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				FOXO1.md
			
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           ## Overview

          -Mutations in the FOXO1 gene, which encodes a member of the forkhead family of transcription factors, play a significant role in diffuse large B-cell lymphoma (DLBCL). Mutations primarily occur in the first exon, with significant portions affecting the N-terminal region and the Forkhead DNA binding domain.[@trinhAnalysisFOXO1Mutations]  These mutations are common in DLBCL, BL and, to a lesser extent, FL.[@schmitzBurkittLymphomaPathogenesis2012; @morinFrequentMutationHistonemodifying2011] FOXO1 mutations can contribute to resistance to certain therapies, such as anti-CD20-based immunotherapies, by repressing MS4A1 (CD20) expression.<sup>4</sup> 

          +Mutations in the FOXO1 gene, which encodes a member of the forkhead family of transcription factors, play a significant role in diffuse large B-cell lymphoma (DLBCL). Mutations primarily occur in the first exon, with significant portions affecting the N-terminal region and the Forkhead DNA binding domain.[@trinhAnalysisFOXO1Mutations]  These mutations are common in DLBCL, BL and, to a lesser extent, FL.[@schmitzBurkittLymphomaPathogenesis2012; @morinFrequentMutationHistonemodifying2011] FOXO1 mutations can contribute to resistance to certain therapies, such as anti-CD20-based immunotherapies, by repressing MS4A1 (CD20) expression.[@pyrzynskaFOXO1PromotesResistance2018] 

           ## Relevance tier by entity

...	...	@@ -6,7 +6,7 @@ link-citations: true
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8	8	## Overview
9		-Mutations in the FOXO1 gene, which encodes a member of the forkhead family of transcription factors, play a significant role in diffuse large B-cell lymphoma (DLBCL). Mutations primarily occur in the first exon, with significant portions affecting the N-terminal region and the Forkhead DNA binding domain.[@trinhAnalysisFOXO1Mutations] These mutations are common in DLBCL, BL and, to a lesser extent, FL.[@schmitzBurkittLymphomaPathogenesis2012; @morinFrequentMutationHistonemodifying2011] FOXO1 mutations can contribute to resistance to certain therapies, such as anti-CD20-based immunotherapies, by repressing MS4A1 (CD20) expression.<sup>4</sup>
	9	+Mutations in the FOXO1 gene, which encodes a member of the forkhead family of transcription factors, play a significant role in diffuse large B-cell lymphoma (DLBCL). Mutations primarily occur in the first exon, with significant portions affecting the N-terminal region and the Forkhead DNA binding domain.[@trinhAnalysisFOXO1Mutations] These mutations are common in DLBCL, BL and, to a lesser extent, FL.[@schmitzBurkittLymphomaPathogenesis2012; @morinFrequentMutationHistonemodifying2011] FOXO1 mutations can contribute to resistance to certain therapies, such as anti-CD20-based immunotherapies, by repressing MS4A1 (CD20) expression.[@pyrzynskaFOXO1PromotesResistance2018]
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12	12	## Relevance tier by entity