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+@article{ryanCellRegulomeLinks2017,
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+ title = {A {{B Cell Regulome Links Notch}} to {{Downstream Oncogenic Pathways}} in {{Small B Cell Lymphomas}}},
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+ author = {Ryan, Russell J. H. and Petrovic, Jelena and Rausch, Dylan M. and Zhou, Yeqiao and Lareau, Caleb A. and Kluk, Michael J. and Christie, Amanda L. and Lee, Winston Y. and Tarjan, Daniel R. and Guo, Bingqian and Donohue, Laura K. H. and Gillespie, Shawn M. and Nardi, Valentina and Hochberg, Ephraim P. and Blacklow, Stephen C. and Weinstock, David M. and Faryabi, Robert B. and Bernstein, Bradley E. and Aster, Jon C. and Pear, Warren S.},
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+ date = {2017-10-17},
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+ journaltitle = {Cell Reports},
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+ shortjournal = {Cell Rep},
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+ volume = {21},
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+ number = {3},
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+ eprint = {29045844},
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+ eprinttype = {pmid},
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+ pages = {784--797},
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+ issn = {2211-1247},
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+ doi = {10.1016/j.celrep.2017.09.066},
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+ abstract = {Gain-of-function Notch mutations are recurrent in mature small B cell lymphomas such as mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL), but the Notch target genes that contribute to B cell oncogenesis are largely unknown. We performed integrative analysis of Notch-regulated transcripts, genomic binding of Notch transcription complexes, and genome conformation data to identify direct Notch target genes in MCL cell lines. This B~cell Notch regulome is largely controlled through Notch-bound distal enhancers and includes genes involved in B cell receptor and cytokine signaling and the oncogene MYC, which sustains proliferation of Notch-dependent MCL cell lines via a Notch-regulated lineage-restricted enhancer complex. Expression of direct Notch target genes is associated with Notch activity in an MCL xenograft model and in CLL lymph node biopsies. Our findings provide key insights into the role of Notch in MCL and other B~cell malignancies and have important implications for therapeutic targeting of Notch-dependent oncogenic pathways.},
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+ langid = {english},
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+ pmcid = {PMC5687286},
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+ keywords = {Animals,B-Lymphocytes,Biopsy,Cell Differentiation,Cell Line Tumor,chronic lymphocytic leukemia,Enhancer Elements Genetic,Gene Expression Regulation Neoplastic,Gene Rearrangement,Humans,Lymph Nodes,lymphoma,Lymphoma B-Cell,mantle cell lymphoma,Mice,MYC,Notch signaling,Oncogenes,Proto-Oncogene Proteins c-myc,Receptors Notch,Signal Transduction,Tumor Microenvironment,Xenograft Model Antitumor Assays},
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+ file = {/Users/rmorin/Zotero/storage/THJV7L2D/Ryan et al. - 2017 - A B Cell Regulome Links Notch to Downstream Oncoge.pdf}
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+}
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@article{lazarianHotspotMutationTranscription2021,
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title = {A Hotspot Mutation in Transcription Factor {{IKZF3}} Drives {{B}} Cell Neoplasia via Transcriptional Dysregulation},
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author = {Lazarian, Gregory and Yin, Shanye and Ten Hacken, Elisa and Sewastianik, Tomasz and Uduman, Mohamed and Font-Tello, Alba and Gohil, Satyen H. and Li, Shuqiang and Kim, Ekaterina and Joyal, Heather and Billington, Leah and Witten, Elizabeth and Zheng, Mei and Huang, Teddy and Severgnini, Mariano and Lefebvre, Valerie and Rassenti, Laura Z. and Gutierrez, Catherine and Georgopoulos, Katia and Ott, Christopher J. and Wang, Lili and Kipps, Thomas J. and Burger, Jan A. and Livak, Kenneth J. and Neuberg, Donna S. and Baran-Marszak, Fanny and Cymbalista, Florence and Carrasco, Ruben D. and Wu, Catherine J.},