.gitignore
... ...
@@ -1 +1,2 @@
1 1
*DS_Store
2
+._*
ABL2.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### FL
17 18
[[include:tables/FL_ABL2.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
ACTB.md
... ...
@@ -21,7 +21,10 @@ ACTB is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_ACTB.md]]
26
+
27
+### FL
25 28
[[include:tables/FL_ACTB.md]]
26 29
27 30
## Mutation pattern and selective pressure estimates
ACTG1.md
... ...
@@ -23,7 +23,10 @@ The function of mutations in ACTB and ACTG1 have not yet been determined.[@witje
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_ACTG1.md]]
28
+
29
+### FL
27 30
[[include:tables/FL_ACTG1.md]]
28 31
29 32
## Mutation pattern and selective pressure estimates
ADNP.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### BL
17 18
[[include:tables/BL_ADNP.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
AFAP1L2.md
... ...
@@ -18,6 +18,7 @@ nocite: |
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_AFAP1L2.md]]
22 23
23 24
## Mutation pattern and selective pressure estimates
AICDA.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_AICDA.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
ALPK2.md
... ...
@@ -20,6 +20,7 @@ nocite: |
20 20
21 21
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
22 22
23
+### BL
23 24
[[include:tables/BL_ALPK2.md]]
24 25
25 26
## Mutation pattern and selective pressure estimates
ATM.md
... ...
@@ -23,6 +23,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_ATM.md]]
27 28
28 29
## Mutation pattern and selective pressure estimates
ATP6AP1.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### FL
17 18
[[include:tables/FL_ATP6AP1.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
ATP6V1B2.md
... ...
@@ -18,6 +18,7 @@ Driver mutations affecting this gene in FL have been experimentally demonstrated
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### FL
21 22
[[include:tables/FL_ATP6V1B2.md]]
22 23
23 24
## Mutation pattern and selective pressure estimates
B2M.md
... ...
@@ -24,7 +24,10 @@ B2M mutations in B-cell lymphomas, particularly in DLBCL and PMBCL, lead to redu
24 24
25 25
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
26 26
27
+### DLBCL
27 28
[[include:tables/DLBCL_B2M.md]]
29
+
30
+### FL
28 31
[[include:tables/FL_B2M.md]]
29 32
30 33
## Mutation pattern and selective pressure estimates
BACH2.md
... ...
@@ -22,6 +22,7 @@ Driver mutations affecting this gene in BL have been experimentally demonstrated
22 22
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25
+### BL
25 26
[[include:tables/BL_BACH2.md]]
26 27
27 28
## Mutation pattern and selective pressure estimates
BCL10.md
... ...
@@ -26,7 +26,10 @@ BCL10 missense mutations in the CARD domain and truncating mutations have distin
26 26
27 27
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
28 28
29
+### DLBCL
29 30
[[include:tables/DLBCL_BCL10.md]]
31
+
32
+### FL
30 33
[[include:tables/FL_BCL10.md]]
31 34
32 35
BIRC6.md
... ...
@@ -19,7 +19,10 @@ BIRC6, as a negative regulator of non-canonical NF-κB signaling, is implicated
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_BIRC6.md]]
24
+
25
+### FL
23 26
[[include:tables/FL_BIRC6.md]]
24 27
25 28
## Mutation pattern and selective pressure estimates
BMP7.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### BL
17 18
[[include:tables/BL_BMP7.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
BRAF.md
... ...
@@ -30,6 +30,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
30 30
31 31
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
32 32
33
+### DLBCL
33 34
[[include:tables/DLBCL_BRAF.md]]
34 35
35 36
## Mutation pattern and selective pressure estimates
BTG2.md
... ...
@@ -25,7 +25,10 @@ BTG2 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
25 25
26 26
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
27 27
28
+### DLBCL
28 29
[[include:tables/DLBCL_BTG2.md]]
30
+
31
+### FL
29 32
[[include:tables/FL_BTG2.md]]
30 33
31 34
## Mutation pattern and selective pressure estimates
BTK.md
... ...
@@ -19,7 +19,10 @@ Driver mutations affecting this gene in FL/DLBCL have been experimentally demons
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_BTK.md]]
24
+
25
+### FL
23 26
[[include:tables/FL_BTK.md]]
24 27
25 28
## Mutation pattern and selective pressure estimates
CCND3.md
... ...
@@ -21,8 +21,13 @@ Somatic mutations in CCND3 often stabilize the Cyclin D3 protein by altering the
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_CCND3.md]]
26
+
27
+### FL
25 28
[[include:tables/FL_CCND3.md]]
29
+
30
+### BL
26 31
[[include:tables/BL_CCND3.md]]
27 32
28 33
## Mutation pattern and selective pressure estimates
CD58.md
... ...
@@ -23,6 +23,7 @@ This is often accompanied by mutations in the β2-Microglobulin gene, which furt
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_CD58.md]]
27 28
28 29
## Mutation pattern and selective pressure estimates
CD70.md
... ...
@@ -26,7 +26,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
26 26
27 27
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
28 28
29
+### DLBCL
29 30
[[include:tables/DLBCL_CD70.md]]
31
+
32
+### FL
30 33
[[include:tables/FL_CD70.md]]
31 34
32 35
## Mutation pattern and selective pressure estimates
CD74.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_CD74.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
CD83.md
... ...
@@ -23,7 +23,10 @@ Mutations in this gene were first described in DLBCL in 2013 by Morin et al[@mor
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_CD83.md]]
28
+
29
+### FL
27 30
[[include:tables/FL_CD83.md]]
28 31
29 32
## Mutation pattern and selective pressure estimates
CDKN2A.md
... ...
@@ -21,6 +21,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_CDKN2A.md]]
25 26
26 27
## Mutation pattern and selective pressure estimates
CHD8.md
... ...
@@ -18,7 +18,10 @@ nocite: |
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_CHD8.md]]
23
+
24
+### BL
22 25
[[include:tables/BL_CHD8.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
CIITA.md
... ...
@@ -21,7 +21,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_CIITA.md]]
26
+
27
+### FL
25 28
[[include:tables/FL_CIITA.md]]
26 29
27 30
## Mutation pattern and selective pressure estimates
CREBBP.md
... ...
@@ -25,8 +25,13 @@ Mutations in CREBBP and EP300 affect a common pathway and have been described as
25 25
26 26
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
27 27
28
+### DLBCL
28 29
[[include:tables/DLBCL_CREBBP.md]]
30
+
31
+### FL
29 32
[[include:tables/FL_CREBBP.md]]
33
+
34
+### BL
30 35
[[include:tables/BL_CREBBP.md]]
31 36
32 37
## Mutation pattern and selective pressure estimates
CTSS.md
... ...
@@ -19,7 +19,10 @@ Driver mutations affecting this gene in FL have been experimentally demonstrated
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_CTSS.md]]
24
+
25
+### FL
23 26
[[include:tables/FL_CTSS.md]]
24 27
25 28
## Mutation pattern and selective pressure estimates
CXCR4.md
... ...
@@ -25,7 +25,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
25 25
26 26
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
27 27
28
+### DLBCL
28 29
[[include:tables/DLBCL_CXCR4.md]]
30
+
31
+### FL
29 32
[[include:tables/FL_CXCR4.md]]
30 33
31 34
## Mutation pattern and selective pressure estimates
DDX3X.md
... ...
@@ -22,8 +22,13 @@ Driver mutations affecting this gene in DLBCL/BL have been experimentally demons
22 22
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25
+### DLBCL
25 26
[[include:tables/DLBCL_DDX3X.md]]
27
+
28
+### FL
26 29
[[include:tables/FL_DDX3X.md]]
30
+
31
+### BL
27 32
[[include:tables/BL_DDX3X.md]]
28 33
29 34
## Mutation pattern and selective pressure estimates
DTX1.md
... ...
@@ -18,7 +18,10 @@ Mutations in the DTX1 gene, which encodes the E3 ubiquitin ligase Deltex 1, have
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_DTX1.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_DTX1.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
DUSP2.md
... ...
@@ -23,7 +23,10 @@ The mutation pattern in DLBCL implies the preferential accumulation of *inactiva
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_DUSP2.md]]
28
+
29
+### FL
27 30
[[include:tables/FL_DUSP2.md]]
28 31
29 32
## Mutation pattern and selective pressure estimates
EBF1.md
... ...
@@ -23,7 +23,10 @@ Driver mutations affecting this gene in DLBCL/FL have been experimentally demons
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_EBF1.md]]
28
+
29
+### FL
27 30
[[include:tables/FL_EBF1.md]]
28 31
29 32
## Mutation pattern and selective pressure estimates
EEF1A1.md
... ...
@@ -18,7 +18,10 @@ This gene has some recurrent sites of mutations (hot spots). The mutation patter
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_EEF1A1.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_EEF1A1.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
EP300.md
... ...
@@ -22,7 +22,10 @@ Studies using genome-wide CRISPR-Cas9 screens have identified synthetic lethal i
22 22
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25
+### DLBCL
25 26
[[include:tables/DLBCL_EP300.md]]
27
+
28
+### FL
26 29
[[include:tables/FL_EP300.md]]
27 30
28 31
## Mutation pattern and selective pressure estimates
EPHB2.md
... ...
@@ -23,6 +23,7 @@ nocite: |
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### BL
26 27
[[include:tables/BL_EPHB2.md]]
27 28
28 29
## Mutation pattern and selective pressure estimates
ETS1.md
... ...
@@ -26,7 +26,10 @@ The mutation pattern in DLBCL implies the preferential accumulation of *inactiva
26 26
27 27
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
28 28
29
+### DLBCL
29 30
[[include:tables/DLBCL_ETS1.md]]
31
+
32
+### FL
30 33
[[include:tables/FL_ETS1.md]]
31 34
32 35
## Mutation pattern and selective pressure estimates
ETV6.md
... ...
@@ -26,6 +26,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
26 26
27 27
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
28 28
29
+### DLBCL
29 30
[[include:tables/DLBCL_ETV6.md]]
30 31
31 32
## Mutation pattern and selective pressure estimates
EZH2.md
... ...
@@ -28,7 +28,10 @@ Combination therapies including EZH2 inhibitors are also under exploration for D
28 28
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
29 29
30 30
31
+### DLBCL
31 32
[[include:tables/DLBCL_EZH2.md]]
33
+
34
+### FL
32 35
[[include:tables/FL_EZH2.md]]
33 36
34 37
## Mutation pattern and selective pressure estimates
FAS.md
... ...
@@ -25,7 +25,10 @@ Driver mutations affecting this gene in FL/DLBCL have been experimentally demons
25 25
26 26
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
27 27
28
+### DLBCL
28 29
[[include:tables/DLBCL_FAS.md]]
30
+
31
+### FL
29 32
[[include:tables/FL_FAS.md]]
30 33
31 34
## Mutation pattern and selective pressure estimates
FBXO11.md
... ...
@@ -23,7 +23,10 @@ Driver mutations affecting this gene in DLBCL/BL have been experimentally demons
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_FBXO11.md]]
28
+
29
+### BL
27 30
[[include:tables/BL_FBXO11.md]]
28 31
29 32
## Mutation pattern and selective pressure estimates
FBXW7.md
... ...
@@ -24,6 +24,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
24 24
25 25
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
26 26
27
+### DLBCL
27 28
[[include:tables/DLBCL_FBXW7.md]]
28 29
29 30
## Mutation pattern and selective pressure estimates
FOXO1.md
... ...
@@ -21,8 +21,13 @@ Driver mutations affecting this gene in FL/DLBCL/BL have been experimentally dem
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_FOXO1.md]]
26
+
27
+### FL
25 28
[[include:tables/FL_FOXO1.md]]
29
+
30
+### BL
26 31
[[include:tables/BL_FOXO1.md]]
27 32
28 33
## Mutation pattern and selective pressure estimates
GNA13.md
... ...
@@ -22,8 +22,13 @@ Driver mutations affecting this gene in BL/FL/DLBCL have been experimentally dem
22 22
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25
+### DLBCL
25 26
[[include:tables/DLBCL_GNA13.md]]
27
+
28
+### FL
26 29
[[include:tables/FL_GNA13.md]]
30
+
31
+### BL
27 32
[[include:tables/BL_GNA13.md]]
28 33
29 34
## Mutation pattern and selective pressure estimates
GNAI2.md
... ...
@@ -23,8 +23,13 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_GNAI2.md]]
28
+
29
+### FL
27 30
[[include:tables/FL_GNAI2.md]]
31
+
32
+### BL
28 33
[[include:tables/BL_GNAI2.md]]
29 34
30 35
## Mutation pattern and selective pressure estimates
GRB2.md
... ...
@@ -20,6 +20,7 @@ Further research is needed to elucidate its specific role in DLBCL.
20 20
21 21
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
22 22
23
+### DLBCL
23 24
[[include:tables/DLBCL_GRB2.md]]
24 25
25 26
## Mutation pattern and selective pressure estimates
GRHPR.md
... ...
@@ -17,6 +17,7 @@ GRHPR is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
17 17
18 18
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
19 19
20
+### DLBCL
20 21
[[include:tables/DLBCL_GRHPR.md]]
21 22
22 23
## Mutation pattern and selective pressure estimates
HIST1H1E.md
... ...
@@ -21,8 +21,13 @@ Mutations in this gene were first described in DLBCL in 2013 by Morin et al.[@mo
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_HIST1H1E.md]]
26
+
27
+### FL
25 28
[[include:tables/FL_HIST1H1E.md]]
29
+
30
+### BL
26 31
[[include:tables/BL_HIST1H1E.md]]
27 32
28 33
## Mutation pattern and selective pressure estimates
HLA-A.md
... ...
@@ -22,6 +22,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
22 22
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25
+### DLBCL
25 26
[[include:tables/DLBCL_HLA-A.md]]
26 27
27 28
## Mutation pattern and selective pressure estimates
HLA-B.md
... ...
@@ -22,7 +22,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
22 22
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25
+### DLBCL
25 26
[[include:tables/DLBCL_HLA-B.md]]
27
+
28
+### FL
26 29
[[include:tables/FL_HLA-B.md]]
27 30
28 31
## Mutation pattern and selective pressure estimates
HLA-C.md
... ...
@@ -23,6 +23,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_HLA-C.md]]
27 28
28 29
## Mutation pattern and selective pressure estimates
HLA-DMB.md
... ...
@@ -19,6 +19,7 @@ Mutations in this gene were first described in DLBCL by [Hübschmann et al](pape
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_HLA-DMB.md]]
23 24
24 25
## Mutation pattern and selective pressure estimates
HVCN1.md
... ...
@@ -17,7 +17,10 @@ HVCN1, a voltage-gated proton channel, has been identified as recurrently mutate
17 17
18 18
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
19 19
20
+### DLBCL
20 21
[[include:tables/DLBCL_HVCN1.md]]
22
+
23
+### FL
21 24
[[include:tables/FL_HVCN1.md]]
22 25
23 26
## Mutation pattern and selective pressure estimates
Home.md
... ...
@@ -43,7 +43,7 @@ To get started, select one of the gene lists from the table below then select th
43 43
44 44
## History
45 45
46
-### DLBCL, FL and BL
46
+### DLBCL, FL and BL studies
47 47
48 48
```mermaid
49 49
---
... ...
@@ -168,7 +168,7 @@ BL RNA-seq, Schmitz 2012, 19
168 168
```
169 169
170 170
171
-### History of lymphoma genes in rare entities
171
+### MCL, MZL and PMBL
172 172
173 173
```mermaid
174 174
---
... ...
@@ -294,7 +294,7 @@ PMBL panel, Desch 2020, 10
294 294
295 295
**Tier 3** - Tier 3 is reserved for genes that were once nominated as a driver but have since been retired due to a lack of support in the original study nominating them.
296 296
297
-For more details, visit (this page)(Supplemental_Methods_and_Results)
297
+For more details, visit [this page](Supplemental_Methods_and_Results)
298 298
299 299
## Other resources available for each gene
300 300
ID3.md
... ...
@@ -19,7 +19,10 @@ The existence of mutations in DLBCL were described in 2012 by Schmitz et al[@sch
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_ID3.md]]
24
+
25
+### BL
23 26
[[include:tables/BL_ID3.md]]
24 27
25 28
## Mutation pattern and selective pressure estimates
IKZF3.md
... ...
@@ -21,7 +21,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_IKZF3.md]]
26
+
27
+### BL
25 28
[[include:tables/BL_IKZF3.md]]
26 29
27 30
## Mutation pattern and selective pressure estimates
IL4R.md
... ...
@@ -21,6 +21,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_IL4R.md]]
25 26
26 27
## Mutation pattern and selective pressure estimates
IRF4.md
... ...
@@ -20,7 +20,10 @@ There are a few mutation hotspots in this gene. The functional role of mutations
20 20
21 21
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
22 22
23
+### DLBCL
23 24
[[include:tables/DLBCL_IRF4.md]]
25
+
26
+### FL
24 27
[[include:tables/FL_IRF4.md]]
25 28
26 29
## Mutation pattern and selective pressure estimates
IRF8.md
... ...
@@ -25,8 +25,13 @@ Driver mutations affecting this gene in DLBCL/FL have been experimentally demons
25 25
26 26
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
27 27
28
+### DLBCL
28 29
[[include:tables/DLBCL_IRF8.md]]
30
+
31
+### FL
29 32
[[include:tables/FL_IRF8.md]]
33
+
34
+### BL
30 35
[[include:tables/BL_IRF8.md]]
31 36
32 37
## Mutation pattern and selective pressure estimates
ITPKB.md
... ...
@@ -21,7 +21,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_ITPKB.md]]
26
+
27
+### FL
25 28
[[include:tables/FL_ITPKB.md]]
26 29
27 30
## Mutation pattern and selective pressure estimates
JUNB.md
... ...
@@ -25,6 +25,7 @@ Mutations in this gene were reported to be inflated in the original results acco
25 25
26 26
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
27 27
28
+### DLBCL
28 29
[[include:tables/DLBCL_JUNB.md]]
29 30
30 31
KLF2.md
... ...
@@ -20,7 +20,10 @@ Contradictory to this, the mutation pattern in DLBCL implies selective pressure
20 20
21 21
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
22 22
23
+### DLBCL
23 24
[[include:tables/DLBCL_KLF2.md]]
25
+
26
+### FL
24 27
[[include:tables/FL_KLF2.md]]
25 28
26 29
## Mutation pattern and selective pressure estimates
KLHL14.md
... ...
@@ -21,6 +21,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_KLHL14.md]]
25 26
26 27
## Mutation pattern and selective pressure estimates
KLHL6.md
... ...
@@ -22,7 +22,10 @@ Driver mutations affecting this gene in DLBCL/FL have been experimentally demons
22 22
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25
+### DLBCL
25 26
[[include:tables/DLBCL_KLHL6.md]]
27
+
28
+### FL
26 29
[[include:tables/FL_KLHL6.md]]
27 30
28 31
## Mutation pattern and selective pressure estimates
KMT2C.md
... ...
@@ -18,7 +18,10 @@ This gene has been reported to be recurrently mutated in DLBCL. The rate of muta
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_KMT2C.md]]
23
+
24
+### BL
22 25
[[include:tables/BL_KMT2C.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
KMT2D.md
... ...
@@ -27,8 +27,13 @@ Driver mutations affecting this gene in BL/DLBCL/FL have been experimentally dem
27 27
28 28
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
29 29
30
+### DLBCL
30 31
[[include:tables/DLBCL_KMT2D.md]]
32
+
33
+### FL
31 34
[[include:tables/FL_KMT2D.md]]
35
+
36
+### BL
32 37
[[include:tables/BL_KMT2D.md]]
33 38
34 39
## Mutation pattern and selective pressure estimates
KRAS.md
... ...
@@ -21,6 +21,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_KRAS.md]]
25 26
26 27
## Mutation pattern and selective pressure estimates
LRRN3.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_LRRN3.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
LTB.md
... ...
@@ -17,8 +17,13 @@ LTB (Lymphotoxin Beta) is a member of the tumor necrosis factor (TNF) superfamil
17 17
18 18
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
19 19
20
+### DLBCL
20 21
[[include:tables/DLBCL_LTB.md]]
22
+
23
+### FL
21 24
[[include:tables/FL_LTB.md]]
25
+
26
+### BL
22 27
[[include:tables/BL_LTB.md]]
23 28
24 29
## Mutation pattern and selective pressure estimates
MAP2K1.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in FL have been experimentally demonstrated
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_MAP2K1.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_MAP2K1.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
MEF2B.md
... ...
@@ -21,7 +21,10 @@ Thus far, there is limited information about the consequence of MEF2B mutations
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_MEF2B.md]]
26
+
27
+### FL
25 28
[[include:tables/FL_MEF2B.md]]
26 29
27 30
## Mutation pattern and selective pressure estimates
MEF2C.md
... ...
@@ -19,7 +19,10 @@ Mutations in this gene were first described in DLBCL by [Arthur et al](papers/ar
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_MEF2C.md]]
24
+
25
+### DLBCL
23 26
[[include:tables/DLBCL_MEF2C.md]]
24 27
25 28
MGA.md
... ...
@@ -21,6 +21,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_MGA.md]]
25 26
26 27
## Mutation pattern and selective pressure estimates
MPEG1.md
... ...
@@ -17,6 +17,7 @@ Mutations in MPEG1 have been described in DLBCL[@morinMutationalStructuralAnalys
17 17
18 18
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
19 19
20
+### DLBCL
20 21
[[include:tables/DLBCL_MPEG1.md]]
21 22
22 23
## Mutation pattern and selective pressure estimates
MS4A1.md
... ...
@@ -24,6 +24,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
24 24
25 25
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
26 26
27
+### DLBCL
27 28
[[include:tables/DLBCL_MS4A1.md]]
28 29
29 30
## Mutation pattern and selective pressure estimates
MTOR.md
... ...
@@ -28,7 +28,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
28 28
29 29
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
30 30
31
+### DLBCL
31 32
[[include:tables/DLBCL_MTOR.md]]
33
+
34
+### BL
32 35
[[include:tables/BL_MTOR.md]]
33 36
34 37
## Mutation pattern and selective pressure estimates
MYC.md
... ...
@@ -21,8 +21,13 @@ Driver mutations affecting this gene in DLBCL/FL/BL have been experimentally dem
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_MYC.md]]
26
+
27
+### FL
25 28
[[include:tables/FL_MYC.md]]
29
+
30
+### BL
26 31
[[include:tables/BL_MYC.md]]
27 32
28 33
## Mutation pattern and selective pressure estimates
MYD88.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_MYD88.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_MYD88.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
NFKBIA.md
... ...
@@ -21,7 +21,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_NFKBIA.md]]
26
+
27
+### FL
25 28
[[include:tables/FL_NFKBIA.md]]
26 29
27 30
## Mutation pattern and selective pressure estimates
NFKBIE.md
... ...
@@ -23,6 +23,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_NFKBIE.md]]
27 28
28 29
## Mutation pattern and selective pressure estimates
NFKBIZ.md
... ...
@@ -21,6 +21,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_NFKBIZ.md]]
25 26
26 27
## Mutation pattern and selective pressure estimates
NOL9.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_NOL9.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
NOTCH1.md
... ...
@@ -27,7 +27,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
27 27
28 28
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
29 29
30
+### DLBCL
30 31
[[include:tables/DLBCL_NOTCH1.md]]
32
+
33
+### BL
31 34
[[include:tables/BL_NOTCH1.md]]
32 35
33 36
## Mutation pattern and selective pressure estimates
NOTCH2.md
... ...
@@ -20,6 +20,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
20 20
21 21
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
22 22
23
+### DLBCL
23 24
[[include:tables/DLBCL_NOTCH2.md]]
24 25
25 26
## Mutation pattern and selective pressure estimates
OSBPL10.md
... ...
@@ -17,6 +17,7 @@ OSBPL10 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ash
17 17
18 18
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
19 19
20
+### DLBCL
20 21
[[include:tables/DLBCL_OSBPL10.md]]
21 22
22 23
## Mutation pattern and selective pressure estimates
P2RY8.md
... ...
@@ -23,7 +23,10 @@ Driver mutations affecting this gene in BL/DLBCL have been experimentally demons
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_P2RY8.md]]
28
+
29
+### BL
27 30
[[include:tables/BL_P2RY8.md]]
28 31
29 32
## Mutation pattern and selective pressure estimates
PCBP1.md
... ...
@@ -15,7 +15,10 @@ nocite: |
15 15
16 16
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
17 17
18
+### DLBCL
18 19
[[include:tables/DLBCL_PCBP1.md]]
20
+
21
+### BL
19 22
[[include:tables/BL_PCBP1.md]]
20 23
21 24
## Mutation pattern and selective pressure estimates
PHF6.md
... ...
@@ -15,7 +15,10 @@ nocite: |
15 15
16 16
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
17 17
18
+### DLBCL
18 19
[[include:tables/DLBCL_PHF6.md]]
20
+
21
+### BL
19 22
[[include:tables/BL_PHF6.md]]
20 23
21 24
## Mutation pattern and selective pressure estimates
PIM1.md
... ...
@@ -25,8 +25,13 @@ Driver mutations affecting this gene in FL/DLBCL have been experimentally demons
25 25
26 26
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
27 27
28
+### DLBCL
28 29
[[include:tables/DLBCL_PIM1.md]]
30
+
31
+### FL
29 32
[[include:tables/FL_PIM1.md]]
33
+
34
+### BL
30 35
[[include:tables/BL_PIM1.md]]
31 36
32 37
## Mutation pattern and selective pressure estimates
PIM2.md
... ...
@@ -18,6 +18,7 @@ PIM2 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_PIM2.md]]
22 23
23 24
## Mutation pattern and selective pressure estimates
POU2AF1.md
... ...
@@ -22,7 +22,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
22 22
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25
+### DLBCL
25 26
[[include:tables/DLBCL_POU2AF1.md]]
27
+
28
+### FL
26 29
[[include:tables/FL_POU2AF1.md]]
27 30
28 31
## Mutation pattern and selective pressure estimates
POU2F2.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in FL/DLBCL have been experimentally demons
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_POU2F2.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_POU2F2.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
PRDM1.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_PRDM1.md]]
23
+
24
+### BL
22 25
[[include:tables/BL_PRDM1.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
PTEN.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in BL/DLBCL have been experimentally demons
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_PTEN.md]]
23
+
24
+### BL
22 25
[[include:tables/BL_PTEN.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
PTPN6.md
... ...
@@ -18,6 +18,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_PTPN6.md]]
22 23
23 24
## Mutation pattern and selective pressure estimates
RB1.md
... ...
@@ -19,6 +19,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_RB1.md]]
23 24
24 25
## Mutation pattern and selective pressure estimates
RFX7.md
... ...
@@ -22,7 +22,10 @@ Driver mutations affecting this gene in DLBCL/BL have been experimentally demons
22 22
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25
+### DLBCL
25 26
[[include:tables/DLBCL_RFX7.md]]
27
+
28
+### BL
26 29
[[include:tables/BL_RFX7.md]]
27 30
28 31
## Mutation pattern and selective pressure estimates
RHOA.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in DLBCL/BL have been experimentally demons
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_RHOA.md]]
23
+
24
+### BL
22 25
[[include:tables/BL_RHOA.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
RRAGC.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in DLBCL/FL have been experimentally demons
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_RRAGC.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_RRAGC.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
S1PR2.md
... ...
@@ -21,8 +21,13 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
21 21
22 22
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
23 23
24
+### DLBCL
24 25
[[include:tables/DLBCL_S1PR2.md]]
26
+
27
+### FL
25 28
[[include:tables/FL_S1PR2.md]]
29
+
30
+### BL
26 31
[[include:tables/BL_S1PR2.md]]
27 32
28 33
## Mutation pattern and selective pressure estimates
SETD1B.md
... ...
@@ -10,7 +10,7 @@ nocite: |
10 10
11 11
## Experimental Evidence
12 12
13
-Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).[@]
13
+Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).
14 14
15 15
## Relevance tier by entity
16 16
... ...
@@ -18,6 +18,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_SETD1B.md]]
22 23
23 24
## Mutation pattern and selective pressure estimates
SF3B1.md
... ...
@@ -23,7 +23,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_SF3B1.md]]
28
+
29
+### BL
27 30
[[include:tables/BL_SF3B1.md]]
28 31
29 32
## Mutation pattern and selective pressure estimates
SGK1.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in FL/DLBCL have been experimentally demons
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_SGK1.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_SGK1.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
SIN3A.md
... ...
@@ -15,7 +15,10 @@ nocite: |
15 15
16 16
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
17 17
18
+### DLBCL
18 19
[[include:tables/DLBCL_SIN3A.md]]
20
+
21
+### BL
19 22
[[include:tables/BL_SIN3A.md]]
20 23
21 24
## Mutation pattern and selective pressure estimates
SMARCA4.md
... ...
@@ -24,8 +24,13 @@ Driver mutations affecting this gene in DLBCL/FL/BL have been experimentally dem
24 24
25 25
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
26 26
27
+### DLBCL
27 28
[[include:tables/DLBCL_SMARCA4.md]]
29
+
30
+### FL
28 31
[[include:tables/FL_SMARCA4.md]]
32
+
33
+### BL
29 34
[[include:tables/BL_SMARCA4.md]]
30 35
31 36
## Mutation pattern and selective pressure estimates
SOCS1.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in FL/DLBCL have been experimentally demons
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_SOCS1.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_SOCS1.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
SPEN.md
... ...
@@ -15,6 +15,7 @@ nocite: |
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17 17
18
+### DLBCL
18 19
[[include:tables/DLBCL_SPEN.md]]
19 20
20 21
## Mutation pattern and selective pressure estimates
STAT3.md
... ...
@@ -20,6 +20,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
20 20
21 21
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
22 22
23
+### DLBCL
23 24
[[include:tables/DLBCL_STAT3.md]]
24 25
25 26
## Mutation pattern and selective pressure estimates
STAT6.md
... ...
@@ -23,7 +23,10 @@ Driver mutations affecting this gene in DLBCL/FL have been experimentally demons
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### DLBCL
26 27
[[include:tables/DLBCL_STAT6.md]]
28
+
29
+### FL
27 30
[[include:tables/FL_STAT6.md]]
28 31
29 32
## Mutation pattern and selective pressure estimates
TAF1.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_TAF1.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
TBL1XR1.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in FL/DLBCL have been experimentally demons
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_TBL1XR1.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_TBL1XR1.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
TCF3.md
... ...
@@ -19,7 +19,10 @@ Driver mutations affecting this gene in BL have been experimentally demonstrated
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_TCF3.md]]
24
+
25
+### BL
23 26
[[include:tables/BL_TCF3.md]]
24 27
25 28
## Mutation pattern and selective pressure estimates
TCL1A.md
... ...
@@ -15,7 +15,10 @@ nocite: |
15 15
16 16
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
17 17
18
+### DLBCL
18 19
[[include:tables/DLBCL_TCL1A.md]]
20
+
21
+### BL
19 22
[[include:tables/BL_TCL1A.md]]
20 23
21 24
## Mutation pattern and selective pressure estimates
TET2.md
... ...
@@ -19,6 +19,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_TET2.md]]
23 24
24 25
## Mutation pattern and selective pressure estimates
TFAP4.md
... ...
@@ -22,7 +22,10 @@ Driver mutations affecting this gene in BL have been experimentally demonstrated
22 22
23 23
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
24 24
25
+### DLBCL
25 26
[[include:tables/DLBCL_TFAP4.md]]
27
+
28
+### BL
26 29
[[include:tables/BL_TFAP4.md]]
27 30
28 31
## Mutation pattern and selective pressure estimates
TMEM30A.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_TMEM30A.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_TMEM30A.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
TMSB4X.md
... ...
@@ -18,7 +18,10 @@ TMSB4X is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_TMSB4X.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_TMSB4X.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
TNFAIP3.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in FL/DLBCL have been experimentally demons
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_TNFAIP3.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_TNFAIP3.md]]
23 26
24 27
## Mutation pattern and selective pressure estimates
TNFRSF14.md
... ...
@@ -12,7 +12,7 @@ nocite: |
12 12
13 13
## Experimental Evidence
14 14
15
-Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).[@]
15
+Driver mutations affecting this gene in DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).
16 16
17 17
## Relevance tier by entity
18 18
... ...
@@ -20,7 +20,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
20 20
21 21
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
22 22
23
+### DLBCL
23 24
[[include:tables/DLBCL_TNFRSF14.md]]
25
+
26
+### FL
24 27
[[include:tables/FL_TNFRSF14.md]]
25 28
26 29
## Mutation pattern and selective pressure estimates
TOX.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_TOX.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
TP53.md
... ...
@@ -19,8 +19,13 @@ Driver mutations affecting this gene in BL/FL/DLBCL have been experimentally dem
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_TP53.md]]
24
+
25
+### FL
23 26
[[include:tables/FL_TP53.md]]
27
+
28
+### BL
24 29
[[include:tables/BL_TP53.md]]
25 30
26 31
## Mutation pattern and selective pressure estimates
UBE2A.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_UBE2A.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
USP7.md
... ...
@@ -14,7 +14,10 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_USP7.md]]
19
+
20
+### BL
18 21
[[include:tables/BL_USP7.md]]
19 22
20 23
## Mutation pattern and selective pressure estimates
WEE1.md
... ...
@@ -17,6 +17,7 @@ WEE1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm)
17 17
18 18
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
19 19
20
+### DLBCL
20 21
[[include:tables/DLBCL_WEE1.md]]
21 22
22 23
## Mutation pattern and selective pressure estimates
WNK1.md
... ...
@@ -14,7 +14,10 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_WNK1.md]]
19
+
20
+### BL
18 21
[[include:tables/BL_WNK1.md]]
19 22
20 23
## Mutation pattern and selective pressure estimates
XPO1.md
... ...
@@ -19,6 +19,7 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
19 19
20 20
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
21 21
22
+### DLBCL
22 23
[[include:tables/DLBCL_XPO1.md]]
23 24
24 25
## Mutation pattern and selective pressure estimates
ZC3H12A.md
... ...
@@ -18,7 +18,10 @@ Driver mutations affecting this gene in DLBCL have been experimentally demonstra
18 18
19 19
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
20 20
21
+### DLBCL
21 22
[[include:tables/DLBCL_ZC3H12A.md]]
23
+
24
+### FL
22 25
[[include:tables/FL_ZC3H12A.md]]
23 26
24 27
ZCCHC7.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_ZCCHC7.md]]
18 19
19 20
ZFP36L1.md
... ...
@@ -17,7 +17,10 @@ ZFP36L1 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ash
17 17
18 18
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
19 19
20
+### DLBCL
20 21
[[include:tables/DLBCL_ZFP36L1.md]]
22
+
23
+### BL
21 24
[[include:tables/BL_ZFP36L1.md]]
22 25
23 26
## Mutation pattern and selective pressure estimates
ZNF217.md
... ...
@@ -14,8 +14,13 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_ZNF217.md]]
19
+
20
+### FL
18 21
[[include:tables/FL_ZNF217.md]]
22
+
23
+### BL
19 24
[[include:tables/BL_ZNF217.md]]
20 25
21 26
## Mutation pattern and selective pressure estimates
ZNF229.md
... ...
@@ -23,6 +23,7 @@ Due to [minimal support](ZNF229#representative-mutation) in the original primary
23 23
24 24
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
25 25
26
+### BL
26 27
[[include:tables/BL_ZNF229.md]]
27 28
28 29
## Mutation pattern and selective pressure estimates
ZNF292.md
... ...
@@ -14,6 +14,7 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_ZNF292.md]]
18 19
19 20
## Mutation pattern and selective pressure estimates
ZNF608.md
... ...
@@ -14,7 +14,10 @@ nocite: |
14 14
15 15
## Mutation incidence in large patient cohorts (GAMBL reanalysis)
16 16
17
+### DLBCL
17 18
[[include:tables/DLBCL_ZNF608.md]]
19
+
20
+### FL
18 21
[[include:tables/FL_ZNF608.md]]
19 22
20 23
## Mutation pattern and selective pressure estimates