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### Gene Tiers
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-**Tier 2 Genes**
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+**Tier 2**
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Any gene described as significantly or recurrently mutated in one or more types of B-cell lymphoma is initially assigned to Tier 2 for that entity. The study describing the mutation of that gene in a particular entity is considered the originating study.
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-**Tier 1 Genes**
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+**Tier 1**
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Genes can transition to Tier 1 only after additional studies have demonstrated the recurrence of mutations in the same entity.
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