JUNB.md
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[[_TOC_]]
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+<<Warn("Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)")>>
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## Overview
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JUNB has been reported to be frequently mutated in T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL).<sup>[@schuhmacherJUNBDUSP2SGK12019]</sup> Mutations have also been reported in DLBCL but the mutation rate in the earliest study<sup>[@reddyGeneticFunctionalDrivers2017]</sup> was likely an over-estimate.<sup>[@drevalRevisitingReddyDLBCL2023]</sup> According to one study, mutations are often enriched at somatic hypermutation hotspot sites, indicating the involvement of aberrant somatic hypermutation in the pathogenesis of these lymphomas.<sup>[@schuhmacherJUNBDUSP2SGK12019]</sup>
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[[include:dnds_JUNB.md]]
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-> [!WARNING]
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-> Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)
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[[include:browser_JUNB.md]]
ZFX.md
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[[_TOC_]]
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## Relevance tier by entity
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-> [!WARNING]
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-> Mutations in this gene were reported to be inflated in the original results according to [Dreval K](https://www.biorxiv.org/content/10.1101/2023.11.21.567983v1)
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[[include:browser_ZFX.md]]
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