FAS.md
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# FAS
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## Overview
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-FAS encodes a cell surface receptor involved in the induction of apoptosis. FAS mutations are common in DLBCL and may be more frequent in primary gastric DLBCL.<sup>1</sup>
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+FAS encodes a cell surface receptor involved in the induction of apoptosis. FAS mutations are common in DLBCL and may be more frequent in primary gastric DLBCL.<sup>1,2</sup> Mutations also occur in FL at a lower rate.<sup>3</sup>
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## Relevance tier by entity
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|FL |No |Yes | 0.000 |176.866 |
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-> [!NOTE]
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-> First described in DLBCL in 2007 by [Scholl V](https://pubmed.ncbi.nlm.nih.gov/17487740). First described in FL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
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View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/FAS_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/FAS_protein_hg38.html)
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![image](images/proteinpaint/FAS_NM_000043.svg)
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## References
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1. *Wohlfart, S., Sebinger, D., Gruber, P., Buch, J., Polgar, D., Krupitza, G., Rosner, M., Hengstschläger, M., Raderer, M., Chott, A., & Müllauer, L. (2004). FAS (CD95) mutations are rare in gastric MALT lymphoma but occur more frequently in primary gastric diffuse large B-cell lymphoma.. The American journal of pathology, 164 3, 1081-9 . https://doi.org/10.1016/S0002-9440(10)63195-1.*
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+2. *Scholl V, Stefanoff CG, Hassan R, Spector N, Renault IZ. Mutations within the 5' region of FAS/CD95 gene in nodal diffuse large B-cell lymphoma. Leuk Lymphoma. 2007 May;48(5):957-63. doi: 10.1080/10428190701230858. PMID: 17487740.*
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+3. *Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298-303. doi: 10.1038/nature10351. PMID: 21796119; PMCID: PMC3210554.*