FOXO1.md
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## Overview
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-Mutations in the FOXO1 gene, which encodes a member of the forkhead family of transcription factors, play a significant role in diffuse large B-cell lymphoma (DLBCL). Mutations primarily occur in the first exon, with significant portions affecting the N-terminal region and the Forkhead DNA binding domain.<sup>1</sup> These mutations are common in DLBCL, BL and, to a lesser extent, FL.<sup>2,3</sup> FOXO1 mutations can contribute to resistance to certain therapies, such as anti-CD20-based immunotherapies, by repressing MS4A1 (CD20) expression.<sup>4</sup>
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+Mutations in the FOXO1 gene, which encodes a member of the forkhead family of transcription factors, play a significant role in diffuse large B-cell lymphoma (DLBCL). Mutations primarily occur in the first exon, with significant portions affecting the N-terminal region and the Forkhead DNA binding domain.[@trinhAnalysisFOXO1Mutations] These mutations are common in DLBCL, BL and, to a lesser extent, FL.[@schmitzBurkittLymphomaPathogenesis2012; @morinFrequentMutationHistonemodifying2011] FOXO1 mutations can contribute to resistance to certain therapies, such as anti-CD20-based immunotherapies, by repressing MS4A1 (CD20) expression.<sup>4</sup>
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