BTG1.md
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|:--------:|:----------:|:--------:|:------------------------------------------------------------------------------------------:|:------------------:|
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|chr12 |92537999 |92539598|[TSS](https://genome.ucsc.edu/s/rdmorin/GAMBL%20hg19?position=chr12%3A92537999%2D92539598)|active_promoter |
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-> [!NOTE]
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-> First described in BL in 2022 by [Burkhardt B](https://pubmed.ncbi.nlm.nih.gov/35794096). First described in DLBCL in 2011 by [Morin RD](https://pubmed.ncbi.nlm.nih.gov/21796119)
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## BTG1 Hotspots
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*Q36H* Conditional knock-in mouse models expressing the BTG1 Q36H mutation in B cells have shown that these mutations lead to earlier onset of lymphoma, shorter survival, and dysplastic B cell infiltration into non-lymphoid organs. These findings reinforce the role of BTG1 mutations in enhancing lymphoma aggressiveness.<sup>3</sup>
Home.md
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## B-cell Lymphoma gene lists
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| entity | Tier 1 (high-confidence) | Tier 2 (low-confidence) |
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| ----- | ----------- | ---------- |
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-| DLBCL | [(152 genes)](tier1_dlbcl) |[(173 genes)](tier2_dlbcl) |
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-| FL | [(65 genes)](tier1_fl) |[(50 genes)](tier2_fl) |
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-| BL | [(29 genes)](tier1_bl) |[(188 genes)](tier2_bl) |
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-| MCL | [(24 genes)](tier1_mcl) |[(29 genes)](tier2_mcl) |
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+| DLBCL | [(128 genes)](DLBCL_genes#tier-1-dlbcl-genes) |[(198 genes)](DLBCL_genes#tier-2-dlbcl-genes) |
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+| FL | [(66 genes)](FL_genes#tier-1-fl-genes) |[(50 genes)](FL_genes#tier-2-fl-genes) |
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+| BL | [(29 genes)](BL_genes#tier-1-bl-genes) |[(157 genes)](BL_genes#tier-2-bl-genes) |
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+| MCL | [(23 genes)](MCL_genes#tier-1-mcl-genes) |[(46 genes)](MCL_genes#tier-2-mcl-genes) |
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## Origins of B-cell lymphoma gene lists
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TBL1XR1.md
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|FL |No |No |12.400 |18.940 |
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-> [!NOTE]
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-> First described in DLBCL in 2016 by [Mareschal S](https://pubmed.ncbi.nlm.nih.gov/26608593)
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## TBL1XR1 Hotspots
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| Chromosome |Coordinate (hg19) | ref>alt | HGVSp |