Changes in cb8ca2e: Updated HNRNPU (markdown)

				HNRNPU.md
			
          @@ -1,6 +1,6 @@

           # HNRNPU

           ## Overview

          -HNRNPU is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.

          +HNRNPU is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. Mutations in HNRNPU are haploinsufficient and significantly alter the transcriptome of MYC-driven lymphomas. These mutations were found in a notable percentage of high-grade B-cell lymphomas with double-hit BCL2 translocations (HGBL-DH-BCL2) and Burkitt lymphoma (BL).<sup>1</sup>

           ## Relevance tier by entity

          @@ -54,3 +54,6 @@ View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAM

           View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/HNRNPU.html)  or [hg38](https://morinlab.github.io/LLMPP/GAMBL/HNRNPU_hg38.html)

           ![image](images/proteinpaint/HNRNPU.svg)

          +

          +## References

          +1. *Qureshi, Q., Coyle, K., Thomas, N., Collinge, B., Dreval, K., Hilton, L., Wong, J., Scott, D., Audas, T., & Morin, R. (2023). Hnrnpu mutations Are Haploinsufficient and Alter the Transcriptome of MYC-Driven Lymphomas. Blood. https://doi.org/10.1182/blood-2023-190409.*

...	...	@@ -1,6 +1,6 @@
1	1	# HNRNPU
2	2	## Overview
3		-HNRNPU is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
	3	+HNRNPU is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. Mutations in HNRNPU are haploinsufficient and significantly alter the transcriptome of MYC-driven lymphomas. These mutations were found in a notable percentage of high-grade B-cell lymphomas with double-hit BCL2 translocations (HGBL-DH-BCL2) and Burkitt lymphoma (BL).<sup>1</sup>
4	4
5	5	## Relevance tier by entity
6	6
...	...	@@ -54,3 +54,6 @@ View coding variants in ProteinPaint [hg19](https://morinlab.github.io/LLMPP/GAM
54	54	View all variants in GenomePaint [hg19](https://morinlab.github.io/LLMPP/GAMBL/HNRNPU.html) or [hg38](https://morinlab.github.io/LLMPP/GAMBL/HNRNPU_hg38.html)
55	55
56	56	![image](images/proteinpaint/HNRNPU.svg)
	57	+
	58	+## References
	59	+1. Qureshi, Q., Coyle, K., Thomas, N., Collinge, B., Dreval, K., Hilton, L., Wong, J., Scott, D., Audas, T., & Morin, R. (2023). Hnrnpu mutations Are Haploinsufficient and Alter the Transcriptome of MYC-Driven Lymphomas. Blood. https://doi.org/10.1182/blood-2023-190409.