update

+|[RHOA](RHOA)|Tier 1 GE[@richterRecurrentMutationID32012a], FE[@ohayreInactivatingMutationsGNA132016]|[Richter et al](papers/richterRecurrentMutationID32012a)|[@zhangGeneticHeterogeneityDiffuse2013]||

+@article{ohayreInactivatingMutationsGNA132016,

+ title = {Inactivating Mutations in {{GNA13}} and {{RHOA}} in {{Burkitt}}'s Lymphoma and Diffuse Large {{B-cell}} Lymphoma: A Tumor Suppressor Function for the {{Gα13}}/{{RhoA}} Axis in {{B}} Cells},

+ shorttitle = {Inactivating Mutations in {{GNA13}} and {{RHOA}} in {{Burkitt}}'s Lymphoma and Diffuse Large {{B-cell}} Lymphoma},

+ author = {O'Hayre, M. and Inoue, A. and Kufareva, I. and Wang, Z. and Mikelis, C. M. and Drummond, R. A. and Avino, S. and Finkel, K. and Kalim, K. W. and DiPasquale, G. and Guo, F. and Aoki, J. and Zheng, Y. and Lionakis, M. S. and Molinolo, A. A. and Gutkind, J. S.},

+ date = {2016-07-21},

+ journaltitle = {Oncogene},

+ shortjournal = {Oncogene},

+ volume = {35},

+ number = {29},

+ eprint = {26616858},

+ eprinttype = {pmid},

+ pages = {3771--3780},

+ issn = {1476-5594},

+ doi = {10.1038/onc.2015.442},

+ abstract = {G proteins and their cognate G protein-coupled receptors (GPCRs) function as critical signal transduction molecules that regulate cell survival, proliferation, motility and differentiation. The aberrant expression and/or function of these molecules have been linked to the growth, progression and metastasis of various cancers. As such, the analysis of mutations in the genes encoding GPCRs, G proteins and their downstream targets provides important clues regarding how these signaling cascades contribute to malignancy. Recent genome-wide sequencing efforts have unveiled the presence of frequent mutations in GNA13, the gene encoding the G protein Gα13, in Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL). We found that mutations in the downstream target of Gα13, RhoA, are also present in Burkitt's lymphoma and DLBCL. By multiple complementary approaches, we now show that that these cancer-specific GNA13 and RHOA mutations are inhibitory in nature, and that the expression of wild-type Gα13 in B-cell lymphoma cells with mutant GNA13 has limited impact in vitro but results in a remarkable growth inhibition in vivo. Thus, although Gα13 and RhoA activity has previously been linked to cellular transformation and metastatic potential of epithelial cancers, our findings support a tumor suppressive role for Gα13 and RhoA in Burkitt's lymphoma and DLBCL.},

+ langid = {english},

+ pmcid = {PMC4885800},

+ keywords = {Animals,B-Lymphocytes,Blotting Western,Burkitt Lymphoma,Cell Line Tumor,DNA Mutational Analysis,Dogs,GTP-Binding Protein alpha Subunits G12-G13,HEK293 Cells,Humans,Lymphoma Large B-Cell Diffuse,Madin Darby Canine Kidney Cells,Mice Inbred NOD,Mice Knockout,Mice SCID,Microscopy Confocal,Mutation,rhoA GTP-Binding Protein,Signal Transduction,Transplantation Heterologous,Tumor Suppressor Proteins},

+ file = {/Users/rmorin/Zotero/storage/A7M48FAC/O'Hayre et al. - 2016 - Inactivating mutations in GNA13 and RHOA in Burkit.pdf}

+}

+