MGA.md
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# MGA
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## Overview
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-MGA acts as a transcriptional repressor and interacts with MYC, a well-known oncogene. Mutations in MGA have been described in DLBCL.<sup>1</sup> One study suggested MGA mutations were more common in DLBCLs in patients of African ancestry.<sup>2</sup>
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+MGA acts as a transcriptional repressor and interacts with MYC, a well-known oncogene. Mutations in MGA have been described in DLBCL.<sup>1</sup> One study suggested MGA mutations were more common in DLBCLs in patients of African ancestry.<sup>2</sup> The mutation pattern in MGA is consistent with a role as a tumour suppressor gene.
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## Relevance tier by entity
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|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
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|:------:|:----:|:---------------------:|:----------------:|:----------------:|
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-|BL |No |No |2.443 | 3.733 |
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|DLBCL |No |No |1.432 |12.504 |
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+|BL |No |No |2.443 | 3.733 |
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|FL |No |No |0.000 | 0.000 |
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-> [!NOTE]
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-> First described in DLBCL in 2013 by [Zhang J](https://pubmed.ncbi.nlm.nih.gov/23292937)
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View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/MGA_protein.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/MGA_protein_hg38.html)
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![image](images/proteinpaint/MGA_NM_001164273.svg)