morinlab.bib
... ...
@@ -1,3 +1,23 @@
1
+@article{zhangDisruptionKMT2DPerturbs2015b,
2
+ title = {Disruption of {{KMT2D}} Perturbs Germinal Center {{B}} Cell Development and Promotes Lymphomagenesis},
3
+ author = {Zhang, Jiyuan and Dominguez-Sola, David and Hussein, Shafinaz and Lee, Ji-Eun and Holmes, Antony B. and Bansal, Mukesh and Vlasevska, Sofija and Mo, Tongwei and Tang, Hongyan and Basso, Katia and Ge, Kai and Dalla-Favera, Riccardo and Pasqualucci, Laura},
4
+ date = {2015-10},
5
+ journaltitle = {Nature Medicine},
6
+ shortjournal = {Nat Med},
7
+ volume = {21},
8
+ number = {10},
9
+ eprint = {26366712},
10
+ eprinttype = {pmid},
11
+ pages = {1190--1198},
12
+ issn = {1546-170X},
13
+ doi = {10.1038/nm.3940},
14
+ abstract = {Mutations in the gene encoding the KMT2D (or MLL2) methyltransferase are highly recurrent and occur early during tumorigenesis in diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL). However, the functional consequences of these mutations and their role in lymphomagenesis are unknown. Here we show that FL- and DLBCL-associated KMT2D mutations impair KMT2D enzymatic activity, leading to diminished global H3K4 methylation in germinal-center (GC) B cells and DLBCL cells. Conditional deletion of Kmt2d early during B cell development, but not after initiation of the GC reaction, results in an increase in GC B cells and enhances B cell proliferation in mice. Moreover, genetic ablation of Kmt2d in mice overexpressing Bcl2 increases the incidence of GC-derived lymphomas resembling human tumors. These findings suggest that KMT2D acts as a tumor suppressor gene whose early loss facilitates lymphomagenesis by remodeling the epigenetic landscape of the cancer precursor cells. Eradication of KMT2D-deficient cells may thus represent a rational therapeutic approach for targeting early tumorigenic events.},
15
+ langid = {english},
16
+ pmcid = {PMC5145002},
17
+ keywords = {Animals,B-Lymphocytes,Cell Proliferation,DNA Methylation,DNA-Binding Proteins,Epigenesis Genetic,Gene Silencing,Germinal Center,Humans,Lymphoma Large B-Cell Diffuse,Mice,Mutation Missense,Neoplasm Proteins,Transcription Genetic},
18
+ file = {/Users/rmorin/Zotero/storage/3WZ3HYIK/Zhang et al. - 2015 - Disruption of KMT2D perturbs germinal center B cel.pdf}
19
+}
20
+
1 21
@article{choiLossKLHL6Promotes2018,
2 22
title = {Loss of {{KLHL6}} Promotes Diffuse Large {{B-cell}} Lymphoma Growth and Survival by Stabilizing the {{mRNA}} Decay Factor Roquin2},
3 23
author = {Choi, Jaewoo and Lee, Kyutae and Ingvarsdottir, Kristin and Bonasio, Roberto and Saraf, Anita and Florens, Laurence and Washburn, Michael P. and Tadros, Saber and Green, Michael R. and Busino, Luca},