HIST1H2AM.md
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@@ -5,35 +5,30 @@ This gene encodes the H2A protein, one of the core proteins comprising nucleosom
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|Entity|Tier|Description |
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|:------:|:----:|--------------------------------------|
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-|BL |2 |relevance in BL not firmly established|
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|DLBCL |1 |high-confidence DLBCL gene |
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|FL |1 |high-confidence FL gene |
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+|BL |2 |relevance in BL not firmly established|
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## Mutation incidence in large patient cohorts (GAMBL reanalysis)
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|Entity|source |frequency (%)|
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|:------:|:---------------------:|:-------------:|
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-|BL |GAMBL genomes+capture|1.85 |
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-|BL |Thomas cohort |1.70 |
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-|BL |Panea cohort |3.00 |
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|DLBCL |GAMBL genomes |5.93 |
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|DLBCL |Schmitz cohort |5.74 |
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|DLBCL |Reddy cohort |4.80 |
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|DLBCL |Chapuy cohort |5.98 |
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|FL |GAMBL genomes |3.70 |
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+|BL |GAMBL genomes+capture|1.85 |
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+|BL |Thomas cohort |1.70 |
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+|BL |Panea cohort |3.00 |
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## Mutation pattern and selective pressure estimates
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|Entity|aSHM|Significant selection|dN/dS (missense)|dN/dS (nonsense)|
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|:------:|:----:|:---------------------:|:----------------:|:----------------:|
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-|BL |No |No |2.149 |0 |
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|DLBCL |No |No |1.844 |0 |
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|FL |No |No |1.845 |0 |
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-> [!NOTE]
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-> First described in BL in 2019 by [Panea RI](https://pubmed.ncbi.nlm.nih.gov/31558468)
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+|BL |No |No |2.149 |0 |
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## HIST1H2AM Hotspots
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