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rdmorin committed 2024-12-27 17:39:29 -0800 commit d32ec7272085a5d7f015367696267da826ba7d46

				P2RY8.md
			
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           ## Overview

          -P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.[@muppidiLossSignalingGa132014] Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL and BL.[muppidiLossSignalingGa132014] 

          +P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.[@muppidiLossSignalingGa132014] 

          +Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL and BL.[@muppidiLossSignalingGa132014] 

           ## Relevance tier by entity

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10	10	## Overview
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12		-P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.[@muppidiLossSignalingGa132014] Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL and BL.[muppidiLossSignalingGa132014]
	12	+P2RY8 encodes a G protein–coupled receptor that is expressed on germinal center B cells. Signals through this receptor promote confinement of B cells to the GC niche.[@muppidiLossSignalingGa132014]
	13	+Downstream signaling through Galpha13 (encoded by GNA13) and S1PR2 is distrupted by mutations of one of these genes in GC lymphomas including the GCB subgroup of DLBCL and BL.[@muppidiLossSignalingGa132014]
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15	16	## Relevance tier by entity