@russler-germainMutationsAssociatedProgression2023b]|[@morinFrequentMutationHistonemodifying2011]|

+|[CD79B](CD79B)|2||[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]|

+|[CILP](CILP)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[CPNE8](CPNE8)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[CXCR4](CXCR4)|2, aSHM|[@krysiakRecurrentSomaticMutations2017b]|[@paneaWholeGenomeLandscape2019; @khodabakhshiRecurrentTargetsAberrant2012]|

+|[CYP2A6](CYP2A6)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[DDX3X](DDX3X)|2||[@schmitzBurkittLymphomaPathogenesis2012; @schmitzGeneticsPathogenesisDiffuse2018a; @mottokIntegrativeGenomicAnalysis2019b]|

+|[DHX15](DHX15)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[DUSP2](DUSP2)|2, aSHM||[@morinMutationalStructuralAnalysis2013; @dunsCharacterizationDLBCLPMBL2021b]|

+|[EGR1](EGR1)|2|[@krysiakRecurrentSomaticMutations2017b]|[@reichelFlowSortingExome2015a; @rossiCodingGenomeSplenic2012c]|

+|[FZR1](FZR1)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[GBP7](GBP7)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[GRM6](GRM6)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[HIST1H2BM](HIST1H2BM)|2, aSHM|[@krysiakRecurrentSomaticMutations2017b]||

+|[HIST1H3I](HIST1H3I)|2, aSHM|[@krysiakRecurrentSomaticMutations2017b]|[@paneaWholeGenomeLandscape2019]|

+|[HLA-B](HLA-B)|2||[@wienandGenomicAnalysesFlowsorted2019b]|

+|[HNRNPD](HNRNPD)|2|||

+|[IGLL5](IGLL5)|2, aSHM|[@russler-germainMutationsAssociatedProgression2023b]|[@deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019]|

+|[JUP](JUP)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[KIR3DL1](KIR3DL1)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[LAPTM5](LAPTM5)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[MAGEC1](MAGEC1)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[MAP7D1](MAP7D1)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[MGEA5](MGEA5)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[MKI67](MKI67)|2|[@russler-germainMutationsAssociatedProgression2023b]|[@schmitzBurkittLymphomaPathogenesis2012]|

+|[MYC](MYC)|2, aSHM||[@johnstonCmycHypermutationBurkitt1992; @jalladesExomeSequencingIdentifies2017; @dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]|

+|[MYCBP2](MYCBP2)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[MYD88](MYD88)|2||[@ngoOncogenicallyActiveMYD882011a; @yanBCRTLRSignaling2012a]|

+|[NFKBIA](NFKBIA)|2|[@russler-germainMutationsAssociatedProgression2023b]|[@wienandGenomicAnalysesFlowsorted2019b; @lakeMutationsNFKBIAEncoding2009]|

+|[OR8H2](OR8H2)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[P2RY8](P2RY8)|2||[@muppidiLossSignalingGa132014b; @lohrDiscoveryPrioritizationSomatic2012a]|

+|[PDS5B](PDS5B)|2|[@hubschmannMutationalMechanismsShaping2021b]|[@morinMutationalStructuralAnalysis2013]|

+|[PPP4C](PPP4C)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[PRKDC](PRKDC)|2|[@hubschmannMutationalMechanismsShaping2021b]|[@schmitzGeneticsPathogenesisDiffuse2018a]|

+|[PZP](PZP)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[RBM6](RBM6)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[SESN1](SESN1)|2|[@oricchioGeneticEpigeneticInactivation2017b]||

+|[SHROOM3](SHROOM3)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[SRRM2](SRRM2)|2|[@russler-germainMutationsAssociatedProgression2023b]|[@morinMutationalStructuralAnalysis2013]|

+|[STAB2](STAB2)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[TMEM30A](TMEM30A)|2|[@morinFrequentMutationHistonemodifying2011]||

+|[TPP1](TPP1)|2|[@hubschmannMutationalMechanismsShaping2021b]||

+|[XIRP2](XIRP2)|2|[@russler-germainMutationsAssociatedProgression2023b]||

+|[ZC3H12A](ZC3H12A)|2||[@arthurGenomewideDiscoverySomatic2018]|

+|[ZNF608](ZNF608)|2|[@krysiakRecurrentSomaticMutations2017b]|[@zhangGeneticHeterogeneityDiffuse2013]|

+|Gene|Tier| First MCL evidence | Other entities |

+|:-:|:-:|:-|:-|

+|[ATM](ATM)|1|[@beaLandscapeSomaticMutations2013]|[@reddyGeneticFunctionalDrivers2017; @braggioGenomicAnalysisMarginal2012]|

+|[BIRC3](BIRC3)|1|[@beaLandscapeSomaticMutations2013]|[@arthurGenomewideDiscoverySomatic2018; @rossiAlterationBIRC3Multiple2011a; @dunsCharacterizationDLBCLPMBL2021b]|

+|[CARD11](CARD11)|1|[@wuGeneticHeterogeneityPrimary2016]|[@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011; @lenzOncogenicCARD11Mutations2008; @yanBCRTLRSignaling2012a]|

+|[CCND1](CCND1)|1, aSHM|[@beaLandscapeSomaticMutations2013]||

+|[DAZAP1](DAZAP1)|1|[@pararajalingamCodingNoncodingDrivers2020]||

+|[EWSR1](EWSR1)|1|[@pararajalingamCodingNoncodingDrivers2020]||

+|[HNRNPH1](HNRNPH1)|1, noncoding|[@pararajalingamCodingNoncodingDrivers2020]||

+|[KMT2D](KMT2D)|1|[@beaLandscapeSomaticMutations2013]|[@rossiCodingGenomeSplenic2012c; @deschGenotypingCirculatingTumor2020; @morinFrequentMutationHistonemodifying2011; @grandeGenomewideDiscoverySomatic2019]|

+|[MEF2B](MEF2B)|1|[@beaLandscapeSomaticMutations2013]|[@morinFrequentMutationHistonemodifying2011]|

+|[NFKBIE](NFKBIE)|1|[@pararajalingamCodingNoncodingDrivers2020]|[@morinGeneticLandscapesRelapsed2016; @mansouriFrequentNFKBIEDeletions2016]|

+|[NOTCH1](NOTCH1)|1|[@beaLandscapeSomaticMutations2013]|[@rossiCodingGenomeSplenic2012c; @pasqualucciAnalysisCodingGenome2011; @loveGeneticLandscapeMutations2012]|

+|[NOTCH2](NOTCH2)|1|[@beaLandscapeSomaticMutations2013]|[@rossiCodingGenomeSplenic2012c; @troenNOTCH2MutationsMarginal2008; @paneaWholeGenomeLandscape2019]|

+|[NSD2](NSD2)|1|[@beaLandscapeSomaticMutations2013]||

+|[POT1](POT1)|1|[@zhangGenomicLandscapeMantle2014]||

+|[RB1](RB1)|1|[@zhangGenomicLandscapeMantle2014]|[@morinMutationalStructuralAnalysis2013]|

+|[S1PR1](S1PR1)|1|[@pararajalingamCodingNoncodingDrivers2020]||

+|[SMARCA4](SMARCA4)|1|[@nadeuGenomicEpigenomicInsights2020b]|[@krysiakRecurrentSomaticMutations2017b; @zhangGeneticHeterogeneityDiffuse2013; @richterRecurrentMutationID32012a]|

+|[SP140](SP140)|1|[@beaLandscapeSomaticMutations2013]||

+|[SYNE1](SYNE1)|1|[@nadeuGenomicEpigenomicInsights2020b]||

+|[TERT](TERT)|1, noncoding|[@nadeuGenomicEpigenomicInsights2020b]||

+|[TLR2](TLR2)|1|[@beaLandscapeSomaticMutations2013]|[@chapuyMolecularSubtypesDiffuse2018b]|

+|[TP53](TP53)|1|[@beaLandscapeSomaticMutations2013]|[@morinFrequentMutationHistonemodifying2011; @tiacciPervasiveMutationsJAKSTAT2018b; @rossiCodingGenomeSplenic2012c; @wildaInactivationARFMDM2p53Pathway2004]|

+|[UBR5](UBR5)|1|[@pararajalingamCodingNoncodingDrivers2020]|[@zhangGeneticHeterogeneityDiffuse2013]|

+|Gene|Tier| First MCL evidence | Other entities |

+|:-:|:-:|:-|:-|

+|[ABCA3](ABCA3)|2|[@beaLandscapeSomaticMutations2013]||

+|[ABCC9](ABCC9)|2|[@beaLandscapeSomaticMutations2013]||

+|[ANK2](ANK2)|2|[@zhangGenomicLandscapeMantle2014]||

+|[ARID1B](ARID1B)|2||[@reddyGeneticFunctionalDrivers2017]|

+|[ATP11C](ATP11C)|2|[@zhangGenomicLandscapeMantle2014]||

+|[B2M](B2M)|2|[@pararajalingamCodingNoncodingDrivers2020]|[@morinFrequentMutationHistonemodifying2011; @reichelFlowSortingExome2015a]|

+|[BCOR](BCOR)|2|[@nadeuGenomicEpigenomicInsights2020b]|[@jalladesExomeSequencingIdentifies2017]|

+|[CDH8](CDH8)|2|[@zhangGenomicLandscapeMantle2014]||

+|[CHMP4C](CHMP4C)|2|[@beaLandscapeSomaticMutations2013]||

+|[COL11A1](COL11A1)|2|[@zhangGenomicLandscapeMantle2014]||

+|[COL16A1](COL16A1)|2|[@zhangGenomicLandscapeMantle2014]||

+|[CRYBG3](CRYBG3)|2|[@beaLandscapeSomaticMutations2013]||

+|[CTNNA2](CTNNA2)|2|[@zhangGenomicLandscapeMantle2014]||

+|[DCP1B](DCP1B)|2|[@beaLandscapeSomaticMutations2013]||

+|[DHDH](DHDH)|2|[@zhangGenomicLandscapeMantle2014]||

+|[DLC1](DLC1)|2|[@zhangGenomicLandscapeMantle2014]||

+|[DLGAP2](DLGAP2)|2|[@beaLandscapeSomaticMutations2013]||

+|[DNAJC6](DNAJC6)|2|[@beaLandscapeSomaticMutations2013]||

+|[EIF2AK4](EIF2AK4)|2|[@zhangGenomicLandscapeMantle2014]||

+|[ESX1](ESX1)|2|[@zhangGenomicLandscapeMantle2014]||

+|[FAT4](FAT4)|2|[@zhangGenomicLandscapeMantle2014]|[@parryWholeExomeSequencing2013; @morinMutationalStructuralAnalysis2013]|

+|[GRIN2A](GRIN2A)|2|[@zhangGenomicLandscapeMantle2014]||

+|[HEPH](HEPH)|2|[@zhangGenomicLandscapeMantle2014]||

+|[KCNC2](KCNC2)|2|[@beaLandscapeSomaticMutations2013]||

+|[KIAA1671](KIAA1671)|2|[@beaLandscapeSomaticMutations2013]||

+|[KMT2C](KMT2C)|2|[@zhangGenomicLandscapeMantle2014]|[@zhouSporadicEndemicBurkitt2019; @zhangGeneticHeterogeneityDiffuse2013; @sarkozyMutationalLandscapeGray2021a]|

+|[LUZP4](LUZP4)|2|[@beaLandscapeSomaticMutations2013]||

+|[MRGPRF](MRGPRF)|2|[@zhangGenomicLandscapeMantle2014]||

+|[NIN](NIN)|2|[@zhangGenomicLandscapeMantle2014]||

+|[OGDHL](OGDHL)|2|[@zhangGenomicLandscapeMantle2014]||

+|[PCDHB2](PCDHB2)|2|[@zhangGenomicLandscapeMantle2014]||

+|[PCSK2](PCSK2)|2|[@beaLandscapeSomaticMutations2013]||

+|[PDLIM3](PDLIM3)|2|[@beaLandscapeSomaticMutations2013]||

+|[PLXNB3](PLXNB3)|2|[@zhangGenomicLandscapeMantle2014]|[@spinaGeneticsNodalMarginal2016b]|

+|[RGS4](RGS4)|2|[@beaLandscapeSomaticMutations2013]||

+|[ROBO2](ROBO2)|2|[@zhangGenomicLandscapeMantle2014]||

+|[SALL3](SALL3)|2|[@zhangGenomicLandscapeMantle2014]|[@loveGeneticLandscapeMutations2012]|

+|[SI](SI)|2|[@zhangGenomicLandscapeMantle2014]||

+|[SLC17A6](SLC17A6)|2|[@beaLandscapeSomaticMutations2013]||

+|[SMARCB1](SMARCB1)|2|[@nadeuGenomicEpigenomicInsights2020b]||

+|[SMC1A](SMC1A)|2|[@zhangGenomicLandscapeMantle2014]||

+|[TBC1D26](TBC1D26)|2|[@zhangGenomicLandscapeMantle2014]||

+|[TNRC6B](TNRC6B)|2|[@beaLandscapeSomaticMutations2013]||

+|[TRPM6](TRPM6)|2|[@beaLandscapeSomaticMutations2013]||

+|[ZNF117](ZNF117)|2|[@zhangGenomicLandscapeMantle2014]||

+|[ZNF296](ZNF296)|2|[@zhangGenomicLandscapeMantle2014]||

+|Gene|Tier| First MZL evidence | Other entities |

+|:-:|:-:|:-|:-|

+|[ACTB](ACTB)|1||[@wienandGenomicAnalysesFlowsorted2019b; @lohrDiscoveryPrioritizationSomatic2012a]|

+|[ARID1A](ARID1A)|1|[@rossiCodingGenomeSplenic2012c]|[@krysiakRecurrentSomaticMutations2017b; @zhangGeneticHeterogeneityDiffuse2013; @wienandGenomicAnalysesFlowsorted2019b; @loveGeneticLandscapeMutations2012]|

+|[ATM](ATM)|1|[@braggioGenomicAnalysisMarginal2012]|[@reddyGeneticFunctionalDrivers2017; @beaLandscapeSomaticMutations2013]|

+|[BCL10](BCL10)|1|[@spinaGeneticsNodalMarginal2016b]|[@russler-germainMutationsAssociatedProgression2023b; @morinFrequentMutationHistonemodifying2011]|

+|[BCL7A](BCL7A)|1||[@arthurGenomewideDiscoverySomatic2018; @grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a]|

+|[BIRC3](BIRC3)|1|[@rossiAlterationBIRC3Multiple2011a]|[@beaLandscapeSomaticMutations2013; @arthurGenomewideDiscoverySomatic2018; @dunsCharacterizationDLBCLPMBL2021b]|

+|[BRAF](BRAF)|1||[@tiacciBRAFMutationsHairycell2011a; @loveGeneticLandscapeMutations2012]|

+|[BTG1](BTG1)|1||[@morinFrequentMutationHistonemodifying2011; @burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a]|

+|[CARD11](CARD11)|1|[@yanBCRTLRSignaling2012a]|[@paneaWholeGenomeLandscape2019; @wuGeneticHeterogeneityPrimary2016; @morinFrequentMutationHistonemodifying2011; @lenzOncogenicCARD11Mutations2008]|

+|[CCND3](CCND3)|1|[@jalladesExomeSequencingIdentifies2017]|[@morinFrequentMutationHistonemodifying2011; @deschGenotypingCirculatingTumor2020; @richterRecurrentMutationID32012a]|

+|[CXCR4](CXCR4)|1||[@paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b; @khodabakhshiRecurrentTargetsAberrant2012]|

+|[DTX1](DTX1)|1|[@rossiCodingGenomeSplenic2012c]|[@gomezUltraDeepSequencingReveals2023; @schmitzGeneticsPathogenesisDiffuse2018a; @paneaWholeGenomeLandscape2019]|

+|[EP300](EP300)|1|[@rossiCodingGenomeSplenic2012c]|[@paneaWholeGenomeLandscape2019; @pasqualucciInactivatingMutationsAcetyltransferase2011a]|

+|[EZH2](EZH2)|1||[@mottokIntegrativeGenomicAnalysis2019b; @morinSomaticMutationsAltering2010a; @loveGeneticLandscapeMutations2012]|

+|[FAS](FAS)|1|[@spinaGeneticsNodalMarginal2016b]|[@schollMutationsRegionFAS2007]|

+|[FAT1](FAT1)|1|[@spinaGeneticsNodalMarginal2016b]||

+|[FOXO1](FOXO1)|1||[@morinFrequentMutationHistonemodifying2011; @dunsCharacterizationDLBCLPMBL2021b; @schmitzBurkittLymphomaPathogenesis2012]|

+|[H1-4](H1-4)|1|||

+|[H1-5](H1-5)|1|||

+|[ID3](ID3)|1|[@spinaGeneticsNodalMarginal2016b]|[@schmitzBurkittLymphomaPathogenesis2012; @richterRecurrentMutationID32012a]|

+|[KLF2](KLF2)|1|[@jalladesExomeSequencingIdentifies2017]|[@deschGenotypingCirculatingTumor2020; @pasqualucciAnalysisCodingGenome2011]|

+|[KLHL6](KLHL6)|1|[@ganapathiGeneticLandscapeDural2016]|[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]|

+|[KMT2D](KMT2D)|1|[@rossiCodingGenomeSplenic2012c]|[@morinFrequentMutationHistonemodifying2011; @grandeGenomewideDiscoverySomatic2019; @deschGenotypingCirculatingTumor2020; @beaLandscapeSomaticMutations2013]|

+|[MAP3K14](MAP3K14)|1|[@rossiAlterationBIRC3Multiple2011a]|[@ottoGeneticLesionsTRAF32012a]|

+|[MPEG1](MPEG1)|1||[@morinMutationalStructuralAnalysis2013]|

+|[MYD88](MYD88)|1|[@yanBCRTLRSignaling2012a]|[@ngoOncogenicallyActiveMYD882011a]|

+|[NCOR2](NCOR2)|1|[@spinaGeneticsNodalMarginal2016b]|[@schmitzBurkittLymphomaPathogenesis2012; @sarkozyMutationalLandscapeGray2021a]|

+|[NOL9](NOL9)|1|[@spinaGeneticsNodalMarginal2016b]|[@schmitzGeneticsPathogenesisDiffuse2018a]|

+|[NOTCH1](NOTCH1)|1|[@rossiCodingGenomeSplenic2012c]|[@pasqualucciAnalysisCodingGenome2011; @beaLandscapeSomaticMutations2013; @loveGeneticLandscapeMutations2012]|

+|[NOTCH2](NOTCH2)|1|[@rossiCodingGenomeSplenic2012c]|[@paneaWholeGenomeLandscape2019; @beaLandscapeSomaticMutations2013; @troenNOTCH2MutationsMarginal2008]|

+|[PCLO](PCLO)|1||[@lohrDiscoveryPrioritizationSomatic2012a]|

+|[POU2AF1](POU2AF1)|1||[@krysiakRecurrentSomaticMutations2017b]|

+|[PTPRD](PTPRD)|1|[@spinaGeneticsNodalMarginal2016b]||

+|[SIN3A](SIN3A)|1|[@rossiCodingGenomeSplenic2012c]|[@grandeGenomewideDiscoverySomatic2019]|

+|[SOCS1](SOCS1)|1||[@morinFrequentMutationHistonemodifying2011; @wenigerMutationsTumorSuppressor2006a]|

+|[SPEN](SPEN)|1|[@rossiCodingGenomeSplenic2012c]|[@sarkozyMutationalLandscapeGray2021a]|

+|[STAT6](STAT6)|1||[@yildizActivatingSTAT6Mutations2015c; @ritzRecurrentMutationsSTAT62009a]|

+|[TBL1XR1](TBL1XR1)|1|[@rossiCodingGenomeSplenic2012c]|[@mareschalWholeExomeSequencing2016]|

+|[TNFAIP3](TNFAIP3)|1|[@rossiAlterationBIRC3Multiple2011a]|[@compagnoMutationsMultipleGenes2009a; @schmitzTNFAIP3A20Tumor2009a]|

+|[TNFRSF14](TNFRSF14)|1|[@spinaGeneticsNodalMarginal2016b]|[@cheungAcquiredTNFRSF14Mutations2010a]|

+|[TP53](TP53)|1|[@rossiCodingGenomeSplenic2012c]|[@morinFrequentMutationHistonemodifying2011; @wildaInactivationARFMDM2p53Pathway2004; @beaLandscapeSomaticMutations2013; @tiacciPervasiveMutationsJAKSTAT2018b]|

+|[TRAF3](TRAF3)|1|[@rossiAlterationBIRC3Multiple2011a]|[@pasqualucciAnalysisCodingGenome2011; @ottoGeneticLesionsTRAF32012a]|

+|Gene|Tier| First MZL evidence | Other entities |

+|:-:|:-:|:-|:-|

+|[ABCA13](ABCA13)|2|[@spinaGeneticsNodalMarginal2016b]|[@sarkozyMutationalLandscapeGray2021a]|

+|[ACTG1](ACTG1)|2|[@spinaGeneticsNodalMarginal2016b]|[@hubschmannMutationalMechanismsShaping2021b; @deschGenotypingCirculatingTumor2020]|

+|[ADD2](ADD2)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[AMN](AMN)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[AMOTL1](AMOTL1)|2|[@parryWholeExomeSequencing2013]||

+|[AOC2](AOC2)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[ARHGAP20](ARHGAP20)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[ARHGEF15](ARHGEF15)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[ARHGEF17](ARHGEF17)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[BCOR](BCOR)|2|[@jalladesExomeSequencingIdentifies2017]|[@nadeuGenomicEpigenomicInsights2020b]|

+|[C6orf103](C6orf103)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[CBFA2T3](CBFA2T3)|2|[@parryWholeExomeSequencing2013]||

+|[CD79A](CD79A)|2|[@rossiCodingGenomeSplenic2012c]|[@burkhardtClinicalRelevanceMolecular2022b]|

+|[CD9B](CD9B)|2|[@vandenbrandRecurrentMutationsGenes2017]||

+|[CDC42BPB](CDC42BPB)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[CDKN2A](CDKN2A)|2|[@spinaGeneticsNodalMarginal2016b]|[@morinMutationalStructuralAnalysis2013; @grandeGenomewideDiscoverySomatic2019]|

+|[CLGN](CLGN)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[CNKSR2](CNKSR2)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[CREBBP](CREBBP)|2|[@parryWholeExomeSequencing2013]|[@loveGeneticLandscapeMutations2012; @pasqualucciInactivatingMutationsAcetyltransferase2011a; @dunsCharacterizationDLBCLPMBL2021b]|

+|[DNAH5](DNAH5)|2|[@jalladesExomeSequencingIdentifies2017]|[@morinMutationalStructuralAnalysis2013]|

+|[DNAH7](DNAH7)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[DNAI1](DNAI1)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[DOCK6](DOCK6)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[DSP](DSP)|2|||

+|[DTNB](DTNB)|2|||

+|[DTX3L](DTX3L)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[EGR1](EGR1)|2|[@rossiCodingGenomeSplenic2012c]|[@krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a]|

+|[EGR2](EGR2)|2|[@rossiCodingGenomeSplenic2012c]||

+|[EZH1](EZH1)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[FAT4](FAT4)|2|[@parryWholeExomeSequencing2013]|[@morinMutationalStructuralAnalysis2013; @zhangGenomicLandscapeMantle2014]|

+|[FBXO11](FBXO11)|2|[@parryWholeExomeSequencing2013]|[@richterRecurrentMutationID32012a; @hubschmannMutationalMechanismsShaping2021b]|

+|[GPR98](GPR98)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[GPS2](GPS2)|2|[@rossiCodingGenomeSplenic2012c]||

+|[HIST1H1D](HIST1H1D)|2|[@jalladesExomeSequencingIdentifies2017]|[@krysiakRecurrentSomaticMutations2017b; @morinMutationalStructuralAnalysis2013]|

+|[HIST1H2AD](HIST1H2AD)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[HIST1H2AG](HIST1H2AG)|2|[@rossiCodingGenomeSplenic2012c]|[@morinMutationalStructuralAnalysis2013; @paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b]|

+|[HIST1H2BK](HIST1H2BK)|2|[@rossiCodingGenomeSplenic2012c]|[@paneaWholeGenomeLandscape2019]|

+|[HIST4H4](HIST4H4)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[HRAS](HRAS)|2|[@jalladesExomeSequencingIdentifies2017]|[@reddyGeneticFunctionalDrivers2017]|

+|[IKBKB](IKBKB)|2|[@rossiAlterationBIRC3Multiple2011a]|[@wienandGenomicAnalysesFlowsorted2019b; @reddyGeneticFunctionalDrivers2017]|

+|[KAT6A](KAT6A)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[KDM6A](KDM6A)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[KIF26A](KIF26A)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[LRP1B](LRP1B)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[MCRS1](MCRS1)|2|[@rossiCodingGenomeSplenic2012c]||

+|[MGA](MGA)|2|[@jalladesExomeSequencingIdentifies2017]|[@zhangGeneticHeterogeneityDiffuse2013]|

+|[MSL2](MSL2)|2|[@rossiCodingGenomeSplenic2012c]||

+|[MYC](MYC)|2|[@jalladesExomeSequencingIdentifies2017]|[@johnstonCmycHypermutationBurkitt1992; @dunsCharacterizationDLBCLPMBL2021b; @pasqualucciHypermutationMultipleProtooncogenes2001a]|

+|[MYLK](MYLK)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[NCOA6](NCOA6)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[NRAS](NRAS)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[PACRG](PACRG)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[PARK2](PARK2)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[PLA2G4D](PLA2G4D)|2|[@parryWholeExomeSequencing2013]||

+|[PLXNB3](PLXNB3)|2|[@spinaGeneticsNodalMarginal2016b]|[@zhangGenomicLandscapeMantle2014]|

+|[RAF1](RAF1)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[RAPGEF2](RAPGEF2)|2|||

+|[RCOR1](RCOR1)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[RFTN1](RFTN1)|2||[@arthurGenomewideDiscoverySomatic2018; @dunsCharacterizationDLBCLPMBL2021b]|

+|[ROCK1](ROCK1)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[RPL1L](RPL1L)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[SAMD5](SAMD5)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[SCG3](SCG3)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[STXBP5](STXBP5)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[SWAP70](SWAP70)|2|[@rossiCodingGenomeSplenic2012c]||

+|[TAF1](TAF1)|2|[@spinaGeneticsNodalMarginal2016b]|[@morinMutationalStructuralAnalysis2013]|

+|[TBK1](TBK1)|2|[@jalladesExomeSequencingIdentifies2017]||

+|[TCTN2](TCTN2)|2|[@spinaGeneticsNodalMarginal2016b]||

+|[TNIP2](TNIP2)|2|[@vandenbrandRecurrentMutationsGenes2017]||

+|[TRRAP](TRRAP)|2|[@rossiCodingGenomeSplenic2012c]|[@parryWholeExomeSequencing2013]|

+|[USH2A](USH2A)|2|[@parryWholeExomeSequencing2013]||

+|[WAC](WAC)|2|[@rossiCodingGenomeSplenic2012c]|[@reddyGeneticFunctionalDrivers2017]|

+|[WNK1](WNK1)|2|[@jalladesExomeSequencingIdentifies2017]|[@hubschmannMutationalMechanismsShaping2021b; @thomasGeneticSubgroupsInform2023]|

+|[ZNF9](ZNF9)|2|[@spinaGeneticsNodalMarginal2016b]||

+|Gene|Tier| First PMBL evidence | Other entities |

+|:-:|:-:|:-|:-|

+|[ACTB](ACTB)|1|[@wienandGenomicAnalysesFlowsorted2019b]|[@lohrDiscoveryPrioritizationSomatic2012a]|

+|[ARID1A](ARID1A)|1|[@wienandGenomicAnalysesFlowsorted2019b]|[@zhangGeneticHeterogeneityDiffuse2013; @rossiCodingGenomeSplenic2012c; @loveGeneticLandscapeMutations2012; @krysiakRecurrentSomaticMutations2017b]|

+|[ARID5B](ARID5B)|1|[@gomezUltraDeepSequencingReveals2023]|[@reddyGeneticFunctionalDrivers2017]|

+|[B2M](B2M)|1|[@reichelFlowSortingExome2015a]|[@morinFrequentMutationHistonemodifying2011; @pararajalingamCodingNoncodingDrivers2020]|

+|[BIRC6](BIRC6)|1|[@sarkozyMutationalLandscapeGray2021a]|[@reddyGeneticFunctionalDrivers2017]|

+|[BTG1](BTG1)|1|[@sarkozyMutationalLandscapeGray2021a]|[@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011]|

+|[CD58](CD58)|1|[@schneiderAlterationsCD58Gene2015a]|[@morinFrequentMutationHistonemodifying2011]|

+|[CD83](CD83)|1|[@dunsCharacterizationDLBCLPMBL2021b]|[@morinMutationalStructuralAnalysis2013; @russler-germainMutationsAssociatedProgression2023b; @paneaWholeGenomeLandscape2019]|

+|[CDKN2A](CDKN2A)|1||[@spinaGeneticsNodalMarginal2016b; @morinMutationalStructuralAnalysis2013; @grandeGenomewideDiscoverySomatic2019]|

+|[CHD8](CHD8)|1||[@reddyGeneticFunctionalDrivers2017; @grandeGenomewideDiscoverySomatic2019]|

+|[CIITA](CIITA)|1|[@mottokGenomicAlterationsCIITA2015b]|[@morinFrequentMutationHistonemodifying2011]|

+|[CISH](CISH)|1|[@mottokIntegrativeGenomicAnalysis2019b]||

+|[CREBBP](CREBBP)|1|[@dunsCharacterizationDLBCLPMBL2021b]|[@loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013; @pasqualucciInactivatingMutationsAcetyltransferase2011a]|

+|[CSF2RB](CSF2RB)|1|[@reichelFlowSortingExome2015a]||

+|[DDX3X](DDX3X)|1|[@mottokIntegrativeGenomicAnalysis2019b]|[@schmitzGeneticsPathogenesisDiffuse2018a; @schmitzBurkittLymphomaPathogenesis2012]|

+|[DTX1](DTX1)|1|[@gomezUltraDeepSequencingReveals2023]|[@schmitzGeneticsPathogenesisDiffuse2018a; @rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]|

+|[DUSP2](DUSP2)|1|[@dunsCharacterizationDLBCLPMBL2021b]|[@morinMutationalStructuralAnalysis2013]|

+|[EBF1](EBF1)|1|[@reichelFlowSortingExome2015a]|[@thomasGeneticSubgroupsInform2023; @bohleRoleEarlyBcell2013]|

+|[EEF1A1](EEF1A1)|1|[@reichelFlowSortingExome2015a]|[@hubschmannMutationalMechanismsShaping2021b]|

+|[ETS1](ETS1)|1||[@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011]|

+|[EWSR1](EWSR1)|1||[@pararajalingamCodingNoncodingDrivers2020]|

+|[EZH2](EZH2)|1|[@mottokIntegrativeGenomicAnalysis2019b]|[@loveGeneticLandscapeMutations2012; @morinSomaticMutationsAltering2010a]|

+|[FAS](FAS)|1||[@schollMutationsRegionFAS2007; @spinaGeneticsNodalMarginal2016b]|

+|[FAT1](FAT1)|1||[@spinaGeneticsNodalMarginal2016b]|

+|[FAT4](FAT4)|1||[@zhangGenomicLandscapeMantle2014; @morinMutationalStructuralAnalysis2013; @parryWholeExomeSequencing2013]|

+|[GNA13](GNA13)|1|[@reichelFlowSortingExome2015a]|[@loveGeneticLandscapeMutations2012; @morinFrequentMutationHistonemodifying2011]|

+|[HIST1H1B](HIST1H1B)|1|[@sarkozyMutationalLandscapeGray2021a]|[@krysiakRecurrentSomaticMutations2017b; @chapuyMolecularSubtypesDiffuse2018b]|

+|[HIST1H1C](HIST1H1C)|1||[@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011]|

+|[HIST1H1D](HIST1H1D)|1||[@krysiakRecurrentSomaticMutations2017b; @morinMutationalStructuralAnalysis2013; @jalladesExomeSequencingIdentifies2017]|

+|[HIST1H1E](HIST1H1E)|1|[@reichelFlowSortingExome2015a]|[@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b; @morinMutationalStructuralAnalysis2013]|

+|[HLA-B](HLA-B)|1|[@wienandGenomicAnalysesFlowsorted2019b]||

+|[IL4R](IL4R)|1|[@viganoSomaticIL4RMutations2018b]|[@dunsCharacterizationDLBCLPMBL2021b]|

+|[IRF8](IRF8)|1|[@mottokIntegrativeGenomicAnalysis2019b]|[@morinFrequentMutationHistonemodifying2011; @paneaWholeGenomeLandscape2019]|

+|[ITPKB](ITPKB)|1|[@reichelFlowSortingExome2015a]|[@schmitzGeneticsPathogenesisDiffuse2018a]|

+|[JAK1](JAK1)|1|[@mottokIntegrativeGenomicAnalysis2019b]|[@zhangGeneticHeterogeneityDiffuse2013]|

+|[KMT2C](KMT2C)|1|[@sarkozyMutationalLandscapeGray2021a]|[@zhangGenomicLandscapeMantle2014; @zhangGeneticHeterogeneityDiffuse2013; @zhouSporadicEndemicBurkitt2019]|

+|[LTB](LTB)|1|[@deschGenotypingCirculatingTumor2020]|[@chapuyMolecularSubtypesDiffuse2018b; @paneaWholeGenomeLandscape2019]|

+|[MAP3K14](MAP3K14)|1|[@ottoGeneticLesionsTRAF32012a]|[@rossiAlterationBIRC3Multiple2011a]|

+|[MS4A1](MS4A1)|1|[@mottokIntegrativeGenomicAnalysis2019b]|[@rushtonGeneticEvolutionaryPatterns2020]|

+|[NFKBIA](NFKBIA)|1|[@wienandGenomicAnalysesFlowsorted2019b]|[@russler-germainMutationsAssociatedProgression2023b; @lakeMutationsNFKBIAEncoding2009]|

+|[NFKBIE](NFKBIE)|1|[@mansouriFrequentNFKBIEDeletions2016]|[@pararajalingamCodingNoncodingDrivers2020; @morinGeneticLandscapesRelapsed2016]|

+|[OSBPL10](OSBPL10)|1||[@arthurGenomewideDiscoverySomatic2018]|

+|[P2RY8](P2RY8)|1||[@lohrDiscoveryPrioritizationSomatic2012a; @muppidiLossSignalingGa132014b]|

+|[PCLO](PCLO)|1||[@lohrDiscoveryPrioritizationSomatic2012a]|

+|[PHIP](PHIP)|1|||

+|[PIM1](PIM1)|1|[@dunsCharacterizationDLBCLPMBL2021b]|[@pasqualucciHypermutationMultipleProtooncogenes2001a; @burkhardtClinicalRelevanceMolecular2022b]|

+|[PIM2](PIM2)|1|[@reichelFlowSortingExome2015a]|[@arthurGenomewideDiscoverySomatic2018]|

+|[PRKDC](PRKDC)|1||[@schmitzGeneticsPathogenesisDiffuse2018a; @hubschmannMutationalMechanismsShaping2021b]|

+|[PTPN1](PTPN1)|1|[@gunawardanaRecurrentSomaticMutations2014c]||

+|[PTPRD](PTPRD)|1||[@spinaGeneticsNodalMarginal2016b]|

+|[RHOA](RHOA)|1||[@richterRecurrentMutationID32012a]|

+|[S1PR2](S1PR2)|1||[@muppidiLossSignalingGa132014b; @morinFrequentMutationHistonemodifying2011]|

+|[SGK1](SGK1)|1|[@dunsCharacterizationDLBCLPMBL2021b]|[@morinFrequentMutationHistonemodifying2011]|

+|[SIN3A](SIN3A)|1||[@rossiCodingGenomeSplenic2012c; @grandeGenomewideDiscoverySomatic2019]|

+|[SMARCA2](SMARCA2)|1|||

+|[SMARCA4](SMARCA4)|1||[@krysiakRecurrentSomaticMutations2017b; @nadeuGenomicEpigenomicInsights2020b; @zhangGeneticHeterogeneityDiffuse2013; @richterRecurrentMutationID32012a]|

+|[SOCS1](SOCS1)|1|[@wenigerMutationsTumorSuppressor2006a]|[@morinFrequentMutationHistonemodifying2011]|

+|[SPEN](SPEN)|1|[@sarkozyMutationalLandscapeGray2021a]|[@rossiCodingGenomeSplenic2012c]|

+|[STAT3](STAT3)|1||[@ohgamiSTAT3MutationsAre2014]|

+|[STAT6](STAT6)|1|[@ritzRecurrentMutationsSTAT62009a]|[@yildizActivatingSTAT6Mutations2015c]|

+|[TAP1](TAP1)|1||[@schmitzGeneticsPathogenesisDiffuse2018a]|

+|[TBL1XR1](TBL1XR1)|1||[@rossiCodingGenomeSplenic2012c; @mareschalWholeExomeSequencing2016]|

+|[TCF3](TCF3)|1||[@schmitzBurkittLymphomaPathogenesis2012]|

+|[TET3](TET3)|1|||

+|[TMSB4X](TMSB4X)|1||[@albuquerqueEnhancingKnowledgeDiscovery2017a]|

+|[TNFAIP3](TNFAIP3)|1|[@schmitzTNFAIP3A20Tumor2009a]|[@rossiAlterationBIRC3Multiple2011a; @compagnoMutationsMultipleGenes2009a]|

+|[TNFRSF1B](TNFRSF1B)|1|||

+|[TP53](TP53)|1|[@tiacciPervasiveMutationsJAKSTAT2018b]|[@morinFrequentMutationHistonemodifying2011; @beaLandscapeSomaticMutations2013; @wildaInactivationARFMDM2p53Pathway2004; @rossiCodingGenomeSplenic2012c]|

+|[TRAF3](TRAF3)|1|[@ottoGeneticLesionsTRAF32012a]|[@rossiAlterationBIRC3Multiple2011a; @pasqualucciAnalysisCodingGenome2011]|

+|[UBE2A](UBE2A)|1|[@reichelFlowSortingExome2015a]|[@reddyGeneticFunctionalDrivers2017]|

+|[UBR5](UBR5)|1||[@pararajalingamCodingNoncodingDrivers2020; @zhangGeneticHeterogeneityDiffuse2013]|

+|[UNC5C](UNC5C)|1|||

+|[VPS13B](VPS13B)|1|||

+|[WEE1](WEE1)|1|[@reichelFlowSortingExome2015a]|[@schmitzGeneticsPathogenesisDiffuse2018a]|

+|[XPO1](XPO1)|1|[@jardinRecurrentMutationsExportin2016a]|[@mareschalWholeExomeSequencing2016]|

+|[ZFP36L1](ZFP36L1)|1|[@reichelFlowSortingExome2015a]|[@paneaWholeGenomeLandscape2019; @morinFrequentMutationHistonemodifying2011]|

+|Gene|Tier| First PMBL evidence | Other entities |

+|:-:|:-:|:-|:-|

+|[ABCA13](ABCA13)|2|[@sarkozyMutationalLandscapeGray2021a]|[@spinaGeneticsNodalMarginal2016b]|

+|[ACTG1](ACTG1)|2|[@deschGenotypingCirculatingTumor2020]|[@spinaGeneticsNodalMarginal2016b; @hubschmannMutationalMechanismsShaping2021b]|

+|[AKAP6](AKAP6)|2|[@tiacciPervasiveMutationsJAKSTAT2018b]||

+|[ARIH2](ARIH2)|2|[@reichelFlowSortingExome2015a]||

+|[AXDND1](AXDND1)|2|[@gomezUltraDeepSequencingReveals2023]||

+|[BCL2](BCL2)|2|[@sarkozyMutationalLandscapeGray2021a]|[@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011; @tanakaFrequentIncidenceSomatic1992]|

+|[BCL7A](BCL7A)|2|[@reichelFlowSortingExome2015a]|[@arthurGenomewideDiscoverySomatic2018; @grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b]|

+|[BIRC3](BIRC3)|2|[@dunsCharacterizationDLBCLPMBL2021b]|[@rossiAlterationBIRC3Multiple2011a; @beaLandscapeSomaticMutations2013; @arthurGenomewideDiscoverySomatic2018]|