d41a2baea10360fbe541afaa928fd7d745221a5c
DLBCL_genes.md
| ... | ... | @@ -11,33 +11,33 @@ link-citations: true |
| 11 | 11 | |
| 12 | 12 | ## Tier 1 DLBCL genes |
| 13 | 13 | |
| 14 | -### *127 total* |
|
| 14 | +### *128 total* |
|
| 15 | 15 | |
| 16 | 16 | |Gene|Tier| First DLBCL evidence | Other entities | |
| 17 | 17 | |:-:|:-:|:--|:-| |
| 18 | 18 | |[ACTB](ACTB)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@wienandGenomicAnalysesFlowsorted2019b]| |
| 19 | -|[ACTG1](ACTG1)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@deschGenotypingCirculatingTumor2020; @spinaGeneticsNodalMarginal2016b]| |
|
| 20 | -|[ARID1A](ARID1A)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@wienandGenomicAnalysesFlowsorted2019b; @loveGeneticLandscapeMutations2012; @krysiakRecurrentSomaticMutations2017b; @rossiCodingGenomeSplenic2012c]| |
|
| 21 | -|[ATM](ATM)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@braggioGenomicAnalysisMarginal2012; @beaLandscapeSomaticMutations2013]| |
|
| 22 | -|[B2M](B2M)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @pararajalingamCodingNoncodingDrivers2020]| |
|
| 23 | -|[BCL10](BCL10)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@spinaGeneticsNodalMarginal2016b; @russler-germainMutationsAssociatedProgression2023b]| |
|
| 24 | -|[BCL2](BCL2)|1|[Tanaka et al](papers/tanakaFrequentIncidenceSomatic1992)[@tanakaFrequentIncidenceSomatic1992]|[@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021a]| |
|
| 19 | +|[ACTG1](ACTG1)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@spinaGeneticsNodalMarginal2016b; @deschGenotypingCirculatingTumor2020]| |
|
| 20 | +|[ARID1A](ARID1A)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@loveGeneticLandscapeMutations2012; @krysiakRecurrentSomaticMutations2017b; @wienandGenomicAnalysesFlowsorted2019b; @rossiCodingGenomeSplenic2012c]| |
|
| 21 | +|[ATM](ATM)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@beaLandscapeSomaticMutations2013; @braggioGenomicAnalysisMarginal2012]| |
|
| 22 | +|[B2M](B2M)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]| |
|
| 23 | +|[BCL10](BCL10)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@russler-germainMutationsAssociatedProgression2023b; @spinaGeneticsNodalMarginal2016b]| |
|
| 24 | +|[BCL2](BCL2)|1|[Tanaka et al](papers/tanakaFrequentIncidenceSomatic1992)[@tanakaFrequentIncidenceSomatic1992]|[@sarkozyMutationalLandscapeGray2021a; @morinFrequentMutationHistonemodifying2011; @burkhardtClinicalRelevanceMolecular2022b]| |
|
| 25 | 25 | |[BCL6](BCL6)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]| |
| 26 | -|[BCL7A](BCL7A)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a]| |
|
| 26 | +|[BCL7A](BCL7A)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019]| |
|
| 27 | 27 | |[BIRC6](BIRC6)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@sarkozyMutationalLandscapeGray2021a]| |
| 28 | 28 | |[BRAF](BRAF)|1|[Tiacci et al](papers/tiacciBRAFMutationsHairycell2011a)[@tiacciBRAFMutationsHairycell2011a]|[@loveGeneticLandscapeMutations2012]| |
| 29 | -|[BTG1](BTG1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@sarkozyMutationalLandscapeGray2021a; @burkhardtClinicalRelevanceMolecular2022b]| |
|
| 29 | +|[BTG1](BTG1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a]| |
|
| 30 | 30 | |[BTG2](BTG2)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]| |
| 31 | 31 | |[BTK](BTK)|1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@krysiakRecurrentSomaticMutations2017b]| |
| 32 | -|[CARD11](CARD11)|1|[Lenz et al](papers/lenzOncogenicCARD11Mutations2008)[@lenzOncogenicCARD11Mutations2008]|[@yanBCRTLRSignaling2012a; @wuGeneticHeterogeneityPrimary2016; @morinFrequentMutationHistonemodifying2011]| |
|
| 33 | -|[CCND3](CCND3)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@richterRecurrentMutationID32012a; @jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020]| |
|
| 32 | +|[CARD11](CARD11)|1|[Lenz et al](papers/lenzOncogenicCARD11Mutations2008)[@lenzOncogenicCARD11Mutations2008]|[@wuGeneticHeterogeneityPrimary2016; @morinFrequentMutationHistonemodifying2011; @yanBCRTLRSignaling2012a]| |
|
| 33 | +|[CCND3](CCND3)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a]| |
|
| 34 | 34 | |[CD58](CD58)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@schneiderAlterationsCD58Gene2015a]| |
| 35 | 35 | |[CD70](CD70)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@russler-germainMutationsAssociatedProgression2023b]| |
| 36 | 36 | |[CD79B](CD79B)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]| |
| 37 | 37 | |[CD83](CD83)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@dunsCharacterizationDLBCLPMBL2021b; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b]| |
| 38 | -|[CDKN2A](CDKN2A)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@spinaGeneticsNodalMarginal2016b; @grandeGenomewideDiscoverySomatic2019]| |
|
| 39 | -|[CREBBP](CREBBP)|1|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013; @dunsCharacterizationDLBCLPMBL2021b]| |
|
| 40 | -|[CXCR4](CXCR4)|1|[Khodabakhshi et al](papers/khodabakhshiRecurrentTargetsAberrant2012)[@khodabakhshiRecurrentTargetsAberrant2012]|[@krysiakRecurrentSomaticMutations2017b; @paneaWholeGenomeLandscape2019]| |
|
| 38 | +|[CDKN2A](CDKN2A)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019; @spinaGeneticsNodalMarginal2016b]| |
|
| 39 | +|[CREBBP](CREBBP)|1|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@dunsCharacterizationDLBCLPMBL2021b; @parryWholeExomeSequencing2013; @loveGeneticLandscapeMutations2012]| |
|
| 40 | +|[CXCR4](CXCR4)|1|[Khodabakhshi et al](papers/khodabakhshiRecurrentTargetsAberrant2012)[@khodabakhshiRecurrentTargetsAberrant2012]|[@paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b]| |
|
| 41 | 41 | |[CXCR5](CXCR5)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@mottokIntegrativeGenomicAnalysis2019b]| |
| 42 | 42 | |[DDX3X](DDX3X)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@schmitzBurkittLymphomaPathogenesis2012; @mottokIntegrativeGenomicAnalysis2019b]| |
| 43 | 43 | |[DTX1](DTX1)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @gomezUltraDeepSequencingReveals2023]| |
| ... | ... | @@ -47,23 +47,23 @@ link-citations: true |
| 47 | 47 | |[EP300](EP300)|1|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@rossiCodingGenomeSplenic2012c]| |
| 48 | 48 | |[ETS1](ETS1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]| |
| 49 | 49 | |[ETV6](ETV6)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| 50 | -|[EZH2](EZH2)|1|[Morin et al](papers/morinSomaticMutationsAltering2010a)[@morinSomaticMutationsAltering2010a]|[@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019b]| |
|
| 50 | +|[EZH2](EZH2)|1|[Morin et al](papers/morinSomaticMutationsAltering2010a)[@morinSomaticMutationsAltering2010a]|[@mottokIntegrativeGenomicAnalysis2019b; @loveGeneticLandscapeMutations2012]| |
|
| 51 | 51 | |[FAS](FAS)|1|[Scholl et al](papers/schollMutationsRegionFAS2007)[@schollMutationsRegionFAS2007]|[@spinaGeneticsNodalMarginal2016b]| |
| 52 | 52 | |[FBXO11](FBXO11)|1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@parryWholeExomeSequencing2013; @richterRecurrentMutationID32012a]| |
| 53 | 53 | |[FBXW7](FBXW7)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 54 | -|[FOXO1](FOXO1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@dunsCharacterizationDLBCLPMBL2021b; @schmitzBurkittLymphomaPathogenesis2012]| |
|
| 54 | +|[FOXO1](FOXO1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@schmitzBurkittLymphomaPathogenesis2012; @dunsCharacterizationDLBCLPMBL2021b]| |
|
| 55 | 55 | |[GNA13](GNA13)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @loveGeneticLandscapeMutations2012]| |
| 56 | 56 | |[GNAI2](GNAI2)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019]| |
| 57 | 57 | |[GRB2](GRB2)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|| |
| 58 | 58 | |[GRHPR](GRHPR)|1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|| |
| 59 | 59 | |[HIST1H1B](HIST1H1B)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@sarkozyMutationalLandscapeGray2021a; @krysiakRecurrentSomaticMutations2017b]| |
| 60 | 60 | |[HIST1H1C](HIST1H1C)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]| |
| 61 | -|[HIST1H1D](HIST1H1D)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@krysiakRecurrentSomaticMutations2017b; @jalladesExomeSequencingIdentifies2017]| |
|
| 62 | -|[HIST1H1E](HIST1H1E)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@reichelFlowSortingExome2015a; @grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b]| |
|
| 61 | +|[HIST1H1D](HIST1H1D)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@jalladesExomeSequencingIdentifies2017; @krysiakRecurrentSomaticMutations2017b]| |
|
| 62 | +|[HIST1H1E](HIST1H1E)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@grandeGenomewideDiscoverySomatic2019; @reichelFlowSortingExome2015a; @krysiakRecurrentSomaticMutations2017b]| |
|
| 63 | 63 | |[HIST1H2AC](HIST1H2AC)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@krysiakRecurrentSomaticMutations2017b]| |
| 64 | -|[HIST1H2AM](HIST1H2AM)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@paneaWholeGenomeLandscape2019; @krysiakRecurrentSomaticMutations2017b]| |
|
| 65 | -|[HIST1H2BC](HIST1H2BC)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@mottokIntegrativeGenomicAnalysis2019b; @krysiakRecurrentSomaticMutations2017b]| |
|
| 66 | -|[HIST1H2BK](HIST1H2BK)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c; @paneaWholeGenomeLandscape2019]| |
|
| 64 | +|[HIST1H2AM](HIST1H2AM)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@krysiakRecurrentSomaticMutations2017b; @paneaWholeGenomeLandscape2019]| |
|
| 65 | +|[HIST1H2BC](HIST1H2BC)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@krysiakRecurrentSomaticMutations2017b; @mottokIntegrativeGenomicAnalysis2019b]| |
|
| 66 | +|[HIST1H2BK](HIST1H2BK)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c]| |
|
| 67 | 67 | |[HIST1H3B](HIST1H3B)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@reichelFlowSortingExome2015a]| |
| 68 | 68 | |[HIST2H2BE](HIST2H2BE)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|| |
| 69 | 69 | |[HLA-A](HLA-A)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@deschGenotypingCirculatingTumor2020]| |
| ... | ... | @@ -75,15 +75,16 @@ link-citations: true |
| 75 | 75 | |[IKZF3](IKZF3)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@paneaWholeGenomeLandscape2019]| |
| 76 | 76 | |[IL4R](IL4R)|1|[Duns et al](papers/dunsCharacterizationDLBCLPMBL2021b)[@dunsCharacterizationDLBCLPMBL2021b]|[@viganoSomaticIL4RMutations2018b]| |
| 77 | 77 | |[IRF4](IRF4)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@mottokIntegrativeGenomicAnalysis2019b]| |
| 78 | -|[IRF8](IRF8)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@mottokIntegrativeGenomicAnalysis2019b; @paneaWholeGenomeLandscape2019]| |
|
| 78 | +|[IRF8](IRF8)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019; @mottokIntegrativeGenomicAnalysis2019b]| |
|
| 79 | 79 | |[ITPKB](ITPKB)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@reichelFlowSortingExome2015a]| |
| 80 | -|[KLF2](KLF2)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017]| |
|
| 80 | +|[KLF2](KLF2)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@jalladesExomeSequencingIdentifies2017; @deschGenotypingCirculatingTumor2020]| |
|
| 81 | 81 | |[KLHL14](KLHL14)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 82 | 82 | |[KLHL6](KLHL6)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@ganapathiGeneticLandscapeDural2016]| |
| 83 | -|[KMT2C](KMT2C)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@zhouSporadicEndemicBurkitt2019; @sarkozyMutationalLandscapeGray2021a; @zhangGenomicLandscapeMantle2014]| |
|
| 84 | -|[KMT2D](KMT2D)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@beaLandscapeSomaticMutations2013; @deschGenotypingCirculatingTumor2020; @rossiCodingGenomeSplenic2012c; @grandeGenomewideDiscoverySomatic2019]| |
|
| 83 | +|[KMT2C](KMT2C)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@sarkozyMutationalLandscapeGray2021a; @zhangGenomicLandscapeMantle2014; @zhouSporadicEndemicBurkitt2019]| |
|
| 84 | +|[KMT2D](KMT2D)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@grandeGenomewideDiscoverySomatic2019; @deschGenotypingCirculatingTumor2020; @rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013]| |
|
| 85 | 85 | |[KRAS](KRAS)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| 86 | 86 | |[LCOR](LCOR)|1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|| |
| 87 | +|[LRRN3](LRRN3)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@sarkozyMutationalLandscapeGray2021a]| |
|
| 87 | 88 | |[LTB](LTB)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@deschGenotypingCirculatingTumor2020]| |
| 88 | 89 | |[MEF2B](MEF2B)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@beaLandscapeSomaticMutations2013]| |
| 89 | 90 | |[MEF2C](MEF2C)|1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|| |
| ... | ... | @@ -91,13 +92,13 @@ link-citations: true |
| 91 | 92 | |[MPEG1](MPEG1)|1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|| |
| 92 | 93 | |[MS4A1](MS4A1)|1|[Rushton et al](papers/rushtonGeneticEvolutionaryPatterns2020)[@rushtonGeneticEvolutionaryPatterns2020]|[@mottokIntegrativeGenomicAnalysis2019b]| |
| 93 | 94 | |[MTOR](MTOR)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@paneaWholeGenomeLandscape2019]| |
| 94 | -|[MYC](MYC)|1|[Pasqualucci et al](papers/pasqualucciHypermutationMultipleProtooncogenes2001a)[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@jalladesExomeSequencingIdentifies2017; @dunsCharacterizationDLBCLPMBL2021b; @johnstonCmycHypermutationBurkitt1992]| |
|
| 95 | +|[MYC](MYC)|1|[Pasqualucci et al](papers/pasqualucciHypermutationMultipleProtooncogenes2001a)[@pasqualucciHypermutationMultipleProtooncogenes2001a]|[@dunsCharacterizationDLBCLPMBL2021b; @jalladesExomeSequencingIdentifies2017; @johnstonCmycHypermutationBurkitt1992]| |
|
| 95 | 96 | |[MYD88](MYD88)|1|[Ngo et al](papers/ngoOncogenicallyActiveMYD882011a)[@ngoOncogenicallyActiveMYD882011a]|[@yanBCRTLRSignaling2012a]| |
| 96 | -|[NFKBIA](NFKBIA)|1|[Lake et al](papers/lakeMutationsNFKBIAEncoding2009)[@lakeMutationsNFKBIAEncoding2009]|[@wienandGenomicAnalysesFlowsorted2019b; @russler-germainMutationsAssociatedProgression2023b]| |
|
| 97 | -|[NFKBIE](NFKBIE)|1|[Morin et al](papers/morinGeneticLandscapesRelapsed2016)[@morinGeneticLandscapesRelapsed2016]|[@pararajalingamCodingNoncodingDrivers2020; @mansouriFrequentNFKBIEDeletions2016]| |
|
| 97 | +|[NFKBIA](NFKBIA)|1|[Lake et al](papers/lakeMutationsNFKBIAEncoding2009)[@lakeMutationsNFKBIAEncoding2009]|[@russler-germainMutationsAssociatedProgression2023b; @wienandGenomicAnalysesFlowsorted2019b]| |
|
| 98 | +|[NFKBIE](NFKBIE)|1|[Morin et al](papers/morinGeneticLandscapesRelapsed2016)[@morinGeneticLandscapesRelapsed2016]|[@mansouriFrequentNFKBIEDeletions2016; @pararajalingamCodingNoncodingDrivers2020]| |
|
| 98 | 99 | |[NFKBIZ](NFKBIZ)|1|[Morin et al](papers/morinGeneticLandscapesRelapsed2016)[@morinGeneticLandscapesRelapsed2016]|| |
| 99 | 100 | |[NOL9](NOL9)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@spinaGeneticsNodalMarginal2016b]| |
| 100 | -|[NOTCH1](NOTCH1)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c; @loveGeneticLandscapeMutations2012]| |
|
| 101 | +|[NOTCH1](NOTCH1)|1|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|[@loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @beaLandscapeSomaticMutations2013]| |
|
| 101 | 102 | |[NOTCH2](NOTCH2)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c]| |
| 102 | 103 | |[OSBPL10](OSBPL10)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 103 | 104 | |[P2RY8](P2RY8)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@muppidiLossSignalingGa132014b]| |
| ... | ... | @@ -117,7 +118,7 @@ link-citations: true |
| 117 | 118 | |[SF3B1](SF3B1)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@loveGeneticLandscapeMutations2012]| |
| 118 | 119 | |[SGK1](SGK1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@dunsCharacterizationDLBCLPMBL2021b]| |
| 119 | 120 | |[SIN3A](SIN3A)|1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]| |
| 120 | -|[SMARCA4](SMARCA4)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@richterRecurrentMutationID32012a; @nadeuGenomicEpigenomicInsights2020b; @krysiakRecurrentSomaticMutations2017b]| |
|
| 121 | +|[SMARCA4](SMARCA4)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@krysiakRecurrentSomaticMutations2017b; @richterRecurrentMutationID32012a; @nadeuGenomicEpigenomicInsights2020b]| |
|
| 121 | 122 | |[SOCS1](SOCS1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@wenigerMutationsTumorSuppressor2006a]| |
| 122 | 123 | |[SPEN](SPEN)|1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@sarkozyMutationalLandscapeGray2021a; @rossiCodingGenomeSplenic2012c]| |
| 123 | 124 | |[STAT3](STAT3)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| ... | ... | @@ -130,7 +131,7 @@ link-citations: true |
| 130 | 131 | |[TNFAIP3](TNFAIP3)|1|[Compagno et al](papers/compagnoMutationsMultipleGenes2009a)[@compagnoMutationsMultipleGenes2009a]|[@schmitzTNFAIP3A20Tumor2009a; @rossiAlterationBIRC3Multiple2011a]| |
| 131 | 132 | |[TNFRSF14](TNFRSF14)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@cheungAcquiredTNFRSF14Mutations2010a; @spinaGeneticsNodalMarginal2016b]| |
| 132 | 133 | |[TOX](TOX)|1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| 133 | -|[TP53](TP53)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@beaLandscapeSomaticMutations2013; @rossiCodingGenomeSplenic2012c; @wildaInactivationARFMDM2p53Pathway2004; @morinFrequentMutationHistonemodifying2011; @tiacciPervasiveMutationsJAKSTAT2018b]| |
|
| 134 | +|[TP53](TP53)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@rossiCodingGenomeSplenic2012c; @morinFrequentMutationHistonemodifying2011; @beaLandscapeSomaticMutations2013; @tiacciPervasiveMutationsJAKSTAT2018b; @wildaInactivationARFMDM2p53Pathway2004]| |
|
| 134 | 135 | |[TRRAP](TRRAP)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@rossiCodingGenomeSplenic2012c]| |
| 135 | 136 | |[UBE2A](UBE2A)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@reichelFlowSortingExome2015a]| |
| 136 | 137 | |[UNC5C](UNC5C)|1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| ... | ... | @@ -139,13 +140,13 @@ link-citations: true |
| 139 | 140 | |[WEE1](WEE1)|1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@reichelFlowSortingExome2015a]| |
| 140 | 141 | |[XPO1](XPO1)|1|[Mareschal et al](papers/mareschalWholeExomeSequencing2016)[@mareschalWholeExomeSequencing2016]|[@jardinRecurrentMutationsExportin2016a]| |
| 141 | 142 | |[ZC3H12A](ZC3H12A)|1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|| |
| 142 | -|[ZFP36L1](ZFP36L1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@reichelFlowSortingExome2015a; @paneaWholeGenomeLandscape2019]| |
|
| 143 | +|[ZFP36L1](ZFP36L1)|1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019; @reichelFlowSortingExome2015a]| |
|
| 143 | 144 | |[ZNF292](ZNF292)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 144 | 145 | |[ZNF608](ZNF608)|1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@krysiakRecurrentSomaticMutations2017b]| |
| 145 | 146 | |
| 146 | 147 | ## Tier 2 DLBCL genes |
| 147 | 148 | |
| 148 | -### *176 total* |
|
| 149 | +### *179 total* |
|
| 149 | 150 | |
| 150 | 151 | |Gene|Tier| First DLBCL evidence | Other entities | |
| 151 | 152 | |:-:|:-:|:--|:-| |
| ... | ... | @@ -153,13 +154,14 @@ link-citations: true |
| 153 | 154 | |[ADAMTS1](ADAMTS1)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|| |
| 154 | 155 | |[AICDA](AICDA)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|| |
| 155 | 156 | |[ANKRD12](ANKRD12)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|| |
| 157 | +|[ANKRD17](ANKRD17)|2|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 156 | 158 | |[ARID5B](ARID5B)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@gomezUltraDeepSequencingReveals2023]| |
| 157 | 159 | |[ASXL3](ASXL3)|2|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|| |
| 158 | 160 | |[ATR](ATR)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| 159 | 161 | |[BCL11A](BCL11A)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|| |
| 160 | 162 | |[BCOR](BCOR)|2||[@jalladesExomeSequencingIdentifies2017; @nadeuGenomicEpigenomicInsights2020b]| |
| 161 | 163 | |[BCR](BCR)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| 162 | -|[BIRC3](BIRC3)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|[@dunsCharacterizationDLBCLPMBL2021b; @rossiAlterationBIRC3Multiple2011a; @beaLandscapeSomaticMutations2013]| |
|
| 164 | +|[BIRC3](BIRC3)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|[@beaLandscapeSomaticMutations2013; @dunsCharacterizationDLBCLPMBL2021b; @rossiAlterationBIRC3Multiple2011a]| |
|
| 163 | 165 | |[BLK](BLK)|2||| |
| 164 | 166 | |[BRINP3](BRINP3)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| 165 | 167 | |[BTBD3](BTBD3)|2|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| ... | ... | @@ -179,6 +181,7 @@ link-citations: true |
| 179 | 181 | |[CPS1](CPS1)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| 180 | 182 | |[CRIP1](CRIP1)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|| |
| 181 | 183 | |[DAZAP1](DAZAP1)|2|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]|| |
| 184 | +|[DDX10](DDX10)|2|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 182 | 185 | |[DHX16](DHX16)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|| |
| 183 | 186 | |[DNAH5](DNAH5)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@jalladesExomeSequencingIdentifies2017]| |
| 184 | 187 | |[DNM2](DNM2)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|| |
| ... | ... | @@ -191,7 +194,7 @@ link-citations: true |
| 191 | 194 | |[FAM102A](FAM102A)|2||| |
| 192 | 195 | |[FANK1](FANK1)|2||| |
| 193 | 196 | |[FAT2](FAT2)|2|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|| |
| 194 | -|[FAT4](FAT4)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@parryWholeExomeSequencing2013; @zhangGenomicLandscapeMantle2014]| |
|
| 197 | +|[FAT4](FAT4)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@zhangGenomicLandscapeMantle2014; @parryWholeExomeSequencing2013]| |
|
| 195 | 198 | |[FCRL3](FCRL3)|2||| |
| 196 | 199 | |[FNBP1](FNBP1)|2||| |
| 197 | 200 | |[FOXC1](FOXC1)|2|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|| |
| ... | ... | @@ -204,17 +207,17 @@ link-citations: true |
| 204 | 207 | |[GSG2](GSG2)|2|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|| |
| 205 | 208 | |[H1FOO](H1FOO)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| 206 | 209 | |[HDAC7](HDAC7)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|| |
| 207 | -|[HIST1H2AG](HIST1H2AG)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@krysiakRecurrentSomaticMutations2017b; @paneaWholeGenomeLandscape2019; @rossiCodingGenomeSplenic2012c]| |
|
| 210 | +|[HIST1H2AG](HIST1H2AG)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@rossiCodingGenomeSplenic2012c; @krysiakRecurrentSomaticMutations2017b; @paneaWholeGenomeLandscape2019]| |
|
| 208 | 211 | |[HIST1H2AL](HIST1H2AL)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| 209 | 212 | |[HIST1H2BO](HIST1H2BO)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| 210 | 213 | |[HLA-DMA](HLA-DMA)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|| |
| 211 | 214 | |[HNF1B](HNF1B)|2|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|| |
| 212 | 215 | |[HNRNPD](HNRNPD)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| 213 | 216 | |[HNRNPH1](HNRNPH1)|2|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]|| |
| 214 | -|[ID3](ID3)|2|[Schmitz et al](papers/schmitzBurkittLymphomaPathogenesis2012)[@schmitzBurkittLymphomaPathogenesis2012]|[@spinaGeneticsNodalMarginal2016b; @richterRecurrentMutationID32012a]| |
|
| 217 | +|[ID3](ID3)|2|[Schmitz et al](papers/schmitzBurkittLymphomaPathogenesis2012)[@schmitzBurkittLymphomaPathogenesis2012]|[@richterRecurrentMutationID32012a; @spinaGeneticsNodalMarginal2016b]| |
|
| 215 | 218 | |[IFNGR1](IFNGR1)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|| |
| 216 | -|[IGLL5](IGLL5)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@paneaWholeGenomeLandscape2019; @deschGenotypingCirculatingTumor2020; @russler-germainMutationsAssociatedProgression2023b]| |
|
| 217 | -|[IKBKB](IKBKB)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@wienandGenomicAnalysesFlowsorted2019b; @rossiAlterationBIRC3Multiple2011a]| |
|
| 219 | +|[IGLL5](IGLL5)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b; @deschGenotypingCirculatingTumor2020]| |
|
| 220 | +|[IKBKB](IKBKB)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@rossiAlterationBIRC3Multiple2011a; @wienandGenomicAnalysesFlowsorted2019b]| |
|
| 218 | 221 | |[IKBKE](IKBKE)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|| |
| 219 | 222 | |[IL16](IL16)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| 220 | 223 | |[IL6](IL6)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|| |
| ... | ... | @@ -234,7 +237,7 @@ link-citations: true |
| 234 | 237 | |[MAGT1](MAGT1)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| 235 | 238 | |[MALAT1](MALAT1)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|| |
| 236 | 239 | |[MAP2K1](MAP2K1)|2|[Shin et al](papers/shinBRAFV600EMAP2K12015)[@shinBRAFV600EMAP2K12015]|[@louissaintPediatrictypeNodalFollicular2016a]| |
| 237 | -|[MCL1](MCL1)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@paneaWholeGenomeLandscape2019; @dunsCharacterizationDLBCLPMBL2021b]| |
|
| 240 | +|[MCL1](MCL1)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@dunsCharacterizationDLBCLPMBL2021b; @paneaWholeGenomeLandscape2019]| |
|
| 238 | 241 | |[MECOM](MECOM)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| 239 | 242 | |[MET](MET)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| 240 | 243 | |[MIR142](MIR142)|2|[Kwanhian et al](papers/kwanhianMicroRNA142Mutated202012b)[@kwanhianMicroRNA142Mutated202012b]|[@grandeGenomewideDiscoverySomatic2019]| |
| ... | ... | @@ -246,7 +249,7 @@ link-citations: true |
| 246 | 249 | |[MYOM2](MYOM2)|2|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]|| |
| 247 | 250 | |[NAV1](NAV1)|2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|| |
| 248 | 251 | |[NCOA3](NCOA3)|2||| |
| 249 | -|[NCOR2](NCOR2)|2||[@schmitzBurkittLymphomaPathogenesis2012; @spinaGeneticsNodalMarginal2016b; @sarkozyMutationalLandscapeGray2021a]| |
|
| 252 | +|[NCOR2](NCOR2)|2||[@spinaGeneticsNodalMarginal2016b; @schmitzBurkittLymphomaPathogenesis2012; @sarkozyMutationalLandscapeGray2021a]| |
|
| 250 | 253 | |[NEAT1](NEAT1)|2|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]|| |
| 251 | 254 | |[NF1](NF1)|2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| 252 | 255 | |[NFKB1](NFKB1)|2||| |
| ... | ... | @@ -265,6 +268,7 @@ link-citations: true |
| 265 | 268 | |[PCLO](PCLO)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| 266 | 269 | |[PDGFC](PDGFC)|2|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|| |
| 267 | 270 | |[PDS5B](PDS5B)|2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@hubschmannMutationalMechanismsShaping2021b]| |
| 271 | +|[PIK3CD](PIK3CD)|2|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 268 | 272 | |[PIK3R1](PIK3R1)|2|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@paneaWholeGenomeLandscape2019]| |
| 269 | 273 | |[PNPO](PNPO)|2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|| |
| 270 | 274 | |[PPP1R9B](PPP1R9B)|2||| |
| ... | ... | @@ -328,7 +332,7 @@ link-citations: true |
| 328 | 332 | |
| 329 | 333 | ## Tier 3 DLBCL genes |
| 330 | 334 | |
| 331 | -### *389 total* |
|
| 335 | +### *385 total* |
|
| 332 | 336 | |
| 333 | 337 | |Gene|Tier| First DLBCL evidence | Other entities | |
| 334 | 338 | |:-:|:-:|:--|:-| |
| ... | ... | @@ -353,7 +357,6 @@ link-citations: true |
| 353 | 357 | |[AMIGO3](AMIGO3)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 354 | 358 | |[AMPH](AMPH)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 355 | 359 | |[ANK2](ANK2)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@zhangGenomicLandscapeMantle2014]| |
| 356 | -|[ANKRD17](ANKRD17)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 357 | 360 | |[ANKRD44](ANKRD44)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 358 | 361 | |[ANTXR1](ANTXR1)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 359 | 362 | |[AP1G2](AP1G2)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| ... | ... | @@ -423,7 +426,6 @@ link-citations: true |
| 423 | 426 | |[CYYR1](CYYR1)|3|[Fan et al](papers/fanComprehensiveCharacterizationDriver2020b)[@fanComprehensiveCharacterizationDriver2020b]|| |
| 424 | 427 | |[DCAF6](DCAF6)|3|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| 425 | 428 | |[DDB1](DDB1)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 426 | -|[DDX10](DDX10)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 427 | 429 | |[DGCR8](DGCR8)|3|[Fan et al](papers/fanComprehensiveCharacterizationDriver2020b)[@fanComprehensiveCharacterizationDriver2020b]|| |
| 428 | 430 | |[DHX33](DHX33)|3|[Fan et al](papers/fanComprehensiveCharacterizationDriver2020b)[@fanComprehensiveCharacterizationDriver2020b]|| |
| 429 | 431 | |[DIAPH3](DIAPH3)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| ... | ... | @@ -537,7 +539,6 @@ link-citations: true |
| 537 | 539 | |[LRP10](LRP10)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 538 | 540 | |[LRP1B](LRP1B)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@spinaGeneticsNodalMarginal2016b]| |
| 539 | 541 | |[LRP3](LRP3)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 540 | -|[LRRN3](LRRN3)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@sarkozyMutationalLandscapeGray2021a]| |
|
| 541 | 542 | |[LYST](LYST)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 542 | 543 | |[MAP2K3](MAP2K3)|3|[Fan et al](papers/fanComprehensiveCharacterizationDriver2020b)[@fanComprehensiveCharacterizationDriver2020b]|| |
| 543 | 544 | |[MAP4K4](MAP4K4)|3|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|| |
| ... | ... | @@ -602,7 +603,6 @@ link-citations: true |
| 602 | 603 | |[PFN1](PFN1)|3|[Fan et al](papers/fanComprehensiveCharacterizationDriver2020b)[@fanComprehensiveCharacterizationDriver2020b]|| |
| 603 | 604 | |[PGR](PGR)|3|[Fan et al](papers/fanComprehensiveCharacterizationDriver2020b)[@fanComprehensiveCharacterizationDriver2020b]|| |
| 604 | 605 | |[PHF6](PHF6)|3|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@thomasGeneticSubgroupsInform2023]| |
| 605 | -|[PIK3CD](PIK3CD)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
|
| 606 | 606 | |[PKD1](PKD1)|3|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|| |
| 607 | 607 | |[PLA2G4B](PLA2G4B)|3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|| |
| 608 | 608 | |[PLCB4](PLCB4)|3|[Fan et al](papers/fanComprehensiveCharacterizationDriver2020b)[@fanComprehensiveCharacterizationDriver2020b]|| |
papers/zhangGeneticHeterogeneityDiffuse2013.md
| ... | ... | @@ -8,7 +8,7 @@ bibliography: 'morinlab.bib' |
| 8 | 8 | |
| 9 | 9 | |Entity| Tier 1 genes| Tier 2 genes|Tier 3 genes| |
| 10 | 10 | |:-:|:-:|:-:|:-:| |
| 11 | -|DLBCL|15|13|272| |
|
| 11 | +|DLBCL|16|13|271| |
|
| 12 | 12 | ```mermaid |
| 13 | 13 | --- |
| 14 | 14 | config: |
| ... | ... | @@ -22,12 +22,12 @@ config: |
| 22 | 22 | suffix: ' genes)' |
| 23 | 23 | --- |
| 24 | 24 | sankey-beta |
| 25 | -This study, New Tier 1, 15 |
|
| 26 | -New Tier 1, DLBCL Tier 1, 15 |
|
| 25 | +This study, New Tier 1, 16 |
|
| 26 | +New Tier 1, DLBCL Tier 1, 16 |
|
| 27 | 27 | This study, New Tier 2, 13 |
| 28 | 28 | New Tier 2, DLBCL Tier 2, 13 |
| 29 | -This study, New Tier 3, 272 |
|
| 30 | -New Tier 3, DLBCL Tier 3, 272 |
|
| 29 | +This study, New Tier 3, 271 |
|
| 30 | +New Tier 3, DLBCL Tier 3, 271 |
|
| 31 | 31 | All other DLBCL studies, DLBCL Tier 1, 112 |
| 32 | 32 | All other DLBCL studies, DLBCL Tier 2, 166 |
| 33 | 33 | All other DLBCL studies, DLBCL Tier 3, 114 |
| ... | ... | @@ -45,6 +45,7 @@ All other DLBCL studies, DLBCL Tier 3, 114 |
| 45 | 45 | |[HIST1H2BK](../HIST1H2BK)|1 | |
| 46 | 46 | |[KLHL14](../KLHL14)|1 | |
| 47 | 47 | |[KMT2C](../KMT2C)|1 | |
| 48 | +|[LRRN3](../LRRN3)|1 | |
|
| 48 | 49 | |[MGA](../MGA)|1 | |
| 49 | 50 | |[MTOR](../MTOR)|1 | |
| 50 | 51 | |[NOTCH2](../NOTCH2)|1 | |
| ... | ... | @@ -225,7 +226,6 @@ All other DLBCL studies, DLBCL Tier 3, 114 |
| 225 | 226 | |[LRP10](../LRP10)|3 | |
| 226 | 227 | |[LRP1B](../LRP1B)|3 | |
| 227 | 228 | |[LRP3](../LRP3)|3 | |
| 228 | -|[LRRN3](../LRRN3)|3 | |
|
| 229 | 229 | |[LYST](../LYST)|3 | |
| 230 | 230 | |[MARCHF7](../MARCHF7)|3 | |
| 231 | 231 | |[MBL2](../MBL2)|3 | |