CARD4.md
... ...
@@ -23,12 +23,6 @@ timeline
23 23
|BL |Thomas cohort |NA |
24 24
|BL |Panea cohort |NA |
25 25
26
-## Mutation pattern and selective pressure estimates
27
-
28
-|
29
-
30
-
31
-
32 26
33 27
View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/CARD4_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/CARD4_protein_hg38.html)
34 28
... ...
@@ -41,5 +35,12 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
41 35
<!-- ORIGIN: loveGeneticLandscapeMutations2012 -->
42 36
<!-- BL: loveGeneticLandscapeMutations2012 -->
43 37
38
+## Representative Mutations
39
+
40
+![](primary/Love_CARD4.svg)
41
+**Rating**
42
+&starf; &starf; &starf; &starf; &star;
43
+
44
+
44 45
## References
45 46
1. Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID: PMC3674561
papers/loveGeneticLandscapeMutations2012.md
... ...
@@ -51,7 +51,7 @@ All other BL studies, BL Tier 2, 101
51 51
|[BTG2](../BTG2)|2 |&starf; &star; &star; &star; &star;|
52 52
|[C6orf27](../C6orf27)|2 |&starf; &star; &star; &star; &star;|
53 53
|[CAD](../CAD)|2 |&starf; &star; &star; &star; &star;|
54
-|[CARD4](../CARD4)|2 ||
54
+|[CARD4](../CARD4)|2 |&starf; &starf; &starf; &starf; &star;|
55 55
|[CCT6B](../CCT6B)|2 ||
56 56
|[CDC73](../CDC73)|2 |&starf; &starf; &starf; &star; &star;|
57 57
|[CDH17](../CDH17)|2 ||
papers/loveGeneticLandscapeMutations2012_tmp.html
... ...
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+ </script>
368
+<h1 id="lovegeneticlandscapemutations2012">@loveGeneticLandscapeMutations2012</h1>
369
+<h2 id="summary-of-novel-genes">Summary of novel genes</h2>
370
+<table>
371
+<thead>
372
+<tr>
373
+<th style="text-align:center">Entity</th>
374
+<th style="text-align:center">Tier 1 genes</th>
375
+<th style="text-align:center">Tier 2 genes</th>
376
+</tr>
377
+</thead>
378
+<tbody>
379
+<tr>
380
+<td style="text-align:center">BL</td>
381
+<td style="text-align:center">3</td>
382
+<td style="text-align:center">56</td>
383
+</tr>
384
+</tbody>
385
+</table>
386
+<pre><code class="language-mermaid"><div class="mermaid">---
387
+config:
388
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389
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390
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391
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392
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393
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394
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395
+ suffix: ' genes)'
396
+---
397
+sankey-beta
398
+This study, New Tier 1, 3
399
+New Tier 1, BL Tier 1, 3
400
+This study, New Tier 2, 56
401
+New Tier 2, BL Tier 2, 56
402
+All other BL studies, BL Tier 1, 26
403
+All other BL studies, BL Tier 2, 101
404
+</div></code></pre>
405
+<h2 id="novel-genes-reported-in-this-study">Novel genes reported in this study</h2>
406
+<h3 id="tier-1">Tier 1</h3>
407
+<table>
408
+<thead>
409
+<tr>
410
+<th style="text-align:left">New gene</th>
411
+<th style="text-align:center">BL tier</th>
412
+</tr>
413
+</thead>
414
+<tbody>
415
+<tr>
416
+<td style="text-align:left"><a href="../ARID1A">ARID1A</a></td>
417
+<td style="text-align:center">1</td>
418
+</tr>
419
+<tr>
420
+<td style="text-align:left"><a href="../GNA13">GNA13</a></td>
421
+<td style="text-align:center">1</td>
422
+</tr>
423
+<tr>
424
+<td style="text-align:left"><a href="../PTEN">PTEN</a></td>
425
+<td style="text-align:center">1</td>
426
+</tr>
427
+</tbody>
428
+</table>
429
+<h3 id="tier-2">Tier 2</h3>
430
+<table>
431
+<thead>
432
+<tr>
433
+<th style="text-align:left">New gene</th>
434
+<th style="text-align:center">BL tier</th>
435
+<th style="text-align:center">Rating of reviewed variants</th>
436
+</tr>
437
+</thead>
438
+<tbody>
439
+<tr>
440
+<td style="text-align:left"><a href="../ACAD9">ACAD9</a></td>
441
+<td style="text-align:center">2</td>
442
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
443
+</tr>
444
+<tr>
445
+<td style="text-align:left"><a href="../ACE">ACE</a></td>
446
+<td style="text-align:center">2</td>
447
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
448
+</tr>
449
+<tr>
450
+<td style="text-align:left"><a href="../ATP2C2">ATP2C2</a></td>
451
+<td style="text-align:center">2</td>
452
+<td style="text-align:center">★ ★ ☆ ☆ ☆</td>
453
+</tr>
454
+<tr>
455
+<td style="text-align:left"><a href="../BCL6">BCL6</a></td>
456
+<td style="text-align:center">2</td>
457
+<td style="text-align:center">★ ★ ★ ★ ☆</td>
458
+</tr>
459
+<tr>
460
+<td style="text-align:left"><a href="../BRAF">BRAF</a></td>
461
+<td style="text-align:center">2</td>
462
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
463
+</tr>
464
+<tr>
465
+<td style="text-align:left"><a href="../BRD4">BRD4</a></td>
466
+<td style="text-align:center">2</td>
467
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
468
+</tr>
469
+<tr>
470
+<td style="text-align:left"><a href="../BTG2">BTG2</a></td>
471
+<td style="text-align:center">2</td>
472
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
473
+</tr>
474
+<tr>
475
+<td style="text-align:left"><a href="../C6orf27">C6orf27</a></td>
476
+<td style="text-align:center">2</td>
477
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
478
+</tr>
479
+<tr>
480
+<td style="text-align:left"><a href="../CAD">CAD</a></td>
481
+<td style="text-align:center">2</td>
482
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
483
+</tr>
484
+<tr>
485
+<td style="text-align:left"><a href="../CARD4">CARD4</a></td>
486
+<td style="text-align:center">2</td>
487
+<td style="text-align:center">★ ★ ★ ★ ☆</td>
488
+</tr>
489
+<tr>
490
+<td style="text-align:left"><a href="../CCT6B">CCT6B</a></td>
491
+<td style="text-align:center">2</td>
492
+<td style="text-align:center"></td>
493
+</tr>
494
+<tr>
495
+<td style="text-align:left"><a href="../CDC73">CDC73</a></td>
496
+<td style="text-align:center">2</td>
497
+<td style="text-align:center">★ ★ ★ ☆ ☆</td>
498
+</tr>
499
+<tr>
500
+<td style="text-align:left"><a href="../CDH17">CDH17</a></td>
501
+<td style="text-align:center">2</td>
502
+<td style="text-align:center"></td>
503
+</tr>
504
+<tr>
505
+<td style="text-align:left"><a href="../COL4A2">COL4A2</a></td>
506
+<td style="text-align:center">2</td>
507
+<td style="text-align:center"></td>
508
+</tr>
509
+<tr>
510
+<td style="text-align:left"><a href="../CREBBP">CREBBP</a></td>
511
+<td style="text-align:center">2</td>
512
+<td style="text-align:center"></td>
513
+</tr>
514
+<tr>
515
+<td style="text-align:left"><a href="../CYB5D1">CYB5D1</a></td>
516
+<td style="text-align:center">2</td>
517
+<td style="text-align:center"></td>
518
+</tr>
519
+<tr>
520
+<td style="text-align:left"><a href="../CYP4F22">CYP4F22</a></td>
521
+<td style="text-align:center">2</td>
522
+<td style="text-align:center"></td>
523
+</tr>
524
+<tr>
525
+<td style="text-align:left"><a href="../DLGAP1">DLGAP1</a></td>
526
+<td style="text-align:center">2</td>
527
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
528
+</tr>
529
+<tr>
530
+<td style="text-align:left"><a href="../DTX1">DTX1</a></td>
531
+<td style="text-align:center">2</td>
532
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
533
+</tr>
534
+<tr>
535
+<td style="text-align:left"><a href="../EIF2C4">EIF2C4</a></td>
536
+<td style="text-align:center">2</td>
537
+<td style="text-align:center"></td>
538
+</tr>
539
+<tr>
540
+<td style="text-align:left"><a href="../EML2">EML2</a></td>
541
+<td style="text-align:center">2</td>
542
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
543
+</tr>
544
+<tr>
545
+<td style="text-align:left"><a href="../ENTPD3">ENTPD3</a></td>
546
+<td style="text-align:center">2</td>
547
+<td style="text-align:center"></td>
548
+</tr>
549
+<tr>
550
+<td style="text-align:left"><a href="../EPHB2">EPHB2</a></td>
551
+<td style="text-align:center">2</td>
552
+<td style="text-align:center"></td>
553
+</tr>
554
+<tr>
555
+<td style="text-align:left"><a href="../EZH2">EZH2</a></td>
556
+<td style="text-align:center">2</td>
557
+<td style="text-align:center"></td>
558
+</tr>
559
+<tr>
560
+<td style="text-align:left"><a href="../FAM129B">FAM129B</a></td>
561
+<td style="text-align:center">2</td>
562
+<td style="text-align:center"></td>
563
+</tr>
564
+<tr>
565
+<td style="text-align:left"><a href="../FGFR3">FGFR3</a></td>
566
+<td style="text-align:center">2</td>
567
+<td style="text-align:center"></td>
568
+</tr>
569
+<tr>
570
+<td style="text-align:left"><a href="../FTCD">FTCD</a></td>
571
+<td style="text-align:center">2</td>
572
+<td style="text-align:center"></td>
573
+</tr>
574
+<tr>
575
+<td style="text-align:left"><a href="../GGTLA4">GGTLA4</a></td>
576
+<td style="text-align:center">2</td>
577
+<td style="text-align:center"></td>
578
+</tr>
579
+<tr>
580
+<td style="text-align:left"><a href="../GRIK5">GRIK5</a></td>
581
+<td style="text-align:center">2</td>
582
+<td style="text-align:center"></td>
583
+</tr>
584
+<tr>
585
+<td style="text-align:left"><a href="../ICK">ICK</a></td>
586
+<td style="text-align:center">2</td>
587
+<td style="text-align:center"></td>
588
+</tr>
589
+<tr>
590
+<td style="text-align:left"><a href="../ITPR3">ITPR3</a></td>
591
+<td style="text-align:center">2</td>
592
+<td style="text-align:center"></td>
593
+</tr>
594
+<tr>
595
+<td style="text-align:left"><a href="../KIFC3">KIFC3</a></td>
596
+<td style="text-align:center">2</td>
597
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
598
+</tr>
599
+<tr>
600
+<td style="text-align:left"><a href="../MAP3K6">MAP3K6</a></td>
601
+<td style="text-align:center">2</td>
602
+<td style="text-align:center"></td>
603
+</tr>
604
+<tr>
605
+<td style="text-align:left"><a href="../MYH10">MYH10</a></td>
606
+<td style="text-align:center">2</td>
607
+<td style="text-align:center"></td>
608
+</tr>
609
+<tr>
610
+<td style="text-align:left"><a href="../NBEAL1">NBEAL1</a></td>
611
+<td style="text-align:center">2</td>
612
+<td style="text-align:center"></td>
613
+</tr>
614
+<tr>
615
+<td style="text-align:left"><a href="../NOTCH1">NOTCH1</a></td>
616
+<td style="text-align:center">2</td>
617
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
618
+</tr>
619
+<tr>
620
+<td style="text-align:left"><a href="../NRXN2">NRXN2</a></td>
621
+<td style="text-align:center">2</td>
622
+<td style="text-align:center"></td>
623
+</tr>
624
+<tr>
625
+<td style="text-align:left"><a href="../P2RY2">P2RY2</a></td>
626
+<td style="text-align:center">2</td>
627
+<td style="text-align:center"></td>
628
+</tr>
629
+<tr>
630
+<td style="text-align:left"><a href="../PC">PC</a></td>
631
+<td style="text-align:center">2</td>
632
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
633
+</tr>
634
+<tr>
635
+<td style="text-align:left"><a href="../POLRMT">POLRMT</a></td>
636
+<td style="text-align:center">2</td>
637
+<td style="text-align:center"></td>
638
+</tr>
639
+<tr>
640
+<td style="text-align:left"><a href="../POR">POR</a></td>
641
+<td style="text-align:center">2</td>
642
+<td style="text-align:center"></td>
643
+</tr>
644
+<tr>
645
+<td style="text-align:left"><a href="../PRSS22">PRSS22</a></td>
646
+<td style="text-align:center">2</td>
647
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
648
+</tr>
649
+<tr>
650
+<td style="text-align:left"><a href="../PTPRN">PTPRN</a></td>
651
+<td style="text-align:center">2</td>
652
+<td style="text-align:center"></td>
653
+</tr>
654
+<tr>
655
+<td style="text-align:left"><a href="../RANBP6">RANBP6</a></td>
656
+<td style="text-align:center">2</td>
657
+<td style="text-align:center"></td>
658
+</tr>
659
+<tr>
660
+<td style="text-align:left"><a href="../RBP3">RBP3</a></td>
661
+<td style="text-align:center">2</td>
662
+<td style="text-align:center"></td>
663
+</tr>
664
+<tr>
665
+<td style="text-align:left"><a href="../RET">RET</a></td>
666
+<td style="text-align:center">2</td>
667
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
668
+</tr>
669
+<tr>
670
+<td style="text-align:left"><a href="../SALL3">SALL3</a></td>
671
+<td style="text-align:center">2</td>
672
+<td style="text-align:center"></td>
673
+</tr>
674
+<tr>
675
+<td style="text-align:left"><a href="../SAPS2">SAPS2</a></td>
676
+<td style="text-align:center">2</td>
677
+<td style="text-align:center"></td>
678
+</tr>
679
+<tr>
680
+<td style="text-align:left"><a href="../SBF1">SBF1</a></td>
681
+<td style="text-align:center">2</td>
682
+<td style="text-align:center"></td>
683
+</tr>
684
+<tr>
685
+<td style="text-align:left"><a href="../SF3B1">SF3B1</a></td>
686
+<td style="text-align:center">2</td>
687
+<td style="text-align:center"></td>
688
+</tr>
689
+<tr>
690
+<td style="text-align:left"><a href="../SHANK1">SHANK1</a></td>
691
+<td style="text-align:center">2</td>
692
+<td style="text-align:center"></td>
693
+</tr>
694
+<tr>
695
+<td style="text-align:left"><a href="../SLC29A2">SLC29A2</a></td>
696
+<td style="text-align:center">2</td>
697
+<td style="text-align:center"></td>
698
+</tr>
699
+<tr>
700
+<td style="text-align:left"><a href="../SYNGAP1">SYNGAP1</a></td>
701
+<td style="text-align:center">2</td>
702
+<td style="text-align:center">★ ☆ ☆ ☆ ☆</td>
703
+</tr>
704
+<tr>
705
+<td style="text-align:left"><a href="../TBC1D9B">TBC1D9B</a></td>
706
+<td style="text-align:center">2</td>
707
+<td style="text-align:center"></td>
708
+</tr>
709
+<tr>
710
+<td style="text-align:left"><a href="../TIGD6">TIGD6</a></td>
711
+<td style="text-align:center">2</td>
712
+<td style="text-align:center"></td>
713
+</tr>
714
+<tr>
715
+<td style="text-align:left"><a href="../TPST2">TPST2</a></td>
716
+<td style="text-align:center">2</td>
717
+<td style="text-align:center"></td>
718
+</tr>
719
+<tr>
720
+<td style="text-align:left"><a href="../ZNF229">ZNF229</a></td>
721
+<td style="text-align:center">2</td>
722
+<td style="text-align:center"><em>Germline</em></td>
723
+</tr>
724
+</tbody>
725
+</table>
726
+<h1 id="details">Details</h1>
727
+
728
+</body>
729
+</html>
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