add refs

+@article{barariaCathepsinAlterationsInduce2020,

+ title = {Cathepsin {S} {Alterations} {Induce} a {Tumor}-{Promoting} {Immune} {Microenvironment} in {Follicular} {Lymphoma}},

+ volume = {31},

+ issn = {2211-1247},

+ doi = {10.1016/j.celrep.2020.107522},

+ abstract = {Tumor cells orchestrate their microenvironment. Here, we provide biochemical, structural, functional, and clinical evidence that Cathepsin S (CTSS) alterations induce a tumor-promoting immune microenvironment in follicular lymphoma (FL). We found CTSS mutations at Y132 in 6\% of FL (19/305). Another 13\% (37/286) had CTSS amplification, which was associated with higher CTSS expression. CTSS Y132 mutations lead to accelerated autocatalytic conversion from an enzymatically inactive profrom to active CTSS and increased substrate cleavage, including CD74, which regulates major histocompatibility complex class II (MHC class II)-restricted antigen presentation. Lymphoma cells with hyperactive CTSS more efficiently activated antigen-specific CD4+ T cells in vitro. Tumors with hyperactive CTSS showed increased CD4+ T cell infiltration and proinflammatory cytokine perturbation in a mouse model and in human FLs. In mice, this CTSS-induced immune microenvironment promoted tumor growth. Clinically, patients with CTSS-hyperactive FL had better treatment outcomes with standard immunochemotherapies, indicating that these immunosuppressive regimens target both the lymphoma cells and the tumor-promoting immune microenvironment.},

+ language = {eng},

+ number = {5},

+ journal = {Cell Reports},

+ author = {Bararia, Deepak and Hildebrand, Johannes A. and Stolz, Sebastian and Haebe, Sarah and Alig, Stefan and Trevisani, Christopher P. and Osorio-Barrios, Francisco and Bartoschek, Michael D. and Mentz, Michael and Pastore, Alessandro and Gaitzsch, Erik and Heide, Michael and Jurinovic, Vindi and Rautter, Katharina and Gunawardana, Jay and Sabdia, Muhammed B. and Szczepanowski, Monika and Richter, Julia and Klapper, Wolfram and Louissaint, Abner and Ludwig, Christina and Bultmann, Sebastian and Leonhardt, Heinrich and Eustermann, Sebastian and Hopfner, Karl-Peter and Hiddemann, Wolfgang and von Bergwelt-Baildon, Michael and Steidl, Christian and Kridel, Robert and Tobin, Joshua W. D. and Gandhi, Maher K. and Weinstock, David M. and Schmidt-Supprian, Marc and Sárosi, Menyhárt B. and Rudelius, Martina and Passerini, Verena and Mautner, Josef and Weigert, Oliver},

+ month = may,

+ year = {2020},

+ pmid = {32330423},

+ keywords = {Animals, Humans, Antigen Presentation, Mice, Cytokines, Lymphoma, Follicular, follicular lymphoma, Tumor Microenvironment, Antigens, Differentiation, B-Lymphocyte, antigen processing and presentation, cathepsin S, Cathepsins, cysteine-protease, Histocompatibility Antigens Class II, immune microenvironment, Immunosuppression Therapy, T cell activation, Lymphopedia},

+ pages = {107522},

+ file = {Full Text:/Users/rmorin/Zotero/storage/D9BZZT9L/Bararia et al. - 2020 - Cathepsin S Alterations Induce a Tumor-Promoting I.pdf:application/pdf},

+}

+