CCND3.md
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## Overview
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CCND3 (Cyclin D3) is a gene that encodes a protein involved in the regulation of the cell cycle. Mutations in CCND3 are implicated in various types of B-cell lymphomas, including Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL).<sup>1,2</sup> Somatic mutations in CCND3 often stabilize the Cyclin D3 protein by altering the phosphorylation motif, which is crucial for proteasomal degradation. These mutations are associated with an increase in Cyclin D3 protein stability and oncogenic potential.
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+```mermaid
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+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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+timeline
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+ title Publication timing
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+ 2011-07-27 : Morin : DLBCL
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+ 2012-11-11 : Richter : BL
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+ 2017-07-27 : Jallades : MZL
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+ 2019-08-20 : Desch : PMBL
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+```
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+
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## Relevance tier by entity
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|Entity|Tier|Description |
CREBBP.md
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## Overview
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CREBBP mutations are highly prevalent in both DLBCL and FL. These mutations often affect the histone acetyltransferase (HAT) domain, crucial for regulating gene expression through chromatin modification, or generate a truncated protein.<sup>1</sup> This gene has some recurrent sites of mutations (hotspots), mostly in the HAT domain. The pattern of mutations in DLBCL is distinct from FL with the latter having more HAT domain mutations relative to truncating mutations.<sup>2</sup>
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-## Relevance tier by entity
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+## History
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```mermaid
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%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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@@ -13,6 +13,8 @@ timeline
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2013-12-13 : Parry : MZL
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2021-07-15 : Duns : PMBL
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```
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+## Relevance tier by entity
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+
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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|![MZL](images/icons/MZL_tier2.png)|2|relevance in MZL not firmly established|