CREBBP.md
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@@ -15,17 +15,7 @@ CREBBP missense mutations often affect the histone acetyltransferase (HAT) domai
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In a transgenic mouse model, CREBBP loss cooperated with BCL2 overexpression to promote B-cell lymphomagenesis.[@garcia-ramirezCrebbpLossCooperates2017]
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Mutations in CREBBP and EP300 affect a common pathway and have been described as mutually exclusive due to some functional redundancy.[@pasqualucciInactivatingMutationsAcetyltransferase2011; @veazeyCARM1InhibitionReduces2020] Studies using genome-wide CRISPR-Cas9 screens have identified synthetic lethal interactions between CREBBP and EP300, suggesting that targeting one may affect the viability of cells with mutations in the other.[@nieGenomewideCRISPRScreens2021]
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-## History
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-
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-```mermaid
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-%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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-timeline
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- title Publication timing
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- 2011-03-10 : Pasqualucci : DLBCL
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- 2012-12-01 : Love : BL
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- 2013-12-13 : Parry : MZL
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- 2021-07-15 : Duns : PMBL
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-```
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+
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## Relevance tier by entity
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@@ -113,6 +103,8 @@ View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/C
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[745](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/745_reports.html)
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[851](https://www.bcgsc.ca/downloads/morinlab/GAMBL/Love/851_reports.html)
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+[[include:mermaid_CREBBP.md]]
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+
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# References
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<!-- PMBL: dunsCharacterizationDLBCLPMBL2021b -->
mermaid_CREBBP.md
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@@ -0,0 +1,10 @@
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+## History
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+```mermaid
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+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
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+timeline
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+ title Publication timing
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+ 2011-03-10 : Pasqualucci : DLBCL
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+ 2012-12-01 : Love : BL
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+ 2013-12-13 : Parry : MZL
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+ 2021-07-15 : Duns : PMBL
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+```