MEF2C.md
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------|
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-|![DLBCL](images/icons/DLBCL_tier1.png) |1-a | aSHM target and high-confidence DLBCL gene[@arthurGenomewideDiscoverySomatic2018]|
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-|![FL](images/icons/FL_tier1.png) |1-a | aSHM target and high-confidence FL gene |
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+|![DLBCL](images/icons/DLBCL_tier1.png) |1 | aSHM target and high-confidence DLBCL gene[@arthurGenomewideDiscoverySomatic2018]|
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+|![FL](images/icons/FL_tier1.png) |1 | aSHM target and high-confidence FL gene |
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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P2RY8.md
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link-citations: true
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---
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[[_TOC_]]
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-P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.<sup>1</sup> Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL<sup>2</sup> and BL.<sup>1</sup>
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+P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.<sup>1</sup> Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL and BL.[muppidiLossSignalingGa132014]
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## Relevance tier by entity