bca231cb1f31b4f356bb33da4cd6934eea246dca
JUNB.md
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| 1 | 1 | # JUNB |
| 2 | +## Overview |
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| 3 | +JUNB has been reported to be frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) and, to a lesser extent, DLBCL. According to one study, mutations are often enriched at somatic hypermutation hotspot sites, indicating the involvement of aberrant somatic hypermutation in the pathogenesis of these lymphomas.<sup>1</sup> |
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| 2 | 4 | |
| 3 | 5 | ## Relevance tier by entity |
| 4 | 6 | |
| ... | ... | @@ -38,3 +40,6 @@ View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAM |
| 38 | 40 | View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/JUNB.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/JUNB_hg38.html) |
| 39 | 41 | |
| 40 | 42 |  |
| 43 | + |
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| 44 | +## References |
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| 45 | +1. *Schuhmacher, B., Bein, J., Rausch, T., Beneš, V., Tousseyn, T., Vornanen, M., Ponzoni, M., Thurner, L., Gascoyne, R., Steidl, C., Küppers, R., Hansmann, M., & Hartmann, S. (2018). JUNB, DUSP2, SGK1, SOCS1 and CREBBP are frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma. Haematologica, 104, 330 - 337. https://doi.org/10.3324/haematol.2018.203224.* |