BTG1.md
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|:--------:|:----------:|:--------:|:------------------------------------------------------------------------------------------:|:------------------:|
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|chr12 |92537999 |92539598|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr12%3A92537999%2D92539598)|active_promoter |
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-> [!NOTE]
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-> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
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## BTG1 Hotspots
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*Q36H* Conditional knock-in mouse models expressing the BTG1 Q36H mutation in B cells have shown that these mutations lead to earlier onset of lymphoma, shorter survival, and dysplastic B cell infiltration into non-lymphoid organs. These findings reinforce the role of BTG1 mutations in enhancing lymphoma aggressiveness.<sup>3</sup>