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**aSHM** - Denotes genes as affected by aberrant somatic hypermutation (aSHM). Tier 1 and Tier 2 genes can have this designation, respectively abbreviated as *1-a* and *2-a*. For example, see [BCL7A](BCL7A).
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+**orphan** - Designates a gene whose mutation pattern has not been reproduced in subsequent comprehensive studies of the same entity. These genes remain in Tier 2 but should be approached with caution.
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```mermaid
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---
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config: