cce06a54928800951764d1b543b5bac6db354dd3
C6orf27.md
| ... | ... | @@ -15,9 +15,7 @@ Due to [minimal support](C6orf27#representative-mutation) in the original primar |
| 15 | 15 | |
| 16 | 16 | ## Relevance tier by entity |
| 17 | 17 | |
| 18 | -|Entity|Tier|Description | |
|
| 19 | -|:------:|:----:|--------------------------------------| |
|
| 20 | -| |3 |Retired, Failed QC[@loveGeneticLandscapeMutations2012]| |
|
| 18 | +[[include:table1_C6orf27.md]] |
|
| 21 | 19 | |
| 22 | 20 | ## Warnings |
| 23 | 21 |
C9.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_C9.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CAD.md
| ... | ... | @@ -15,9 +15,7 @@ Due to [minimal support](CAD#representative-mutation) in the original primary da |
| 15 | 15 | |
| 16 | 16 | ## Relevance tier by entity |
| 17 | 17 | |
| 18 | -|Entity|Tier|Description | |
|
| 19 | -|:------:|:----:|--------------------------------------| |
|
| 20 | -| |3 |Retired, Failed QC[@loveGeneticLandscapeMutations2012]| |
|
| 18 | +[[include:table1_CAD.md]] |
|
| 21 | 19 | |
| 22 | 20 | ## Warnings |
| 23 | 21 |
CADPS2.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in DLBCL in 2021 by Hübschmann et a |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |2 |relevance in DLBCL not firmly established[@hubschmannMutationalMechanismsShaping2021]| |
|
| 17 | +[[include:table1_CADPS2.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
CAMTA1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@pasqualucciAnalysisCodingGenome2011]| |
|
| 16 | +[[include:table1_CAMTA1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CAPN5.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CAPN5.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CAPN7.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CAPN7.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CARD11.md
| ... | ... | @@ -20,12 +20,7 @@ The functional effect of CARD11 mutations in DLBCL was explored in the original |
| 20 | 20 | |
| 21 | 21 | ## Relevance tier by entity |
| 22 | 22 | |
| 23 | -|Entity|Tier|Description | |
|
| 24 | -|:------:|:----:|--------------------------------------| |
|
| 25 | -||1|high-confidence MZL gene[@yanBCRTLRSignaling2012]| |
|
| 26 | -| |1 |high-confidence DLBCL gene [@lenzOncogenicCARD11Mutations2008]| |
|
| 27 | -| |1 |high-confidence FL gene [@morinFrequentMutationHistonemodifying2011]| |
|
| 28 | -| |1 |high-confidence MCL gene [@wuGeneticHeterogeneityPrimary2016]| |
|
| 23 | +[[include:table1_CARD11.md]] |
|
| 29 | 24 | |
| 30 | 25 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 31 | 26 |
CARD4.md
| ... | ... | @@ -14,9 +14,7 @@ nocite: | |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|--------------------------------------| |
|
| 19 | -| |2 |relevance in BL not firmly established[@loveGeneticLandscapeMutations2012]| |
|
| 17 | +[[include:table1_CARD4.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
CASP8.md
| ... | ... | @@ -15,9 +15,7 @@ Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.[@re |
| 15 | 15 | |
| 16 | 16 | ## Relevance tier by entity |
| 17 | 17 | |
| 18 | -|Entity|Tier|Description | |
|
| 19 | -|:------:|:----:|--------------------------| |
|
| 20 | -| |1 |high-confidence DLBCL gene[@reddyGeneticFunctionalDrivers2017]| |
|
| 18 | +[[include:table1_CASP8.md]] |
|
| 21 | 19 | |
| 22 | 20 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 23 | 21 |
CBFA2T3.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MZL not firmly established[@parryWholeExomeSequencing2013]| |
|
| 16 | +[[include:table1_CBFA2T3.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CBLB.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.[@re |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |3 |Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]| |
|
| 17 | +[[include:table1_CBLB.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Warnings |
| 22 | 20 |
CBX3.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_CBX3.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CCDC132.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CCDC132.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CCDC46.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CCDC46.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CCDC97.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CCDC97.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CCL4.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|-----------------------------------------| |
|
| 16 | -| |2 |relevance in DLBCL not firmly established[@chapuyMolecularSubtypesDiffuse2018]| |
|
| 14 | +[[include:table1_CCL4.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CCND1.md
| ... | ... | @@ -10,9 +10,7 @@ nocite: | |
| 10 | 10 | |
| 11 | 11 | ## Relevance tier by entity |
| 12 | 12 | |
| 13 | -|Entity|Tier|Description | |
|
| 14 | -|:------:|:----:|------------------------| |
|
| 15 | -| |1 |high-confidence MCL gene[@beaLandscapeSomaticMutations2013]| |
|
| 13 | +[[include:table1_CCND1.md]] |
|
| 16 | 14 | |
| 17 | 15 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 18 | 16 |
CCNF.md
| ... | ... | @@ -10,9 +10,7 @@ nocite: | |
| 10 | 10 | |
| 11 | 11 | ## Relevance tier by entity |
| 12 | 12 | |
| 13 | -|Entity|Tier|Description | |
|
| 14 | -|:------:|:----:|--------------------------------------| |
|
| 15 | -| |2 |relevance in BL not firmly established[@abateDistinctViralMutational2015]| |
|
| 13 | +[[include:table1_CCNF.md]] |
|
| 16 | 14 | |
| 17 | 15 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 18 | 16 |
CCT6B.md
| ... | ... | @@ -16,9 +16,7 @@ Due to [minimal support](CCT6B#representative-mutations) in the original primary |
| 16 | 16 | |
| 17 | 17 | ## Relevance tier by entity |
| 18 | 18 | |
| 19 | -|Entity|Tier|Description | |
|
| 20 | -|:------:|:----:|--------------------------------------| |
|
| 21 | -| |3 |Retired, Failed QC[@loveGeneticLandscapeMutations2012]| |
|
| 19 | +[[include:table1_CCT6B.md]] |
|
| 22 | 20 | |
| 23 | 21 | ## Warnings |
| 24 | 22 |
CD22.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.[@re |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |2 |relevance in DLBCL not firmly established[@reddyGeneticFunctionalDrivers2017]| |
|
| 17 | +[[include:table1_CD22.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
CD274.md
| ... | ... | @@ -14,9 +14,7 @@ Although rare, mutations have the potential to impact PD-L1 expression and could |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|--------------------------| |
|
| 19 | -| |1 |high-confidence DLBCL gene[@morinFrequentMutationHistonemodifying2011]| |
|
| 17 | +[[include:table1_CD274.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
CD36.md
| ... | ... | @@ -14,9 +14,7 @@ CD36 is a transmembrane glycoprotein involved in fatty acid metabolism, glucose |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|--------------------------| |
|
| 19 | -| |1 |high-confidence DLBCL gene[@pasqualucciAnalysisCodingGenome2011]| |
|
| 17 | +[[include:table1_CD36.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
CD44.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|-----------------------------------------| |
|
| 16 | -| |2 | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@arthurGenomewideDiscoverySomatic2018]| |
|
| 14 | +[[include:table1_CD44.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CD58.md
| ... | ... | @@ -19,10 +19,7 @@ This is often accompanied by mutations in the β2-Microglobulin gene, which furt |
| 19 | 19 | |
| 20 | 20 | ## Relevance tier by entity |
| 21 | 21 | |
| 22 | -|Entity|Tier|Description | |
|
| 23 | -|:------:|:----:|--------------------------------------| |
|
| 24 | -||1|high-confidence PMBL/cHL/GZL gene[@schneiderAlterationsCD58Gene2015]| |
|
| 25 | -| |1 |high-confidence DLBCL gene [@morinFrequentMutationHistonemodifying2011]| |
|
| 22 | +[[include:table1_CD58.md]] |
|
| 26 | 23 | |
| 27 | 24 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 28 | 25 |
CD70.md
| ... | ... | @@ -18,10 +18,7 @@ In mouse models, CD70 loss promoted lymphomagenesis, consistent with its role as |
| 18 | 18 | |
| 19 | 19 | ## Relevance tier by entity |
| 20 | 20 | |
| 21 | -|Entity|Tier|Description | |
|
| 22 | -|:------:|:----:|--------------------------------------| |
|
| 23 | -| |1 |high-confidence DLBCL gene [@morinFrequentMutationHistonemodifying2011]| |
|
| 24 | -| |2 |relevance in FL not firmly established[@russler-germainMutationsAssociatedProgression2023]| |
|
| 21 | +[[include:table1_CD70.md]] |
|
| 25 | 22 | |
| 26 | 23 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 27 | 24 |
CD74.md
| ... | ... | @@ -10,9 +10,7 @@ nocite: | |
| 10 | 10 | |
| 11 | 11 | ## Relevance tier by entity |
| 12 | 12 | |
| 13 | -|Entity|Tier|Description | |
|
| 14 | -|:------:|:----:|-----------------------------------------| |
|
| 15 | -| |2 | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous [@arthurGenomewideDiscoverySomatic2018]| |
|
| 13 | +[[include:table1_CD74.md]] |
|
| 16 | 14 | |
| 17 | 15 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 18 | 16 |
CD79A.md
| ... | ... | @@ -11,10 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|--------------------------------------| |
|
| 16 | -||2|relevance in MZL not firmly established[@rossiCodingGenomeSplenic2012]| |
|
| 17 | -| |2 |relevance in BL not firmly established[@burkhardtClinicalRelevanceMolecular2022]| |
|
| 14 | +[[include:table1_CD79A.md]] |
|
| 18 | 15 | |
| 19 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 20 | 17 |
CD79B.md
| ... | ... | @@ -20,11 +20,7 @@ This and other common mutations primarily occur in the immunoreceptor tyrosine-b |
| 20 | 20 | |
| 21 | 21 | ## Relevance tier by entity |
| 22 | 22 | |
| 23 | -|Entity|Tier|Description | |
|
| 24 | -|:------:|:----:|--------------------------------------| |
|
| 25 | -| |1 |high-confidence DLBCL gene with functional evidence[@davisChronicActiveBcellreceptor2010;@morinFrequentMutationHistonemodifying2011]| |
|
| 26 | -| |2 |relevance in FL not firmly established| |
|
| 27 | -| |3 |Retired, Failed QC[@paneaWholeGenomeLandscape2019]| |
|
| 23 | +[[include:table1_CD79B.md]] |
|
| 28 | 24 | |
| 29 | 25 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 30 | 26 |
CD83.md
| ... | ... | @@ -19,12 +19,7 @@ Mutations in this gene were first described in DLBCL in 2013 by Morin et al[@mor |
| 19 | 19 | |
| 20 | 20 | ## Relevance tier by entity |
| 21 | 21 | |
| 22 | -|Entity|Tier|Description | |
|
| 23 | -|:------:|:----:|--------------------------------------| |
|
| 24 | -||1|high-confidence PMBL/cHL/GZL gene[@dunsCharacterizationDLBCLPMBL2021]| |
|
| 25 | -| |1 | aSHM target and high-confidence DLBCL gene [@morinMutationalStructuralAnalysis2013; @schmitzGeneticsPathogenesisDiffuse2018; @reddyGeneticFunctionalDrivers2017]| |
|
| 26 | -| |1 | aSHM target and high-confidence FL gene [@russler-germainMutationsAssociatedProgression2023]| |
|
| 27 | -| |2 | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@paneaWholeGenomeLandscape2019]| |
|
| 22 | +[[include:table1_CD83.md]] |
|
| 28 | 23 | |
| 29 | 24 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 30 | 25 |
CD9B.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MZL not firmly established[@vandenbrandRecurrentMutationsGenes2017]| |
|
| 16 | +[[include:table1_CD9B.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CDC123.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CDC123.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CDC27.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in BL not firmly established[@maSubtypespecificCooccurringGenetic2022]| |
|
| 16 | +[[include:table1_CDC27.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CDC42BPB.md
| ... | ... | @@ -14,10 +14,7 @@ Mutations in this gene were first described in FL in 2021 by Hübschmann et al.[ |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|--------------------------------------| |
|
| 19 | -| |2 |relevance in FL not firmly established[@hubschmannMutationalMechanismsShaping2021]| |
|
| 20 | -||2|relevance in MZL not firmly established| |
|
| 17 | +[[include:table1_CDC42BPB.md]] |
|
| 21 | 18 | |
| 22 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 23 | 20 |
CDC73.md
| ... | ... | @@ -14,10 +14,7 @@ Mutations in this gene were first described in BL in 2012 by Love et al[@loveGen |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |2 |relevance in BL not firmly established [@loveGeneticLandscapeMutations2012]| |
|
| 20 | -| |2 |relevance in DLBCL not firmly established[@reddyGeneticFunctionalDrivers2017]| |
|
| 17 | +[[include:table1_CDC73.md]] |
|
| 21 | 18 | |
| 22 | 19 | ## Warnings |
| 23 | 20 |
CDH1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_CDH1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CDH10.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CDH10.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CDH17.md
| ... | ... | @@ -15,9 +15,7 @@ Due to [minimal support](CDH17#representative-mutations) in the original primary |
| 15 | 15 | |
| 16 | 16 | ## Relevance tier by entity |
| 17 | 17 | |
| 18 | -|Entity|Tier|Description | |
|
| 19 | -|:------:|:----:|--------------------------------------| |
|
| 20 | -| |3 |Retired, Failed QC[@loveGeneticLandscapeMutations2012]| |
|
| 18 | +[[include:table1_CDH17.md]] |
|
| 21 | 19 | |
| 22 | 20 | ## Warnings |
| 23 | 21 |
CDH2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in PMBL/cHL/GZL not firmly established[@deschGenotypingCirculatingTumor2020]| |
|
| 16 | +[[include:table1_CDH2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CDH5.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in PMBL/cHL/GZL not firmly established[@gomezUltraDeepSequencingReveals2023]| |
|
| 16 | +[[include:table1_CDH5.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CDH7.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CDH7.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CDH8.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|---------------------------------------| |
|
| 16 | -| |2 |relevance in MCL not firmly established[@zhangGenomicLandscapeMantle2014]| |
|
| 14 | +[[include:table1_CDH8.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CDH9.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|-----------------------------------------| |
|
| 16 | -| |2 |relevance in DLBCL not firmly established[@morinMutationalStructuralAnalysis2013]| |
|
| 14 | +[[include:table1_CDH9.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CDK3.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CDK3.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CDKN1A.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_CDKN1A.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CDKN2A.md
| ... | ... | @@ -13,12 +13,7 @@ Although CDKN2A aberrations are common in DLBCL, this gene is predominantly affe |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description | |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||1|high-confidence PMBL/cHL/GZL gene| |
|
| 19 | -||2|relevance in MZL not firmly established[@spinaGeneticsNodalMarginal2016]| |
|
| 20 | -| |1 |high-confidence DLBCL gene [@morinMutationalStructuralAnalysis2013]| |
|
| 21 | -| |2 |relevance in BL not firmly established[@grandeGenomewideDiscoverySomatic2019]| |
|
| 16 | +[[include:table1_CDKN2A.md]] |
|
| 22 | 17 | |
| 23 | 18 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 24 | 19 |
CDKN2C.md
| ... | ... | @@ -10,9 +10,7 @@ nocite: | |
| 10 | 10 | |
| 11 | 11 | ## Relevance tier by entity |
| 12 | 12 | |
| 13 | -|Entity|Tier|Description | |
|
| 14 | -|:------:|:----:|--------------------------------------| |
|
| 15 | -| |2 |relevance in BL not firmly established[@thomasGeneticSubgroupsInform2023]| |
|
| 13 | +[[include:table1_CDKN2C.md]] |
|
| 16 | 14 | |
| 17 | 15 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 18 | 16 |
CECR1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CECR1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CELSR2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CELSR2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CEP164.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@albuquerqueEnhancingKnowledgeDiscovery2017]| |
|
| 16 | +[[include:table1_CEP164.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CGN.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_CGN.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CHD1.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.[@re |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |2 |relevance in DLBCL not firmly established[@reddyGeneticFunctionalDrivers2017]| |
|
| 17 | +[[include:table1_CHD1.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Warnings |
| 22 | 20 |
CHD3.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CHD3.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CHD4.md
| ... | ... | @@ -10,9 +10,7 @@ nocite: | |
| 10 | 10 | |
| 11 | 11 | ## Relevance tier by entity |
| 12 | 12 | |
| 13 | -|Entity|Tier|Description | |
|
| 14 | -|:------:|:----:|--------------------------------------| |
|
| 15 | -| |2 |relevance in BL not firmly established[@burkhardtClinicalRelevanceMolecular2022]| |
|
| 13 | +[[include:table1_CHD4.md]] |
|
| 16 | 14 | |
| 17 | 15 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 18 | 16 |
CHEK2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_CHEK2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CHMP4C.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MCL not firmly established[@beaLandscapeSomaticMutations2013]| |
|
| 16 | +[[include:table1_CHMP4C.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CHRM5.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CHRM5.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CHST2.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.[@re |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |3 |Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]| |
|
| 17 | +[[include:table1_CHST2.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Warnings |
| 22 | 20 |
CIC.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CIC.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CIITA.md
| ... | ... | @@ -13,10 +13,7 @@ CIITA encodes the major histocompatibility complex (MHC) class II transactivator |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description | |
|
| 17 | -|:------:|:----:|--------------------------| |
|
| 18 | -||1|high-confidence PMBL/cHL/GZL gene[@mottokGenomicAlterationsCIITA2015]| |
|
| 19 | -| |1 | aSHM target and high-confidence DLBCL gene[@morinFrequentMutationHistonemodifying2011]| |
|
| 16 | +[[include:table1_CIITA.md]] |
|
| 20 | 17 | |
| 21 | 18 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 19 |
CILP.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|--------------------------------------| |
|
| 16 | -| |2 |relevance in FL not firmly established[@russler-germainMutationsAssociatedProgression2023]| |
|
| 14 | +[[include:table1_CILP.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CISH.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||1|high-confidence PMBL/cHL/GZL gene[@mottokIntegrativeGenomicAnalysis2019]| |
|
| 16 | +[[include:table1_CISH.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CLGN.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MZL not firmly established[@spinaGeneticsNodalMarginal2016]| |
|
| 16 | +[[include:table1_CLGN.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CNBP.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MZL not firmly established[@spinaGeneticsNodalMarginal2016]| |
|
| 16 | +[[include:table1_CNBP.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CNGA4.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CNGA4.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CNKSR2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MZL not firmly established[@spinaGeneticsNodalMarginal2016]| |
|
| 16 | +[[include:table1_CNKSR2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CNOT2.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in DLBCL in 2021 by Hübschmann et a |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |2 |relevance in DLBCL not firmly established[@hubschmannMutationalMechanismsShaping2021]| |
|
| 17 | +[[include:table1_CNOT2.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
CNOT6.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CNOT6.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CNP.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CNP.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CNTN6.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CNTN6.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CNTNAP5.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in DLBCL in 2013 by Morin et al.[@mo |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |2 |relevance in DLBCL not firmly established[@morinMutationalStructuralAnalysis2013]| |
|
| 17 | +[[include:table1_CNTNAP5.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
COL11A1.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|---------------------------------------| |
|
| 16 | -| |2 |relevance in MCL not firmly established[@zhangGenomicLandscapeMantle2014]| |
|
| 14 | +[[include:table1_COL11A1.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
COL12A1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@novakWholeexomeAnalysisReveals2015]| |
|
| 16 | +[[include:table1_COL12A1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
COL16A1.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|---------------------------------------| |
|
| 16 | -| |2 |relevance in MCL not firmly established[@zhangGenomicLandscapeMantle2014]| |
|
| 14 | +[[include:table1_COL16A1.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
COL4A2.md
| ... | ... | @@ -17,9 +17,7 @@ Due to [minimal support](COL4A2#representative-mutations) in the original primar |
| 17 | 17 | |
| 18 | 18 | ## Relevance tier by entity |
| 19 | 19 | |
| 20 | -|Entity|Tier|Description | |
|
| 21 | -|:------:|:----:|--------------------------------------| |
|
| 22 | -| |3 |Retired, Failed QC[@loveGeneticLandscapeMutations2012]| |
|
| 20 | +[[include:table1_COL4A2.md]] |
|
| 23 | 21 | |
| 24 | 22 | ## Warnings |
| 25 | 23 |
COL5A2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_COL5A2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
COQ7.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|-----------------------------------------| |
|
| 16 | -| |2 |relevance in DLBCL not firmly established[@chapuyMolecularSubtypesDiffuse2018]| |
|
| 14 | +[[include:table1_COQ7.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CORO2A.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CORO2A.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CORO7.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CORO7.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CPNE8.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in FL in 2021 by Hübschmann et al.[ |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|--------------------------------------| |
|
| 19 | -| |2 |relevance in FL not firmly established[@hubschmannMutationalMechanismsShaping2021]| |
|
| 17 | +[[include:table1_CPNE8.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
CPS1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@lohrDiscoveryPrioritizationSomatic2012]| |
|
| 16 | +[[include:table1_CPS1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CPXM2.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|--------------------------------------| |
|
| 16 | -| |2 |relevance in BL not firmly established[@burkhardtClinicalRelevanceMolecular2022]| |
|
| 14 | +[[include:table1_CPXM2.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CRELD2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CRELD2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CRIP1.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|-----------------------------------------| |
|
| 16 | -| |2 |relevance in DLBCL not firmly established[@chapuyMolecularSubtypesDiffuse2018]| |
|
| 14 | +[[include:table1_CRIP1.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CRTC3.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CRTC3.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CRYBG3.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MCL not firmly established[@beaLandscapeSomaticMutations2013]| |
|
| 16 | +[[include:table1_CRYBG3.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CSF2RB.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||1|high-confidence PMBL/cHL/GZL gene[@reichelFlowSortingExome2015]| |
|
| 16 | +[[include:table1_CSF2RB.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
CSNK1A1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_CSNK1A1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CSNK2A1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_CSNK2A1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CST7.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CST7.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CTCF.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|--------------------------------------| |
|
| 16 | -| |3 |Retired, Failed QC[@paneaWholeGenomeLandscape2019]| |
|
| 14 | +[[include:table1_CTCF.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Warnings |
| 19 | 17 |
CTNNA2.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|---------------------------------------| |
|
| 16 | -| |2 |relevance in MCL not firmly established[@zhangGenomicLandscapeMantle2014]| |
|
| 14 | +[[include:table1_CTNNA2.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CTNNA3.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CTNNA3.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CTSS.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|-----------------------| |
|
| 16 | -| |1 |high-confidence FL gene[@barariaCathepsinAlterationsInduce2020]| |
|
| 14 | +[[include:table1_CTSS.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CXCR4.md
| ... | ... | @@ -17,12 +17,7 @@ Mutations in this gene were first described in DLBCL in 2012 [@khodabakhshiRecur |
| 17 | 17 | |
| 18 | 18 | ## Relevance tier by entity |
| 19 | 19 | |
| 20 | -|Entity|Tier|Description | |
|
| 21 | -|:------:|:----:|--------------------------------------| |
|
| 22 | -||1|high-confidence MZL gene| |
|
| 23 | -| |1 | aSHM target and high-confidence DLBCL gene [@khodabakhshiRecurrentTargetsAberrant2012]| |
|
| 24 | -| |2 | aSHM target; Although recurrent, the relevance of mutations in FL is tenuous [@krysiakRecurrentSomaticMutations2017]| |
|
| 25 | -| |2 | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous [@paneaWholeGenomeLandscape2019]| |
|
| 20 | +[[include:table1_CXCR4.md]] |
|
| 26 | 21 | |
| 27 | 22 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 28 | 23 |
CXCR5.md
| ... | ... | @@ -14,10 +14,7 @@ CXCR5 is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|--------------------------| |
|
| 19 | -||2|relevance in PMBL/cHL/GZL not firmly established[@mottokIntegrativeGenomicAnalysis2019]| |
|
| 20 | -| |1 | aSHM target and high-confidence DLBCL gene[@schmitzGeneticsPathogenesisDiffuse2018]| |
|
| 17 | +[[include:table1_CXCR5.md]] |
|
| 21 | 18 | |
| 22 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 23 | 20 |
CYB5D1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description | |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -| |3 |Retired, Failed QC[@loveGeneticLandscapeMutations2012]| |
|
| 16 | +[[include:table1_CYB5D1.md]] |
|
| 19 | 17 | |
| 20 | 18 | ## Warnings |
| 21 | 19 |
CYP24A1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CYP24A1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CYP2A6.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|--------------------------------------| |
|
| 16 | -| |2 |relevance in FL not firmly established[@russler-germainMutationsAssociatedProgression2023]| |
|
| 14 | +[[include:table1_CYP2A6.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
CYP2C18.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_CYP2C18.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CYP4F22.md
| ... | ... | @@ -15,9 +15,7 @@ Due to [minimal support](CYP4F22#representative-mutation) in the original primar |
| 15 | 15 | |
| 16 | 16 | ## Relevance tier by entity |
| 17 | 17 | |
| 18 | -|Entity|Tier|Description | |
|
| 19 | -|:------:|:----:|--------------------------------------| |
|
| 20 | -| |3 |Retired, Failed QC[@loveGeneticLandscapeMutations2012]| |
|
| 18 | +[[include:table1_CYP4F22.md]] |
|
| 21 | 19 | |
| 22 | 20 | ## Warnings |
| 23 | 21 |
CYTSB.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@pasqualucciAnalysisCodingGenome2011]| |
|
| 16 | +[[include:table1_CYTSB.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
CYYR1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_CYYR1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DAZAP1.md
| ... | ... | @@ -13,10 +13,7 @@ This gene has some recurrent sites of mutations (hot spots). The mutation patter |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description | |
|
| 17 | -|:------:|:----:|--------------------------| |
|
| 18 | -| |1 |high-confidence DLBCL gene[@pararajalingamCodingNoncodingDrivers2020]| |
|
| 19 | -| |1 |high-confidence MCL gene [@pararajalingamCodingNoncodingDrivers2020]| |
|
| 16 | +[[include:table1_DAZAP1.md]] |
|
| 20 | 17 | |
| 21 | 18 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 19 |
DCAF6.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in DLBCL in 2017 by Reddy et al.[@re |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |3 |Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]| |
|
| 17 | +[[include:table1_DCAF6.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Warnings |
| 22 | 20 |
DCHS1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@pasqualucciAnalysisCodingGenome2011]| |
|
| 16 | +[[include:table1_DCHS1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DCP1B.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MCL not firmly established[@beaLandscapeSomaticMutations2013]| |
|
| 16 | +[[include:table1_DCP1B.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
DDB1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_DDB1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DDX10.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|-----------------------------------------| |
|
| 16 | -| |2 |Relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 14 | +[[include:table1_DDX10.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
DGCR8.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_DGCR8.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DGKB.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in PMBL/cHL/GZL not firmly established[@tiacciPervasiveMutationsJAKSTAT2018]| |
|
| 16 | +[[include:table1_DGKB.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
DHCR7.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in BL not firmly established[@schmitzBurkittLymphomaPathogenesis2012]| |
|
| 16 | +[[include:table1_DHCR7.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
DHDH.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|---------------------------------------| |
|
| 16 | -| |2 |relevance in MCL not firmly established[@zhangGenomicLandscapeMantle2014]| |
|
| 14 | +[[include:table1_DHDH.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
DHX15.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in FL in 2021 by Hübschmann et al.[ |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|--------------------------------------| |
|
| 19 | -| |2 |relevance in FL not firmly established[@hubschmannMutationalMechanismsShaping2021]| |
|
| 17 | +[[include:table1_DHX15.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
DHX16.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in DLBCL in 2021 by Hübschmann et a |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |2 |relevance in DLBCL not firmly established[@hubschmannMutationalMechanismsShaping2021]| |
|
| 17 | +[[include:table1_DHX16.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
DHX33.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_DHX33.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DIAPH2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@novakWholeexomeAnalysisReveals2015]| |
|
| 16 | +[[include:table1_DIAPH2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DIAPH3.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_DIAPH3.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DICER1.md
| ... | ... | @@ -10,9 +10,7 @@ nocite: | |
| 10 | 10 | |
| 11 | 11 | ## Relevance tier by entity |
| 12 | 12 | |
| 13 | -|Entity|Tier|Description | |
|
| 14 | -|:------:|:----:|-----------------------------------------| |
|
| 15 | -| |3 |Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]| |
|
| 13 | +[[include:table1_DICER1.md]] |
|
| 16 | 14 | |
| 17 | 15 | <<Warn("The variants reported in this gene in DLBCL failed QC")>> |
| 18 | 16 |
DIP2B.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_DIP2B.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DLC1.md
| ... | ... | @@ -10,9 +10,7 @@ nocite: | |
| 10 | 10 | |
| 11 | 11 | ## Relevance tier by entity |
| 12 | 12 | |
| 13 | -|Entity|Tier|Description | |
|
| 14 | -|:------:|:----:|---------------------------------------| |
|
| 15 | -| |2 |relevance in MCL not firmly established[@zhangGenomicLandscapeMantle2014]| |
|
| 13 | +[[include:table1_DLC1.md]] |
|
| 16 | 14 | |
| 17 | 15 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 18 | 16 |
DLGAP1.md
| ... | ... | @@ -14,9 +14,7 @@ Due to [minimal support](DLGAP1#representative-mutation) in the original primary |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|--------------------------------------| |
|
| 19 | -| |3 |Retired, Failed QC[@loveGeneticLandscapeMutations2012]| |
|
| 17 | +[[include:table1_DLGAP1.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Warnings |
| 22 | 20 |
DLGAP2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MCL not firmly established[@beaLandscapeSomaticMutations2013]| |
|
| 16 | +[[include:table1_DLGAP2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
DMD.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in PMBL/cHL/GZL not firmly established[@reichelFlowSortingExome2015]| |
|
| 16 | +[[include:table1_DMD.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
DMXL1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_DMXL1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DNAH12.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in PMBL/cHL/GZL not firmly established[@wienandGenomicAnalysesFlowsorted2019]| |
|
| 16 | +[[include:table1_DNAH12.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
DNAH5.md
| ... | ... | @@ -10,10 +10,7 @@ nocite: | |
| 10 | 10 | |
| 11 | 11 | ## Relevance tier by entity |
| 12 | 12 | |
| 13 | -|Entity|Tier|Description | |
|
| 14 | -|:------:|:----:|-----------------------------------------| |
|
| 15 | -||2|relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017]| |
|
| 16 | -| |2 |relevance in DLBCL not firmly established[@morinMutationalStructuralAnalysis2013]| |
|
| 13 | +[[include:table1_DNAH5.md]] |
|
| 17 | 14 | |
| 18 | 15 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 16 |
DNAH7.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017]| |
|
| 16 | +[[include:table1_DNAH7.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
DNAI1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017]| |
|
| 16 | +[[include:table1_DNAI1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
DNAJC6.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MCL not firmly established[@beaLandscapeSomaticMutations2013]| |
|
| 16 | +[[include:table1_DNAJC6.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
DNM2.md
| ... | ... | @@ -14,9 +14,7 @@ Mutations in this gene were first described in DLBCL and FL in 2021 by Hübschma |
| 14 | 14 | |
| 15 | 15 | ## Relevance tier by entity |
| 16 | 16 | |
| 17 | -|Entity|Tier|Description | |
|
| 18 | -|:------:|:----:|-----------------------------------------| |
|
| 19 | -| |2 |relevance in DLBCL not firmly established[@hubschmannMutationalMechanismsShaping2021]| |
|
| 17 | +[[include:table1_DNM2.md]] |
|
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 22 | 20 |
DNMT1.md
| ... | ... | @@ -10,9 +10,7 @@ nocite: | |
| 10 | 10 | |
| 11 | 11 | ## Relevance tier by entity |
| 12 | 12 | |
| 13 | -|Entity|Tier|Description | |
|
| 14 | -|:------:|:----:|--------------------------------------| |
|
| 15 | -| |3 |Retired, Failed QC[@paneaWholeGenomeLandscape2019]| |
|
| 13 | +[[include:table1_DNMT1.md]] |
|
| 16 | 14 | |
| 17 | 15 | ## Warnings |
| 18 | 16 |
DNMT3A.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description | |
|
| 17 | -|:------:|:----:|-----------------------------------------| |
|
| 18 | -| |3 |Retired, Failed QC[@reddyGeneticFunctionalDrivers2017]| |
|
| 16 | +[[include:table1_DNMT3A.md]] |
|
| 19 | 17 | |
| 20 | 18 | ## Warnings |
| 21 | 19 |
DNMT3B.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@albuquerqueEnhancingKnowledgeDiscovery2017]| |
|
| 16 | +[[include:table1_DNMT3B.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DOCK1.md
| ... | ... | @@ -11,9 +11,7 @@ nocite: | |
| 11 | 11 | |
| 12 | 12 | ## Relevance tier by entity |
| 13 | 13 | |
| 14 | -|Entity|Tier|Description | |
|
| 15 | -|:------:|:----:|-----------------------------------------| |
|
| 16 | -| |2 |relevance in DLBCL not firmly established[@chapuyMolecularSubtypesDiffuse2018]| |
|
| 14 | +[[include:table1_DOCK1.md]] |
|
| 17 | 15 | |
| 18 | 16 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
| 19 | 17 |
DOCK2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_DOCK2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DOCK5.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@fanComprehensiveCharacterizationDriver2020]| |
|
| 16 | +[[include:table1_DOCK5.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DOCK6.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in MZL not firmly established[@jalladesExomeSequencingIdentifies2017]| |
|
| 16 | +[[include:table1_DOCK6.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 | ## Mutation incidence in large patient cohorts (GAMBL reanalysis) |
DOLK.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_DOLK.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DPYD.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@pasqualucciAnalysisCodingGenome2011]| |
|
| 16 | +[[include:table1_DPYD.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DSC2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_DSC2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DSC3.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@pasqualucciAnalysisCodingGenome2011]| |
|
| 16 | +[[include:table1_DSC3.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DSCAML1.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_DSCAML1.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DSEL.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||2|relevance in DLBCL not firmly established[@morinMutationalStructuralAnalysis2013]| |
|
| 16 | +[[include:table1_DSEL.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |
DSG2.md
| ... | ... | @@ -13,9 +13,7 @@ nocite: | |
| 13 | 13 | |
| 14 | 14 | ## Relevance tier by entity |
| 15 | 15 | |
| 16 | -|Entity|Tier|Description| |
|
| 17 | -|:------:|:----:|--------------------------------------| |
|
| 18 | -||3|relevance in DLBCL not firmly established[@zhangGeneticHeterogeneityDiffuse2013]| |
|
| 16 | +[[include:table1_DSG2.md]] |
|
| 19 | 17 | |
| 20 | 18 | |
| 21 | 19 |