d824dca7cb6aa42c3584b49b27aee11ec1130fd7
DLBCL_genes.md
| ... | ... | @@ -13,41 +13,41 @@ link-citations: true |
| 13 | 13 | |
| 14 | 14 | ### *124 total* |
| 15 | 15 | |
| 16 | -|Gene|Tier| First DLBCL study | Other entities | QC result | |
|
| 16 | +|Gene|Summary| First DLBCL study | Other entities | QC result | |
|
| 17 | 17 | |:-:|:-:|:-:|:-|:-| |
| 18 | 18 | |[ACTB](ACTB)|Tier 1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@wienandGenomicAnalysesFlowsorted2019b]|| |
| 19 | 19 | |[ACTG1](ACTG1)|Tier 1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@deschGenotypingCirculatingTumor2020; @spinaGeneticsNodalMarginal2016b]|| |
| 20 | 20 | |[ARID1A](ARID1A)|Tier 1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@krysiakRecurrentSomaticMutations2017b; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c; @wienandGenomicAnalysesFlowsorted2019b]|| |
| 21 | 21 | |[ATM](ATM)|Tier 1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@beaLandscapeSomaticMutations2013; @braggioGenomicAnalysisMarginal2012]|| |
| 22 | -|[B2M](B2M)|Tier 1; EE; CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]|| |
|
| 23 | -|[BCL10](BCL10)|Tier 1; EE; CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@russler-germainMutationsAssociatedProgression2023b; @spinaGeneticsNodalMarginal2016b]|| |
|
| 24 | -|[BCL2](BCL2)|Tier 1; EE; CE|[Tanaka et al](papers/tanakaFrequentIncidenceSomatic1992)[@tanakaFrequentIncidenceSomatic1992]|[@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021a]|| |
|
| 25 | -|[BCL6](BCL6)|Tier 1; EE; CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|| |
|
| 26 | -|[BCL7A](BCL7A)|Tier 1; EE; CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a]|| |
|
| 22 | +|[B2M](B2M)|Tier 1, EE, CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@pararajalingamCodingNoncodingDrivers2020; @reichelFlowSortingExome2015a]|| |
|
| 23 | +|[BCL10](BCL10)|Tier 1, EE, CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@russler-germainMutationsAssociatedProgression2023b; @spinaGeneticsNodalMarginal2016b]|| |
|
| 24 | +|[BCL2](BCL2)|Tier 1, EE, CE|[Tanaka et al](papers/tanakaFrequentIncidenceSomatic1992)[@tanakaFrequentIncidenceSomatic1992]|[@burkhardtClinicalRelevanceMolecular2022b; @morinFrequentMutationHistonemodifying2011; @sarkozyMutationalLandscapeGray2021a]|| |
|
| 25 | +|[BCL6](BCL6)|Tier 1, EE, CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|| |
|
| 26 | +|[BCL7A](BCL7A)|Tier 1, EE, CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@grandeGenomewideDiscoverySomatic2019; @krysiakRecurrentSomaticMutations2017b; @reichelFlowSortingExome2015a]|| |
|
| 27 | 27 | |[BIRC6](BIRC6)|Tier 1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@sarkozyMutationalLandscapeGray2021a]|| |
| 28 | 28 | |[BRAF](BRAF)|Tier 1|[Tiacci et al](papers/tiacciBRAFMutationsHairycell2011a)[@tiacciBRAFMutationsHairycell2011a]|[@loveGeneticLandscapeMutations2012]|| |
| 29 | -|[BTG1](BTG1)|Tier 1; EE; CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a]|| |
|
| 30 | -|[BTG2](BTG2)|Tier 1; EE; CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|| |
|
| 29 | +|[BTG1](BTG1)|Tier 1, EE, CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@burkhardtClinicalRelevanceMolecular2022b; @sarkozyMutationalLandscapeGray2021a]|| |
|
| 30 | +|[BTG2](BTG2)|Tier 1, EE, CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@loveGeneticLandscapeMutations2012]|| |
|
| 31 | 31 | |[BTK](BTK)|Tier 1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@krysiakRecurrentSomaticMutations2017b]|| |
| 32 | -|[CARD11](CARD11)|Tier 1; EE; CE|[Lenz et al](papers/lenzOncogenicCARD11Mutations2008)[@lenzOncogenicCARD11Mutations2008]|[@morinFrequentMutationHistonemodifying2011; @wuGeneticHeterogeneityPrimary2016; @yanBCRTLRSignaling2012a]|| |
|
| 33 | -|[CCND3](CCND3)|Tier 1; EE; CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a]|| |
|
| 34 | -|[CD58](CD58)|Tier 1; EE; CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@schneiderAlterationsCD58Gene2015a]|| |
|
| 32 | +|[CARD11](CARD11)|Tier 1, EE, CE|[Lenz et al](papers/lenzOncogenicCARD11Mutations2008)[@lenzOncogenicCARD11Mutations2008]|[@morinFrequentMutationHistonemodifying2011; @wuGeneticHeterogeneityPrimary2016; @yanBCRTLRSignaling2012a]|| |
|
| 33 | +|[CCND3](CCND3)|Tier 1, EE, CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@deschGenotypingCirculatingTumor2020; @jalladesExomeSequencingIdentifies2017; @richterRecurrentMutationID32012a]|| |
|
| 34 | +|[CD58](CD58)|Tier 1, EE, CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@schneiderAlterationsCD58Gene2015a]|| |
|
| 35 | 35 | |[CD70](CD70)|Tier 1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@russler-germainMutationsAssociatedProgression2023b]|| |
| 36 | -|[CD79B](CD79B)|Tier 1; EE; CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|| |
|
| 36 | +|[CD79B](CD79B)|Tier 1, EE, CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|| |
|
| 37 | 37 | |[CD83](CD83)|Tier 1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@dunsCharacterizationDLBCLPMBL2021b; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b]|| |
| 38 | -|[CDKN2A](CDKN2A)|Tier 1; EE; CE|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019; @spinaGeneticsNodalMarginal2016b]|| |
|
| 39 | -|[CREBBP](CREBBP)|Tier 1; EE; CE|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@dunsCharacterizationDLBCLPMBL2021b; @loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013]|| |
|
| 38 | +|[CDKN2A](CDKN2A)|Tier 1, EE, CE|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]|[@grandeGenomewideDiscoverySomatic2019; @spinaGeneticsNodalMarginal2016b]|| |
|
| 39 | +|[CREBBP](CREBBP)|Tier 1, EE, CE|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@dunsCharacterizationDLBCLPMBL2021b; @loveGeneticLandscapeMutations2012; @parryWholeExomeSequencing2013]|| |
|
| 40 | 40 | |[CXCR4](CXCR4)|Tier 1|[Khodabakhshi et al](papers/khodabakhshiRecurrentTargetsAberrant2012)[@khodabakhshiRecurrentTargetsAberrant2012]|[@krysiakRecurrentSomaticMutations2017b; @paneaWholeGenomeLandscape2019]|| |
| 41 | 41 | |[CXCR5](CXCR5)|Tier 1|[Schmitz et al](papers/schmitzGeneticsPathogenesisDiffuse2018a)[@schmitzGeneticsPathogenesisDiffuse2018a]|[@mottokIntegrativeGenomicAnalysis2019b]|| |
| 42 | -|[DDX3X](DDX3X)|Tier 1; EE; CE|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@mottokIntegrativeGenomicAnalysis2019b; @schmitzBurkittLymphomaPathogenesis2012]|| |
|
| 42 | +|[DDX3X](DDX3X)|Tier 1, EE, CE|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@mottokIntegrativeGenomicAnalysis2019b; @schmitzBurkittLymphomaPathogenesis2012]|| |
|
| 43 | 43 | |[DTX1](DTX1)|Tier 1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@gomezUltraDeepSequencingReveals2023; @loveGeneticLandscapeMutations2012; @rossiCodingGenomeSplenic2012c]|| |
| 44 | 44 | |[DUSP2](DUSP2)|Tier 1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]|[@dunsCharacterizationDLBCLPMBL2021b]|| |
| 45 | 45 | |[EBF1](EBF1)|Tier 1|[Bohle et al](papers/bohleRoleEarlyBcell2013)[@bohleRoleEarlyBcell2013]|[@reichelFlowSortingExome2015a; @thomasGeneticSubgroupsInform2023]|| |
| 46 | 46 | |[EEF1A1](EEF1A1)|Tier 1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@reichelFlowSortingExome2015a]|| |
| 47 | -|[EP300](EP300)|Tier 1; EE; CE|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@rossiCodingGenomeSplenic2012c]|| |
|
| 47 | +|[EP300](EP300)|Tier 1, EE, CE|[Pasqualucci et al](papers/pasqualucciInactivatingMutationsAcetyltransferase2011a)[@pasqualucciInactivatingMutationsAcetyltransferase2011a]|[@rossiCodingGenomeSplenic2012c]|| |
|
| 48 | 48 | |[ETS1](ETS1)|Tier 1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@paneaWholeGenomeLandscape2019]|| |
| 49 | 49 | |[ETV6](ETV6)|Tier 1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||| |
| 50 | -|[EZH2](EZH2)|Tier 1; EE; CE|[Morin et al](papers/morinSomaticMutationsAltering2010a)[@morinSomaticMutationsAltering2010a]|[@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019b]|| |
|
| 50 | +|[EZH2](EZH2)|Tier 1, EE, CE|[Morin et al](papers/morinSomaticMutationsAltering2010a)[@morinSomaticMutationsAltering2010a]|[@loveGeneticLandscapeMutations2012; @mottokIntegrativeGenomicAnalysis2019b]|| |
|
| 51 | 51 | |[FAS](FAS)|Tier 1|[Scholl et al](papers/schollMutationsRegionFAS2007)[@schollMutationsRegionFAS2007]|[@spinaGeneticsNodalMarginal2016b]|| |
| 52 | 52 | |[FBXO11](FBXO11)|Tier 1|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]|[@parryWholeExomeSequencing2013; @richterRecurrentMutationID32012a]|| |
| 53 | 53 | |[FBXW7](FBXW7)|Tier 1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||| |
| ... | ... | @@ -87,7 +87,7 @@ link-citations: true |
| 87 | 87 | |[LCOR](LCOR)|Tier 1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]||| |
| 88 | 88 | |[LRRN3](LRRN3)|Tier 1|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@sarkozyMutationalLandscapeGray2021a]|| |
| 89 | 89 | |[LTB](LTB)|Tier 1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@deschGenotypingCirculatingTumor2020]|| |
| 90 | -|[MEF2B](MEF2B)|Tier 1; EE; CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@beaLandscapeSomaticMutations2013]|| |
|
| 90 | +|[MEF2B](MEF2B)|Tier 1, EE, CE|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@beaLandscapeSomaticMutations2013]|| |
|
| 91 | 91 | |[MEF2C](MEF2C)|Tier 1|[Arthur et al](papers/arthurGenomewideDiscoverySomatic2018)[@arthurGenomewideDiscoverySomatic2018]||| |
| 92 | 92 | |[MGA](MGA)|Tier 1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@jalladesExomeSequencingIdentifies2017]|| |
| 93 | 93 | |[MPEG1](MPEG1)|Tier 1|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]||| |
| ... | ... | @@ -118,7 +118,7 @@ link-citations: true |
| 118 | 118 | |[SF3B1](SF3B1)|Tier 1|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@loveGeneticLandscapeMutations2012]|| |
| 119 | 119 | |[SGK1](SGK1)|Tier 1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@dunsCharacterizationDLBCLPMBL2021b]|| |
| 120 | 120 | |[SIN3A](SIN3A)|Tier 1|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@grandeGenomewideDiscoverySomatic2019; @rossiCodingGenomeSplenic2012c]|| |
| 121 | -|[SMARCA4](SMARCA4)|Tier 1; EE; CE|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@krysiakRecurrentSomaticMutations2017b; @nadeuGenomicEpigenomicInsights2020b; @richterRecurrentMutationID32012a]|| |
|
| 121 | +|[SMARCA4](SMARCA4)|Tier 1, EE, CE|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]|[@krysiakRecurrentSomaticMutations2017b; @nadeuGenomicEpigenomicInsights2020b; @richterRecurrentMutationID32012a]|| |
|
| 122 | 122 | |[SOCS1](SOCS1)|Tier 1|[Morin et al](papers/morinFrequentMutationHistonemodifying2011)[@morinFrequentMutationHistonemodifying2011]|[@wenigerMutationsTumorSuppressor2006a]|| |
| 123 | 123 | |[SPEN](SPEN)|Tier 1|[Albuquerque et al](papers/albuquerqueEnhancingKnowledgeDiscovery2017a)[@albuquerqueEnhancingKnowledgeDiscovery2017a]|[@rossiCodingGenomeSplenic2012c; @sarkozyMutationalLandscapeGray2021a]|| |
| 124 | 124 | |[STAT3](STAT3)|Tier 1|[Lohr et al](papers/lohrDiscoveryPrioritizationSomatic2012a)[@lohrDiscoveryPrioritizationSomatic2012a]||| |
| ... | ... | @@ -144,7 +144,7 @@ link-citations: true |
| 144 | 144 | |
| 145 | 145 | ### *181 total* |
| 146 | 146 | |
| 147 | -|Gene|Tier| First DLBCL study | Other entities | QC result | |
|
| 147 | +|Gene|Summary| First DLBCL study | Other entities | QC result | |
|
| 148 | 148 | |:-:|:-:|:-:|:-|:-| |
| 149 | 149 | |[ABI3BP](ABI3BP)|Tier 2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]||PASS| |
| 150 | 150 | |[ADAMTS1](ADAMTS1)|Tier 2|[Hubschmann et al](papers/hubschmannMutationalMechanismsShaping2021b)[@hubschmannMutationalMechanismsShaping2021b]||PASS| |
| ... | ... | @@ -209,7 +209,7 @@ link-citations: true |
| 209 | 209 | |[HLA-DMA](HLA-DMA)|Tier 2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]||| |
| 210 | 210 | |[HNF1B](HNF1B)|Tier 2|[Pasqualucci et al](papers/pasqualucciAnalysisCodingGenome2011)[@pasqualucciAnalysisCodingGenome2011]||| |
| 211 | 211 | |[HNRNPD](HNRNPD)|Tier 2|[Reddy et al](papers/reddyGeneticFunctionalDrivers2017)[@reddyGeneticFunctionalDrivers2017]||| |
| 212 | -|[HNRNPH1](HNRNPH1)|Tier 2; EE; CE|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]||| |
|
| 212 | +|[HNRNPH1](HNRNPH1)|Tier 2, EE, CE|[Pararajalingam et al](papers/pararajalingamCodingNoncodingDrivers2020)[@pararajalingamCodingNoncodingDrivers2020]||| |
|
| 213 | 213 | |[ID3](ID3)|Tier 2|[Schmitz et al](papers/schmitzBurkittLymphomaPathogenesis2012)[@schmitzBurkittLymphomaPathogenesis2012]|[@richterRecurrentMutationID32012a; @spinaGeneticsNodalMarginal2016b]|| |
| 214 | 214 | |[IFNGR1](IFNGR1)|Tier 2|[Morin et al](papers/morinMutationalStructuralAnalysis2013)[@morinMutationalStructuralAnalysis2013]||PASS| |
| 215 | 215 | |[IGLL5](IGLL5)|Tier 2|[Chapuy et al](papers/chapuyMolecularSubtypesDiffuse2018b)[@chapuyMolecularSubtypesDiffuse2018b]|[@deschGenotypingCirculatingTumor2020; @paneaWholeGenomeLandscape2019; @russler-germainMutationsAssociatedProgression2023b]|| |
| ... | ... | @@ -332,7 +332,7 @@ link-citations: true |
| 332 | 332 | |
| 333 | 333 | ### *386 total* |
| 334 | 334 | |
| 335 | -|Gene|Tier| First DLBCL study | Other entities | QC result | |
|
| 335 | +|Gene|Summary| First DLBCL study | Other entities | QC result | |
|
| 336 | 336 | |:-:|:-:|:-:|:-|:-| |
| 337 | 337 | |[ABCA3](ABCA3)|Tier 3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]|[@beaLandscapeSomaticMutations2013]|| |
| 338 | 338 | |[ABCA4](ABCA4)|Tier 3|[Zhang et al](papers/zhangGeneticHeterogeneityDiffuse2013)[@zhangGeneticHeterogeneityDiffuse2013]||| |