MEF2B.md
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-# [MEF2B]
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-MEF2B mutations are observed in a significant subset of follicular lymphoma cases, as well as in other B-cell lymphomas, including diffuse large B-cell lymphoma (DLBCL). MEF2B has known hotspot mutations that affect multiple distinct domains of the protein.
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+MEF2B is one of [a number of genes](https://github.com/morinlab/LLMPP/wiki/ashm) affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus. MEF2B mutations are observed in a significant subset of follicular lymphoma cases, as well as in other B-cell lymphomas, including diffuse large B-cell lymphoma (DLBCL). MEF2B has known hotspot mutations that affect multiple distinct domains of the protein.
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## Mutation tier
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|chr19 |19279635 |19281441|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr19%3A19279635%2D19281441)|active_promoter |
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- ## MEF2B Hotspots
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+## MEF2B Hotspots
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### DNA-Binding Domain (MADS-box and MEF2 Domain):
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**R24 (Arginine 24)** A recurrent hotspot mutation. This position is located within the MADS-box domain, which is crucial for DNA binding and dimerization with other MEF2 family members.
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View all variants in GenomePaint [hg19](https://www.bcgsc.ca/downloads/morinlab/GAMBL/test/genes/MEF2B.html) or [hg38](https://www.bcgsc.ca/downloads/morinlab/GAMBL/test/genes/MEF2B_hg38.html)
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![image](images/proteinpaint/MEF2B.svg)
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+## References
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+1.