DLBCL_genes.md
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@@ -116,7 +116,7 @@ link-citations: true
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|[S1PR2](S1PR2)|Tier 1 GE[@morinFrequentMutationHistonemodifying2011]|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)|[@muppidiLossSignalingGa132014b]||
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|[SETD1B](SETD1B)|Tier 1 GE[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)|||
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|[SF3B1](SF3B1)|Tier 1 GE[@reddyGeneticFunctionalDrivers2017]|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)|[@loveGeneticLandscapeMutations2012]||
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-|[SGK1](SGK1)|Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@hartmannHighlyRecurrentMutations2016b]|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)|[@dunsCharacterizationDLBCLPMBL2021b]||
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+|[SGK1](SGK1)|Tier 1 GE[@morinFrequentMutationHistonemodifying2011], FE[@hartmannHighlyRecurrentMutations2016b], CE[@guoSGK1MutationStatus2022b]|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)|[@dunsCharacterizationDLBCLPMBL2021b]||
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|[SIN3A](SIN3A)|Tier 1 GE[@chapuyMolecularSubtypesDiffuse2018b]|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)|[@grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]||
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|[SMARCA4](SMARCA4)|Tier 1 GE[@reddyGeneticFunctionalDrivers2017], FE[@dengSMARCA4HaploinsufficientCell2024]|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)|[@krysiakRecurrentSomaticMutations2017b; @nadeuGenomicEpigenomicInsights2020b; @richterRecurrentMutationID32012a]||
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|[SOCS1](SOCS1)|Tier 1 GE[@morinFrequentMutationHistonemodifying2011]|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)|[@wenigerMutationsTumorSuppressor2006a]||
morinlab.bib
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+@article{guoSGK1MutationStatus2022b,
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+ title = {{{SGK1}} Mutation Status Can Further Stratify Patients with Germinal Center {{B-cell-like}} Diffuse Large {{B-cell}} Lymphoma into Different Prognostic Subgroups},
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+ author = {Guo, Baoping and Huang, Yujie and Duan, Ying and Liao, Chengcheng and Cen, Hong},
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+ date = {2022-03},
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+ journaltitle = {Cancer Medicine},
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+ shortjournal = {Cancer Med},
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+ volume = {11},
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+ number = {5},
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+ eprint = {35106936},
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+ eprinttype = {pmid},
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+ pages = {1281--1291},
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+ issn = {2045-7634},
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+ doi = {10.1002/cam4.4550},
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+ abstract = {There are over a 100 driver gene mutations in patients with diffuse large B-cell lymphoma (DLBCL), but their clinical significance remains unclear. Here, we first analyzed the DLBCL dataset from the UK-based Haematological Malignancy Research Network. Patients were divided into high- and low-risk groups based on whether lymphoma progressed within 24~months. Genes showing significantly different frequencies between groups were selected. Survival data for patients with the selected mutant genes were analyzed. The results were validated using two other large databases to evaluate the relationship between the selected mutant genes and prognosis. The mutation frequencies of 11 genes (MYD88[L265P], SGK1, MPEG1, TP53, SPEN, NOTCH1, ETV6, TNFRSF14, MGA, CIITA, and PIM1) significantly differed between the high- and low-risk groups. The relationships between these mutant genes and patient survival were analyzed. Patients who harbored SGK1 (serum and glucocorticoid-inducible kinase 1) mutations exhibited the best prognosis. Most patients with SGK1 mutation are germinal center B-cell (GCB) subtype. Among patients with GCB DLBCL, those harboring SGK1 mutations exhibited better prognosis than those without SGK1 mutations. Most SGK1 mutations were single-base substitutions, primarily scattered throughout the catalytic domain-encoding region. Multiple SGK1 mutations were identified in a single patient. Thus, SGK1 mutations are a marker of good prognosis for DLBCL and occur predominantly in the GCB subtype of DLBCL. SGK1 mutation status can further stratify patients with GCB DLBCL into different prognostic subgroups.},
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+ langid = {english},
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+ pmcid = {PMC8894717},
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+ keywords = {B-Lymphocytes,classification,diffuse large B-cell lymphoma,genetics,Germinal Center,Humans,Immediate-Early Proteins,Lymphoma Large B-Cell Diffuse,Mutation,prognosis,Prognosis,Protein Serine-Threonine Kinases,SGK1},
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+ file = {/Users/rmorin/Zotero/storage/L8FH6723/Guo et al. - 2022 - SGK1 mutation status can further stratify patients.pdf}
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+}
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+
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@article{jingjingNovelMEF2CMutation2020,
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title = {A Novel {{MEF2C}} Mutation in Lymphoid Neoplasm Diffuse Large {{B-cell}} Lymphoma Promotes Tumorigenesis by Increasing c-{{JUN}} Expression},
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author = {Jingjing, Zhao and Lei, Miao and Jie, Zhang and Sha, Cao and Yapeng, Hu and Weimin, Zhang and Chunluan, Yuan},