BCL2.md
... ...
@@ -7,9 +7,11 @@ BCL2 mutations are frequently found in DLBCL, particularly in the germinal cente
7 7
8 8
|Entity|Tier|Description |
9 9
|:------:|:----:|--------------------------------------|
10
-|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
11 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a |high-confidence DLBCL gene, hypermutated |
12
-|![FL](images/icons/FL_tier1.png) |1-a |high-confidence FL gene, hypermutated |
11
+|![FL](images/icons/FL_tier1.png) |1-a |high-confidence FL gene, hypermutated
12
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
13
+|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
14
+ |
13 15
14 16
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
15 17
CD58.md
... ...
@@ -7,6 +7,7 @@ CD58, also known as lymphocyte function-associated antigen 3 (LFA-3), is crucial
7 7
8 8
|Entity|Tier|Description |
9 9
|:------:|:----:|--------------------------------------|
10
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
11 12
12 13
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
CD83.md
... ...
@@ -11,6 +11,7 @@ Mutations in this gene were first described in DLBCL in 2013 by Morin et al<sup>
11 11
12 12
|Entity|Tier|Description |
13 13
|:------:|:----:|--------------------------------------|
14
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
14 15
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
15 16
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
16 17
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
CDKN2A.md
... ...
@@ -10,6 +10,8 @@ Mutations in this gene were first described in DLBCL and FL in 2013 by Morin et
10 10
11 11
|Entity|Tier|Description |
12 12
|:------:|:----:|--------------------------------------|
13
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
14
+|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|
13 15
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
14 16
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
15 17
CREBBP.md
... ...
@@ -6,6 +6,8 @@ CREBBP mutations are highly prevalent in both DLBCL and FL. These mutations ofte
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|
10
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
10 12
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
11 13
|![BL](images/icons/BL_tier2.png) |2 |association with BL is tenuous|
CXCR5.md
... ...
@@ -6,6 +6,7 @@ CXCR5 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene|
10 11
11 12
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
DDX3X.md
... ...
@@ -6,6 +6,7 @@ Mutations in the DDX3X gene, which encodes an RNA helicase involved in various a
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![BL](images/icons/BL_tier1.png) |1 | high-confidence BL gene |
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 | high-confidence DLBCL gene |
11 12
|![FL](images/icons/FL_tier2.png) |2 | Although recurrent, the relevance of mutations in FL is tenuous |
DTX1.md
... ...
@@ -6,6 +6,8 @@ Mutations in the DTX1 gene, which encodes the E3 ubiquitin ligase Deltex 1, have
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
10
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
9 11
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
10 12
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
11 13
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
DUSP2.md
... ...
@@ -7,6 +7,7 @@ DUSP2 functions as a negative regulator of MAPK signaling, particularly affectin
7 7
8 8
|Entity|Tier|Description |
9 9
|:------:|:----:|--------------------------------------|
10
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
11 12
|![FL](images/icons/FL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in FL is tenuous |
12 13
EBF1.md
... ...
@@ -8,6 +8,7 @@ EBF1 is a critical transcription factor in early B-cell development, regulating
8 8
9 9
|Entity|Tier|Description |
10 10
|:------:|:----:|--------------------------------------|
11
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
11 12
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
12 13
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
13 14
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
EEF1A1.md
... ...
@@ -9,6 +9,7 @@ Mutations in this gene were first described in DLBCL and FL in 2021 by Hübschma
9 9
10 10
|Entity|Tier|Description |
11 11
|:------:|:----:|--------------------------------------|
12
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
12 13
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
13 14
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene|
14 15
ETS1.md
... ...
@@ -6,6 +6,7 @@ ETS1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
10 11
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
11 12
EZH2.md
... ...
@@ -6,6 +6,8 @@ EZH2 encodes a histone methyltransferase that is a component of the polycomb rep
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
10
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
10 12
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
11 13
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
EZR.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous |
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
FAS.md
... ...
@@ -6,6 +6,8 @@ FAS encodes a cell surface receptor involved in the induction of apoptosis. FAS
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
10
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
9 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
10 12
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
11 13
FAT4.md
... ...
@@ -4,6 +4,8 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
8
+|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|
7 9
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 10
|![MCL](images/icons/MCL_tier2.png) |2 |relevance in MCL not firmly established |
9 11
FOXO1.md
... ...
@@ -6,6 +6,8 @@ Mutations in the FOXO1 gene, which encodes a member of the forkhead family of tr
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
10
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
9 11
|![BL](images/icons/BL_tier1.png) |1 |high-confidence BL gene |
10 12
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
11 13
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
GNA13.md
... ...
@@ -6,6 +6,7 @@ Mutations in GNA13, which encodes a G protein alpha subunit involved in multiple
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![BL](images/icons/BL_tier1.png) |1 |high-confidence BL gene |
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
11 12
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
HIST1H1B.md
... ...
@@ -5,6 +5,7 @@ This is one of several genes that encode linker histone proteins that are recurr
5 5
6 6
|Entity|Tier|Description |
7 7
|:------:|:----:|--------------------------------------|
8
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
8 9
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
10 11
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
HIST1H1C.md
... ...
@@ -10,6 +10,7 @@ Mutations in this gene were first described in DLBCL and FL in 2011 by Morin et
10 10
11 11
|Entity|Tier|Description |
12 12
|:------:|:----:|--------------------------------------|
13
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
13 14
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
14 15
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
15 16
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
HIST1H1D.md
... ...
@@ -5,6 +5,8 @@ This is one of several genes that encode linker histone proteins that are recurr
5 5
6 6
|Entity|Tier|Description |
7 7
|:------:|:----:|--------------------------------------|
8
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9
+|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|
8 10
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
9 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
10 12
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
HIST1H1E.md
... ...
@@ -9,6 +9,7 @@ Mutations in this gene were first described in DLBCL in 2013 by Morin et al.<sup
9 9
10 10
|Entity|Tier|Description |
11 11
|:------:|:----:|--------------------------------------|
12
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
12 13
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
13 14
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
14 15
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
HIST1H2BC.md
... ...
@@ -6,6 +6,7 @@ This gene encodes the H2A protein, one of the core proteins comprising nucleosom
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
10 11
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
11 12
HIST1H3B.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
8 9
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
9 10
HLA-A.md
... ...
@@ -6,6 +6,7 @@ Mutations in the HLA-B gene have been associated with a loss of cell surface exp
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
9 10
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
11 12
HLA-B.md
... ...
@@ -6,6 +6,7 @@ Mutations in the HLA-B gene have been associated with a loss of cell surface exp
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
11 12
|![FL](images/icons/FL_tier2.png) |2 |relevance in FL not firmly established|
HLA-C.md
... ...
@@ -6,6 +6,7 @@ Mutations in the HLA-C gene have been associated with a loss of cell surface exp
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
10 11
11 12
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
IGLL5.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
8 9
|![DLBCL](images/icons/DLBCL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous |
9 10
|![FL](images/icons/FL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in FL is tenuous |
IKBKB.md
... ...
@@ -4,6 +4,8 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
8
+|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|
7 9
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 10
9 11
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
IL4R.md
... ...
@@ -6,6 +6,7 @@ Mutations in IL4R have been identified in various types of B-cell lymphomas, par
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene|
10 11
11 12
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
IRF4.md
... ...
@@ -6,6 +6,7 @@ IRF4 (Interferon Regulatory Factor 4) encodes a transcription factor that plays
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene|
10 11
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
11 12
IRF8.md
... ...
@@ -6,6 +6,7 @@ IRF8 (Interferon Regulatory Factor 8) is a transcription factor critical for the
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
11 12
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
ITPKB.md
... ...
@@ -6,6 +6,7 @@ The ITPKB gene encodes inositol-trisphosphate 3-kinase B, an enzyme involved in
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene|
10 11
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
11 12
JAK1.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
JUNB.md
... ...
@@ -6,6 +6,7 @@ JUNB has been reported to be frequently mutated in T-cell/histiocyte-rich large
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
10 11
11 12
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
KLF2.md
... ...
@@ -6,6 +6,8 @@ KLF2 (Kruppel-like factor 2) is a transcription factor involved in the regulatio
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
10
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
9 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene|
10 12
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
11 13
KMT2C.md
... ...
@@ -6,6 +6,7 @@ This gene has been reported to be recurrently mutated in DLBCL. The rate of muta
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|---------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established |
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
11 12
|![MCL](images/icons/MCL_tier2.png) |2 |relevance in MCL not firmly established|
KMT2D.md
... ...
@@ -10,6 +10,8 @@ Mutations were later described in MCL in 2013 by Bea et al.<sup>4</sup> KMT2D mu
10 10
11 11
|Entity|Tier|Description |
12 12
|:------:|:----:|--------------------------|
13
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
14
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
13 15
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
14 16
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
15 17
|![BL](images/icons/BL_tier1.png) |1 |high-confidence BL gene |
LRRN3.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
LTB.md
... ...
@@ -6,6 +6,7 @@ LTB (Lymphotoxin Beta) is a member of the tumor necrosis factor (TNF) superfamil
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
10 11
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
11 12
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
MCL1.md
... ...
@@ -6,6 +6,7 @@ MCL1 (Myeloid Cell Leukemia 1) is a member of the BCL2 family of proteins that p
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
9 10
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
11 12
MPDZ.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
MS4A1.md
... ...
@@ -6,6 +6,7 @@ MS4A1 encodes the CD20 protein, which is the target of rituximab and other thera
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene|
10 11
11 12
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
MYB.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
MYC.md
... ...
@@ -6,6 +6,8 @@ MYC is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) a
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
10
+|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|
9 11
|![BL](images/icons/BL_tier1.png) |1-a | aSHM target and high-confidence BL gene |
10 12
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
11 13
|![FL](images/icons/FL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in FL is tenuous |
NCOR2.md
... ...
@@ -6,6 +6,8 @@ Mutations in this gene are relatively rare in DLBCL overall but show a pattern o
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
10
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
9 11
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
10 12
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
11 13
NFKB2.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
NFKBIA.md
... ...
@@ -6,6 +6,7 @@ NFKBIA encodes IκBα, an inhibitor of NF-κB, which regulates the NF-κB signal
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
10 11
|![FL](images/icons/FL_tier2.png) |2 |relevance in FL not firmly established|
11 12
NFKBIE.md
... ...
@@ -6,6 +6,7 @@ NFKBIE encodes IκBε, a negative regulator of NF-κB. Mutations in NFKBIE can d
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
10 11
|![MCL](images/icons/MCL_tier1.png) |1 |high-confidence MCL gene |
11 12
OSBPL10.md
... ...
@@ -6,6 +6,7 @@ OSBPL10 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ash
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
10 11
11 12
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
P2RY8.md
... ...
@@ -5,6 +5,7 @@ P2RY8 encodes a G protein–coupled receptor that is expressed on germinal cente
5 5
6 6
|Entity|Tier|Description |
7 7
|:------:|:----:|--------------------------------------|
8
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
8 9
|![BL](images/icons/BL_tier1.png) |1 |high-confidence BL gene |
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
10 11
|![FL](images/icons/FL_tier2.png) |2 |relevance in FL not firmly established|
PCBP1.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![BL](images/icons/BL_tier2.png) |1 |high-confidence BL gene |
8 9
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
9 10
PCLO.md
... ...
@@ -5,6 +5,8 @@
5 5
6 6
|Entity|Tier|Description |
7 7
|:------:|:----:|-----------------------------------------|
8
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
8 10
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
9 11
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
10 12
PIM1.md
... ...
@@ -6,6 +6,7 @@ PIM1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
11 12
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
PIM2.md
... ...
@@ -6,6 +6,7 @@ PIM2 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene|
10 11
11 12
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
PRKDC.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
8 9
|![FL](images/icons/FL_tier2.png) |2 |relevance in FL not firmly established|
9 10
PTPN1.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous |
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
PTPRD.md
... ...
@@ -4,6 +4,8 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------|
7
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
8
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 9
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
8 10
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
9 11
RFTN1.md
... ...
@@ -4,6 +4,8 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
8
+|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|
7 9
|![DLBCL](images/icons/DLBCL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous |
8 10
9 11
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
RHOA.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![BL](images/icons/BL_tier1.png) |1 |high-confidence BL gene |
8 9
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
9 10
S1PR2.md
... ...
@@ -6,6 +6,7 @@ S1PR2 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
10 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
11 12
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
SETD5.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
SGK1.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
8 9
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
9 10
SIAH2.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
SIN3A.md
... ...
@@ -6,6 +6,7 @@ Mutations in this gene were first described in MZL in 2012 by Rossi et al<sup>1<
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![BL](images/icons/BL_tier1.png) |1 |high-confidence BL gene |
10 11
|![MZL](images/icons/MZL_tier1.png) |1 |high-confidence MZL gene |
11 12
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
SMARCA4.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![BL](images/icons/BL_tier1.png) |1 |high-confidence BL gene |
8 9
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
9 10
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
SOCS1.md
... ...
@@ -4,6 +4,8 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------------------|
7
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
8
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 9
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
8 10
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
9 11
SPEN.md
... ...
@@ -4,6 +4,8 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------|
7
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
8
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 9
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
8 10
9 11
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
STAT3.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
STAT5B.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
STAT6.md
... ...
@@ -6,6 +6,8 @@ The STAT6 gene, which encodes a transcription factor involved in the JAK-STAT si
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
10
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
10 12
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
11 13
TAP1.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
TBL1XR1.md
... ...
@@ -4,6 +4,8 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------------------|
7
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
8
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 9
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
8 10
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
9 11
TMSB4X.md
... ...
@@ -6,6 +6,7 @@ TMSB4X is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm
6 6
7 7
|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
10 11
|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
11 12
TNFAIP3.md
... ...
@@ -4,6 +4,8 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
8
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
7 9
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
8 10
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
9 11
TP53.md
... ...
@@ -5,6 +5,8 @@
5 5
6 6
|Entity|Tier|Description |
7 7
|:------:|:----:|--------------------------|
8
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
8 10
|![BL](images/icons/BL_tier1.png) |1 |high-confidence BL gene |
9 11
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
10 12
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |
TRAF3.md
... ...
@@ -4,6 +4,8 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
8
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
7 9
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 10
9 11
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
UBE2A.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
UBR5.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
8 9
|![MCL](images/icons/MCL_tier1.png) |1 |high-confidence MCL gene |
9 10
UNC5C.md
... ...
@@ -4,6 +4,7 @@
4 4
5 5
|Entity|Tier|Description |
6 6
|:------:|:----:|--------------------------|
7
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
7 8
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
8 9
9 10
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
VPS13B.md
... ...
@@ -4,6 +4,7 @@
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------|
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+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
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|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
WEE1.md
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@@ -6,6 +6,7 @@ WEE1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
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|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
ZFP36L1.md
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@@ -6,6 +6,7 @@ ZFP36L1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ash
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|Entity|Tier|Description |
8 8
|:------:|:----:|--------------------------------------|
9
+|![PMBL](images/icons/PMBL_tier1.png)|1|high-confidence PMBL/cHL/GZL gene|
9 10
|![BL](images/icons/BL_tier2.png) |2-a | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous |
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|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene |
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ZNF217.md
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@@ -4,6 +4,7 @@
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|Entity|Tier|Description |
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|:------:|:----:|-----------------------------------------|
7
+|![PMBL](images/icons/PMBL_tier2.png)|2|relevance in PMBL/cHL/GZL not firmly established|
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|![DLBCL](images/icons/DLBCL_tier2.png) |2 |relevance in DLBCL not firmly established|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)