BL_genes_with_bib.md
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+# BL genes
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+
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+## Origins of BL genes![sankey](BL_sankey-1.svg)
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+
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+## Tier 1 BL genes
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+
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+| Gene | Tier | Relevant references |
8
+|:------------------:|:----:|:-------------------------------------------------------------:|
9
+| [ARID1A](ARID1A) | 1 | (Love et al. 2012; Krysiak et al. 2017; Zhang et al. 2013) |
10
+| [BMP7](BMP7) | 1 | (Panea et al. 2019) |
11
+| [CCND3](CCND3) | 1 | (Richter et al. 2012; Morin et al. 2011, 2011) |
12
+| [CHD8](CHD8) | 1 | (Grande et al. 2019; Reddy et al. 2017) |
13
+| [DDX3X](DDX3X) | 1 | (Schmitz et al. 2012, 2018) |
14
+| [EIF4A1](EIF4A1) | 1 | (Panea et al. 2019) |
15
+| [EPPK1](EPPK1) | 1 | (Panea et al. 2019) |
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+| [FBXO11](FBXO11) | 1 | (Richter et al. 2012; Hübschmann et al. 2021) |
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+| [FOXO1](FOXO1) | 1 | (Schmitz et al. 2012; Morin et al. 2011, 2011) |
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+| [GNA13](GNA13) | 1 | (Love et al. 2012; Morin et al. 2011, 2011) |
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+| [GNAI2](GNAI2) | 1 | (Grande et al. 2019; Morin et al. 2013) |
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+| [HNRNPU](HNRNPU) | 1 | (Panea et al. 2019; Reddy et al. 2017) |
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+| [ID3](ID3) | 1 | (Richter et al. 2012; Schmitz et al. 2012) |
22
+| [KMT2D](KMT2D) | 1 | (Grande et al. 2019; Morin et al. 2011, 2011) |
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+| [MYC](MYC) | 1 | (Johnston and Carroll 1992; L. Pasqualucci et al. 2001) |
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+| [P2RY8](P2RY8) | 1 | (Muppidi et al. 2014; Lohr et al. 2012) |
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+| [PHF6](PHF6) | 1 | (Thomas et al. 2023; Reddy et al. 2017) |
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+| [PTEN](PTEN) | 1 | (Love et al. 2012) |
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+| [RFX7](RFX7) | 1 | (Grande et al. 2019) |
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+| [RHOA](RHOA) | 1 | (Richter et al. 2012; L. Pasqualucci et al. 2001) |
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+| [SIN3A](SIN3A) | 1 | (Grande et al. 2019) |
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+| [SMARCA4](SMARCA4) | 1 | (Richter et al. 2012; Krysiak et al. 2017; Zhang et al. 2013) |
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+| [TCF3](TCF3) | 1 | (Schmitz et al. 2012) |
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+| [TCL1A](TCL1A) | 1 | (Grande et al. 2019) |
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+| [TFAP4](TFAP4) | 1 | (Grande et al. 2019) |
34
+| [TP53](TP53) | 1 | (Wilda et al. 2004; Morin et al. 2011) |
35
+| [USP7](USP7) | 1 | (Grande et al. 2019) |
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+| [WNK1](WNK1) | 1 | (Thomas et al. 2023; Hübschmann et al. 2021) |
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+
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+## Tier 2 BL genes
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+
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+| Gene | Tier | Relevant references |
41
+|:----------------------:|:----:|:---------------------------------------------------------------------------------------------------------:|
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+| [ACAD9](ACAD9) | 2 | (Love et al. 2012) |
43
+| [ACE](ACE) | 2 | (Love et al. 2012) |
44
+| [ADAMTS5](ADAMTS5) | 2 | (Burkhardt et al. 2022) |
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+| [ADNP](ADNP) | 2 | (Burkhardt et al. 2022) |
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+| [AGO4](AGO4) | 2 | (Burkhardt et al. 2022) |
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+| [ALPK2](ALPK2) | 2 | (Panea et al. 2019) |
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+| [ARHGEF1](ARHGEF1) | 2 | (Muppidi et al. 2014) |
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+| [ATP2C2](ATP2C2) | 2 | (Love et al. 2012) |
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+| [BACH2](BACH2) | 2 | (Grande et al. 2019) |
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+| [BCL2](BCL2) | 2 | (Burkhardt et al. 2022; Morin et al. 2011; Tanaka et al. 1992) |
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+| [BCL6](BCL6) | 2 | (Love et al. 2012; Morin et al. 2011) |
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+| [BCL7A](BCL7A) | 2 | (Grande et al. 2019; Krysiak et al. 2017; Arthur et al. 2018) |
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+| [BRAF](BRAF) | 2 | (Love et al. 2012; Tiacci et al. 2011) |
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+| [BRD4](BRD4) | 2 | (Love et al. 2012) |
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+| [BTG1](BTG1) | 2 | (Burkhardt et al. 2022; Morin et al. 2011) |
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+| [BTG2](BTG2) | 2 | (Love et al. 2012; Morin et al. 2011, 2011) |
58
+| [C16orf48](C16orf48) | 2 | (Schmitz et al. 2012) |
59
+| [C6orf27](C6orf27) | 2 | (Love et al. 2012) |
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+| [CAD](CAD) | 2 | (Love et al. 2012) |
61
+| [CARD11](CARD11) | 2 | (Panea et al. 2019; Morin et al. 2011; Lenz et al. 2008) |
62
+| [CARD4](CARD4) | 2 | (Love et al. 2012) |
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+| [CCNF](CCNF) | 2 | (Abate et al. 2015) |
64
+| [CCT6B](CCT6B) | 2 | (Love et al. 2012) |
65
+| [CD79A](CD79A) | 2 | (Burkhardt et al. 2022) |
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+| [CD79B](CD79B) | 2 | (Panea et al. 2019; Morin et al. 2011) |
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+| [CD83](CD83) | 2 | (Panea et al. 2019; Russler-Germain et al. 2023; Morin et al. 2013) |
68
+| [CDC73](CDC73) | 2 | (Love et al. 2012; Reddy et al. 2017) |
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+| [CDH17](CDH17) | 2 | (Love et al. 2012) |
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+| [CDKN2A](CDKN2A) | 2 | (Grande et al. 2019; Morin et al. 2013) |
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+| [CDKN2C](CDKN2C) | 2 | (Thomas et al. 2023) |
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+| [CHD4](CHD4) | 2 | (Burkhardt et al. 2022) |
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+| [COL4A2](COL4A2) | 2 | (Love et al. 2012) |
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+| [CPXM2](CPXM2) | 2 | (Burkhardt et al. 2022) |
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+| [CREBBP](CREBBP) | 2 | (Love et al. 2012; Laura Pasqualucci, Dominguez-Sola, et al. 2011, 2011) |
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+| [CTCF](CTCF) | 2 | (Panea et al. 2019) |
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+| [CXCR4](CXCR4) | 2 | (Panea et al. 2019; Krysiak et al. 2017; Khodabakhshi et al. 2012) |
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+| [CYB5D1](CYB5D1) | 2 | (Love et al. 2012) |
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+| [CYP4F22](CYP4F22) | 2 | (Love et al. 2012) |
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+| [DHCR7](DHCR7) | 2 | (Schmitz et al. 2012) |
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+| [DLGAP1](DLGAP1) | 2 | (Love et al. 2012) |
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+| [DNMT1](DNMT1) | 2 | (Panea et al. 2019) |
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+| [DTX1](DTX1) | 2 | (Panea et al. 2019; Schmitz et al. 2018) |
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+| [E2F2](E2F2) | 2 | (Burkhardt et al. 2022) |
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+| [EBF1](EBF1) | 2 | \[@; Bohle et al. (2013)\] |
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+| [EDNRB](EDNRB) | 2 | (Burkhardt et al. 2022) |
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+| [EHD1](EHD1) | 2 | \[@\] |
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+| [EIF2C4](EIF2C4) | 2 | (Love et al. 2012) |
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+| [ELP2](ELP2) | 2 | (Schmitz et al. 2012) |
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+| [EML2](EML2) | 2 | (Love et al. 2012) |
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+| [ENTPD3](ENTPD3) | 2 | (Love et al. 2012) |
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+| [EP300](EP300) | 2 | \[@; Laura Pasqualucci, Dominguez-Sola, et al. (2011); Laura Pasqualucci, Dominguez-Sola, et al. (2011)\] |
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+| [EPHB2](EPHB2) | 2 | (Love et al. 2012) |
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+| [ERAP1](ERAP1) | 2 | (Burkhardt et al. 2022) |
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+| [ETS1](ETS1) | 2 | (Panea et al. 2019; Morin et al. 2011) |
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+| [EXOSC6](EXOSC6) | 2 | (Schmitz et al. 2012) |
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+| [EZH2](EZH2) | 2 | (Love et al. 2012; Morin et al. 2010, 2010) |
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+| [FAM129B](FAM129B) | 2 | (Love et al. 2012) |
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+| [FGFR3](FGFR3) | 2 | (Love et al. 2012) |
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+| [FLYWCH1](FLYWCH1) | 2 | (Schmitz et al. 2012) |
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+| [FTCD](FTCD) | 2 | (Love et al. 2012) |
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+| [FZD3](FZD3) | 2 | (Panea et al. 2019) |
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+| [GGTLA4](GGTLA4) | 2 | (Love et al. 2012) |
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+| [GRB2](GRB2) | 2 | (Panea et al. 2019; Laura Pasqualucci, Trifonov, et al. 2011) |
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+| [GRIK5](GRIK5) | 2 | (Love et al. 2012) |
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+| [GTSE1](GTSE1) | 2 | (Schmitz et al. 2012) |
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+| [HIST1H1B](HIST1H1B) | 2 | (Krysiak et al. 2017; Chapuy et al. 2018) |
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+| [HIST1H1C](HIST1H1C) | 2 | (Panea et al. 2019; Morin et al. 2011, 2011) |
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+| [HIST1H1D](HIST1H1D) | 2 | (Krysiak et al. 2017; Morin et al. 2013) |
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+| [HIST1H1E](HIST1H1E) | 2 | (Grande et al. 2019; Krysiak et al. 2017; Morin et al. 2013) |
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+| [HIST1H2AG](HIST1H2AG) | 2 | (Panea et al. 2019; Krysiak et al. 2017; Morin et al. 2013) |
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+| [HIST1H2AM](HIST1H2AM) | 2 | (Panea et al. 2019; Krysiak et al. 2017) |
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+| [HIST1H2BK](HIST1H2BK) | 2 | (Panea et al. 2019) |
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+| [HIST1H3D](HIST1H3D) | 2 | (Panea et al. 2019) |
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+| [HIST1H3H](HIST1H3H) | 2 | (Panea et al. 2019) |
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+| [HIST1H3I](HIST1H3I) | 2 | (Panea et al. 2019; Krysiak et al. 2017) |
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+| [HIST1H3J](HIST1H3J) | 2 | (Panea et al. 2019) |
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+| [HIST1H4J](HIST1H4J) | 2 | (Panea et al. 2019) |
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+| [HLA-A](HLA-A) | 2 | \[@\] |
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+| [HLA-B](HLA-B) | 2 | \[@\] |
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+| [HLA-DMB](HLA-DMB) | 2 | \[@\] |
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+| [HLA-DQB1](HLA-DQB1) | 2 | (Burkhardt et al. 2022) |
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+| [ICK](ICK) | 2 | (Love et al. 2012) |
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+| [IGLL5](IGLL5) | 2 | (Panea et al. 2019; Russler-Germain et al. 2023) |
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+| [IKZF3](IKZF3) | 2 | (Panea et al. 2019; Morin et al. 2013) |
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+| [IRF8](IRF8) | 2 | (Panea et al. 2019; Morin et al. 2011, 2011) |
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+| [ITPR3](ITPR3) | 2 | (Love et al. 2012) |
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+| [KANK2](KANK2) | 2 | (Schmitz et al. 2012) |
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+| [KCNK10](KCNK10) | 2 | (Panea et al. 2019) |
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+| [KIFC3](KIFC3) | 2 | (Love et al. 2012) |
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+| [KLHL26](KLHL26) | 2 | (Burkhardt et al. 2022) |
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+| [KLHL6](KLHL6) | 2 | \[@; Morin et al. (2011); Morin et al. (2011)\] |
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+| [KMT2C](KMT2C) | 2 | (Zhou et al. 2019; Zhang et al. 2013) |
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+| [LCOR](LCOR) | 2 | \[@; Arthur et al. (2018)\] |
135
+| [LTB](LTB) | 2 | \[@; Chapuy et al. (2018)\] |
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+| [MAP3K6](MAP3K6) | 2 | (Love et al. 2012) |
137
+| [MCL1](MCL1) | 2 | (Panea et al. 2019; Reddy et al. 2017) |
138
+| [MEF2B](MEF2B) | 2 | \[@; Morin et al. (2011); Morin et al. (2011)\] |
139
+| [MIR142](MIR142) | 2 | (Grande et al. 2019; Kwanhian et al. 2012) |
140
+| [MKI67](MKI67) | 2 | (Schmitz et al. 2012; Russler-Germain et al. 2023) |
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+| [MME](MME) | 2 | (Panea et al. 2019) |
142
+| [MTOR](MTOR) | 2 | (Panea et al. 2019; Zhang et al. 2013) |
143
+| [MYH10](MYH10) | 2 | (Love et al. 2012) |
144
+| [MYO18A](MYO18A) | 2 | (Schmitz et al. 2012) |
145
+| [NBEAL1](NBEAL1) | 2 | (Love et al. 2012) |
146
+| [NCOR2](NCOR2) | 2 | (Schmitz et al. 2012) |
147
+| [NOA1](NOA1) | 2 | (Burkhardt et al. 2022) |
148
+| [NOTCH1](NOTCH1) | 2 | (Love et al. 2012; Laura Pasqualucci, Trifonov, et al. 2011) |
149
+| [NOTCH2](NOTCH2) | 2 | (Panea et al. 2019; Trøen et al. 2008) |
150
+| [NRXN2](NRXN2) | 2 | (Love et al. 2012) |
151
+| [P2RY2](P2RY2) | 2 | (Love et al. 2012) |
152
+| [PABPC4L](PABPC4L) | 2 | (Panea et al. 2019) |
153
+| [PC](PC) | 2 | (Love et al. 2012) |
154
+| [PCBP1](PCBP1) | 2 | (Schmitz et al. 2012) |
155
+| [PCDHA11](PCDHA11) | 2 | (Panea et al. 2019) |
156
+| [PDCD11](PDCD11) | 2 | (Schmitz et al. 2012) |
157
+| [PDZRN3](PDZRN3) | 2 | (Panea et al. 2019) |
158
+| [PIK3R1](PIK3R1) | 2 | (Panea et al. 2019; Zhang et al. 2013) |
159
+| [PIM1](PIM1) | 2 | (Burkhardt et al. 2022; L. Pasqualucci et al. 2001) |
160
+| [PLCG2](PLCG2) | 2 | (Panea et al. 2019) |
161
+| [PMAIP1](PMAIP1) | 2 | \[@\] |
162
+| [POLRMT](POLRMT) | 2 | (Love et al. 2012) |
163
+| [POR](POR) | 2 | (Love et al. 2012) |
164
+| [PPP6R2](PPP6R2) | 2 | (Burkhardt et al. 2022) |
165
+| [PRDM1](PRDM1) | 2 | \[@; (**pasqualucciInactivationPRDM1BLIMP12006?**)\] |
166
+| [PREX1](PREX1) | 2 | (Burkhardt et al. 2022) |
167
+| [PRKCD](PRKCD) | 2 | \[@\] |
168
+| [PRSS22](PRSS22) | 2 | (Love et al. 2012) |
169
+| [PTPRN](PTPRN) | 2 | (Love et al. 2012) |
170
+| [PXDNL](PXDNL) | 2 | (Panea et al. 2019) |
171
+| [RAC2](RAC2) | 2 | (Panea et al. 2019; Hübschmann et al. 2021) |
172
+| [RANBP6](RANBP6) | 2 | (Love et al. 2012) |
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+| [RBP3](RBP3) | 2 | (Love et al. 2012) |
174
+| [RET](RET) | 2 | (Love et al. 2012) |
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+| [REV3L](REV3L) | 2 | (Burkhardt et al. 2022) |
176
+| [RNF144B](RNF144B) | 2 | (Panea et al. 2019) |
177
+| [RPL10](RPL10) | 2 | (Burkhardt et al. 2022) |
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+| [RPL22](RPL22) | 2 | \[@\] |
179
+| [S1PR2](S1PR2) | 2 | (Muppidi et al. 2014; Morin et al. 2011) |
180
+| [SAL3](SAL3) | 2 | (Burkhardt et al. 2022) |
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+| [SALL3](SALL3) | 2 | (Love et al. 2012) |
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+| [SAPS2](SAPS2) | 2 | (Love et al. 2012) |
183
+| [SBF1](SBF1) | 2 | (Love et al. 2012) |
184
+| [SEPT10](SEPT10) | 2 | \[@\] |
185
+| [SF3B1](SF3B1) | 2 | (Love et al. 2012) |
186
+| [SHANK1](SHANK1) | 2 | (Love et al. 2012) |
187
+| [SLC29A2](SLC29A2) | 2 | (Love et al. 2012) |
188
+| [SNTB2](SNTB2) | 2 | (Panea et al. 2019) |
189
+| [SP3](SP3) | 2 | (Panea et al. 2019) |
190
+| [SYNCRIP](SYNCRIP) | 2 | (Panea et al. 2019) |
191
+| [SYNGAP1](SYNGAP1) | 2 | (Love et al. 2012) |
192
+| [TBC1D9B](TBC1D9B) | 2 | (Love et al. 2012) |
193
+| [TET2](TET2) | 2 | (Panea et al. 2019; Albuquerque et al. 2017) |
194
+| [TIGD6](TIGD6) | 2 | (Love et al. 2012) |
195
+| [TOP2A](TOP2A) | 2 | (Schmitz et al. 2012) |
196
+| [TPST2](TPST2) | 2 | (Love et al. 2012) |
197
+| [TTN](TTN) | 2 | (Burkhardt et al. 2022) |
198
+| [VWA7](VWA7) | 2 | (Burkhardt et al. 2022) |
199
+| [WDR7](WDR7) | 2 | (Panea et al. 2019) |
200
+| [WDR90](WDR90) | 2 | (Schmitz et al. 2012) |
201
+| [WHAMM](WHAMM) | 2 | (Schmitz et al. 2012) |
202
+| [WNK2](WNK2) | 2 | (Panea et al. 2019) |
203
+| [YY1AP1](YY1AP1) | 2 | (Schmitz et al. 2012) |
204
+| [ZAN](ZAN) | 2 | (Burkhardt et al. 2022) |
205
+| [ZBTB7A](ZBTB7A) | 2 | (Burkhardt et al. 2022; Reddy et al. 2017) |
206
+| [ZFP36L1](ZFP36L1) | 2 | (Panea et al. 2019; Morin et al. 2011) |
207
+| [ZNF229](ZNF229) | 2 | (Love et al. 2012) |
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+| [ZNF85](ZNF85) | 2 | (Burkhardt et al. 2022) |
209
+
210
+# References
211
+
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+<div id="refs" class="references csl-bib-body hanging-indent">
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+Sakellarios Zairis, et al. 2015. “Distinct Viral and Mutational Spectrum
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DLBCL_genes_with_bib.md
... ...
@@ -1,340 +1,342 @@
1 1
# DLBCL genes
2 2
3
+## Origins of DLBCL genes![sankey](DLBCL_sankey-1.svg)
4
+
3 5
## Tier 1 DLBCL genes
4 6
5
-| Gene | Tier | Relevant references |
6
-|:----------------------:|:----:|:------------------------------------------------:|
7
-| [ACTB](ACTB) | 1 | (Lohr et al. 2012) |
8
-| [ACTG1](ACTG1) | 1 | (Hübschmann et al. 2021) |
9
-| [ARID1A](ARID1A) | 1 | (Zhang et al. 2013; Krysiak et al. 2017) |
10
-| [ATM](ATM) | 1 | (Reddy et al. 2017) |
11
-| [B2M](B2M) | 1 | (Morin et al. 2011) |
12
-| [BCL10](BCL10) | 1 | (Morin et al. 2011; Russler-Germain et al. 2023) |
13
-| [BCL11A](BCL11A) | 1 | |
14
-| [BCL2](BCL2) | 1 | (Tanaka et al. 1992; Morin et al. 2011) |
15
-| [BCL6](BCL6) | 1 | (Morin et al. 2011) |
16
-| [BCL7A](BCL7A) | 1 | (Arthur et al. 2018; Krysiak et al. 2017) |
17
-| [BCOR](BCOR) | 1 | |
18
-| [BCR](BCR) | 1 | |
19
-| [BIRC6](BIRC6) | 1 | (Reddy et al. 2017) |
20
-| [BRAF](BRAF) | 1 | (Tiacci et al. 2011) |
21
-| [BTG1](BTG1) | 1 | (Morin et al. 2011) |
22
-| [BTG2](BTG2) | 1 | (Morin et al. 2011) |
23
-| [BTK](BTK) | 1 | (Albuquerque et al. 2017; Krysiak et al. 2017) |
24
-| [CARD11](CARD11) | 1 | (Lenz et al. 2008; Morin et al. 2011) |
25
-| [CASP8](CASP8) | 1 | (Reddy et al. 2017) |
26
-| [CCND3](CCND3) | 1 | (Morin et al. 2011) |
27
-| [CD274](CD274) | 1 | (Morin et al. 2011) |
28
-| [CD36](CD36) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011) |
29
-| [CD58](CD58) | 1 | (Morin et al. 2011) |
30
-| [CD70](CD70) | 1 | (Morin et al. 2011; Russler-Germain et al. 2023) |
31
-| [CD79B](CD79B) | 1 | (Morin et al. 2011) |
32
-| [CD83](CD83) | 1 | (Morin et al. 2013; Russler-Germain et al. 2023) |
33
-| [CDKN2A](CDKN2A) | 1 | (Morin et al. 2013) |
34
-| [CIITA](CIITA) | 1 | (Morin et al. 2011) |
35
-| [CREBBP](CREBBP) | 1 | (Laura Pasqualucci, Dominguez-Sola, et al. 2011) |
36
-| [CXCR4](CXCR4) | 1 | (Khodabakhshi et al. 2012; Krysiak et al. 2017) |
37
-| [CXCR5](CXCR5) | 1 | (Schmitz et al. 2018) |
38
-| [DAZAP1](DAZAP1) | 1 | (Pararajalingam et al. 2020) |
39
-| [DDX3X](DDX3X) | 1 | (Schmitz et al. 2018) |
40
-| [DTX1](DTX1) | 1 | (Schmitz et al. 2018) |
41
-| [DUSP2](DUSP2) | 1 | (Morin et al. 2013) |
42
-| [EBF1](EBF1) | 1 | (Bohle et al. 2013) |
43
-| [EEF1A1](EEF1A1) | 1 | (Hübschmann et al. 2021) |
44
-| [EP300](EP300) | 1 | (Laura Pasqualucci, Dominguez-Sola, et al. 2011) |
45
-| [ETS1](ETS1) | 1 | (Morin et al. 2011) |
46
-| [ETV6](ETV6) | 1 | (Arthur et al. 2018) |
47
-| [EZH2](EZH2) | 1 | (Morin et al. 2010) |
48
-| [FAS](FAS) | 1 | (Scholl et al. 2007) |
49
-| [FBXO11](FBXO11) | 1 | (Hübschmann et al. 2021) |
50
-| [FBXW7](FBXW7) | 1 | (Zhang et al. 2013) |
51
-| [FOXC1](FOXC1) | 1 | (Schmitz et al. 2018) |
52
-| [FOXO1](FOXO1) | 1 | (Morin et al. 2011) |
53
-| [GNA13](GNA13) | 1 | (Morin et al. 2011) |
54
-| [GNAI2](GNAI2) | 1 | (Morin et al. 2013) |
55
-| [GRB2](GRB2) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011) |
56
-| [GRHPR](GRHPR) | 1 | (Arthur et al. 2018) |
57
-| [HIST1H1B](HIST1H1B) | 1 | (Chapuy et al. 2018; Krysiak et al. 2017) |
58
-| [HIST1H1C](HIST1H1C) | 1 | (Morin et al. 2011) |
59
-| [HIST1H1D](HIST1H1D) | 1 | (Morin et al. 2013; Krysiak et al. 2017) |
60
-| [HIST1H1E](HIST1H1E) | 1 | (Morin et al. 2013; Krysiak et al. 2017) |
61
-| [HIST1H2AC](HIST1H2AC) | 1 | (Morin et al. 2013; Krysiak et al. 2017) |
62
-| [HIST1H2AM](HIST1H2AM) | 1 | (Krysiak et al. 2017) |
63
-| [HIST1H2BC](HIST1H2BC) | 1 | (Reddy et al. 2017; Krysiak et al. 2017) |
64
-| [HIST1H2BK](HIST1H2BK) | 1 | |
65
-| [HIST1H3B](HIST1H3B) | 1 | (Zhang et al. 2013) |
66
-| [HIST2H2BE](HIST2H2BE) | 1 | (Schmitz et al. 2018) |
67
-| [HLA-A](HLA-A) | 1 | |
68
-| [HLA-B](HLA-B) | 1 | |
69
-| [HLA-C](HLA-C) | 1 | |
70
-| [HLA-DMA](HLA-DMA) | 1 | |
71
-| [HLA-DMB](HLA-DMB) | 1 | |
72
-| [HLA-DQA1](HLA-DQA1) | 1 | (Hübschmann et al. 2021) |
73
-| [HNRNPD](HNRNPD) | 1 | |
74
-| [HNRNPH1](HNRNPH1) | 1 | (Pararajalingam et al. 2020) |
75
-| [HNRNPU](HNRNPU) | 1 | (Reddy et al. 2017) |
76
-| [HVCN1](HVCN1) | 1 | (Krysiak et al. 2017) |
77
-| [IKZF3](IKZF3) | 1 | (Morin et al. 2013) |
78
-| [IL16](IL16) | 1 | |
79
-| [IL4R](IL4R) | 1 | (Duns et al. 2021) |
80
-| [IRF4](IRF4) | 1 | (Morin et al. 2011) |
81
-| [IRF8](IRF8) | 1 | (Morin et al. 2011) |
82
-| [ITPKB](ITPKB) | 1 | (Schmitz et al. 2018) |
83
-| [JUNB](JUNB) | 1 | (Reddy et al. 2017) |
84
-| [KLF2](KLF2) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011) |
85
-| [KLHL14](KLHL14) | 1 | (Zhang et al. 2013) |
86
-| [KLHL6](KLHL6) | 1 | (Morin et al. 2011) |
87
-| [KMT2C](KMT2C) | 1 | (Zhang et al. 2013) |
88
-| [KMT2D](KMT2D) | 1 | (Morin et al. 2011) |
89
-| [KRAS](KRAS) | 1 | (Lohr et al. 2012) |
90
-| [LCOR](LCOR) | 1 | (Arthur et al. 2018) |
91
-| [LTB](LTB) | 1 | (Chapuy et al. 2018) |
92
-| [LYN](LYN) | 1 | (Chapuy et al. 2018) |
93
-| [MCL1](MCL1) | 1 | (Reddy et al. 2017) |
94
-| [MEF2B](MEF2B) | 1 | (Morin et al. 2011) |
95
-| [MEF2C](MEF2C) | 1 | (Arthur et al. 2018) |
96
-| [MGA](MGA) | 1 | (Zhang et al. 2013) |
97
-| [MPEG1](MPEG1) | 1 | (Morin et al. 2013) |
98
-| [MS4A1](MS4A1) | 1 | (Rushton et al. 2020) |
99
-| [MTOR](MTOR) | 1 | (Zhang et al. 2013) |
100
-| [MYC](MYC) | 1 | (L. Pasqualucci et al. 2001) |
101
-| [MYD88](MYD88) | 1 | (Ngo et al. 2011) |
102
-| [MYOM2](MYOM2) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011) |
103
-| [NCOR2](NCOR2) | 1 | |
104
-| [NFKB1](NFKB1) | 1 | |
105
-| [NFKBIA](NFKBIA) | 1 | (Lake et al. 2009; Russler-Germain et al. 2023) |
106
-| [NFKBIE](NFKBIE) | 1 | (Morin et al. 2016) |
107
-| [NFKBIZ](NFKBIZ) | 1 | (Morin et al. 2016) |
108
-| [NLRC5](NLRC5) | 1 | |
109
-| [NOL9](NOL9) | 1 | (Schmitz et al. 2018) |
110
-| [NOTCH1](NOTCH1) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011) |
111
-| [NOTCH2](NOTCH2) | 1 | (Trøen et al. 2008) |
112
-| [OSBPL10](OSBPL10) | 1 | (Arthur et al. 2018) |
113
-| [P2RY8](P2RY8) | 1 | (Lohr et al. 2012) |
114
-| [PCBP1](PCBP1) | 1 | |
115
-| [PIM1](PIM1) | 1 | (L. Pasqualucci et al. 2001) |
116
-| [PIM2](PIM2) | 1 | (Arthur et al. 2018) |
117
-| [POU2AF1](POU2AF1) | 1 | (Krysiak et al. 2017) |
118
-| [POU2F2](POU2F2) | 1 | (Zhang et al. 2013; Krysiak et al. 2017) |
119
-| [PRDM1](PRDM1) | 1 | (**pasqualucciInactivationPRDM1BLIMP12006?**) |
120
-| [PRKDC](PRKDC) | 1 | (Schmitz et al. 2018; Hübschmann et al. 2021) |
121
-| [PTEN](PTEN) | 1 | |
122
-| [PTPRD](PTPRD) | 1 | |
123
-| [RB1](RB1) | 1 | (Morin et al. 2013) |
124
-| [RFX7](RFX7) | 1 | |
125
-| [RFXAP](RFXAP) | 1 | |
126
-| [RHOA](RHOA) | 1 | (L. Pasqualucci et al. 2001) |
127
-| [RRAGC](RRAGC) | 1 | (Okosun et al. 2016) |
128
-| [S1PR2](S1PR2) | 1 | (Morin et al. 2011) |
129
-| [SETD1B](SETD1B) | 1 | (Reddy et al. 2017) |
130
-| [SF3B1](SF3B1) | 1 | |
131
-| [SGK1](SGK1) | 1 | (Morin et al. 2011) |
132
-| [SIN3A](SIN3A) | 1 | |
133
-| [SMARCA4](SMARCA4) | 1 | (Zhang et al. 2013; Krysiak et al. 2017) |
134
-| [SOCS1](SOCS1) | 1 | (Morin et al. 2011) |
135
-| [SPEN](SPEN) | 1 | (Rossi et al. 2012) |
136
-| [STAT3](STAT3) | 1 | (Ohgami et al. 2014) |
137
-| [STAT6](STAT6) | 1 | (Yildiz et al. 2015) |
138
-| [TAF1](TAF1) | 1 | (Morin et al. 2013) |
139
-| [TBL1XR1](TBL1XR1) | 1 | (Mareschal et al. 2016) |
140
-| [TET2](TET2) | 1 | (Albuquerque et al. 2017) |
141
-| [TMEM30A](TMEM30A) | 1 | (Morin et al. 2011) |
142
-| [TMSB4X](TMSB4X) | 1 | (Albuquerque et al. 2017) |
143
-| [TNFAIP3](TNFAIP3) | 1 | (Compagno et al. 2009) |
144
-| [TNFRSF14](TNFRSF14) | 1 | (Cheung et al. 2010) |
145
-| [TOX](TOX) | 1 | (Reddy et al. 2017) |
146
-| [TP53](TP53) | 1 | (Morin et al. 2011) |
147
-| [TRIP12](TRIP12) | 1 | |
148
-| [TRRAP](TRRAP) | 1 | (Parry et al. 2013) |
149
-| [UBE2A](UBE2A) | 1 | (Reddy et al. 2017) |
150
-| [UNC5C](UNC5C) | 1 | |
151
-| [USP7](USP7) | 1 | |
152
-| [VPS13B](VPS13B) | 1 | |
153
-| [WEE1](WEE1) | 1 | (Schmitz et al. 2018) |
154
-| [XPO1](XPO1) | 1 | (Mareschal et al. 2016) |
155
-| [ZC3H12A](ZC3H12A) | 1 | (Arthur et al. 2018) |
156
-| [ZFP36L1](ZFP36L1) | 1 | (Morin et al. 2011) |
157
-| [ZNF292](ZNF292) | 1 | (Zhang et al. 2013) |
158
-| [ZNF608](ZNF608) | 1 | (Zhang et al. 2013; Krysiak et al. 2017) |
7
+| Gene | Tier | Relevant references |
8
+|:----------------------:|:----:|:-------------------------------------------------------------------:|
9
+| [ACTB](ACTB) | 1 | (Lohr et al. 2012) |
10
+| [ACTG1](ACTG1) | 1 | (Hübschmann et al. 2021) |
11
+| [ARID1A](ARID1A) | 1 | (Zhang et al. 2013; Krysiak et al. 2017; Love et al. 2012) |
12
+| [ATM](ATM) | 1 | (Reddy et al. 2017) |
13
+| [B2M](B2M) | 1 | (Morin et al. 2011) |
14
+| [BCL10](BCL10) | 1 | (Morin et al. 2011; Russler-Germain et al. 2023) |
15
+| [BCL11A](BCL11A) | 1 | |
16
+| [BCL2](BCL2) | 1 | (Tanaka et al. 1992; Morin et al. 2011; Burkhardt et al. 2022) |
17
+| [BCL6](BCL6) | 1 | (Morin et al. 2011; Love et al. 2012) |
18
+| [BCL7A](BCL7A) | 1 | (Arthur et al. 2018; Krysiak et al. 2017; Grande et al. 2019) |
19
+| [BCOR](BCOR) | 1 | |
20
+| [BCR](BCR) | 1 | |
21
+| [BIRC6](BIRC6) | 1 | (Reddy et al. 2017) |
22
+| [BRAF](BRAF) | 1 | (Tiacci et al. 2011; Love et al. 2012) |
23
+| [BTG1](BTG1) | 1 | (Morin et al. 2011; Burkhardt et al. 2022) |
24
+| [BTG2](BTG2) | 1 | (Morin et al. 2011; Love et al. 2012) |
25
+| [BTK](BTK) | 1 | (Albuquerque et al. 2017; Krysiak et al. 2017) |
26
+| [CARD11](CARD11) | 1 | (Lenz et al. 2008; Morin et al. 2011; Panea et al. 2019) |
27
+| [CASP8](CASP8) | 1 | (Reddy et al. 2017) |
28
+| [CCND3](CCND3) | 1 | (Morin et al. 2011; Richter et al. 2012) |
29
+| [CD274](CD274) | 1 | (Morin et al. 2011) |
30
+| [CD36](CD36) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011) |
31
+| [CD58](CD58) | 1 | (Morin et al. 2011) |
32
+| [CD70](CD70) | 1 | (Morin et al. 2011; Russler-Germain et al. 2023) |
33
+| [CD79B](CD79B) | 1 | (Morin et al. 2011; Panea et al. 2019) |
34
+| [CD83](CD83) | 1 | (Morin et al. 2013; Russler-Germain et al. 2023; Panea et al. 2019) |
35
+| [CDKN2A](CDKN2A) | 1 | (Morin et al. 2013; Grande et al. 2019) |
36
+| [CIITA](CIITA) | 1 | (Morin et al. 2011) |
37
+| [CREBBP](CREBBP) | 1 | (Laura Pasqualucci, Dominguez-Sola, et al. 2011; Love et al. 2012) |
38
+| [CXCR4](CXCR4) | 1 | (Khodabakhshi et al. 2012; Krysiak et al. 2017; Panea et al. 2019) |
39
+| [CXCR5](CXCR5) | 1 | (Schmitz et al. 2018) |
40
+| [DAZAP1](DAZAP1) | 1 | (Pararajalingam et al. 2020) |
41
+| [DDX3X](DDX3X) | 1 | (Schmitz et al. 2018, 2012) |
42
+| [DTX1](DTX1) | 1 | (Schmitz et al. 2018; Panea et al. 2019) |
43
+| [DUSP2](DUSP2) | 1 | (Morin et al. 2013) |
44
+| [EBF1](EBF1) | 1 | \[Bohle et al. (2013); @\] |
45
+| [EEF1A1](EEF1A1) | 1 | (Hübschmann et al. 2021) |
46
+| [EP300](EP300) | 1 | \[Laura Pasqualucci, Dominguez-Sola, et al. (2011); @\] |
47
+| [ETS1](ETS1) | 1 | (Morin et al. 2011; Panea et al. 2019) |
48
+| [ETV6](ETV6) | 1 | (Arthur et al. 2018) |
49
+| [EZH2](EZH2) | 1 | (Morin et al. 2010; Love et al. 2012) |
50
+| [FAS](FAS) | 1 | (Scholl et al. 2007) |
51
+| [FBXO11](FBXO11) | 1 | (Hübschmann et al. 2021; Richter et al. 2012) |
52
+| [FBXW7](FBXW7) | 1 | (Zhang et al. 2013) |
53
+| [FOXC1](FOXC1) | 1 | (Schmitz et al. 2018) |
54
+| [FOXO1](FOXO1) | 1 | (Morin et al. 2011; Schmitz et al. 2012) |
55
+| [GNA13](GNA13) | 1 | (Morin et al. 2011; Love et al. 2012) |
56
+| [GNAI2](GNAI2) | 1 | (Morin et al. 2013; Grande et al. 2019) |
57
+| [GRB2](GRB2) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011; Panea et al. 2019) |
58
+| [GRHPR](GRHPR) | 1 | (Arthur et al. 2018) |
59
+| [HIST1H1B](HIST1H1B) | 1 | (Chapuy et al. 2018; Krysiak et al. 2017) |
60
+| [HIST1H1C](HIST1H1C) | 1 | (Morin et al. 2011; Panea et al. 2019) |
61
+| [HIST1H1D](HIST1H1D) | 1 | (Morin et al. 2013; Krysiak et al. 2017) |
62
+| [HIST1H1E](HIST1H1E) | 1 | (Morin et al. 2013; Krysiak et al. 2017; Grande et al. 2019) |
63
+| [HIST1H2AC](HIST1H2AC) | 1 | (Morin et al. 2013; Krysiak et al. 2017) |
64
+| [HIST1H2AM](HIST1H2AM) | 1 | (Krysiak et al. 2017; Panea et al. 2019) |
65
+| [HIST1H2BC](HIST1H2BC) | 1 | (Reddy et al. 2017; Krysiak et al. 2017) |
66
+| [HIST1H2BK](HIST1H2BK) | 1 | (Panea et al. 2019) |
67
+| [HIST1H3B](HIST1H3B) | 1 | (Zhang et al. 2013) |
68
+| [HIST2H2BE](HIST2H2BE) | 1 | (Schmitz et al. 2018) |
69
+| [HLA-A](HLA-A) | 1 | \[@\] |
70
+| [HLA-B](HLA-B) | 1 | \[@\] |
71
+| [HLA-C](HLA-C) | 1 | |
72
+| [HLA-DMA](HLA-DMA) | 1 | |
73
+| [HLA-DMB](HLA-DMB) | 1 | \[@\] |
74
+| [HLA-DQA1](HLA-DQA1) | 1 | (Hübschmann et al. 2021) |
75
+| [HNRNPD](HNRNPD) | 1 | |
76
+| [HNRNPH1](HNRNPH1) | 1 | (Pararajalingam et al. 2020) |
77
+| [HNRNPU](HNRNPU) | 1 | (Reddy et al. 2017; Panea et al. 2019) |
78
+| [HVCN1](HVCN1) | 1 | (Krysiak et al. 2017) |
79
+| [IKZF3](IKZF3) | 1 | (Morin et al. 2013; Panea et al. 2019) |
80
+| [IL16](IL16) | 1 | |
81
+| [IL4R](IL4R) | 1 | (Duns et al. 2021) |
82
+| [IRF4](IRF4) | 1 | (Morin et al. 2011) |
83
+| [IRF8](IRF8) | 1 | (Morin et al. 2011; Panea et al. 2019) |
84
+| [ITPKB](ITPKB) | 1 | (Schmitz et al. 2018) |
85
+| [JUNB](JUNB) | 1 | (Reddy et al. 2017) |
86
+| [KLF2](KLF2) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011) |
87
+| [KLHL14](KLHL14) | 1 | (Zhang et al. 2013) |
88
+| [KLHL6](KLHL6) | 1 | \[Morin et al. (2011); @\] |
89
+| [KMT2C](KMT2C) | 1 | (Zhang et al. 2013; Zhou et al. 2019) |
90
+| [KMT2D](KMT2D) | 1 | (Morin et al. 2011; Grande et al. 2019) |
91
+| [KRAS](KRAS) | 1 | (Lohr et al. 2012) |
92
+| [LCOR](LCOR) | 1 | \[Arthur et al. (2018); @\] |
93
+| [LTB](LTB) | 1 | \[Chapuy et al. (2018); @\] |
94
+| [LYN](LYN) | 1 | (Chapuy et al. 2018) |
95
+| [MCL1](MCL1) | 1 | (Reddy et al. 2017; Panea et al. 2019) |
96
+| [MEF2B](MEF2B) | 1 | \[Morin et al. (2011); @\] |
97
+| [MEF2C](MEF2C) | 1 | (Arthur et al. 2018) |
98
+| [MGA](MGA) | 1 | (Zhang et al. 2013) |
99
+| [MPEG1](MPEG1) | 1 | (Morin et al. 2013) |
100
+| [MS4A1](MS4A1) | 1 | (Rushton et al. 2020) |
101
+| [MTOR](MTOR) | 1 | (Zhang et al. 2013; Panea et al. 2019) |
102
+| [MYC](MYC) | 1 | (L. Pasqualucci et al. 2001; Johnston and Carroll 1992) |
103
+| [MYD88](MYD88) | 1 | (Ngo et al. 2011) |
104
+| [MYOM2](MYOM2) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011) |
105
+| [NCOR2](NCOR2) | 1 | (Schmitz et al. 2012) |
106
+| [NFKB1](NFKB1) | 1 | |
107
+| [NFKBIA](NFKBIA) | 1 | (Lake et al. 2009; Russler-Germain et al. 2023) |
108
+| [NFKBIE](NFKBIE) | 1 | (Morin et al. 2016) |
109
+| [NFKBIZ](NFKBIZ) | 1 | (Morin et al. 2016) |
110
+| [NLRC5](NLRC5) | 1 | |
111
+| [NOL9](NOL9) | 1 | (Schmitz et al. 2018) |
112
+| [NOTCH1](NOTCH1) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011; Love et al. 2012) |
113
+| [NOTCH2](NOTCH2) | 1 | (Trøen et al. 2008; Panea et al. 2019) |
114
+| [OSBPL10](OSBPL10) | 1 | (Arthur et al. 2018) |
115
+| [P2RY8](P2RY8) | 1 | (Lohr et al. 2012; Muppidi et al. 2014) |
116
+| [PCBP1](PCBP1) | 1 | (Schmitz et al. 2012) |
117
+| [PIM1](PIM1) | 1 | (L. Pasqualucci et al. 2001; Burkhardt et al. 2022) |
118
+| [PIM2](PIM2) | 1 | (Arthur et al. 2018) |
119
+| [POU2AF1](POU2AF1) | 1 | (Krysiak et al. 2017) |
120
+| [POU2F2](POU2F2) | 1 | (Zhang et al. 2013; Krysiak et al. 2017) |
121
+| [PRDM1](PRDM1) | 1 | \[(**pasqualucciInactivationPRDM1BLIMP12006?**); @\] |
122
+| [PRKDC](PRKDC) | 1 | (Schmitz et al. 2018; Hübschmann et al. 2021) |
123
+| [PTEN](PTEN) | 1 | (Love et al. 2012) |
124
+| [PTPRD](PTPRD) | 1 | |
125
+| [RB1](RB1) | 1 | (Morin et al. 2013) |
126
+| [RFX7](RFX7) | 1 | (Grande et al. 2019) |
127
+| [RFXAP](RFXAP) | 1 | |
128
+| [RHOA](RHOA) | 1 | (L. Pasqualucci et al. 2001; Richter et al. 2012) |
129
+| [RRAGC](RRAGC) | 1 | (Okosun et al. 2016) |
130
+| [S1PR2](S1PR2) | 1 | (Morin et al. 2011; Muppidi et al. 2014) |
131
+| [SETD1B](SETD1B) | 1 | (Reddy et al. 2017) |
132
+| [SF3B1](SF3B1) | 1 | (Love et al. 2012) |
133
+| [SGK1](SGK1) | 1 | (Morin et al. 2011) |
134
+| [SIN3A](SIN3A) | 1 | (Grande et al. 2019) |
135
+| [SMARCA4](SMARCA4) | 1 | (Zhang et al. 2013; Krysiak et al. 2017; Richter et al. 2012) |
136
+| [SOCS1](SOCS1) | 1 | (Morin et al. 2011) |
137
+| [SPEN](SPEN) | 1 | (Rossi et al. 2012) |
138
+| [STAT3](STAT3) | 1 | (Ohgami et al. 2014) |
139
+| [STAT6](STAT6) | 1 | (Yildiz et al. 2015) |
140
+| [TAF1](TAF1) | 1 | (Morin et al. 2013) |
141
+| [TBL1XR1](TBL1XR1) | 1 | (Mareschal et al. 2016) |
142
+| [TET2](TET2) | 1 | (Albuquerque et al. 2017; Panea et al. 2019) |
143
+| [TMEM30A](TMEM30A) | 1 | (Morin et al. 2011) |
144
+| [TMSB4X](TMSB4X) | 1 | (Albuquerque et al. 2017) |
145
+| [TNFAIP3](TNFAIP3) | 1 | (Compagno et al. 2009) |
146
+| [TNFRSF14](TNFRSF14) | 1 | (Cheung et al. 2010) |
147
+| [TOX](TOX) | 1 | (Reddy et al. 2017) |
148
+| [TP53](TP53) | 1 | (Morin et al. 2011; Wilda et al. 2004) |
149
+| [TRIP12](TRIP12) | 1 | |
150
+| [TRRAP](TRRAP) | 1 | (Parry et al. 2013) |
151
+| [UBE2A](UBE2A) | 1 | (Reddy et al. 2017) |
152
+| [UNC5C](UNC5C) | 1 | |
153
+| [USP7](USP7) | 1 | (Grande et al. 2019) |
154
+| [VPS13B](VPS13B) | 1 | |
155
+| [WEE1](WEE1) | 1 | (Schmitz et al. 2018) |
156
+| [XPO1](XPO1) | 1 | (Mareschal et al. 2016) |
157
+| [ZC3H12A](ZC3H12A) | 1 | (Arthur et al. 2018) |
158
+| [ZFP36L1](ZFP36L1) | 1 | (Morin et al. 2011; Panea et al. 2019) |
159
+| [ZNF292](ZNF292) | 1 | (Zhang et al. 2013) |
160
+| [ZNF608](ZNF608) | 1 | (Zhang et al. 2013; Krysiak et al. 2017) |
159 161
160 162
## Tier 2 DLBCL genes
161 163
162
-| Gene | Tier | Relevant references |
163
-|:----------------------:|:----:|:------------------------------------------------:|
164
-| [ABI3BP](ABI3BP) | 2 | (Morin et al. 2013) |
165
-| [ADAMTS1](ADAMTS1) | 2 | (Hübschmann et al. 2021) |
166
-| [AICDA](AICDA) | 2 | (Arthur et al. 2018) |
167
-| [ANKRD12](ANKRD12) | 2 | (Hübschmann et al. 2021) |
168
-| [ANKRD17](ANKRD17) | 2 | (Reddy et al. 2017) |
169
-| [ARID1B](ARID1B) | 2 | (Reddy et al. 2017) |
170
-| [ARID5B](ARID5B) | 2 | (Reddy et al. 2017) |
171
-| [ATR](ATR) | 2 | (Reddy et al. 2017) |
172
-| [BIRC3](BIRC3) | 2 | (Arthur et al. 2018) |
173
-| [BLK](BLK) | 2 | |
174
-| [BRINP3](BRINP3) | 2 | (Reddy et al. 2017) |
175
-| [BTBD3](BTBD3) | 2 | (Reddy et al. 2017) |
176
-| [CADPS2](CADPS2) | 2 | (Hübschmann et al. 2021) |
177
-| [CBLB](CBLB) | 2 | (Reddy et al. 2017) |
178
-| [CCL4](CCL4) | 2 | (Chapuy et al. 2018) |
179
-| [CD22](CD22) | 2 | (Reddy et al. 2017) |
180
-| [CD44](CD44) | 2 | (Arthur et al. 2018) |
181
-| [CD74](CD74) | 2 | (Arthur et al. 2018) |
182
-| [CDC73](CDC73) | 2 | (Reddy et al. 2017) |
183
-| [CDH9](CDH9) | 2 | (Morin et al. 2013) |
184
-| [CHD1](CHD1) | 2 | (Reddy et al. 2017) |
185
-| [CHD8](CHD8) | 2 | (Reddy et al. 2017) |
186
-| [CHST2](CHST2) | 2 | (Reddy et al. 2017) |
187
-| [CNOT2](CNOT2) | 2 | (Hübschmann et al. 2021) |
188
-| [CNTNAP5](CNTNAP5) | 2 | (Morin et al. 2013) |
189
-| [COQ7](COQ7) | 2 | (Chapuy et al. 2018) |
190
-| [CRIP1](CRIP1) | 2 | (Chapuy et al. 2018) |
191
-| [DCAF6](DCAF6) | 2 | (Reddy et al. 2017) |
192
-| [DDX10](DDX10) | 2 | (Reddy et al. 2017) |
193
-| [DHX16](DHX16) | 2 | (Hübschmann et al. 2021) |
194
-| [DICER1](DICER1) | 2 | (Reddy et al. 2017) |
195
-| [DNAH5](DNAH5) | 2 | (Morin et al. 2013) |
196
-| [DNM2](DNM2) | 2 | (Hübschmann et al. 2021) |
197
-| [DNMT3A](DNMT3A) | 2 | (Reddy et al. 2017) |
198
-| [DOCK1](DOCK1) | 2 | (Chapuy et al. 2018) |
199
-| [DSG4](DSG4) | 2 | (Morin et al. 2013) |
200
-| [EIF2AK3](EIF2AK3) | 2 | |
201
-| [EZR](EZR) | 2 | |
202
-| [FAM102A](FAM102A) | 2 | |
203
-| [FAM38B](FAM38B) | 2 | (Morin et al. 2013) |
204
-| [FANK1](FANK1) | 2 | |
205
-| [FAT4](FAT4) | 2 | (Morin et al. 2013) |
206
-| [FCRL3](FCRL3) | 2 | |
207
-| [FNBP1](FNBP1) | 2 | |
208
-| [FNDC1](FNDC1) | 2 | (Morin et al. 2013) |
209
-| [FOXP1](FOXP1) | 2 | (Reddy et al. 2017) |
210
-| [FUBP1](FUBP1) | 2 | (Reddy et al. 2017) |
211
-| [FUT5](FUT5) | 2 | (Chapuy et al. 2018) |
212
-| [GABRA2](GABRA2) | 2 | (Chapuy et al. 2018) |
213
-| [GAK](GAK) | 2 | (Hübschmann et al. 2021) |
214
-| [GNAS](GNAS) | 2 | (Reddy et al. 2017) |
215
-| [GOLGA5](GOLGA5) | 2 | (Reddy et al. 2017) |
216
-| [GPC5](GPC5) | 2 | (Schmitz et al. 2018) |
217
-| [GSG2](GSG2) | 2 | (Schmitz et al. 2018) |
218
-| [HDAC7](HDAC7) | 2 | (Morin et al. 2013) |
219
-| [HIST1H2AG](HIST1H2AG) | 2 | (Morin et al. 2013; Krysiak et al. 2017) |
220
-| [HNF1B](HNF1B) | 2 | (Laura Pasqualucci, Trifonov, et al. 2011) |
221
-| [HRAS](HRAS) | 2 | (Reddy et al. 2017) |
222
-| [ID3](ID3) | 2 | (Schmitz et al. 2012) |
223
-| [IER2](IER2) | 2 | (Morin et al. 2013) |
224
-| [IFNGR1](IFNGR1) | 2 | (Morin et al. 2013) |
225
-| [IGLL5](IGLL5) | 2 | (Russler-Germain et al. 2023) |
226
-| [IKBKB](IKBKB) | 2 | (Reddy et al. 2017) |
227
-| [IKBKE](IKBKE) | 2 | (Hübschmann et al. 2021) |
228
-| [IL6](IL6) | 2 | (Chapuy et al. 2018) |
229
-| [INO80](INO80) | 2 | (Zhang et al. 2013) |
230
-| [IRAG2](IRAG2) | 2 | |
231
-| [IRF1](IRF1) | 2 | (Hübschmann et al. 2021) |
232
-| [JAK1](JAK1) | 2 | (Zhang et al. 2013) |
233
-| [JAK3](JAK3) | 2 | (Zhang et al. 2013) |
234
-| [KCMF1](KCMF1) | 2 | (Reddy et al. 2017) |
235
-| [KLHL21](KLHL21) | 2 | (Schmitz et al. 2018) |
236
-| [LAMA5](LAMA5) | 2 | (Schmitz et al. 2018) |
237
-| [LAPTM5](LAPTM5) | 2 | (Hübschmann et al. 2021) |
238
-| [LIN54](LIN54) | 2 | (Reddy et al. 2017) |
239
-| [LPP](LPP) | 2 | (Arthur et al. 2018) |
240
-| [LRP12](LRP12) | 2 | (Hübschmann et al. 2021) |
241
-| [LRRN3](LRRN3) | 2 | (Morin et al. 2013) |
242
-| [MAGT1](MAGT1) | 2 | (Reddy et al. 2017) |
243
-| [MALAT1](MALAT1) | 2 | (Arthur et al. 2018) |
244
-| [MAP2K1](MAP2K1) | 2 | (Shin et al. 2015; Louissaint et al. 2016) |
245
-| [MAP4K4](MAP4K4) | 2 | (Reddy et al. 2017) |
246
-| [MARK1](MARK1) | 2 | (Reddy et al. 2017) |
247
-| [MECOM](MECOM) | 2 | (Reddy et al. 2017) |
248
-| [MET](MET) | 2 | (Reddy et al. 2017) |
249
-| [MIR142](MIR142) | 2 | (Kwanhian et al. 2012) |
250
-| [MIR155HG](MIR155HG) | 2 | |
251
-| [MPDZ](MPDZ) | 2 | (Morin et al. 2013) |
252
-| [MSH2](MSH2) | 2 | (Reddy et al. 2017) |
253
-| [MSH6](MSH6) | 2 | (Reddy et al. 2017) |
254
-| [MYB](MYB) | 2 | (Reddy et al. 2017) |
255
-| [MYBPC2](MYBPC2) | 2 | (Schmitz et al. 2018) |
256
-| [MYO1E](MYO1E) | 2 | |
257
-| [N2RF2](N2RF2) | 2 | (Hübschmann et al. 2021) |
258
-| [NANOG](NANOG) | 2 | (Chapuy et al. 2018) |
259
-| [NAV1](NAV1) | 2 | (Chapuy et al. 2018) |
260
-| [NCOA3](NCOA3) | 2 | |
261
-| [NCOR1](NCOR1) | 2 | (Reddy et al. 2017) |
262
-| [NEAT1](NEAT1) | 2 | (Arthur et al. 2018) |
263
-| [NF1](NF1) | 2 | (Reddy et al. 2017) |
264
-| [NFKB2](NFKB2) | 2 | (Reddy et al. 2017) |
265
-| [NLRP5](NLRP5) | 2 | (Morin et al. 2013) |
266
-| [NLRP8](NLRP8) | 2 | (Chapuy et al. 2018) |
267
-| [ODZ3](ODZ3) | 2 | (Morin et al. 2013) |
268
-| [P2RX5](P2RX5) | 2 | (Morin et al. 2013) |
269
-| [PAPOLG](PAPOLG) | 2 | (Schmitz et al. 2018) |
270
-| [PASK](PASK) | 2 | (Morin et al. 2013) |
271
-| [PAX5](PAX5) | 2 | (L. Pasqualucci et al. 2001) |
272
-| [PCDHB11](PCDHB11) | 2 | (Morin et al. 2013) |
273
-| [PCLO](PCLO) | 2 | (Lohr et al. 2012) |
274
-| [PDE4DIP](PDE4DIP) | 2 | (Chapuy et al. 2018) |
275
-| [PDS5B](PDS5B) | 2 | (Morin et al. 2013; Hübschmann et al. 2021) |
276
-| [PHF6](PHF6) | 2 | (Reddy et al. 2017) |
277
-| [PIK3CD](PIK3CD) | 2 | (Reddy et al. 2017) |
278
-| [PIK3R1](PIK3R1) | 2 | (Zhang et al. 2013) |
279
-| [PKD1](PKD1) | 2 | (Morin et al. 2013) |
280
-| [PNPO](PNPO) | 2 | (Hübschmann et al. 2021) |
281
-| [POGZ](POGZ) | 2 | (Morin et al. 2013) |
282
-| [PPP1R9B](PPP1R9B) | 2 | |
283
-| [PRKCB](PRKCB) | 2 | (Morin et al. 2013) |
284
-| [PRPS1](PRPS1) | 2 | (Chapuy et al. 2018) |
285
-| [PTMA](PTMA) | 2 | |
286
-| [PTPN1](PTPN1) | 2 | |
287
-| [PTPN23](PTPN23) | 2 | (Morin et al. 2013) |
288
-| [PTPN6](PTPN6) | 2 | (Reddy et al. 2017) |
289
-| [PTPRK](PTPRK) | 2 | (Reddy et al. 2017) |
290
-| [RAC2](RAC2) | 2 | (Hübschmann et al. 2021) |
291
-| [RAD9A](RAD9A) | 2 | (Chapuy et al. 2018) |
292
-| [RARA](RARA) | 2 | (Reddy et al. 2017) |
293
-| [RCC](RCC) | 2 | |
294
-| [RFTN1](RFTN1) | 2 | (Arthur et al. 2018) |
295
-| [RHEX](RHEX) | 2 | |
296
-| [RHOH](RHOH) | 2 | |
297
-| [RUBCNL](RUBCNL) | 2 | |
298
-| [RUNX1](RUNX1) | 2 | (Reddy et al. 2017) |
299
-| [SAMD9L](SAMD9L) | 2 | (Morin et al. 2013) |
300
-| [SARM1](SARM1) | 2 | (Morin et al. 2013) |
301
-| [SEL1L3](SEL1L3) | 2 | |
302
-| [SEPTIN9](SEPTIN9) | 2 | |
303
-| [SERPINA9](SERPINA9) | 2 | (Arthur et al. 2018) |
304
-| [SETD2](SETD2) | 2 | (Zhang et al. 2013) |
305
-| [SETD5](SETD5) | 2 | (Reddy et al. 2017) |
306
-| [SIAH2](SIAH2) | 2 | (Hübschmann et al. 2021) |
307
-| [SLC34A2](SLC34A2) | 2 | (Hübschmann et al. 2021) |
308
-| [SMEK1](SMEK1) | 2 | (Chapuy et al. 2018) |
309
-| [SRRM2](SRRM2) | 2 | (Morin et al. 2013; Russler-Germain et al. 2023) |
310
-| [ST6GAL1](ST6GAL1) | 2 | (Arthur et al. 2018) |
311
-| [STAT5B](STAT5B) | 2 | (Zhang et al. 2013) |
312
-| [SYK](SYK) | 2 | (Reddy et al. 2017) |
313
-| [SYPL1](SYPL1) | 2 | (Morin et al. 2013) |
314
-| [TAP1](TAP1) | 2 | (Schmitz et al. 2018) |
315
-| [TBC1D4](TBC1D4) | 2 | (Arthur et al. 2018) |
316
-| [TCL1A](TCL1A) | 2 | |
317
-| [TGFBR2](TGFBR2) | 2 | (Reddy et al. 2017) |
318
-| [TIPARP](TIPARP) | 2 | (Reddy et al. 2017) |
319
-| [TLR2](TLR2) | 2 | (Chapuy et al. 2018) |
320
-| [TRAF3](TRAF3) | 2 | (Laura Pasqualucci, Trifonov, et al. 2011) |
321
-| [TRAF6](TRAF6) | 2 | (Hübschmann et al. 2021) |
322
-| [UBE2J1](UBE2J1) | 2 | |
323
-| [UBR5](UBR5) | 2 | (Zhang et al. 2013) |
324
-| [UNC5B](UNC5B) | 2 | (Hübschmann et al. 2021) |
325
-| [UNC5D](UNC5D) | 2 | |
326
-| [WAC](WAC) | 2 | (Reddy et al. 2017) |
327
-| [WDFY3](WDFY3) | 2 | (Morin et al. 2013) |
328
-| [WNK1](WNK1) | 2 | (Hübschmann et al. 2021) |
329
-| [XBP1](XBP1) | 2 | |
330
-| [YY1](YY1) | 2 | (Reddy et al. 2017) |
331
-| [ZBTB7A](ZBTB7A) | 2 | (Reddy et al. 2017) |
332
-| [ZCCHC7](ZCCHC7) | 2 | (Arthur et al. 2018) |
333
-| [ZEB2](ZEB2) | 2 | (Zhang et al. 2013) |
334
-| [ZFAT](ZFAT) | 2 | (Reddy et al. 2017) |
335
-| [ZFX](ZFX) | 2 | (Reddy et al. 2017) |
336
-| [ZNF217](ZNF217) | 2 | (Hübschmann et al. 2021) |
337
-| [ZNF423](ZNF423) | 2 | (Chapuy et al. 2018) |
164
+| Gene | Tier | Relevant references |
165
+|:----------------------:|:----:|:-----------------------------------------------------------:|
166
+| [ABI3BP](ABI3BP) | 2 | (Morin et al. 2013) |
167
+| [ADAMTS1](ADAMTS1) | 2 | (Hübschmann et al. 2021) |
168
+| [AICDA](AICDA) | 2 | (Arthur et al. 2018) |
169
+| [ANKRD12](ANKRD12) | 2 | (Hübschmann et al. 2021) |
170
+| [ANKRD17](ANKRD17) | 2 | (Reddy et al. 2017) |
171
+| [ARID1B](ARID1B) | 2 | (Reddy et al. 2017) |
172
+| [ARID5B](ARID5B) | 2 | (Reddy et al. 2017) |
173
+| [ATR](ATR) | 2 | (Reddy et al. 2017) |
174
+| [BIRC3](BIRC3) | 2 | (Arthur et al. 2018) |
175
+| [BLK](BLK) | 2 | |
176
+| [BRINP3](BRINP3) | 2 | (Reddy et al. 2017) |
177
+| [BTBD3](BTBD3) | 2 | (Reddy et al. 2017) |
178
+| [CADPS2](CADPS2) | 2 | (Hübschmann et al. 2021) |
179
+| [CBLB](CBLB) | 2 | (Reddy et al. 2017) |
180
+| [CCL4](CCL4) | 2 | (Chapuy et al. 2018) |
181
+| [CD22](CD22) | 2 | (Reddy et al. 2017) |
182
+| [CD44](CD44) | 2 | (Arthur et al. 2018) |
183
+| [CD74](CD74) | 2 | (Arthur et al. 2018) |
184
+| [CDC73](CDC73) | 2 | (Reddy et al. 2017; Love et al. 2012) |
185
+| [CDH9](CDH9) | 2 | (Morin et al. 2013) |
186
+| [CHD1](CHD1) | 2 | (Reddy et al. 2017) |
187
+| [CHD8](CHD8) | 2 | (Reddy et al. 2017; Grande et al. 2019) |
188
+| [CHST2](CHST2) | 2 | (Reddy et al. 2017) |
189
+| [CNOT2](CNOT2) | 2 | (Hübschmann et al. 2021) |
190
+| [CNTNAP5](CNTNAP5) | 2 | (Morin et al. 2013) |
191
+| [COQ7](COQ7) | 2 | (Chapuy et al. 2018) |
192
+| [CRIP1](CRIP1) | 2 | (Chapuy et al. 2018) |
193
+| [DCAF6](DCAF6) | 2 | (Reddy et al. 2017) |
194
+| [DDX10](DDX10) | 2 | (Reddy et al. 2017) |
195
+| [DHX16](DHX16) | 2 | (Hübschmann et al. 2021) |
196
+| [DICER1](DICER1) | 2 | (Reddy et al. 2017) |
197
+| [DNAH5](DNAH5) | 2 | (Morin et al. 2013) |
198
+| [DNM2](DNM2) | 2 | (Hübschmann et al. 2021) |
199
+| [DNMT3A](DNMT3A) | 2 | (Reddy et al. 2017) |
200
+| [DOCK1](DOCK1) | 2 | (Chapuy et al. 2018) |
201
+| [DSG4](DSG4) | 2 | (Morin et al. 2013) |
202
+| [EIF2AK3](EIF2AK3) | 2 | |
203
+| [EZR](EZR) | 2 | |
204
+| [FAM102A](FAM102A) | 2 | |
205
+| [FAM38B](FAM38B) | 2 | (Morin et al. 2013) |
206
+| [FANK1](FANK1) | 2 | |
207
+| [FAT4](FAT4) | 2 | (Morin et al. 2013) |
208
+| [FCRL3](FCRL3) | 2 | |
209
+| [FNBP1](FNBP1) | 2 | |
210
+| [FNDC1](FNDC1) | 2 | (Morin et al. 2013) |
211
+| [FOXP1](FOXP1) | 2 | (Reddy et al. 2017) |
212
+| [FUBP1](FUBP1) | 2 | (Reddy et al. 2017) |
213
+| [FUT5](FUT5) | 2 | (Chapuy et al. 2018) |
214
+| [GABRA2](GABRA2) | 2 | (Chapuy et al. 2018) |
215
+| [GAK](GAK) | 2 | (Hübschmann et al. 2021) |
216
+| [GNAS](GNAS) | 2 | (Reddy et al. 2017) |
217
+| [GOLGA5](GOLGA5) | 2 | (Reddy et al. 2017) |
218
+| [GPC5](GPC5) | 2 | (Schmitz et al. 2018) |
219
+| [GSG2](GSG2) | 2 | (Schmitz et al. 2018) |
220
+| [HDAC7](HDAC7) | 2 | (Morin et al. 2013) |
221
+| [HIST1H2AG](HIST1H2AG) | 2 | (Morin et al. 2013; Krysiak et al. 2017; Panea et al. 2019) |
222
+| [HNF1B](HNF1B) | 2 | (Laura Pasqualucci, Trifonov, et al. 2011) |
223
+| [HRAS](HRAS) | 2 | (Reddy et al. 2017) |
224
+| [ID3](ID3) | 2 | (Schmitz et al. 2012; Richter et al. 2012) |
225
+| [IER2](IER2) | 2 | (Morin et al. 2013) |
226
+| [IFNGR1](IFNGR1) | 2 | (Morin et al. 2013) |
227
+| [IGLL5](IGLL5) | 2 | (Russler-Germain et al. 2023; Panea et al. 2019) |
228
+| [IKBKB](IKBKB) | 2 | (Reddy et al. 2017) |
229
+| [IKBKE](IKBKE) | 2 | (Hübschmann et al. 2021) |
230
+| [IL6](IL6) | 2 | (Chapuy et al. 2018) |
231
+| [INO80](INO80) | 2 | (Zhang et al. 2013) |
232
+| [IRAG2](IRAG2) | 2 | |
233
+| [IRF1](IRF1) | 2 | (Hübschmann et al. 2021) |
234
+| [JAK1](JAK1) | 2 | (Zhang et al. 2013) |
235
+| [JAK3](JAK3) | 2 | (Zhang et al. 2013) |
236
+| [KCMF1](KCMF1) | 2 | (Reddy et al. 2017) |
237
+| [KLHL21](KLHL21) | 2 | (Schmitz et al. 2018) |
238
+| [LAMA5](LAMA5) | 2 | (Schmitz et al. 2018) |
239
+| [LAPTM5](LAPTM5) | 2 | (Hübschmann et al. 2021) |
240
+| [LIN54](LIN54) | 2 | (Reddy et al. 2017) |
241
+| [LPP](LPP) | 2 | (Arthur et al. 2018) |
242
+| [LRP12](LRP12) | 2 | (Hübschmann et al. 2021) |
243
+| [LRRN3](LRRN3) | 2 | (Morin et al. 2013) |
244
+| [MAGT1](MAGT1) | 2 | (Reddy et al. 2017) |
245
+| [MALAT1](MALAT1) | 2 | (Arthur et al. 2018) |
246
+| [MAP2K1](MAP2K1) | 2 | (Shin et al. 2015; Louissaint et al. 2016) |
247
+| [MAP4K4](MAP4K4) | 2 | (Reddy et al. 2017) |
248
+| [MARK1](MARK1) | 2 | (Reddy et al. 2017) |
249
+| [MECOM](MECOM) | 2 | (Reddy et al. 2017) |
250
+| [MET](MET) | 2 | (Reddy et al. 2017) |
251
+| [MIR142](MIR142) | 2 | (Kwanhian et al. 2012; Grande et al. 2019) |
252
+| [MIR155HG](MIR155HG) | 2 | |
253
+| [MPDZ](MPDZ) | 2 | (Morin et al. 2013) |
254
+| [MSH2](MSH2) | 2 | (Reddy et al. 2017) |
255
+| [MSH6](MSH6) | 2 | (Reddy et al. 2017) |
256
+| [MYB](MYB) | 2 | (Reddy et al. 2017) |
257
+| [MYBPC2](MYBPC2) | 2 | (Schmitz et al. 2018) |
258
+| [MYO1E](MYO1E) | 2 | |
259
+| [N2RF2](N2RF2) | 2 | (Hübschmann et al. 2021) |
260
+| [NANOG](NANOG) | 2 | (Chapuy et al. 2018) |
261
+| [NAV1](NAV1) | 2 | (Chapuy et al. 2018) |
262
+| [NCOA3](NCOA3) | 2 | |
263
+| [NCOR1](NCOR1) | 2 | (Reddy et al. 2017) |
264
+| [NEAT1](NEAT1) | 2 | (Arthur et al. 2018) |
265
+| [NF1](NF1) | 2 | (Reddy et al. 2017) |
266
+| [NFKB2](NFKB2) | 2 | (Reddy et al. 2017) |
267
+| [NLRP5](NLRP5) | 2 | (Morin et al. 2013) |
268
+| [NLRP8](NLRP8) | 2 | (Chapuy et al. 2018) |
269
+| [ODZ3](ODZ3) | 2 | (Morin et al. 2013) |
270
+| [P2RX5](P2RX5) | 2 | (Morin et al. 2013) |
271
+| [PAPOLG](PAPOLG) | 2 | (Schmitz et al. 2018) |
272
+| [PASK](PASK) | 2 | (Morin et al. 2013) |
273
+| [PAX5](PAX5) | 2 | (L. Pasqualucci et al. 2001) |
274
+| [PCDHB11](PCDHB11) | 2 | (Morin et al. 2013) |
275
+| [PCLO](PCLO) | 2 | (Lohr et al. 2012) |
276
+| [PDE4DIP](PDE4DIP) | 2 | (Chapuy et al. 2018) |
277
+| [PDS5B](PDS5B) | 2 | (Morin et al. 2013; Hübschmann et al. 2021) |
278
+| [PHF6](PHF6) | 2 | (Reddy et al. 2017; Thomas et al. 2023) |
279
+| [PIK3CD](PIK3CD) | 2 | (Reddy et al. 2017) |
280
+| [PIK3R1](PIK3R1) | 2 | (Zhang et al. 2013; Panea et al. 2019) |
281
+| [PKD1](PKD1) | 2 | (Morin et al. 2013) |
282
+| [PNPO](PNPO) | 2 | (Hübschmann et al. 2021) |
283
+| [POGZ](POGZ) | 2 | (Morin et al. 2013) |
284
+| [PPP1R9B](PPP1R9B) | 2 | |
285
+| [PRKCB](PRKCB) | 2 | (Morin et al. 2013) |
286
+| [PRPS1](PRPS1) | 2 | (Chapuy et al. 2018) |
287
+| [PTMA](PTMA) | 2 | |
288
+| [PTPN1](PTPN1) | 2 | |
289
+| [PTPN23](PTPN23) | 2 | (Morin et al. 2013) |
290
+| [PTPN6](PTPN6) | 2 | (Reddy et al. 2017) |
291
+| [PTPRK](PTPRK) | 2 | (Reddy et al. 2017) |
292
+| [RAC2](RAC2) | 2 | (Hübschmann et al. 2021; Panea et al. 2019) |
293
+| [RAD9A](RAD9A) | 2 | (Chapuy et al. 2018) |
294
+| [RARA](RARA) | 2 | (Reddy et al. 2017) |
295
+| [RCC](RCC) | 2 | |
296
+| [RFTN1](RFTN1) | 2 | (Arthur et al. 2018) |
297
+| [RHEX](RHEX) | 2 | |
298
+| [RHOH](RHOH) | 2 | |
299
+| [RUBCNL](RUBCNL) | 2 | |
300
+| [RUNX1](RUNX1) | 2 | (Reddy et al. 2017) |
301
+| [SAMD9L](SAMD9L) | 2 | (Morin et al. 2013) |
302
+| [SARM1](SARM1) | 2 | (Morin et al. 2013) |
303
+| [SEL1L3](SEL1L3) | 2 | |
304
+| [SEPTIN9](SEPTIN9) | 2 | |
305
+| [SERPINA9](SERPINA9) | 2 | (Arthur et al. 2018) |
306
+| [SETD2](SETD2) | 2 | (Zhang et al. 2013) |
307
+| [SETD5](SETD5) | 2 | (Reddy et al. 2017) |
308
+| [SIAH2](SIAH2) | 2 | (Hübschmann et al. 2021) |
309
+| [SLC34A2](SLC34A2) | 2 | (Hübschmann et al. 2021) |
310
+| [SMEK1](SMEK1) | 2 | (Chapuy et al. 2018) |
311
+| [SRRM2](SRRM2) | 2 | (Morin et al. 2013; Russler-Germain et al. 2023) |
312
+| [ST6GAL1](ST6GAL1) | 2 | (Arthur et al. 2018) |
313
+| [STAT5B](STAT5B) | 2 | (Zhang et al. 2013) |
314
+| [SYK](SYK) | 2 | (Reddy et al. 2017) |
315
+| [SYPL1](SYPL1) | 2 | (Morin et al. 2013) |
316
+| [TAP1](TAP1) | 2 | (Schmitz et al. 2018) |
317
+| [TBC1D4](TBC1D4) | 2 | (Arthur et al. 2018) |
318
+| [TCL1A](TCL1A) | 2 | (Grande et al. 2019) |
319
+| [TGFBR2](TGFBR2) | 2 | (Reddy et al. 2017) |
320
+| [TIPARP](TIPARP) | 2 | (Reddy et al. 2017) |
321
+| [TLR2](TLR2) | 2 | (Chapuy et al. 2018) |
322
+| [TRAF3](TRAF3) | 2 | (Laura Pasqualucci, Trifonov, et al. 2011) |
323
+| [TRAF6](TRAF6) | 2 | (Hübschmann et al. 2021) |
324
+| [UBE2J1](UBE2J1) | 2 | |
325
+| [UBR5](UBR5) | 2 | (Zhang et al. 2013) |
326
+| [UNC5B](UNC5B) | 2 | (Hübschmann et al. 2021) |
327
+| [UNC5D](UNC5D) | 2 | |
328
+| [WAC](WAC) | 2 | (Reddy et al. 2017) |
329
+| [WDFY3](WDFY3) | 2 | (Morin et al. 2013) |
330
+| [WNK1](WNK1) | 2 | (Hübschmann et al. 2021; Thomas et al. 2023) |
331
+| [XBP1](XBP1) | 2 | |
332
+| [YY1](YY1) | 2 | (Reddy et al. 2017) |
333
+| [ZBTB7A](ZBTB7A) | 2 | (Reddy et al. 2017; Burkhardt et al. 2022) |
334
+| [ZCCHC7](ZCCHC7) | 2 | (Arthur et al. 2018) |
335
+| [ZEB2](ZEB2) | 2 | (Zhang et al. 2013) |
336
+| [ZFAT](ZFAT) | 2 | (Reddy et al. 2017) |
337
+| [ZFX](ZFX) | 2 | (Reddy et al. 2017) |
338
+| [ZNF217](ZNF217) | 2 | (Hübschmann et al. 2021) |
339
+| [ZNF423](ZNF423) | 2 | (Chapuy et al. 2018) |
338 340
339 341
# References
340 342
... ...
@@ -370,6 +372,17 @@ Lymphoma.” *Leukemia* 27 (3): 671–79.
370 372
371 373
</div>
372 374
375
+<div id="ref-burkhardtClinicalRelevanceMolecular2022b"
376
+class="csl-entry">
377
+
378
+Burkhardt, Birgit, Ulf Michgehl, Jonas Rohde, Tabea Erdmann, Philipp
379
+Berning, Katrin Reutter, Marius Rohde, et al. 2022. “Clinical Relevance
380
+of Molecular Characteristics in Burkitt Lymphoma Differs According to
381
+Age.” *Nature Communications* 13 (1): 3881.
382
+<https://doi.org/10.1038/s41467-022-31355-8>.
383
+
384
+</div>
385
+
373 386
<div id="ref-chapuyMolecularSubtypesDiffuse2018b" class="csl-entry">
374 387
375 388
Chapuy, Bjoern, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas
... ...
@@ -410,6 +423,16 @@ S. Hung, Elizabeth Chavez, Katsuyoshi Takata, et al. 2021.
410 423
411 424
</div>
412 425
426
+<div id="ref-grandeGenomewideDiscoverySomatic2019" class="csl-entry">
427
+
428
+Grande, Bruno M., Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner,
429
+Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, et al. 2019.
430
+“Genome-Wide Discovery of Somatic Coding and Noncoding Mutations in
431
+Pediatric Endemic and Sporadic Burkitt Lymphoma.” *Blood* 133 (12):
432
+1313–24. <https://doi.org/10.1182/blood-2018-09-871418>.
433
+
434
+</div>
435
+
413 436
<div id="ref-hubschmannMutationalMechanismsShaping2021b"
414 437
class="csl-entry">
415 438
... ...
@@ -422,6 +445,14 @@ Germinal Center Derived <span class="nocase">B-cell</span> Lymphomas.”
422 445
423 446
</div>
424 447
448
+<div id="ref-johnstonCmycHypermutationBurkitt1992" class="csl-entry">
449
+
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453
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... ...
@@ -497,6 +528,15 @@ Lymphoma with Frequent MAPK Pathway Mutations.” *Blood* 128 (8):
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+Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of
535
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537
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@@ -550,6 +590,15 @@ Lymphoma Using Whole-Genome Sequencing.” *Blood* 122 (7): 1256–65.
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... ...
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@@ -643,6 +700,16 @@ and Functional Drivers of Diffuse Large B Cell Lymphoma.” *Cell* 171
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</div>
FL_genes_with_bib.md
... ...
@@ -1,130 +1,132 @@
1 1
# FL genes
2 2
3
+## Origins of FL genes![sankey](FL_sankey-1.svg)
4
+
3 5
## Tier 1 FL genes
4 6
5
-| Gene | Tier | Relevant references |
6
-|:----------------------:|:----:|:------------------------------------------------:|
7
-| [ACTB](ACTB) | 1 | (Lohr et al. 2012) |
8
-| [ARID1A](ARID1A) | 1 | (Krysiak et al. 2017; Zhang et al. 2013) |
9
-| [ATP6AP1](ATP6AP1) | 1 | (Okosun et al. 2016) |
10
-| [ATP6V1B2](ATP6V1B2) | 1 | (Okosun et al. 2016) |
11
-| [B2M](B2M) | 1 | (Morin et al. 2011) |
12
-| [BCL2](BCL2) | 1 | (Morin et al. 2011; Tanaka et al. 1992) |
13
-| [BCL6](BCL6) | 1 | (Morin et al. 2011) |
14
-| [BCL7A](BCL7A) | 1 | (Krysiak et al. 2017; Arthur et al. 2018) |
15
-| [BIRC6](BIRC6) | 1 | (Reddy et al. 2017) |
16
-| [BTG1](BTG1) | 1 | (Morin et al. 2011) |
17
-| [BTG2](BTG2) | 1 | (Morin et al. 2011) |
18
-| [BTK](BTK) | 1 | (Krysiak et al. 2017; Albuquerque et al. 2017) |
19
-| [CARD11](CARD11) | 1 | (Morin et al. 2011; Lenz et al. 2008) |
20
-| [CCND3](CCND3) | 1 | (Morin et al. 2011) |
21
-| [CD83](CD83) | 1 | (Russler-Germain et al. 2023; Morin et al. 2013) |
22
-| [CREBBP](CREBBP) | 1 | (Laura Pasqualucci, Dominguez-Sola, et al. 2011) |
23
-| [CTSS](CTSS) | 1 | (Bararia et al. 2020) |
24
-| [DTX1](DTX1) | 1 | (Schmitz et al. 2018) |
25
-| [EBF1](EBF1) | 1 | (Bohle et al. 2013) |
26
-| [EEF1A1](EEF1A1) | 1 | (Hübschmann et al. 2021) |
27
-| [EP300](EP300) | 1 | (Laura Pasqualucci, Dominguez-Sola, et al. 2011) |
28
-| [EZH2](EZH2) | 1 | (Morin et al. 2010) |
29
-| [FAS](FAS) | 1 | (Scholl et al. 2007) |
30
-| [FOXO1](FOXO1) | 1 | (Morin et al. 2011) |
31
-| [GNA13](GNA13) | 1 | (Morin et al. 2011) |
32
-| [GNAI2](GNAI2) | 1 | (Morin et al. 2013) |
33
-| [HIST1H1B](HIST1H1B) | 1 | (Krysiak et al. 2017; Chapuy et al. 2018) |
34
-| [HIST1H1C](HIST1H1C) | 1 | (Morin et al. 2011) |
35
-| [HIST1H1D](HIST1H1D) | 1 | (Krysiak et al. 2017; Morin et al. 2013) |
36
-| [HIST1H1E](HIST1H1E) | 1 | (Krysiak et al. 2017; Morin et al. 2013) |
37
-| [HIST1H2AC](HIST1H2AC) | 1 | (Krysiak et al. 2017; Morin et al. 2013) |
38
-| [HIST1H2AG](HIST1H2AG) | 1 | (Krysiak et al. 2017; Morin et al. 2013) |
39
-| [HIST1H2AM](HIST1H2AM) | 1 | (Krysiak et al. 2017) |
40
-| [HIST1H2BC](HIST1H2BC) | 1 | (Krysiak et al. 2017; Reddy et al. 2017) |
41
-| [HIST1H2BD](HIST1H2BD) | 1 | (Krysiak et al. 2017) |
42
-| [HIST1H2BG](HIST1H2BG) | 1 | (Krysiak et al. 2017) |
43
-| [HIST1H3B](HIST1H3B) | 1 | (Zhang et al. 2013) |
44
-| [HIST1H3G](HIST1H3G) | 1 | (Krysiak et al. 2017) |
45
-| [HVCN1](HVCN1) | 1 | (Krysiak et al. 2017) |
46
-| [IRF4](IRF4) | 1 | (Morin et al. 2011) |
47
-| [IRF8](IRF8) | 1 | (Morin et al. 2011) |
48
-| [ITPKB](ITPKB) | 1 | (Schmitz et al. 2018) |
49
-| [KLF2](KLF2) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011) |
50
-| [KLHL6](KLHL6) | 1 | (Morin et al. 2011) |
51
-| [KMT2D](KMT2D) | 1 | (Morin et al. 2011) |
52
-| [LTB](LTB) | 1 | (Chapuy et al. 2018) |
53
-| [MAP2K1](MAP2K1) | 1 | (Louissaint et al. 2016; Shin et al. 2015) |
54
-| [MEF2B](MEF2B) | 1 | (Morin et al. 2011) |
55
-| [MEF2C](MEF2C) | 1 | (Arthur et al. 2018) |
56
-| [PCLO](PCLO) | 1 | (Lohr et al. 2012) |
57
-| [PIM1](PIM1) | 1 | (L. Pasqualucci et al. 2001) |
58
-| [POU2AF1](POU2AF1) | 1 | (Krysiak et al. 2017) |
59
-| [POU2F2](POU2F2) | 1 | (Krysiak et al. 2017; Zhang et al. 2013) |
60
-| [PTPRD](PTPRD) | 1 | |
61
-| [RRAGC](RRAGC) | 1 | (Okosun et al. 2016) |
62
-| [S1PR2](S1PR2) | 1 | (Morin et al. 2011) |
63
-| [SGK1](SGK1) | 1 | (Morin et al. 2011) |
64
-| [SMARCA4](SMARCA4) | 1 | (Krysiak et al. 2017; Zhang et al. 2013) |
65
-| [SOCS1](SOCS1) | 1 | (Morin et al. 2011) |
66
-| [STAT6](STAT6) | 1 | (Yildiz et al. 2015) |
67
-| [TBL1XR1](TBL1XR1) | 1 | (Mareschal et al. 2016) |
68
-| [TMSB4X](TMSB4X) | 1 | (Albuquerque et al. 2017) |
69
-| [TNFAIP3](TNFAIP3) | 1 | (Compagno et al. 2009) |
70
-| [TNFRSF14](TNFRSF14) | 1 | (Cheung et al. 2010) |
71
-| [TP53](TP53) | 1 | (Morin et al. 2011) |
72
-| [VMA21](VMA21) | 1 | (Hübschmann et al. 2021) |
7
+| Gene | Tier | Relevant references |
8
+|:----------------------:|:----:|:-------------------------------------------------------------------:|
9
+| [ACTB](ACTB) | 1 | (Lohr et al. 2012) |
10
+| [ARID1A](ARID1A) | 1 | (Krysiak et al. 2017; Zhang et al. 2013; Love et al. 2012) |
11
+| [ATP6AP1](ATP6AP1) | 1 | (Okosun et al. 2016) |
12
+| [ATP6V1B2](ATP6V1B2) | 1 | (Okosun et al. 2016) |
13
+| [B2M](B2M) | 1 | (Morin et al. 2011) |
14
+| [BCL2](BCL2) | 1 | (Morin et al. 2011; Tanaka et al. 1992; Burkhardt et al. 2022) |
15
+| [BCL6](BCL6) | 1 | (Morin et al. 2011; Love et al. 2012) |
16
+| [BCL7A](BCL7A) | 1 | (Krysiak et al. 2017; Arthur et al. 2018; Grande et al. 2019) |
17
+| [BIRC6](BIRC6) | 1 | (Reddy et al. 2017) |
18
+| [BTG1](BTG1) | 1 | (Morin et al. 2011; Burkhardt et al. 2022) |
19
+| [BTG2](BTG2) | 1 | (Morin et al. 2011; Love et al. 2012) |
20
+| [BTK](BTK) | 1 | (Krysiak et al. 2017; Albuquerque et al. 2017) |
21
+| [CARD11](CARD11) | 1 | (Morin et al. 2011; Lenz et al. 2008; Panea et al. 2019) |
22
+| [CCND3](CCND3) | 1 | (Morin et al. 2011; Richter et al. 2012) |
23
+| [CD83](CD83) | 1 | (Russler-Germain et al. 2023; Morin et al. 2013; Panea et al. 2019) |
24
+| [CREBBP](CREBBP) | 1 | (Laura Pasqualucci, Dominguez-Sola, et al. 2011; Love et al. 2012) |
25
+| [CTSS](CTSS) | 1 | (Bararia et al. 2020) |
26
+| [DTX1](DTX1) | 1 | (Schmitz et al. 2018; Panea et al. 2019) |
27
+| [EBF1](EBF1) | 1 | \[Bohle et al. (2013); @\] |
28
+| [EEF1A1](EEF1A1) | 1 | (Hübschmann et al. 2021) |
29
+| [EP300](EP300) | 1 | \[Laura Pasqualucci, Dominguez-Sola, et al. (2011); @\] |
30
+| [EZH2](EZH2) | 1 | (Morin et al. 2010; Love et al. 2012) |
31
+| [FAS](FAS) | 1 | (Scholl et al. 2007) |
32
+| [FOXO1](FOXO1) | 1 | (Morin et al. 2011; Schmitz et al. 2012) |
33
+| [GNA13](GNA13) | 1 | (Morin et al. 2011; Love et al. 2012) |
34
+| [GNAI2](GNAI2) | 1 | (Morin et al. 2013; Grande et al. 2019) |
35
+| [HIST1H1B](HIST1H1B) | 1 | (Krysiak et al. 2017; Chapuy et al. 2018) |
36
+| [HIST1H1C](HIST1H1C) | 1 | (Morin et al. 2011; Panea et al. 2019) |
37
+| [HIST1H1D](HIST1H1D) | 1 | (Krysiak et al. 2017; Morin et al. 2013) |
38
+| [HIST1H1E](HIST1H1E) | 1 | (Krysiak et al. 2017; Morin et al. 2013; Grande et al. 2019) |
39
+| [HIST1H2AC](HIST1H2AC) | 1 | (Krysiak et al. 2017; Morin et al. 2013) |
40
+| [HIST1H2AG](HIST1H2AG) | 1 | (Krysiak et al. 2017; Morin et al. 2013; Panea et al. 2019) |
41
+| [HIST1H2AM](HIST1H2AM) | 1 | (Krysiak et al. 2017; Panea et al. 2019) |
42
+| [HIST1H2BC](HIST1H2BC) | 1 | (Krysiak et al. 2017; Reddy et al. 2017) |
43
+| [HIST1H2BD](HIST1H2BD) | 1 | (Krysiak et al. 2017) |
44
+| [HIST1H2BG](HIST1H2BG) | 1 | (Krysiak et al. 2017) |
45
+| [HIST1H3B](HIST1H3B) | 1 | (Zhang et al. 2013) |
46
+| [HIST1H3G](HIST1H3G) | 1 | (Krysiak et al. 2017) |
47
+| [HVCN1](HVCN1) | 1 | (Krysiak et al. 2017) |
48
+| [IRF4](IRF4) | 1 | (Morin et al. 2011) |
49
+| [IRF8](IRF8) | 1 | (Morin et al. 2011; Panea et al. 2019) |
50
+| [ITPKB](ITPKB) | 1 | (Schmitz et al. 2018) |
51
+| [KLF2](KLF2) | 1 | (Laura Pasqualucci, Trifonov, et al. 2011) |
52
+| [KLHL6](KLHL6) | 1 | \[Morin et al. (2011); @\] |
53
+| [KMT2D](KMT2D) | 1 | (Morin et al. 2011; Grande et al. 2019) |
54
+| [LTB](LTB) | 1 | \[Chapuy et al. (2018); @\] |
55
+| [MAP2K1](MAP2K1) | 1 | (Louissaint et al. 2016; Shin et al. 2015) |
56
+| [MEF2B](MEF2B) | 1 | \[Morin et al. (2011); @\] |
57
+| [MEF2C](MEF2C) | 1 | (Arthur et al. 2018) |
58
+| [PCLO](PCLO) | 1 | (Lohr et al. 2012) |
59
+| [PIM1](PIM1) | 1 | (L. Pasqualucci et al. 2001; Burkhardt et al. 2022) |
60
+| [POU2AF1](POU2AF1) | 1 | (Krysiak et al. 2017) |
61
+| [POU2F2](POU2F2) | 1 | (Krysiak et al. 2017; Zhang et al. 2013) |
62
+| [PTPRD](PTPRD) | 1 | |
63
+| [RRAGC](RRAGC) | 1 | (Okosun et al. 2016) |
64
+| [S1PR2](S1PR2) | 1 | (Morin et al. 2011; Muppidi et al. 2014) |
65
+| [SGK1](SGK1) | 1 | (Morin et al. 2011) |
66
+| [SMARCA4](SMARCA4) | 1 | (Krysiak et al. 2017; Zhang et al. 2013; Richter et al. 2012) |
67
+| [SOCS1](SOCS1) | 1 | (Morin et al. 2011) |
68
+| [STAT6](STAT6) | 1 | (Yildiz et al. 2015) |
69
+| [TBL1XR1](TBL1XR1) | 1 | (Mareschal et al. 2016) |
70
+| [TMSB4X](TMSB4X) | 1 | (Albuquerque et al. 2017) |
71
+| [TNFAIP3](TNFAIP3) | 1 | (Compagno et al. 2009) |
72
+| [TNFRSF14](TNFRSF14) | 1 | (Cheung et al. 2010) |
73
+| [TP53](TP53) | 1 | (Morin et al. 2011; Wilda et al. 2004) |
74
+| [VMA21](VMA21) | 1 | (Hübschmann et al. 2021) |
73 75
74 76
## Tier 2 FL genes
75 77
76
-| Gene | Tier | Relevant references |
77
-|:----------------------:|:----:|:------------------------------------------------:|
78
-| [ABL2](ABL2) | 2 | (Russler-Germain et al. 2023) |
79
-| [ACTG1](ACTG1) | 2 | (Hübschmann et al. 2021) |
80
-| [ATP6V1A](ATP6V1A) | 2 | (Hübschmann et al. 2021) |
81
-| [BCL10](BCL10) | 2 | (Russler-Germain et al. 2023; Morin et al. 2011) |
82
-| [CCDC42BPB](CCDC42BPB) | 2 | (Hübschmann et al. 2021) |
83
-| [CD70](CD70) | 2 | (Russler-Germain et al. 2023; Morin et al. 2011) |
84
-| [CD79B](CD79B) | 2 | (Morin et al. 2011) |
85
-| [CILP](CILP) | 2 | (Russler-Germain et al. 2023) |
86
-| [CPNE8](CPNE8) | 2 | (Hübschmann et al. 2021) |
87
-| [CXCR4](CXCR4) | 2 | (Krysiak et al. 2017; Khodabakhshi et al. 2012) |
88
-| [CYP2A6](CYP2A6) | 2 | (Russler-Germain et al. 2023) |
89
-| [DDX3X](DDX3X) | 2 | (Schmitz et al. 2018) |
90
-| [DHX15](DHX15) | 2 | (Hübschmann et al. 2021) |
91
-| [DUSP2](DUSP2) | 2 | (Morin et al. 2013) |
92
-| [EGR1](EGR1) | 2 | (Krysiak et al. 2017) |
93
-| [FZR1](FZR1) | 2 | (Hübschmann et al. 2021) |
94
-| [GBP7](GBP7) | 2 | (Russler-Germain et al. 2023) |
95
-| [GRM6](GRM6) | 2 | (Russler-Germain et al. 2023) |
96
-| [HIST1H2BM](HIST1H2BM) | 2 | (Krysiak et al. 2017) |
97
-| [HIST1H3I](HIST1H3I) | 2 | (Krysiak et al. 2017) |
98
-| [HLA-B](HLA-B) | 2 | |
99
-| [HNRNPD](HNRNPD) | 2 | |
100
-| [IGLL5](IGLL5) | 2 | (Russler-Germain et al. 2023) |
101
-| [JUP](JUP) | 2 | (Hübschmann et al. 2021) |
102
-| [KIR3DL1](KIR3DL1) | 2 | (Russler-Germain et al. 2023) |
103
-| [LAPTM5](LAPTM5) | 2 | (Hübschmann et al. 2021) |
104
-| [MAGEC1](MAGEC1) | 2 | (Russler-Germain et al. 2023) |
105
-| [MAP7D1](MAP7D1) | 2 | (Russler-Germain et al. 2023) |
106
-| [MGEA5](MGEA5) | 2 | (Hübschmann et al. 2021) |
107
-| [MKI67](MKI67) | 2 | (Russler-Germain et al. 2023) |
108
-| [MYC](MYC) | 2 | (L. Pasqualucci et al. 2001) |
109
-| [MYCBP2](MYCBP2) | 2 | (Hübschmann et al. 2021) |
110
-| [MYD88](MYD88) | 2 | (Ngo et al. 2011) |
111
-| [NFKBIA](NFKBIA) | 2 | (Russler-Germain et al. 2023; Lake et al. 2009) |
112
-| [OR8H2](OR8H2) | 2 | (Russler-Germain et al. 2023) |
113
-| [P2RY8](P2RY8) | 2 | (Lohr et al. 2012) |
114
-| [PDS5B](PDS5B) | 2 | (Hübschmann et al. 2021; Morin et al. 2013) |
115
-| [PPP4C](PPP4C) | 2 | (Hübschmann et al. 2021) |
116
-| [PRKDC](PRKDC) | 2 | (Hübschmann et al. 2021; Schmitz et al. 2018) |
117
-| [PZP](PZP) | 2 | (Russler-Germain et al. 2023) |
118
-| [RBM6](RBM6) | 2 | (Hübschmann et al. 2021) |
119
-| [SESN1](SESN1) | 2 | (Oricchio et al. 2017) |
120
-| [SHROOM3](SHROOM3) | 2 | (Russler-Germain et al. 2023) |
121
-| [SRRM2](SRRM2) | 2 | (Russler-Germain et al. 2023; Morin et al. 2013) |
122
-| [STAB2](STAB2) | 2 | (Russler-Germain et al. 2023) |
123
-| [TMEM30A](TMEM30A) | 2 | (Morin et al. 2011) |
124
-| [TPP1](TPP1) | 2 | (Hübschmann et al. 2021) |
125
-| [XIRP2](XIRP2) | 2 | (Russler-Germain et al. 2023) |
126
-| [ZC3H12A](ZC3H12A) | 2 | (Arthur et al. 2018) |
127
-| [ZNF608](ZNF608) | 2 | (Krysiak et al. 2017; Zhang et al. 2013) |
78
+| Gene | Tier | Relevant references |
79
+|:----------------------:|:----:|:------------------------------------------------------------------:|
80
+| [ABL2](ABL2) | 2 | (Russler-Germain et al. 2023) |
81
+| [ACTG1](ACTG1) | 2 | (Hübschmann et al. 2021) |
82
+| [ATP6V1A](ATP6V1A) | 2 | (Hübschmann et al. 2021) |
83
+| [BCL10](BCL10) | 2 | (Russler-Germain et al. 2023; Morin et al. 2011) |
84
+| [CCDC42BPB](CCDC42BPB) | 2 | (Hübschmann et al. 2021) |
85
+| [CD70](CD70) | 2 | (Russler-Germain et al. 2023; Morin et al. 2011) |
86
+| [CD79B](CD79B) | 2 | (Morin et al. 2011; Panea et al. 2019) |
87
+| [CILP](CILP) | 2 | (Russler-Germain et al. 2023) |
88
+| [CPNE8](CPNE8) | 2 | (Hübschmann et al. 2021) |
89
+| [CXCR4](CXCR4) | 2 | (Krysiak et al. 2017; Khodabakhshi et al. 2012; Panea et al. 2019) |
90
+| [CYP2A6](CYP2A6) | 2 | (Russler-Germain et al. 2023) |
91
+| [DDX3X](DDX3X) | 2 | (Schmitz et al. 2018, 2012) |
92
+| [DHX15](DHX15) | 2 | (Hübschmann et al. 2021) |
93
+| [DUSP2](DUSP2) | 2 | (Morin et al. 2013) |
94
+| [EGR1](EGR1) | 2 | (Krysiak et al. 2017) |
95
+| [FZR1](FZR1) | 2 | (Hübschmann et al. 2021) |
96
+| [GBP7](GBP7) | 2 | (Russler-Germain et al. 2023) |
97
+| [GRM6](GRM6) | 2 | (Russler-Germain et al. 2023) |
98
+| [HIST1H2BM](HIST1H2BM) | 2 | (Krysiak et al. 2017) |
99
+| [HIST1H3I](HIST1H3I) | 2 | (Krysiak et al. 2017; Panea et al. 2019) |
100
+| [HLA-B](HLA-B) | 2 | \[@\] |
101
+| [HNRNPD](HNRNPD) | 2 | |
102
+| [IGLL5](IGLL5) | 2 | (Russler-Germain et al. 2023; Panea et al. 2019) |
103
+| [JUP](JUP) | 2 | (Hübschmann et al. 2021) |
104
+| [KIR3DL1](KIR3DL1) | 2 | (Russler-Germain et al. 2023) |
105
+| [LAPTM5](LAPTM5) | 2 | (Hübschmann et al. 2021) |
106
+| [MAGEC1](MAGEC1) | 2 | (Russler-Germain et al. 2023) |
107
+| [MAP7D1](MAP7D1) | 2 | (Russler-Germain et al. 2023) |
108
+| [MGEA5](MGEA5) | 2 | (Hübschmann et al. 2021) |
109
+| [MKI67](MKI67) | 2 | (Russler-Germain et al. 2023; Schmitz et al. 2012) |
110
+| [MYC](MYC) | 2 | (L. Pasqualucci et al. 2001; Johnston and Carroll 1992) |
111
+| [MYCBP2](MYCBP2) | 2 | (Hübschmann et al. 2021) |
112
+| [MYD88](MYD88) | 2 | (Ngo et al. 2011) |
113
+| [NFKBIA](NFKBIA) | 2 | (Russler-Germain et al. 2023; Lake et al. 2009) |
114
+| [OR8H2](OR8H2) | 2 | (Russler-Germain et al. 2023) |
115
+| [P2RY8](P2RY8) | 2 | (Lohr et al. 2012; Muppidi et al. 2014) |
116
+| [PDS5B](PDS5B) | 2 | (Hübschmann et al. 2021; Morin et al. 2013) |
117
+| [PPP4C](PPP4C) | 2 | (Hübschmann et al. 2021) |
118
+| [PRKDC](PRKDC) | 2 | (Hübschmann et al. 2021; Schmitz et al. 2018) |
119
+| [PZP](PZP) | 2 | (Russler-Germain et al. 2023) |
120
+| [RBM6](RBM6) | 2 | (Hübschmann et al. 2021) |
121
+| [SESN1](SESN1) | 2 | (Oricchio et al. 2017) |
122
+| [SHROOM3](SHROOM3) | 2 | (Russler-Germain et al. 2023) |
123
+| [SRRM2](SRRM2) | 2 | (Russler-Germain et al. 2023; Morin et al. 2013) |
124
+| [STAB2](STAB2) | 2 | (Russler-Germain et al. 2023) |
125
+| [TMEM30A](TMEM30A) | 2 | (Morin et al. 2011) |
126
+| [TPP1](TPP1) | 2 | (Hübschmann et al. 2021) |
127
+| [XIRP2](XIRP2) | 2 | (Russler-Germain et al. 2023) |
128
+| [ZC3H12A](ZC3H12A) | 2 | (Arthur et al. 2018) |
129
+| [ZNF608](ZNF608) | 2 | (Krysiak et al. 2017; Zhang et al. 2013) |
128 130
129 131
# References
130 132
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